Support

 Dynamics, Structure, and Function in Biological Systems

Scientific opportunities at ASU Compact X-ray Free Electron Laser

Arizona State University

Biodesign Institute, Center for Applied Structural Discovery

Tempe, AZ

April 6-8, 2018

More information and registration can be found here.

Friday April 6

12:30   Light lunch in Biodesign Atrium, lower level

1:00     Welcome (Sethuraman “Panch” Panchanathan, ASU)

1:05     Intro to CXFEL: Updates on the design and current status (Bill Graves, ASU)

1:20     Experimental outline of the CXLS & CXFEL for discoveries in Biology (Petra Fromme, ASU)

1:40     Special modalities available with CXFEL (John Spence, ASU)

Session 1: Time resolved SFX (Chairs: Petra Fromme and Rick Kirian, ASU)

2:00     Marius Schmidt (UW-Milwaukee)

            Frontiers of macromolecular time resolved crystallography

2:20     Yun-Xing Wang (NCI/NIH)

            Studying RNA conformation change in crystals using XFEL

2:40     Emina Stojkovic (Northeastern Illinois University)

            Myxobacterial phytochromes at CXFEL

3:00     Summary and discussions led by the session chair

3:20     CXFEL Lab tours in Biodesign C and coffee break

Session 2: Electron diffraction methods and Synergies between CXFEL and large XFELs  

 (Chair: John Spence and Dewight Williams, ASU)

4:40     Tamir Gonen (UCLA)

            MicroED conception, practice and future opportunities

5:00     Brent Nannenga (ASU)

            MicroED method development

5:20     Summary and discussions led by the session chair 

6:00     Cocktails & Dinner at University Club

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Saturday April 7

8:30 Breakfast in Biodesign Atrium, lower level.

Workshop will be held in the Biodesign Auditorium, B 105

Session 3: Large and challenging biomolecules (Chairs: Po-Lin Chiu and Hao Yan, ASU)

9:00     Hasan DeMirci (Stanford Pulse Institute)

           Ambient temperature structures of classical and designer antibiotics reveal novel conformations in the ribosome

9:20     Dirksen Bussiere

            Structure-based drug design of the Eg5 Inhibitor NVP-BQS481                 

9:40     Jose Martin-Garcia (ASU)

           ASU CXLS/CXFEL: Breaking Frontiers in Structure Determination and Drug Discovery Science

10:00   Summary and discussions led by the session chair

10:20   Coffee Break

Session 4: Scattering from non-crystalline molecules and assemblies (Chair: Stuart Lindsay, ASU)

10:40   Michael Brown (UA)                                        

            Femtosecond Solution X-Ray Scattering of Membrane Proteins

11:00   Peter Schwander (UW-Milwaukee)

            From Single-Particle Ensembles to Energy Landscapes, Function and Dynamics

11:20   Tom Grant (U Buffalo)

            Solving the phase problem in solution scattering

11:40   Summary and discussions led by the session chair

12:00   Lunch brought in, Biodesign Atrium, lower level.

Session 5: Membrane proteins (Chairs: Brenda Hogue and Rebekka Wachter, ASU)

1:00     Vadim Cherezov (USC)

            Serial Femtosecond Crystallography of GPCRs

1:20     Wei Liu (ASU)

            GPCR-G protein complex studies by CXFEL

1:40     Raimund Fromme (ASU)

           Challenges and limits of membrane protein structure biology in times of X-ray Free Electron Lasers

2:00     Summary and discussions led by the session chair 

Session 6: Applications of tailored x-ray time structure (Chairs: Bill Graves and Uwe Weierstall, ASU)

2:20     Robert Fischetti (ANL APS)

            Monochromatic and Polychromatic Serial Crystallography and the APS-U

2:40     George Phillips (Rice U)  

            Back to the future: What to do with Compact X-ray sources

3:00     Edward Snell (U Buffalo)

           Brilliance, rate, and accessibility – Opportunities for structural biology with an XFEL in your back pocket

3:20     Summary and discussions led by the session chair

3:40     Coffee Break

4:00     Nadia Zatsepin (ASU)

            Low dose serial crystallography

4:20     Ed Lattman (U Buffalo)

           Time resolved diffuse scattering

4:40     Summary and discussions led by the session chair

6:00     Picnic dinner at Papago Park sponsored by the Biodesign Center for Applied Structural Discovery

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Sunday April 8

8:30 Breakfast in Biodesign Atrium, lower level

Workshop will be held in the Biodesign Auditorium, B 105

Session 7: X-ray spectroscopies and novel methods (Chairs: Oliver Beckstein, ASU)

9:00     Junko Yano (UC Berkeley)

            Soft X-ray spectroscopy of biological systems

9:20     Armin Wagner (Diamond Light Source)

            Tender X-rays – Adding Colours to Crystallography

9:40     Ganesh Subramanian (ASU)

            Monitoring Reactions by Spectroscopy: Attoseconds to seconds

10:00   Summary and discussions led by the session chair

10:20   Coffee Break

10:40   Chufeng Li (ASU) Pink beam MX

            PINK beam Serial Crystallography at synchrotron and CXLS

11:00   Alexandra Ros (ASU)

            Microfluidic Tools for XFELs

11:20   Summary and discussions led by the session chair

11:40   Bag lunch and adjourn