- ASU Hosts Nozzle Maker Workshop
- XFEL Science Highlighted in Nature
- BioXFEL researchers capture the highest-resolution protein snapshots ever taken with an X-ray laser, revealing new details in a well-studied protein that acts as an “eye” in bacteria.
- Science Director Dr. John Spence named Royal Society Fellow
- BioXFEL Graduate Student Joey Olmos (Rice) Earns NSF Graduate Research Fellowship
- Monday, 14 August 2017 11:27
A research collaboration led by the University of Wisconsin-Milwaukee has for the first time created a three-dimensional movie showing a virus preparing to infect a healthy cell.
The research has the potential to fundamentally advance our understanding of how biological processes inside the cell work. That could lead to better treatment for the horde of human diseases caused by viruses.
The feat was made possible by UWM physicists, who developed a new generation of powerful algorithms to reconstruct sequential images from an ocean of unsorted, noisy data.
- Thursday, 10 August 2017 10:13
BioXFEL scientist Vadim Cherezov and his colleagues released a new publication to CellPress:
X-ray free electron lasers (XFELs) have the potential to revolutionize macromolecular structural biology due to the unique combination of spatial coherence, extreme peak brilliance, and short duration of X-ray pulses. A recently emerged serial femtosecond (fs) crystallography (SFX) approach using XFEL radiation overcomes some of the biggest hurdles of traditional crystallography related to radiation damage through the diffraction-before-destruction principle.
- Tuesday, 08 August 2017 10:22
BioXFEL scientist Richard A. Kirian, along with his peers, published a research article onto IUCrj:
This study explores the capabilities of the Coherent X-ray Imaging Instrument at the Linac Coherent Light Source to image small biological samples. The weak signal from small samples puts a significant demand on the experiment. Aerosolized Omono River virus particles of ∼40 nm in diameter were injected into the submicrometre X-ray focus at a reduced pressure.
- Thursday, 03 August 2017 10:24
BioXFEL scientist Marc Messerschmidt, along with his colleagues, published a research article in OSA publishing.
Determining fluctuations in focus properties is essential for many experiments at Self-Amplified-Spontaneous-Emission (SASE) based Free-Electron-Lasers (FELs), in particular for imaging single non-crystalline biological particles.
- Tuesday, 01 August 2017 12:32
BioXFEL scientist Vadim Cherezov, along with others, publishes research article in ScienceDirect.
The nicotinamide nucleotide transhydrogenase (TH) is an integral membrane enzyme that uses the proton-motive force to drive hydride transfer from NADH to NADP+ in bacteria and eukaryotes.
Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody
- Thursday, 27 July 2017 11:06
Monoclonal antibodies provide an attractive alternative to small-molecule therapies for a wide range of diseases. Given the importance of G protein-coupled receptors (GPCRs) as pharmaceutical targets, there has been an immense interest in developing therapeutic monoclonal antibodies that act on GPCRs.
- FELIX: an algorithm for indexing multiple crystallites in X-ray free-electron laser snapshot diffraction images
- Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature
- New algorithms extract biological structure from limited data
- Pilus Machine: July PDB Molecule of the Month
- SLAC's Electron Hub Gets New 'Metro Map' for World's Most Powerful X-Ray Laser