- NSF awards $22.5 million to capture biology at the atomic level using X-ray lasers
- BioXFEL Research Support Call for Proposals
- UWM researchers create first 3D movie of virus in action
- Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature
- Protein structure determination using metagenome sequence data
- Wednesday, 06 May 2020
The Linac Coherent Light Source (LCLS), a directorate of SLAC and the world’s first hard x-ray free electron laser, seeks a Research Associate with a background in sample introduction for serial data collection to join the Sample Environment and Delivery group within the LCLS Hard X-Ray department.
- Friday, 24 April 2020
The Hauptman-Woodward Institute seeks a postdoctoral research scientist in the field of synthetic organic chemistry. The successful candidate will work within the National Science Foundation’s BioXFEL Science and Technology Center (www.bioxfel.org), a consortium of 13 research labs across the USA dedicated to the study of protein dynamics by time-resolved structural biology.
- Tuesday, 07 April 2020
A team of scientists from Sweden, Finland, Japan and the United States led by University of Gothenburg researcher Sebastian Westenhoff and BioXFEL member Marius Schmidt from the University of Wisconsin-Milwaukee have shown, for the first time with time-resolved X-ray structures, how photoreceptors in plants respond to light.
- Tuesday, 24 March 2020
BioXFEL scientist Dilano Saldin, Distinguished Professor of Physics of the University of Wisconsin-Milwaukee and Fellow of the American Physical Society, passed away on March 9, 2020 after a long illness. He will be greatly missed by his family, friends, and the scientific community. Below is his obituary.
Remembering Dilano Saldin
For four decades, Dilano made pioneering contributions to condensed matter physics, biophysics, electron optics, and mathematics - an unusual breadth by any measure. These contributions resulted in two US patents, an influential book on surface crystallography, and over 140 peer-reviewed scientific papers cited more than 3,000 times.
When Dilano joined the UWM Physics Department as an assistant professor in 1988, he was already internationally known for groundbreaking work on the interaction of electrons with solids, and for excellent contributions to electron holography. These were important, but difficult intellectual terrains, characteristics which were to become hallmarks of his long and distinguished academic career.
Dilano’s intellectual prowess and enthusiasm for new challenges counteracted the widespread fear of entering unfamiliar fields. He, in contrast, was always curious, and never too busy to discuss an idea, no matter how outlandish. He was one of the first to recognize the revolutionary implications of X-ray free electron lasers, rapidly making important theoretical contributions. This helped UWM exploit the new capabilities of X-ray lasers with agility and impact.
Dilano was a tactful organizer, leading the Department as Assistant Chair and then Chair, and serving as the Director of the Laboratory for Surface Science, Executive Editor of Surface Review and Letters, and a member of the editorial board of the Journal of Holography and Speckle.
His intellectual achievements notwithstanding, Dilano was most proud of his family. He was an attentive husband, and a caring father. We will sorely miss him. To us, he was family.
Fellow of the Royal Society Prof. John Spence writes: I worked with Dilano in Oxford from around 1975. He was a master of the theory of low-energy electron scattering in all its guises, a field to which he made important contributions. These included early work with John Pendry on diffuse LEED, invention of the holographic and tensor LEED methods, photoelectron holography, and X-ray and electron-beam near-edge structure. After early work with Mike Whelan at Oxford on the theory of diffraction contrast, he moved on to the theory of electron energy-loss spectroscopy and four-wave mixing methods, before becoming in involved with X-ray laser scattering.
Prof. Peter Rez writes: I probably knew Dilano longer than anyone. We were at the same North London Grammar School and then we were together in Oxford when I was doing my D. Phil. Dilano was a brilliant chess player. I remember he was the high school Chess Champion, and he would routinely play up to 8 games simultaneously. From what I remember he was the undefeated champion of our Oxford College’s Middle Common Room.
- Friday, 13 March 2020
Deutsches Elektronen-Synchrotron DESY
A Research Centre of the Helmholtz Association
For our location in Hamburg we are seeking:
Postdoc - Optical control of particles for serial crystallography
DESY is one of the world’s leading research centres for photon science, particle and astroparticle physics as well as accelerator physics. More than 2400 employees work at our two locations Hamburg and Zeuthen in science, technology and administration.
We offer an open, inclusive, and international environment with first-class facilities. We are located on a vibrant research campus together with the University of Hamburg Centre for Ultrafast lmaging.
The Coherent lmaging group at the Center for Free-Electron Laser Science, DESY, is developing methods to utilise revolutionary new sources such as X-ray free-electron lasers (XFELs) for obtaining structures of macromolecules at atomic resolution, at room temperature, to explore their dynamics and function. The group has the expertise in the development of sophisticated instrumentation and analysis methods for serial crystallography. lt develops sample delivery and characterisation techniques for biological materials, and new forms of microscopy, holography, and ptychography for the imaging of molecules to cells. The group extensively collaborates with leading structural biology groups throughout the world. One of our goals is to develop opto- fluidic approaches for the precise control of the delivery of protein microcrystals in megahertz serial crystallography experiments at the European XFEL. In collaboration with the Technische Universität Hamburg- Harburg (TUHH), we aim to control the trajectories of particles in microchannels using optical trapping or acoustics, for example, to synchronise them to X-ray pulses.
Develop principles and prototypes for opto-fluidic control of protein microcrystals in microfluidic systems Integrate diagnostics such as particle tracking into microfluidic systems
Create a compact system based on combining optical waveguides and fluid channels using laser-selective etching technology
Deploy operable sample delivery systems for experiments at the European XFEL
Ph.D. in physics, engineering or similar discipline
Background in optics, microfluidics, or velocimetry is preferred
Experience in fibre-based optical systems, instrument control, and machine vision preferred Self-motivated and work well in an interdisciplinary team environment
Very good communication skills in English Excellent interpersonal skills and a friendly nature
The position is limited to 2 years.
Salary and benefits are commensurate with those of public service organisations in Germany. Classification is based upon qualifications and assigned duties. Handicapped persons will be given preference to other equally qualified applicants. DESY operates flexible work schemes. DESY is an equal opportunity, affirmative action employer and encourages applications from women. Vacant positions at DESY are in general open to part-time- work. During each application procedure DESY will assess whether the post can be filled with part-time employees.
We are looking forward to your application via our application system: www.desy.de/onlineapplication
Deutsches Elektronen-Synchrotron DESY
Human Resources Department | Code: FSPO002/2020 Notkestraße 85 | 22607 Hamburg Germany
Phone: +49 40 8998-3392
Deadline for applications: 2020/03/20
- Monday, 02 March 2020
Melatonin discovery may help adjust biological clock
A recent study published in Nature involving a multi-institutional collaboration with BioXFEL researchers has produced novel drug candidates that may help with various sleep disorders. The drugs were designed based on the structure of a melatonin receptor which was published last year by BioXFEL researchers.