BioXFEL at 2017 LCLS Users' Meeting

BioXFEL was well represented at the LCLS/SSRL Users' Meeting with Henry Chapman giving a plenary talk on Serial Femtosecond Crystallography: Past, Present, and Future featuring snippets from data as recent as 24 hours before the talk.  David Bushnell, moderated a session that included the LCLS young investigator award and Linda Horton, Director of the Department of Energy Basic Energy Sciences Materials Science and Engineering Division. A meeting of the joint LCLS and SSRL Users Executive Committee took place with Linda Horton, Petra Fromme, David Bushnell and Edward Snell present.


BioXFEL ASU team among first user groups at Europe’s brightest light source

A team of BioXFEL ASU scientists led by Professor and STC Member Alexandra Ros in the School of Molecular Sciences and the Biodesign Center for Applied Structural Discovery, has been just the second user group to conduct experiments at the brand new European X-ray free electron laser facility (EuXFEL) in Hamburg, Germany. This 1.5-billion-dollar facility is the third, and by far the most powerful, X-ray laser in the world. After ten years of construction, it opened for first experiments just a month ago.


Dr. Abbas Ourmazd (UWM) joint papers cited in background of recent Nobel Prize in Chemistry

On October 4th, 2017, Drs. Jacques Dubochet (formerly of University of Lausanne in Switzerland), Joachim Frank (Columbia University), and Richard Henderson (British Medical Research Council’s Laboratory of Molecular Biology in Cambridge, UK) were awarded the Nobel Prize in Chemistry for developing cryo-electron microscopy (Cryo-EM) for the high resolution structure determination of biomolecules in solution. 


Puerto Rico Assistance Programs


On September 20th, Hurricane Maria made landfall over Puerto Rico and devastated the island. Weeks later, communications and basic necessities have still not been restored. It will likely take months to restore a sense of normalcy and years to fully recover.

In response to this disaster, BioXFEL has created 2 new programs to assist our friends and colleagues of Puerto Rico.


Europe’s X-ray laser fires up

Scientists who make movies of molecules in motion have a new high-speed camera to shoot with. The €1.2-billion (US$1.4-billion) European X-ray Free Electron Laser (XFEL) will start running its first experiments in September near Hamburg, Germany. The European XFEL fires powerful X-rays in bursts of a few hundred femtoseconds: so short that, like strobe lights, they can capture snapshots of jittery molecules frozen in time, and with a wavelength small enough to provide pictures at atomic resolution.


Structural enzymology using X-ray free electron lasers

Mix-and-inject serial crystallography (MISC) is a technique designed to image enzyme catalyzed reactions in which small protein crystals are mixed with a substrate just prior to being probed by an X-ray pulse. This approach offers several advantages over flow cell studies. It provides (i) room temperature structures at near atomic resolution, (ii) time resolution ranging from microseconds to seconds, and (iii) convenient reaction initiation.