Heterogeneity in M. tuberculosis β-lactamase inhibition by Sulbactam

In a paper just published in Nature Communications, a team of BioXFEL researchers and collaborators used mix-and-inject serial crystallography (MISC) to analyze the reaction of the β-lactamase BlaC from tuberculosis bacteria with the suicide inhibitor sulbactam (SUB).


Earliest molecular events of vision revealed

A large international team lead by Valerie Paneels and Gebhard Schertler revealed the molecular mechanism of light receptor activation in the eyes of vertebrae animals by time-resolved serial femtosecond crystallography (TR-SFX). The article appeared in Nature online on March 22 2023. BioXFEL researchers Schmidt and Stojković were invited to write a News and Views article summarizing the general findings focused on the light-activated bovine rhodopsin.

The News and Views article is available here:



Caption: The structure of the eye-pigment rhodopsin in the resting state. The retinal is shown in green in the 11-cis configuration. The retinal is bound via a Schiff-base to a lysine sidechain. BioXFEL researchers Schmidt and Stojković wrote a News and Views article in Nature summarizing newest results on the activation of rhodopsin by light.

2023 BioXFEL Conference


Click here for Conference Agenda


Click here for Welcome Packet  


The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its 10th Annual International Conference May 16 - 18, 2023. The "From Time-Resolved Structure Factor Amplitudes to Structure and Dynamics" workshop with Drs. Marius Schmidt, Sabine Botha, and Sebastian Westenhoff will be held May 15, 2023.


The BioXFEL Annual International Conference brings together experts in a variety of fields (structural biology, physics, biochemistry, and more) to discuss the most recent advances in structural biology using X-ray Free Electron Lasers (XFELs). The conference features talks by leading scientists in the field, a poster session, as well as networking, and professional development opportunities.




Conference Co-chairs:

Edward Snell (Hauptman-Woodward Institute)

Juan Lopez Garriga (University of Puerto Rico at Mayagüez)

Alexandra Ros (Arizona State University) 



***PLEASE NOTE: This list is being added to daily, so please check back to see the updated list as more presenters are added.***

Roberto Alonso Mori (Stanford)

Roberto Alvarez (ASU)

Thomas Barends (Max Planck Institute for Medical Research)

Shibom Basu (European Molecular Biology Laboratory)

Sabine Botha (Arizona State University)

Florian Dworkowski (Paul Scherrer Institute)

Hao Hu (Arizona State University)

Rebecca Jernigan (Arizona State University) (University of Arizona)

Robert Kaindl (Arizona State University)

Jan Kern (Lawrence Berkeley National Laboratory)

Matthias Kling (SLAC/Stanford University)

Juan Lopez-Garriga (University of Puerto Rico at Mayagüez)

Darya Marchany-Rivera (SLAC National Accelerator Laboratory)

Henrike Müller-Werkmeister (University of Potsdam)

Tek Narsingh Malla (University of Wisconsin-Milwaukee)

Lois Pollack (Cornell University)

Matthew Rodrigues (Paul Scherrer Institute)

Alexandra Ros (Arizona State University)

Christina Schmidt (Cornell)

Marius Schmidt (University of Wisconsin-Milwaukee)

Chenghua Shao (RCSB Protein Data Bank)

Megan Shelby (Lawrence Livermore National Laboratory)

Michael Steinmetz (Paul Scherrer Institute)

Emina Stojkovic (Northeastern Illinois University)

Mike Thompson (University of California Merced)

Raphael de Wijn (European XFEL)

Lainey Williamson (Cardiff University)

Sebastian Westenhoff (University of Gothenburg)

Kara Zielinski (Cornell)



Keynote Speaker:

Tabbetha Dobbins - Dept. of Physics & Astronomy (Rowan University)



Poster abstracts can be submitted using this format (download as a Microsoft Word file to edit) to Michael Logar at  This email address is being protected from spambots. You need JavaScript enabled to view it.  

by April 1st. Posters submitted by April 1st may be selected for a talk. We cannot guarantee that abstracts submitted after April 1st will be considered for a talk.

A scientific poster session will be held during the evening on Tuesday, May 16th. 

Poster sizing requirements are 40" x 32" or less.

For BioXFEL members, please download the following template to use for your poster.


Registration Fees:

For more information to register click HERE.  


To Be a Sponsor or Exhibitor: 

Please look over our Sponsorship Brochure and contact Michael Logar at  This email address is being protected from spambots. You need JavaScript enabled to view it.  or 716-898-8594 for more information.


New Education & Diversity Director

Nicole Terranova has a career background in secondary education. She taught biology in California for 17 years, assisted in creating her school district’s Next Generation Science Standards curriculum, developed social-emotional course content and student leadership curriculum content and activities while heading school events and student recognition programs. She completed her undergraduate work in zoology at University of California at Santa Barbara, obtained her teaching credential at California State University at Northridge, and acquired her masters in Curriculum and Instruction at California State University at Bakersfield. She’s looking forward to creating an effective community outreach program in Buffalo that helps more women and underrepresented minorities get into and excel in STEM career fields.

Nicole has two children who are the never-ending source of fun and love that fuel her energetic spirit. Going on adventures with them and vicariously living their childhood with them is the source of her happiness. She likes to play guitar and dabbles in art in her spare time. She also enjoys spending her time outside hiking and enjoying nature. Nicole is an animal enthusiast, and has worked at wildlife rescues, pet stores, and veterinary clinics. She’s traveled to Australia, Mexico, Canada, most states in the U.S., but is hoping to visit Europe in the near future.

Dr. Edward Snell elected as American Crystallographic Association Fellow

Congratulations to Edward Snell on being elected as American Crystallographic Association Fellow!

The American Crystallographic Association – the Structural Science Society – established the Fellows distinction to recognize a high level of excellence in scientific research, teaching, and professional duties, but also service, leadership, and personal engagement in the world of crystallography and science. The Fellows distinction celebrates the excellence of American Crystallographic Association members and promotes their recognition worldwide to constituencies outside, such as their employers, other scientific societies, and the government. Fellows serve as scientific ambassadors to the broader scientific community and the general public to advance science education, research, knowledge, interaction, and collaboration.

Drs. Edward Snell (Chief Executive Officer and President of the Hauptman Woodward Medical Research Institute) was elected fellow of the American Crystallographic Association – The Structural Science Society. 

A Fellow is defined as “a Member whose efforts on behalf of the advancement of crystallography or its applications that are scientifically or socially distinguished.” Examples of areas in which nominees may have made significant contributions are research; teaching; technology; services to professional societies; administration in academia, industry, and government; and communicating and interpreting science to the public. Fellows are elected annually by the current group of Fellows.

Drs. Snell is proud to be joining the ACA Fellow ranks, which include three Nobel laureates. Dr. Snell was “both humbled and honored by this recognition”.  As engaging and active member of the ACA for many years, he is an exemplary scientist and mentor, visionary leader, and strong champions of crystallography and structural science.” It demonstrates the impact of structural biology in Buffalo and its recognition nationally.

Structural biology is solved -- now what?

The splendid computational success of AlphaFold and RoseTTAFold in solving the 60-year-old problem of protein folding raises an obvious question: what new avenues should structural biology explore? We propose a strong pivot toward the goal of reading mechanism and function directly from the amino acid sequence.