News

BioXFEL researchers uncover details of key drug target regulating blood pressure

Designing molecules that selectively bind to a specific receptor type is often challenging, but can be crucial for different therapeutic purposes. Both angiotensin II receptors are important drug targets, since the blockade of AT1R has anti-hypertensive effects, while the modulation of AT2R could be useful for cardioprotection, neuropathic pain relief and the treatment of several other conditions.

Read more...

The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography

Phytochromes are a family of photoreceptors that control light responses of plants, fungi and bacteria. A sequence of structural changes, which is not yet fully understood, leads to activation of an output domain. Time-resolved serial femtosecond crystallography (SFX) can potentially shine light on these conformational changes. Here we report the room temperature crystal structure of the chromophore-binding domains of the Deinococcus radiodurans phytochrome at 2.1 Å resolution.

Read more...

Crystallization of Membrane Proteins in Lipidic Mesophases

Membrane proteins perform critical functions in living cells related to signal transduction, transport and energy transformations, and, as such, are implicated in a multitude of malfunctions and diseases. However, a structural and functional understanding of membrane proteins is strongly lagging behind that of their soluble partners, mainly, due to difficulties associated with their solubilization and generation of diffraction quality crystals.

Read more...

NSF BioXFEL STC Postdoctoral Research Award granted to Benjamin Stauch and Ahmad Hosseinizadeh

The BioXFEL Center is proud to announce the recipients of the Postdoctoral Research Award, Benjamin Stauch and Ahmad Hosseinizadeh. Dr. Stauch is a Postdoctoral Research Associate in the group of Prof. Vadim Cherezov at the Bridge Institute of the University of Southern California in Los Angeles. He received his Master’s degree in Bioinformatics from the University of Frankfurt (Germany) in 2007 and carried out his doctoral research within the EMBL International Ph.D. Programme at EMBL Heidelberg (Germany) and the University of Cambridge (UK) where he obtained a Ph.D. in Biology in 2013.

Read more...

Native phasing of x-ray free-electron laser data for a G protein–coupled receptor

Serial femtosecond crystallography (SFX) takes advantage of extremely bright and ultrashort pulses produced by x-ray free-electron lasers (XFELs), allowing for the collection of high-resolution diffraction intensities from micrometer-sized crystals at room temperature with minimal radiation damage, using the principle of “diffraction-before-destruction.” However, de novo structure factor phase determination using XFELs has been difficult so far.

Read more...

Job Opening: Research Specialist

Arizona State University is currently seeking a research specialist. This position in experimental biophysics would assist scientists in collecting experimental data at the Linac Coherent Light Source (LCLS) X-ray laser near Stanford University, as part of the BioXFEL project https://www.bioxfel.org/.  The job is based at ASU in Tempe, but there will be travel to the LCLS several times a year.  This position would also assist in fabrication of sample delivery devices in the biophysics laboratories of the BioXFEL program.

Read more...