- Science Director Dr. John Spence named Royal Society Fellow
- BioXFEL Graduate Student Joey Olmos (Rice) Earns NSF Graduate Research Fellowship
- NSF BioXFEL researchers create a better way to find out ‘when’
- Mapping Conformational Landscape Through Crystallography
- Taking the initiative on single particle imaging
- Tuesday, 28 February 2017 05:53
X-ray Free Electron Lasers (XFELs) have advanced research in structure biology, by exploiting their ultra-short and bright X-ray pulses. The resulting “diffraction before destruction” experimental approach allows data collection to outrun radiation damage, a crucial factor that has often limited resolution in the structure determination of biological molecules.
- Thursday, 23 February 2017 06:35
The room temperature structure of natively formed protein nanocrystals consisting of 9,000 unit cells has been solved to 2 Å resolution using an unattenuated X-ray free-electron laser (XFEL) beam, representing, by far, the smallest protein crystals used for protein structure determination by X-ray crystallography to date.
Markelz receives $1.35 million to study molecules’ vibrations, opening new possibilities for an emerging field
- Tuesday, 21 February 2017 06:46
Molecules vibrate and resonate. These vibrations enable life to function, they are believed to play a role in photosynthesis in plants and protein folding in general. BioXFEL participant and University at Buffalo physicist Andrea Markelz has recently been awarded $1.35 million in grants, from the Department of Energy and National Science Foundation, to research the nature these vibrations in protein, and to develop instrumentation that aids other researchers doing the same.
- Thursday, 16 February 2017 07:19
Membrane protein perform a variety of functions vital to the survival of an organism. As a result understanding how they work and why they malfunction has been an interest of researchers. However determination of membrane protein structures has remained a challenge in large part due to the difficulty in establishing experimental conditions where the correct conformation of the protein in isolation from its native environment is preserved. This is partly due to the fact that detergents are often used to separate the protein from their lipid membrane encasing. Detergents often also strip away fat molecules crucial to stabilizing the protein. Researchers at the University of Toronto have discovered a new method for stabilizing membrane protein using a polymer originally developed for the auto industry.
- Thursday, 09 February 2017 08:06
A new set of machine learning algorithms developed by University of Toronto researchers allows for quicker and more reliable generation of 3D structures of protein molecules. The algorithms could potentially revolutionize the development of drug therapies for a range of diseases, from Alzheimer's to cancer.
- Tuesday, 07 February 2017 07:52
A new insight into how viruses replicated based on X-ray crystallography work by a team at Thomas Jefferson University could ultimately lead to new antiviral drugs to treat pathogenic DNA viruses.
- Shanghai team develops 'world's brightest VUV free-electron laser'
- Thank You for Another Succesful BioXFEL Conference
- BioXFEL Jazz Trio Performed Live at Caesar’s Palace
- Seeding x-ray free electron lasers with customized electron beams produces incredibly stable laser pulses
- Synthetic nanoparticles achieve the complexity of protein molecules