Real-time molecular scale observation of crystal formation

How molecules in solution form crystal nuclei, which then grow into large crystals, is a poorly understood phenomenon. The classical mechanism of homogeneous crystal nucleation proceeds via the spontaneous random aggregation of species from liquid or solution. However, a non-classical mechanism suggests the formation of an amorphous dense phase that reorders to form stable crystal nuclei. So far it has remained an experimental challenge to observe the formation of crystal nuclei from five to thirty molecules.


Researchers Develop New Way To See Proteins In Motion

A new imaging technique to see proteins live in motion has been developed. The feat achieved by researchers at the UT Southwestern Medical Center comes as a response to electric field pulses and X-rays acting on protein particles.

Given that subtle motions govern protein functions that take place on nano time scales of trillionths of a second, the study offers great potential in knowing how proteins work.


Researchers capture membrane protein folding for first time in 3D and at single-atom level

Membrane proteins are popular drug targets, as they are exposed to the environment surrounding the cell. Capturing their movements in video, the authors say, is potentially a revolutionary step forward in drug development. 


Nature article provides insight toward structural basis for riboswitch gene regulation mechanism

Yun-Xing Wang in collaboration with BioXFEL Researchers, publishes new article "Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography" in Nature. 


BioXFEL STC 4th Annual International Conference


The BioXFEL National Science Foundation Science and Technology Center is pleased to announce that it will be hosting its fourth annual international conference in Las Vegas, NV January 10th - 12th, 2017 


Faculty Postion - University at Buffalo

The University at Buffalo seeks applications and nominations to fill a newly created, full professor position in the area, broadly defined, of the use of x-ray lasers in life sciences, chemistry, or materials sciences. Appointment will be made in an appropriate School and Department, depending on the background and desires of the candidate. The successful candidate will also be a key leader in the BioXFEL Center ( ).