Markelz receives $1.35 million to study molecules’ vibrations, opening new possibilities for an emerging field

Molecules vibrate and resonate. These vibrations enable life to function, they are believed to play a role in photosynthesis in plants and protein folding in general. BioXFEL participant and University at Buffalo physicist Andrea Markelz has recently been awarded $1.35 million in grants, from the Department of Energy and National Science Foundation, to research the nature these vibrations in protein, and to develop instrumentation that aids other researchers doing the same.


New way to discover structures of membrane proteins

Membrane protein perform a variety of functions vital to the survival of an organism. As a result understanding how they work and why they malfunction has been an interest of researchers. However determination of membrane protein structures has remained a challenge in large part due to the difficulty in establishing experimental conditions where the correct conformation of the protein in isolation from its native environment is preserved. This is partly due to the fact that detergents are often used to separate the protein from their lipid membrane encasing. Detergents often also strip away fat molecules crucial to stabilizing the protein. Researchers at the University of Toronto have discovered a new method for stabilizing membrane protein using a polymer originally developed for the auto industry. 


Nature article sheds light on new machine learning algorithms for protein structure predicition

A new set of machine learning algorithms developed by University of Toronto researchers allows for quicker and more reliable generation of 3D structures of protein molecules. The algorithms could potentially revolutionize the development of drug therapies for a range of diseases, from Alzheimer's to cancer.


Measure by measure: X-rays show viral transformation

Viral multiplication

A new insight into how viruses replicated based on X-ray crystallography work by a team at Thomas Jefferson University could ultimately lead to new antiviral drugs to treat pathogenic DNA viruses.


Shanghai team develops 'world's brightest VUV free-electron laser'

Scientists completing a new free-electron laser (FEL) in China say that the facility now delivers the world’s brightest source of light in the vacuum ultraviolet (VUV) spectral region, yielding a tool with unprecedented scientific utility.

The Dalian Coherent Light Source (DCLS) is said to be the only high-gain FEL user facility operating exclusively in the VUV, and after nearly five years in development it produces a photon flux of 1.4 x 1014 photons per pulse.


Thank You for Another Succesful BioXFEL Conference

Thank You for Your Attendance and Sponsorship of the 4th BioXFEL Conference and Single Particle Sample Delivery Workshop

We would like to thank you for your attendance of the SP Workshop and 4th Annual Conference.  Specifically, we would like to thank our Program Chairs & Committee for putting together an excellent meeting as well as the speakers and session chairs who made it such a resounding success.  We’d also like to thank our vendors and sponsors:  Rayonix, Formulatrix, Molecular Dimensions, and Structural Dynamics for their contributions.  We are honored that you continue to support us.