Positions posted based on availability.
Beamline Scientist, I24
Diamond Light Source is the UK’s national synchrotron science facility. Located at Harwell Science & Innovation Campus in Oxfordshire, we enable world-leading research across a wide range of scientific disciplines and industrial applications.
The Microfocus Macromolecular Crystallography beamline I24 provides a high flux (>10^12 ph/s), versatile X-ray beam (5 - 100 µm). A bespoke end-station, automated sample exchange and two detectors: a silicon Pilatus and new CdTe Eiger, combine to provide a state-of-the-art MX beamline. I24 offers users conventional pin-based cryo-crystallography, room temperature experiments, and serial crystallography of microcrystals. We aim to be at the forefront of MX, developing new approaches for the most demanding structural biology problems, for example through serial approaches which have been successfully used at X-ray free electron laser (XFEL) sources such as SACLA, while the recent addition of a CdTe detector opens up a new field of high energy MX.
We are looking to recruit a motivated beamline scientist will work closely with the Principal Beamline Scientist in the continuing development of the beamline including design, procurement, construction, commissioning of upgrades as well as ongoing user support. The Beamline Scientist will take an active role in developing new techniques for microfocus data collection and serial sample delivery at I24. Areas currently under active development include implementation of serial techniques both at synchrotrons and XFELs, dynamic crystallography and high energy microfocus data collection. I24 is a well-established, world-leading beamline and this position represents an exciting opportunity to play a key role in I24’s evolution at a time when both methods and sources are evolving rapidly. The successful candidate will be expected to develop an internationally competitive research program in methods development or structural biology that complements the research and development activities at I24 and the Diamond MX village that includes several beamlines and the UK XFEL hub.
Where relevant, and possible for the role, we will consider flexible working arrangements and secondment opportunities.
Diamond attract talented individuals from around the world and currently employ 39 different nationalities. Reflecting trends in our sector we employ more men than women (78% men and 22% women as at 5 April 2019). Therefore, in accordance with law and good practice, we particularly welcome applications from suitably qualified women.
If you are disabled and would like to be considered under the Guaranteed Interview Scheme, please let us know via the online application process.
Diamond are members of Working Families (the UK’s work-life balance organisation), we have also achieved the Athena SWAN Bronze award and Disability Confident Level One.
Postdoctoral Research Scholar
We are currently looking for a new PostDoc to join our serial crystallography data analysis team at Arizona State University.
For more information please see the job posting at https://apply.interfolio.com/69791 or contact John Spence,
To apply, please send electronically to http://apply.interfolio.com/69791 the following materials: (a) a cover letter, (b) a CV, (c) a publication list, (d) a detailed summary of research experience and interests, and (e) 3 reference letters.
Postdoctoral position for XFEL crystallography/spectroscopy at Berkeley Lab
We are looking for a postdoctoral fellow to study metalloenzymes using X-ray crystallography and spectroscopy at X-ray free electron lasers. The fellow will work in the Kern/Yachandra/Yano group (http://www2.lbl.gov/vkyachan/ and http://biosciences.lbl.gov/profiles/jan-florian-kern/) at Berkeley Lab’s Molecular Biophysics & Integrated Bioimaging Division. We have been conducting a number of XFEL experiments on several different systems and recent publications include:
Chatterjee et al J Synchr Rad 2019 https://onlinelibrary.wiley.com/doi/abs/10.1107/S1600577519007550
Kern et al, Nature 2018 https://www.nature.com/articles/s41586-018-0681-2
Fuller et al, Nature Methods 2017 http://www.nature.com/nmeth/journal/v14/n4/abs/nmeth.4195.html
Kubin et al Structural Dynamics 2017 https://aca.scitation.org/doi/10.1063/1.4986627
Young et al Nature 2016 https://www.nature.com/nature/journal/v540/n7633/full/nature20161.html
Ideally the candidate should have a good background in one or more of the following fields:
- Macromolecular crystallography
- X-ray spectroscopy of dilute transition metal systems/biological systems.
- Design of experimental setups for use at synchrotron/X-ray free laser facilities.
Details of the position and instructions on how to apply can be found here:
Multiple Job Openings at Uppsala University
We are a constellation of young scientists at Uppsala University interested in bioimaging with X-ray lasers.
We have been part several seminal experiments which created the field and are now looking to fill several open positions to create the team that can take the next step!
Research Beamline Scientist - Argonne National Lab
20146 Biochem/Mol Bio
About the Unit
BioCARS is a national user facility for synchrotron-based, dynamic studies in structural biology, located at Sector 14 of the Advanced Photon Source, at Argonne National Laboratory. BioCARS is an integral part of the multi-disciplinary Center for Advanced Radiation Sources (CARS) run by the University of Chicago. The mission of BioCARS is to provide state-of-the-art X-ray and laser facilities, scientific and technical expertise and support to enable national and international scientists to study the dynamic properties of biological systems by X-ray scattering techniques such as time-resolved diffraction and SAXS/WAXS. The overall goal of user experiments is to understand basic biological and biochemical processes in structural and dynamic terms, at the level of atomic resolution and on a time scale from 100 picoseconds to seconds. Scientific problems addressed by BioCARS are fundamental to highly relevant biomedical problems and of practical importance to both pharmaceutical and biotechnological industries.
Responsible for all aspects of research projects and research facilities. Plans and conducts clinical and non-clinical research; facilitates and monitors daily activities of clinical trials or research projects. Directs engineering and technical support activities to develop and maintain tools and computational methods needed to gather and analyze data.
Oversees all aspects of management, scientific technological development, and operations for major research projects or research facilities. Ensures compliance of research activities with institutional, state, and federal regulatory policies, procedures, directives and mandates. Writes articles, reports and manuscripts. Presents research findings at meetings and/or conferences.
P2: Requires knowledge and experience in own discipline; still acquiring higher-level knowledge and skills. Builds knowledge of the organization, processes and customers. Solves a range of straightforward problems. Analyzes possible solutions using standard procedures. Receives a moderate level of guidance and direction.
The job participates in scientific research projects. Ensures compliance of research activities with institutional, state, and federal regulatory policies, procedures, directives and mandates. Analyzes possible solutions using standard procedures. Writes articles, reports and manuscripts. Assists in drafting presentations on research findings.
1) Applies research principles and relevant subject matter knowledge relevant to administer a research project. With a moderate level of direction, manages lab and/or research-related duties and tasks. Helps develop, design and conduct research projects according to plan., 2) Supports data collection and analytical needs of research projects. Conducts literature reviews and helps write reports and manuscripts. Ensures project compliance with different policies, procedures, directives, and mandates., 3) Takes responsibility for the following non-laboratory duties: transcribing and coding data; developing data collection instruments; presenting research; and recruiting and scheduling research subjects. Acquires higher-level skills and knowledge in the process., 4) Takes responsibility for the following laboratory duties: recognizing abnormal results and varying conditions or procedures to correct problems; setting up and performing experiments. Analyze the meaning, significance, causes, and effects of the subject., 5) Performs other related work as needed.
1) Participate in the development and implementation of instrumentation and software for advanced experimental methods in the area of time-resolved X-ray diffraction and solution scattering.
2) Participate in beamline instrumentation maintenance, particularly with ns and ps laser systems, as well as software improvements and development.
3) Provide support and collaborate with users on experiment planning, design and implementation, and data processing and analysis.
4) Assist the BioCARS user community in using the BioCARS facilities.
5) Participate in disseminating BioCARS accomplishments in peer reviewed and other publications, present findings at meetings, participate in workshops to train new scientific users.
6) BioCARS staff members support national and international scientists conducting experiments at the APS. This requires occasional evening and weekend support.
1) Knowledge and experience with ultrafast femtosecond and picosecond laser systems is highly desirable.
2) Knowledge of X-ray optics, detectors, electronics and other synchrotron instrumentation is desirable.
3) Excellent experimental skills to develop advanced instrumentation for ultrafast time-resolved x-ray scattering experiments.
4) Considerable skill in advanced data analysis algorithms and methods.
5) Excellent skill is problem-solving, written and oral communications.
Education, Experience, and Certifications
Minimum requirements include a college or university degree in related field.
Minimum requirements include knowledge and skills developed through 2-5 years of work experience in a related job discipline.
1) Ph.D. in physics, biophysics, physical chemistry, biochemistry or a related field.
1) Experience in X-ray scattering field or ultrafast femtosecond and picosecond laser systems is desirable.
2) Experience in synchrotron instrumentation and beamline controls software is desirable. Excellent relevant computer skills.
3) Ability to work well independently and as a team member. Good organizational and communication skills essential.
Multiple Job Openings at Universität Hamburg: “Cluster of Excellence 'Advanced Imaging of Matter' - Structural Dynamics of Surface Catalytic Reactions investigated at X-ray Free-Electron Lasers”
With the new X-ray free-electron lasers in Hamburg, FLASH at DESY and the European XFEL, it is now possible to perform real-time investigations of the geometric structure during surface chemical reactions.
College of Letters and Science
Department of Physics
Research Associate Position
September 25, 2018
The Department of Physics at the University of Wisconsin-Milwaukee (UWM) seeks an outstanding candidate for a post-doctoral position in the group of Prof. Marius Schmidt to begin as soon as possible. The successful applicant will become part of an interdisciplinary team at the UWM that aims to solve important biological questions using ultra-brilliant, pulsed X-ray sources such as newest generation synchrotron light sources and the expanding global network of free-electron X-ray laser facilities (XFELs, see e.g. Tenboer et al., 2014, Science; Pande et al. 2016, Science; Olmos et al., 2018, BMC-Biology). The successful candidate will have the opportunity to be productive with significant national and international recognition, collaborate with the team of UWM faculty supported by the BioXFEL National Science Foundation (NFS)-Science and Technology Center (STC), and work collaboratively in the STC - a consortium of eight universities across the U.S. including University of Buffalo, Arizona State, Cornell, Stanford, UCSF, Rice, Miami of Ohio, and UWM. Beamtime opportunities at the LCLS and other XFELs (European XFEL, SwissFEL, SACLA) are available within the group and within the BioXFEL STC network. This is a unique opportunity to enter this highly innovative field of research. Research areas of interest include, but are not limited to: time-resolved crystallography, molecular biology, biophysics, time-resolved optical spectroscopy, X-ray diffraction and imaging, and enzymology. UWM is in the Milwaukee metropolitan area, at Lake Michigan, close to the Chicago greater area. Minimum Qualifications: • Doctorate in (Bio)Physics, Biology, (Bio)Chemistry or a related field. • A demonstrated record of research accomplishments (papers). • Willingness to travel to synchrotrons and free electron X-ray lasers in the US, Europe and Japan to collect data. • Familiarity with use of computers, and basic programming skills are required.
Please also check https://uwm.edu/physics/people/schmidt-marius/ and http://people.uwm.edu/smarius/.
Postdoctoral Research Scholar (Job # 12921)
DEPARTMENT OF PHYSICS
ARIZONA STATE UNIVERSITY
The department of Physics at Arizona State University seeks applicants for a postdoctoral research scholar to work in the field of biological sample delivery for X-ray lasers.
ASU is situated near Phoenix, Arizona, and is one of the largest universities in the United States. Recently ranked as one of the top 100 research universities in the world, its 40 Physics department faculty work mainly in Biophysics, Nano and Materials Science, Cosmology and Particle Astrophysics, and hold many honors (http://physics.asu.edu). It is also home the Beyond Center (http://beyond.asu.edu).
The initial review of applications will begin July 2, 2019 if not filled; applications will be reviewed every week thereafter until the search is closed.
A background check is required for employment.
Arizona State University is a VEVRAA Federal Contractor and an Equal Opportunity Affirmative Action Employer. All qualified applicants will be considered without regard to race, color, sex, religion, national origin, disability, protected veteran status, or any other basis protected by law. https://www.asu.edu/aad/manuals/acd/acd401.html. https://www.asu.edu/titleIX.
In compliance with federal law, ASU prepares an annual report on campus security and fire safety programs and resources. ASU’s Annual Security and Fire Safety Report is available online at https://www.asu.edu/police/PDFs/ASU-Clery-Report.pdf. You may request a hard copy of the report by contacting the ASU Police Department at 480-965-3456.