BioXFEL’s mission is to broaden the scientific community’s exposure to the development of new techniques for observing molecular machines. Utilizing the capabilities of X-ray free electron lasers, we will work to develop the tools and software applications needed to expand this knowledge outward. These applications will be applied to a wide range of scientific inquiry, including the studies of photosynthesis, enzyme function at the atomic level and drug-delivery proteins.

OnDA Solution Scattering Monitoring Software

Background description here:


Video tutorial




Download link for .pdf of manual.

Beam Times

Serial Crystallography

Serial Crystallography at LCLS - Resources and tutorial





Single Particles


Data Archives (Single Particles and Nanocrystals)

CXIDB - Practice Datasets from LCLS

Visualizing Crystallographic Concepts

XRay View

Key for types of experiment:

SFX = serial fs crystallography in liquid jet; LCP SFX = lipidic cubic phase SFX; TR = time resolved; 2DX = 2D crystals; FixT = Fixed target; phasing = shape transforms / high intensity / SAD ; SP = single particle; SAXS/WAXS = small/wide angle X-ray scattering; SMX = serial millisecond crystallography, usually with slow jet at synchrotron; FSS = fast solution scattering ; CSX = correlated Xray scattering; SFD = serial fiber diffraction

BioXFEL Beamtime Archive

X-ray Free Electron Lasers

X-ray Free Electron Lasers (XFEL) produce a stream of unimaginably intense X-rays and in unimaginably short pulses, so intense and so rapid that they can capture the fastest biological processes. X-ray Free Electron Lasers offer a unique and exciting opportunity to explore biological mechanisms in areas that were previously thought impossible.



The BioXFEL Center benefits from the research performed at several major universities and laboratories. Here you'll find the descriptions of these projects and the laboratories leading them.