What's New: Past Month


Articles feed

  1. Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptide

    Structural analysis of membrane proteins has traditionally been bottlenecked by the lack of sufficiently large amounts of pure, properly folded and functional membrane proteins. The issue is …


  2. XFEL Resources for Researchers

    LCLS Beam-time Schedules BioXFEL Beamtime Archive *All BioXFEL publications should acknowledge NSF STC award number 1231306 Serial Crystallography Serial Crystallography at LCLS - Resources …


  3. BioXFELbb Mailing List

    Welcome to the new BioXFELbb Mailing List! The purpose of this board is to facilitate communication between members of the biological XFEL community regarding topics related to:  - sample …


  4. NSF Site Visit 2017

     4th Annual National Science Foundation Site Visit The annual site visit for the BioXFEL NSF Science and Technology Center will be hosted at the Hauptman-Woodward Institute in Buffalo, NY from May …


  5. Solution Scattering at XFELs

    OnDA Solution Scattering enables real-time analysis of solution scattering data at XFELs.  Originally designed for serial crystallography by Valerio Mariani at CFEL, OnDA enables real-time …


  6. BioXFEL collaborator Henry Chapman receives 2017 Roentgen Medal

    DESY scientist Henry Chapman has been awarded the Roentgen Medal by the city of Remscheid. The town in which Wilhelm Conrad Roentgen was born has been presenting this award annually since 1951 to …


  7. Youtube Channel Resources

    Resources from the official BioXFEL youtube channel. This channel's mission is to broaden the scientific community’s exposure to the development of new techniques for observing molecular machines. …


  8. Patents

    BioXFEL researchers are pioneering new methods of sample delivery, nano crystallization, and other technologies. We have patented several of our key developments to enable our industrial partners to …


  9. Data Analysis Workshops

    Serial crystallography is a rapidly growing field with a correspondingly rapidly growing user base. One of the main bottlenecks in serial crystallography is the ability to rapidly filter and analyze …


  10. Viscous Jet Supply for Non-Center Members

    LCP injectors offer advantages over liquid injectors in areas including sample consumption and native crystallization environment for membrane proteins. These viscous jets are now regularly used by …


  11. XFEL Crystal Blaser Educational Game

    BioXFEL member and undergraduate researcher, Fiacre Kabayiza, has created a game to help educate school-aged students on the topic of XFEL science. Employing a simple, yet engaging, tap-based …


  12. BioXFEL researchers uncover details of key drug target regulating blood pressure

    Designing molecules that selectively bind to a specific receptor type is often challenging, but can be crucial for different therapeutic purposes. Both angiotensin II receptors are important drug …


  13. The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography

    Phytochromes are a family of photoreceptors that control light responses of plants, fungi and bacteria. A sequence of structural changes, which is not yet fully understood, leads to activation of an …


  14. Crystallization of Membrane Proteins in Lipidic Mesophases

    Membrane proteins perform critical functions in living cells related to signal transduction, transport and energy transformations, and, as such, are implicated in a multitude of malfunctions and …


  15. NSF BioXFEL STC Postdoctoral Research Award granted to Benjamin Stauch and Ahmad Hosseinizadeh

    The BioXFEL Center is proud to announce the recipients of the Postdoctoral Research Award, Benjamin Stauch and Ahmad Hosseinizadeh. Dr. Stauch is a Postdoctoral Research Associate in the group of …


  16. Native phasing of x-ray free-electron laser data for a G protein–coupled receptor

    Serial femtosecond crystallography (SFX) takes advantage of extremely bright and ultrashort pulses produced by x-ray free-electron lasers (XFELs), allowing for the collection of high-resolution …


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Resources feed

  1. Diffraction data of core-shell nanoparticles from an X-ray free electron laser

    11 Apr 2017 | BioXFEL Publications | Contributor(s): Xuanxuan Li, Chun-Ya Chiu, Hsiang-Ju Wang, Stephan Kassemeyer, Sabine Botha, Robert L. Shoeman, Robert M Lawrence, Christopher Kupitz, Richard Kirian, Daniel James, Dingjie Wang, Garrett Charles Nelson, Marc Messerschmidt, Sébastien Boutet, Garth J. Williams, Elisabeth Hartmann, Aliakbar Jafarpour, Lutz M. Foucar, Anton Barty, Henry Chapman, Mengning Liang, Andreas Menzel, Fenglin Wang, Shibom Basu, Raimund Fromme, R. Bruce Doak, Petra Fromme, Uwe Weierstall, Michael H. Huang, John Spence, Ilme Schlichting, Brenda Hogue, Haiguang Liu

    http://dx.doi.org/10.1038/sdata.2017.48 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Li, X. et al., 2017. Diffraction data of core-shell nanoparticles from an X-ray free electron …


  2. Experimental strategies for imaging bioparticles with femtosecond hard X-ray pulses

    07 Apr 2017 | BioXFEL Publications | Contributor(s): Benedikt J. Daurer, Kenta Okamoto, Johan Bielecki, Filipe R. N. C. Maia, Kerstin Mühlig, M. Marvin Seibert, Max F. Hantke, Carl Nettelblad, W. Henry Benner, Martin Svenda, Nicuşor Tîmneanu, Tomas Ekeberg, N. Duane Loh, Alberto Pietrini, Alessandro Zani, Asawari D. Rath, Daniel Westphal, Richard Kirian, Salah Awel, Max Oliver Wiedorn, Gijs Van Der Schot, Gunilla H. Carlsson, Dirk Hasse, Jonas A. Sellberg, Anton Barty, Jakob Andreasson, Sébastien Boutet, Garth Williams, Jason Koglin, Inger Andersson, Janos Hajdu, Daniel S. D. Larsson

    http://dx.doi.org/10.1107/s2052252517003591 This study explores the capabilities of the Coherent X-ray Imaging Instrument at the Linac Coherent Light Source to image small biological samples. The …


  3. Structural basis for selectivity and diversity in angiotensin II receptors

    04 Apr 2017 | BioXFEL Publications | Contributor(s): Haitao Zhang, Gye Won Han, Alexander Batyuk, Andrii Ishchenko, Kate L. White, Nilkanth N Patel, Anastasiia Sadybekov, Beata Zamlynny, Michael T. Rudd, Kaspar Hollenstein, Alexandra Tolstikova, Thomas A. White, Mark S. Hunter, Uwe Weierstall, Wei Liu, Kerim Babaoglu, Eric L. Moore, Ryan D. Katz, Jennifer M. Shipman, Margarita Garcia-Calvo, Sujata Sharma, Payal Sheth, Stephen M. Soisson, Raymond C. Stevens, Vsevolod Katritch, Vadim Cherezov

    http://dx.doi.org/10.1038/nature22035 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Zhang, H. et al., 2017. Structural basis for selectivity and diversity in angiotensin II …


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