Home (bioxfel-2017)

  • UB has been awarded $4.5 million to hire world-class scholars whose work will boost the university’s research enterprise and educational offerings while enhancing innovation in the Buffalo Niagara region. The funding is comprised of three grants from SUNY’s Empire Innovation Program, which helps institutions recruit senior faculty members with trac...
  • X-ray crystallography, the workhorse of structural biology, has been revolutionized by the advent of serial femtosecond crystallography using X-ray free electron lasers. Here, the fast pace and history of discoveries are discussed together with current challenges and the method's great potential to make new structural discoveries, such as the abili...
  • Cherezov lab members in association with researchers from The Scripps Research Institute, Moscow Institute of Physics and Technology, and Institute of Complex Systems have designed, synthesized, and characterized a series of chemically stable lipids resistant to hydrolysis capable of forming a lipidic cubic phase. The phase properties and lattice p...
  • Crystal structure determination of biological macromolecules using the novel technique of serial femtosecond crystallography (SFX) is severely limited by the scarcity of X-ray free-electron laser (XFEL) sources. However, recent and future upgrades render microfocus beamlines at synchrotron-radiation sources suitable for room-temperature serial crys...
  • X-ray crystallography at X-ray free-electron laser sources is a powerful method for studying macromolecules at biologically relevant temperatures. Moreover, when combined with complementary techniques like X-ray emission spectroscopy, both global structures and chemical properties of metalloenzymes can be obtained concurrently, providing insights i...
  • Although protein design has been used to introduce new functions, designed variants generally only function as well as natural proteins after rounds of laboratory evolution. One possibility for this pattern is that designed mutants frequently sample nonfunctional conformations.
  • Burrowed deep under the foothills near Palo Alto, Calif., scientists scurried through an underground laboratory, making final preparations for a series of explosions. THEIR PLAN: blow up tiny crystals of proteins that could reveal one of nature's best-kept secrets—how plant photosynthesis turns light into chemical energy. The potential payoff: a st...
  • Nearly all protein functions require structural change, such as enzymes clamping onto substrates, and ion channels opening and closing. These motions are a target for possible new therapies; however, the control mechanisms are under debate. Calculations have indicated protein vibrations enable structural change. However, previous measurements found...
  • X-ray free-electron lasers provide novel opportunities to conduct single particle analysis on nanoscale particles. Coherent diffractive imaging experiments were performed at the Linac Coherent Light Source (LCLS), SLAC National Laboratory, exposing single inorganic core-shell nanoparticles to femtosecond hard-X-ray pulses.
  • Abbas Ourmazd, a UWM distinguished professor of physics, has been appointed to serve on the Basic Energy Sciences Advisory Committee (BESAC) of the U.S. Department of Energy (DOE). The 25-member committee has a substantial impact on national scientific programs, supporting more than 2,500 principal investigators in physics, chemistry, geology and b...
  • Structural analysis of membrane proteins has traditionally been bottlenecked by the lack of sufficiently large amounts of pure, properly folded and functional membrane proteins. The issue is particularly important considering the fact that membrane proteins constitute a significant proportion of clinical drug targets.
  • DESY scientist Henry Chapman has been awarded the Roentgen Medal by the city of Remscheid. The town in which Wilhelm Conrad Roentgen was born has been presenting this award annually since 1951 to individuals who have made outstanding contributions towards improving and advancing the use of the radiation discovered by Roentgen. Henry Chapman, a Lead...

Latest @BioXFEL

  • Designing molecules that selectively bind to a specific receptor type is often challenging, but can be crucial for different therapeutic purposes. Both angiotensin II receptors are important drug targets, since the blockade of AT1R has anti-hypertensive effects, while the modulation of AT2R could be useful for cardioprotection, neuropathic pain rel...
  • Yun-Xing Wang in collaboration with BioXFEL Researchers, publishes new article "Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography" in Nature. 
  • BioXFEL member and undergraduate researcher, Fiacre Kabayiza, has created a game to help educate school-aged students on the topic of XFEL science. Employing a simple, yet engaging, tap-based gameplay and a time-proven minimal 8-bit graphical art style, he delivers a game that introduces tweens and teens to XFELs, structure determination, and the s...
  • X-ray crystallography is a technique that can be used by scientists to map the 3-dimensional physical space of proteins and other biological molecules to an atomic level of detail. Over the last four decades or so, this technique has been used to map over 100,000 protein structures that can be found in the publicly accessible Protein Data Bank, wit...
  • Researchers for years have been attempting to look at ultrafast motions at the atomic level, for example how light gets transferred into energy by plants during photosynthesis. Finally, with the use of an X-ray Free Electron Laser at Stanford, NSF BioXFEL Science and Technology researchers and collaborators from three other universities have been...
  • NSF BioXFEL researchers create a better way to find out ‘when’ An international team of physicists has created a machine-learning algorithm that improves the accuracy of timing estimates by a factor of up to 300, helping to determine when an event actually happened.

Mailing List

Resources

Video Library

Events

News

Publications