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In a paper just published in Nature Communications, a team of BioXFEL researchers and collaborators used mix-and-inject serial crystallography (MISC) to analyze the reaction of the β-lactamase BlaC from tuberculosis bacteria with the suicide inhibitor sulbactam (SUB). -
A large international team lead by Valerie Paneels and Gebhard Schertler revealed the molecular mechanism of light receptor activation in the eyes of vertebrae animals by time-resolved serial femtosecond crystallography (TR-SFX). The article appeared in Nature online on March 22 2023. BioXFEL researchers Schmidt and Stojković were invited to write ... -
Click here for Conference Agenda Click here for Welcome Packet The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its 10th Annual International Conference May 16 - 18, 2023. The "From Time-Resolved Structure Factor Amplitudes to Structure and Dynamics" workshop with Drs.... -
Nicole Terranova has a career background in secondary education. She taught biology in California for 17 years, assisted in creating her school district’s Next Generation Science Standards curriculum, developed social-emotional course content and student leadership curriculum content and activities while heading school events and student recognitio... -
Congratulations to Edward Snell on being elected as American Crystallographic Association Fellow! The American Crystallographic Association – the Structural Science Society – established the Fellows distinction to recognize a high level of excellence in scientific research, teaching, and professional duties, but also service, leadership, and perso... -
PostDoctoral Associate in Cheminformatics, Structural Chemistry (Rutgers) RCSB Protein Data Bank is seeking a highly motivated postdoctoral researcher with domain expertise in organometallic complexes. The successful candidate will work on the metalloprotein remediation project that leads to modernized and uniform data representation of PDB entrie... -
The splendid computational success of AlphaFold and RoseTTAFold in solving the 60-year-old problem of protein folding raises an obvious question: what new avenues should structural biology explore? We propose a strong pivot toward the goal of reading mechanism and function directly from the amino acid sequence. -
Brookhaven National Laboratory (www.bnl.gov) delivers discovery science and transformative technology to power and secure the nation's future. Brookhaven Lab is a multidisciplinary laboratory with seven Nobel Prize-winning discoveries, 37 R&D 100 Awards, and more than 70 years of pioneering research. The Lab is primarily supported by the U.S. D... -
The structural dynamics of a molecule are determined by the underlying potential energy landscape. Conical intersections are funnels connecting otherwise separate potential energy surfaces. Posited almost a century ago, conical intersections remain the subject of intense scientific interest. -
Research. Enzyme function is potentially linked to the entire protein conformational space sampled by enzyme and enzyme-intermediate complexes during catalysis. Importantly, this holds for lowly populated conformational sub-spaces of higher free energy, which can differ distinctly from the lowest free energy conformational sub-space typically captu... -
Search for Assistant Professor in Biophysics at the University of Wisconsin Milwaukee The University of Wisconsin-Milwaukee (UWM), a research intensive premier public urban university committed to academic excellence, is located in the commercial and industrial hub of Wisconsin. -
The XFEL Hub at Diamond Light Source is seeking a Beamline Scientist for a full time, permanent position. This person will help with the activities of the Hub and its mission to enable and promote dynamic structural biology at Diamond and at X-ray Free Electron Lasers (XFELs).
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Sabine Botha is a Postdoctoral Research Scholar in the group of Prof. John Spence at Arizona State University. She completed her undergraduate education and masters program at the University of Oxford (UK) in Engineering Science, specializing in Biomedical and Information Engineering. -
The NSF BioXFEL Science and Technology Center has funding intended to support research at US institutions. This support is for the application of X-ray free electron lasers to structural biology in collaboration with the BioXFEL STC. -
This Special Issue, “Novel Structural Studies of Coronavirus Proteins”, will gather both research and review articles from experts in the field with the ultimate goal of creating an international platform that provides with rich and reference information on the latest advances and exciting discoveries in the field of X-ray crystallography. -
The European X-Ray Free-Electron Laser Facility (European XFEL, https://www.xfel.eu) encourages the scientific community worldwide to submit proposals for User Experiments via the User Portal to the European XFEL (UPEX) until Wednesday, 16 December 2020 16:00 (local Hamburg/Schenefeld time - CET) Beamtime will be allocated to successful proposals ... -
An international group of researchers led by data scientists at the University of Wisconsin-Milwaukee have applied a machine learning technique they developed to substantially reduce the uncertainty in gestational age estimation. -
A team of scientists from Sweden, Finland, Japan and the United States led by University of Gothenburg researcher Sebastian Westenhoff and BioXFEL member Marius Schmidt from the University of Wisconsin-Milwaukee have shown, for the first time with time-resolved X-ray structures, how photoreceptors in plants respond to light.
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The BioXFEL Science and Technology Center encompasses wide areas of scientific and technical expertise. We strive to reflect our communities and make opportunities available by embracing diversity in people as well as ideas. We aim to ensure the broadest representation expertise and opportunity for education driving our science and building the scientific community for the future.
