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  • The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its sixth annual international conference in San Diego, CA February 12th - 14th, 2019. Our annual External Advisors Meeting will be held Monday, Feb 11th.
  • BioXFEL was well represented at the LCLS/SSRL Users' Meeting with Henry Chapman giving a plenary talk on Serial Femtosecond Crystallography: Past, Present, and Future featuring snippets from data as recent as 24 hours before the talk.  David Bushnell, moderated a session that included the LCLS young investigator award and Linda Horton, Director of ...
  • Scientists who make movies of molecules in motion have a new high-speed camera to shoot with. The €1.2-billion (US$1.4-billion) European X-ray Free Electron Laser (XFEL) will start running its first experiments in September near Hamburg, Germany. The European XFEL fires powerful X-rays in bursts of a few hundred femtoseconds: so short that, like st...
  • Mix-and-inject serial crystallography (MISC) is a technique designed to image enzyme catalyzed reactions in which small protein crystals are mixed with a substrate just prior to being probed by an X-ray pulse. This approach offers several advantages over flow cell studies. It provides (i) room temperature structures at near atomic resolution, (ii) ...
  • BioXFEL researcher Peter Schwander released a publication, along with his peers, to Nature Methods Using a manifold-based analysis of experimental diffraction snapshots from an X-ray free electron laser, we determine the three-dimensional structure and conformational landscape of the PR772 virus to a detector-limited resolution of 9 nm. Our result...
  • A research collaboration led by the University of Wisconsin-Milwaukee has for the first time created a three-dimensional movie showing a virus preparing to infect a healthy cell. The research has the potential to fundamentally advance our understanding of how biological processes inside the cell work. That could lead to better treatment for the ho...
  • BioXFEL scientist Vadim Cherezov and his colleagues released a new publication to CellPress: X-ray free electron lasers (XFELs) have the potential to revolutionize macromolecular structural biology due to the unique combination of spatial coherence, extreme peak brilliance, and short duration of X-ray pulses. A recently emerged serial femtosecond ...
  • BioXFEL scientist Richard A. Kirian, along with his peers, published a research article onto IUCrj: This study explores the capabilities of the Coherent X-ray Imaging Instrument at the Linac Coherent Light Source to image small biological samples. The weak signal from small samples puts a significant demand on the experiment. Aerosolized Omono Riv...
  • BioXFEL scientist Marc Messerschmidt, along with his colleagues, published a research article in OSA publishing. Summary: Determining fluctuations in focus properties is essential for many experiments at Self-Amplified-Spontaneous-Emission (SASE) based Free-Electron-Lasers (FELs), in particular for imaging single non-crystalline biological partic...
  • BioXFEL scientist Vadim Cherezov, along with others, publishes research article in ScienceDirect. Abstract: The nicotinamide nucleotide transhydrogenase (TH) is an integral membrane enzyme that uses the proton-motive force to drive hydride transfer from NADH to NADP+ in bacteria and eukaryotes.
  • Monoclonal antibodies provide an attractive alternative to small-molecule therapies for a wide range of diseases. Given the importance of G protein-coupled receptors (GPCRs) as pharmaceutical targets, there has been an immense interest in developing therapeutic monoclonal antibodies that act on GPCRs.
  • A novel algorithm for indexing multiple crystals in snapshot X-ray diffraction images, especially suited for serial crystallography data, is presented. The algorithm, FELIX, utilizes a generalized parametrization of the Rodrigues–Frank space, in which all crystal systems can be represented without singularities.

Latest @BioXFEL

  • A team of researchers, led by scientists from DESY, has demonstrated the successful use of a new type of liquid jet at high pulse repetition rates at FLASH. The study shows that liquid jets recover in time for the next pulse even at very short inter-pulse times of only 220 nanoseconds. Furthermore, the researchers conducted the first crystal diffra...
  • In September of 2017, Hurricane Maria hit Puerto Rico with 175 mph winds, cutting the island in half and unleashing torrents of rain and devastation. Now, almost a year later, Buffalo is helping displaced students rebuild their education while Puerto Rico is still rebuilding from the storm.
  • The BioXFEL External Conference & Professional Development Travel Scholarship was created to support the continuing education of our BioXFEL Scholars. BioXFEL encourages its students and postdocs to attend external conference and workshops that will benefit their career progression and professional development. This scholarship will support up ...
  • Discover Magazine has done a feature on the National Science Foundation's Science and Technology Center Program.  Below is an excerpt regarding BioXFEL.  Read full article here.
  • Job description: DOE funded postdoc position for the study of photosynthesis proteins and enzymes using terahertz light. We are seeking a highly independent and skilled researcher to join our effort to establish THz techniques that characterize protein structural dynamics. The position involves instrumentation development, sample preparation and...
  • New research published today in Nature Methods by BioXFEL researcher Tom Grant opens up new avenues for studying the structures of particles floating in solution.  Typically, molecular structures are determined using a technique known as crystallography, where molecules are chemically induced to align next to each other in a large 3D lattice.

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