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  • Burrowed deep under the foothills near Palo Alto, Calif., scientists scurried through an underground laboratory, making final preparations for a series of explosions. THEIR PLAN: blow up tiny crystals of proteins that could reveal one of nature's best-kept secrets—how plant photosynthesis turns light into chemical energy. The potential payoff: a st...
  • Nearly all protein functions require structural change, such as enzymes clamping onto substrates, and ion channels opening and closing. These motions are a target for possible new therapies; however, the control mechanisms are under debate. Calculations have indicated protein vibrations enable structural change. However, previous measurements found...
  • X-ray free-electron lasers provide novel opportunities to conduct single particle analysis on nanoscale particles. Coherent diffractive imaging experiments were performed at the Linac Coherent Light Source (LCLS), SLAC National Laboratory, exposing single inorganic core-shell nanoparticles to femtosecond hard-X-ray pulses.
  • Abbas Ourmazd, a UWM distinguished professor of physics, has been appointed to serve on the Basic Energy Sciences Advisory Committee (BESAC) of the U.S. Department of Energy (DOE). The 25-member committee has a substantial impact on national scientific programs, supporting more than 2,500 principal investigators in physics, chemistry, geology and b...
  • Structural analysis of membrane proteins has traditionally been bottlenecked by the lack of sufficiently large amounts of pure, properly folded and functional membrane proteins. The issue is particularly important considering the fact that membrane proteins constitute a significant proportion of clinical drug targets.
  • DESY scientist Henry Chapman has been awarded the Roentgen Medal by the city of Remscheid. The town in which Wilhelm Conrad Roentgen was born has been presenting this award annually since 1951 to individuals who have made outstanding contributions towards improving and advancing the use of the radiation discovered by Roentgen. Henry Chapman, a Lead...
  • Phytochromes are a family of photoreceptors that control light responses of plants, fungi and bacteria. A sequence of structural changes, which is not yet fully understood, leads to activation of an output domain. Time-resolved serial femtosecond crystallography (SFX) can potentially shine light on these conformational changes. Here we report the r...
  • Membrane proteins perform critical functions in living cells related to signal transduction, transport and energy transformations, and, as such, are implicated in a multitude of malfunctions and diseases. However, a structural and functional understanding of membrane proteins is strongly lagging behind that of their soluble partners, mainly, due to...
  • The BioXFEL Center is proud to announce the recipients of the Postdoctoral Research Award, Benjamin Stauch and Ahmad Hosseinizadeh. Dr. Stauch is a Postdoctoral Research Associate in the group of Prof. Vadim Cherezov at the Bridge Institute of the University of Southern California in Los Angeles. He received his Master’s degree in Bioinformatics fr...
  • Serial femtosecond crystallography (SFX) takes advantage of extremely bright and ultrashort pulses produced by x-ray free-electron lasers (XFELs), allowing for the collection of high-resolution diffraction intensities from micrometer-sized crystals at room temperature with minimal radiation damage, using the principle of “diffraction-before-destruc...
  • Arizona State University is currently seeking a research specialist. This position in experimental biophysics would assist scientists in collecting experimental data at the Linac Coherent Light Source (LCLS) X-ray laser near Stanford University, as part of the BioXFEL project https://www.bioxfel.org/.  The job is based at ASU in Tempe, but there ...
  • Describing the multiple conformations of proteins is important for understanding the relationship between molecular flexibility and function. However, most methods for interpreting data from X-ray crystallography focus on building a single structure of the protein, which limits the potential for biological insights. Here we introduce an improved al...

Latest @BioXFEL

  • Designing molecules that selectively bind to a specific receptor type is often challenging, but can be crucial for different therapeutic purposes. Both angiotensin II receptors are important drug targets, since the blockade of AT1R has anti-hypertensive effects, while the modulation of AT2R could be useful for cardioprotection, neuropathic pain rel...
  • Yun-Xing Wang in collaboration with BioXFEL Researchers, publishes new article "Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography" in Nature. 
  • BioXFEL member and undergraduate researcher, Fiacre Kabayiza, has created a game to help educate school-aged students on the topic of XFEL science. Employing a simple, yet engaging, tap-based gameplay and a time-proven minimal 8-bit graphical art style, he delivers a game that introduces tweens and teens to XFELs, structure determination, and the s...
  • X-ray crystallography is a technique that can be used by scientists to map the 3-dimensional physical space of proteins and other biological molecules to an atomic level of detail. Over the last four decades or so, this technique has been used to map over 100,000 protein structures that can be found in the publicly accessible Protein Data Bank, wit...
  • Researchers for years have been attempting to look at ultrafast motions at the atomic level, for example how light gets transferred into energy by plants during photosynthesis. Finally, with the use of an X-ray Free Electron Laser at Stanford, NSF BioXFEL Science and Technology researchers and collaborators from three other universities have been...
  • NSF BioXFEL researchers create a better way to find out ‘when’ An international team of physicists has created a machine-learning algorithm that improves the accuracy of timing estimates by a factor of up to 300, helping to determine when an event actually happened.

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