Science Director Dr. John Spence named Royal Society Fellow

Professor John Spence ForMemRS

BioXFEL Scientific Director Dr. John Spece has been appointed fellow of the prestigious Royal Society for his innovative world-leading contributions to both biology and materials science.


BioXFEL Graduate Student Joey Olmos (Rice) Earns NSF Graduate Research Fellowship

Joey Olmos, graduate student in Dr. Phillips lab at Rice University, has received the prestigious NSF Graduate Research Fellowship. Only 2,000 students across the country were offered this fellowship award from more than 16,000 applicants.


Structural biologist named president of UK Royal Society

 A Nobel-prizewinning structural biologist will be the next president of the Royal Society, the United Kingdom's pre-eminent scientific institution. Venkatraman (Venki) Ramakrishnan will take over from geneticist Paul Nurse, also a Nobel laureate, on 1 December.


Mapping Conformational Landscape Through Crystallography

Determining the interconverting conformations of dynamic proteins in atomic detail is a major challenge for structural biology. Conformational heterogeneity in the active site of the dynamic enzyme cyclophilin A (CypA) has been previously linked to its catalytic function. Here we compare the conformational ensembles of CypA by fixed-target X-ray free electron laser (XFEL) crystallography and multitemperature synchrotron crystallography.


3-D snapshot of protein highlights potential drug target for breast cancer

3-D snapshot of protein highlights potential drug target for breast cancerThe genome of a cell is under constant attack, suffering DNA damage that requires an army of repair mechanisms to keep the cell healthy and alive. Understanding the behavior of the enzymes defending these assaults helps determine how - and where - cancer gets its foothold and flourishes. New research published in an Advance Online Publication of Nature Structural & Molecular Biology shows that one of these enzymes - human DNA polymerase theta (POLQ) - may be a promising drug therapy target for inhibiting breast cancer.


The DOE Office of Science Graduate Student Research (SCGSR) Program is Now Accepting Applications

The SCGSR program supports supplemental awards to outstanding U.S. graduate students to conduct part of their graduate thesis research at a DOE national laboratory in collaboration with a DOE laboratory scientist for a period of 3 to 12 consecutive months—with the goal of preparing graduate students for scientific and technical careers critically important to the DOE Office of Science mission.