News

2015 IUCr Crystal Growing Competition for Schoolchildren

Following the great success of the IYCr2014 competition, the IUCr announces the 2015 edition of a worldwide competition, open to all schoolchildren, to introduce students to the exciting, challenging and sometimes frustrating world of growing crystals. The winners will be those who most successfully convey their experiences to the panel of judges in a video report.

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Towards time-resolved serial crystallography in a microfluidic device.

Serial methods for crystallography have the potential to enable dynamic structural studies of protein targets that have been resistant to single-crystal strategies. The use of serial data-collection strategies can circumvent challenges associated with radiation damage and repeated reaction initiation. This work utilizes a microfluidic crystallization platform for the serial time-resolved Laue diffraction analysis of macroscopic crystals of photoactive yellow protein (PYP).

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Dr. Petra Fromme Investigates Potential Tularemia Vaccine

A team of experts led by Petra Fromme, BioXFEL Co-PI and director of Arizona State University’s Center for Membrane Proteins in Infectious Diseases, is examining a key component responsible for the infectious character of tularemia, where the pathogen involved could be used as a biological weapon.

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Special Issue of Structural Dynamics "Biology with X-ray Lasers 2"

Structural Dynamics has recently published a special issue devoted to Biology with X-ray Lasers.  Containing several articles from BioXFEL researchers and presented at the 2nd International BioXFEL Conference held in Puerto Rico in January, this special issue acts as the proceedings from this highly successful meeting.

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Phenix workshop at Rice University now available online

Videos from the 2015 Phenix Workshop at Rice University held on April 9th and 10th are now available online through BioXFEL.org. Phenix developers Pavel Afonine, Paul Adams, and Tom Terwilliger discuss topics such as experimental phasing, molecular replacement, structure refinement, and model validation.

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Room temperature structures beyond 1.5 Å by serial femtosecond crystallography

We push the resolution of macromolecular serial femtosecond crystallography to 1.46 Å. Anisotropic B-factor refinement starts to become possible with SFX data at that resolution. The structures show little to no evidence of radiation damage even at ambient temperatures and are comparable to ultrahigh (atomic) resolution structures.

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