- Science Director Dr. John Spence named Royal Society Fellow
- BioXFEL Graduate Student Joey Olmos (Rice) Earns NSF Graduate Research Fellowship
- NSF BioXFEL researchers create a better way to find out ‘when’
- Mapping Conformational Landscape Through Crystallography
- Taking the initiative on single particle imaging
Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody
- Thursday, 27 July 2017 11:06
Monoclonal antibodies provide an attractive alternative to small-molecule therapies for a wide range of diseases. Given the importance of G protein-coupled receptors (GPCRs) as pharmaceutical targets, there has been an immense interest in developing therapeutic monoclonal antibodies that act on GPCRs.
FELIX: an algorithm for indexing multiple crystallites in X-ray free-electron laser snapshot diffraction images
- Tuesday, 25 July 2017 11:26
A novel algorithm for indexing multiple crystals in snapshot X-ray diffraction images, especially suited for serial crystallography data, is presented. The algorithm, FELIX, utilizes a generalized parametrization of the Rodrigues–Frank space, in which all crystal systems can be represented without singularities.
Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature
- Tuesday, 18 July 2017 13:34
Cytochrome c oxidase (CcO), the terminal enzyme in the electron transfer chain, translocates protons across the inner mitochondrial membrane by harnessing the free energy generated by the reduction of oxygen to water.
- Wednesday, 12 July 2017 12:16
Understanding the 3D molecular structure of important nano-objects like proteins and viruses is crucial in biology and medicine. With recent advances in X-ray technology, scientists can now collect diffraction images from individual particles, ultimately allowing researchers to visualize molecules at room temperature.
- Tuesday, 11 July 2017 11:53
Bacteria live in complex ecologies, filled with competitors, environmental dangers, and defensive hosts. They face these challenges in many ways: by gathering together into tough biofilm communities, by sharing genetic information encoding useful proteins, and by picking up and moving when things look better elsewhere.
- Friday, 07 July 2017 11:01
The central hub for powerful electron beams at the Department of Energy’s SLAC National Accelerator Laboratory is getting a makeover to prepare for the installation of LCLS-II – a major upgrade to the Linac Coherent Light Source (LCLS), the world’s first hard X-ray free-electron laser. LCLS-II will deliver the most powerful X-rays ever made in a lab, with beams that are 10,000 times brighter than before, opening up unprecedented research opportunities in chemistry, materials science, biology and energy research.
- European XFEL enters operation phase
- Adenine Riboswitch in Action
- X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex
- Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography
- UB receives $4.5 million from SUNY to recruit top faculty