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Metals in Structural Biology Workshop

Metals in protein environments can confer unique reactivity, and challenging chemistry often involves complex metallocofactors. Synchrotron-based techniques enable experiments that closely measure and monitor metal active site geometry and protein structure.  For redox-active crystal samples on which X-ray diffraction data is obtained, parallel spectroscopic methods are being increasingly used to investigate whether the observed 3-dimensional structure is in an enzymatically active or inactive state, as well as whether the metal oxidation state has been altered in the X-ray beam. In this workshop on Metals in Structural Biology we will emphasize the use of spectroscopic methods and crystallography to study metalloenzyme structure and function.

• Organizers:  Sarah Bowman (HWI), Aina Cohen (SLAC/SSRL), Jennifer Wierman (SLAC/SSRL)

• Invited Speakers:

Elizabeth Wittenborn (UC Berkeley)
Akif Tezcan (UC San Diego)
Gloria Borgstahl (U Nebraska Medical Center)
Kelly Chacon (Reed College)
Roseanne Sension (U Michigan)
Tim Stemmler (Wayne State U)
Nozomi Ando (Cornell U)
Ailiena Maggiolo (Caltech)

• Panelists:

Graham George (U Saskatchewan)
Tom Poulos (UC Irvine)
Sarah Bowman (HWI)

Point of contact:  Sarah Bowman sbowman@hwi.buffalo.edu

For more information click HERE.