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Examples of Biological Small Angle Scattering

By Eaton E Lattman1, Thomas D. Grant, Edward Snell2

1. Department of Structural Biology, SUNY Buffalo 2. Hauptman-Woodward Medical Research Institute - SUNY Buffalo

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Category

BioXFEL Publications

Published on

Type

book

Author

Eaton E. Lattman and Thomas D. Grant and Edward H. Snell

Citation

Lattman, E.E., Grant, T.D. & Snell, E.H., 2018. Examples of Biological Small Angle Scattering. Oxford Scholarship Online. Available at: http://dx.doi.org/10.1093/oso/9780199670871.003.0012.

Abstract

In this chapter we illustrate the biological applications of small angle scattering. We cover examples of contrast matching has been used in the neutron case and with SAXS,. time-resolved studies that have helped reveal mechanism and how SAXS or SANS as a solution technique can access information missing from other studies, in particular residues that may be crystallographically undefined. We show examples of puting known structural information in context, and following large-scale functional changes or show when distinct populations co-exist in solution. The list of examples provided is not exhaustive and should be seen as a glimpse of the potential of biological mechanisms where SAXS or SANS can provide unique information complementary to other methods and help define function and mechanism.

DOI

http://dx.doi.org/10.1093/oso/9780199670871.003.0012