Crystal Cryocooling Distorts Conformational Heterogeneity in a Model Michaelis Complex of DHFR

By Daniel A. Keedy, Henry Van den Bedem, David A. Sivak, Gregory A. Petsko, Dagmar Ringe1, Mark A. Wilson, James S. Fraser

1. Brandeis University

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Published on

Type

journal-article

Author

Daniel A. Keedy and Henry van den Bedem and David A. Sivak and Gregory A. Petsko and Dagmar Ringe and Mark A. Wilson and James S. Fraser

Citation

Keedy, D.A. et al., 2014. Crystal Cryocooling Distorts Conformational Heterogeneity in a Model Michaelis Complex of DHFR. Structure, 22(6), pp.899–910. Available at: http://dx.doi.org/10.1016/j.str.2014.04.016.

DOI

Funding

NSF-STC Biology with X-ray Lasers (NSF-1231306)