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Pump-Probe Time-Resolved Serial Femtosecond Crystallography at X-Ray Free Electron Lasers

By Suraj Pandey1, Ishwor Poudyal1, Tek Narsingh Malla1

1. University of Wisconsin - Milwaukee

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Category

BioXFEL Publications

Published on

Type

journal-article

Author

Suraj Pandey and Ishwor Poudyal and Tek Narsingh Malla

Citation

Pandey, S., Poudyal, I. & Malla, T.N., 2020. Pump-Probe Time-Resolved Serial Femtosecond Crystallography at X-Ray Free Electron Lasers. Crystals, 10(7), p.628. Available at: http://dx.doi.org/10.3390/cryst10070628.

Abstract

With time-resolved crystallography (TRX), it is possible to follow the reaction dynamics in biological macromolecules by investigating the structure of transient states along the reaction coordinate. X-ray free electron lasers (XFELs) have enabled TRX experiments on previously uncharted femtosecond timescales. Here, we review the recent developments, opportunities, and challenges of pump-probe TRX at XFELs.

DOI

http://dx.doi.org/10.3390/cryst10070628

Funding

NSF-STC Biology with X-ray Lasers (NSF-1231306)