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An 81 base-pair deletion in SARS-CoV-2 ORF7a identified from sentinel surveillance in Arizona (Jan-Mar 2020)

By LaRinda A. Holland, Emily A. Kaelin, Rabia Maqsood, Bereket Estifanos, Lily I. Wu, Arvind Varsani, Rolf U. Halden, Brenda Hogue1, Matthew Scotch, Efrem S. Lim

1. Arizona State University

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Category

BioXFEL Publications

Published on

Type

posted-content

Author

LaRinda A. Holland and Emily A. Kaelin and Rabia Maqsood and Bereket Estifanos and Lily I. Wu and Arvind Varsani and Rolf U. Halden and Brenda G. Hogue and Matthew Scotch and Efrem S. Lim

Citation

Holland, L.A. et al., 2020. An 81 base-pair deletion in SARS-CoV-2 ORF7a identified from sentinel surveillance in Arizona (Jan-Mar 2020). Available at: http://dx.doi.org/10.1101/2020.04.17.20069641.

Abstract

On January 26 2020, the first Coronavirus Disease 2019 (COVID-19) case was reported in Arizona of an individual with travel history (3rd case in the US) (1). Here, we report on early SARS-CoV-2 sentinel surveillance in Tempe, Arizona (USA). Genomic characterization identified an isolate encoding a 27 amino acid in-frame deletion in accessory protein ORF7a, the ortholog of SARS-CoV immune antagonist ORF7a/X4.

DOI

http://dx.doi.org/10.1101/2020.04.17.20069641

Funding

NSF-STC Biology with X-ray Lasers (NSF-1231306)