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Advances in methods for atomic resolution macromolecular structure determination

By Michael Thompson1, Todd O. Yeates, Jose A. Rodriguez

1. University of California - San Francisco

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Category

BioXFEL Publications

Published on

Type

journal-article

Author

Michael C. Thompson and Todd O. Yeates and Jose A. Rodriguez

Citation

Thompson, M.C., Yeates, T.O. & Rodriguez, J.A., 2020. Advances in methods for atomic resolution macromolecular structure determination. F1000Research, 9, p.667. Available at: http://dx.doi.org/10.12688/f1000research.25097.1.

Abstract

Recent technical advances have dramatically increased the power and scope of structural biology. New developments in high-resolution cryo-electron microscopy, serial X-ray crystallography, and electron diffraction have been especially transformative. Here we highlight some of the latest advances and current challenges at the frontiers of atomic resolution methods for elucidating the structures and dynamical properties of macromolecules and their complexes.

DOI

http://dx.doi.org/10.12688/f1000research.25097.1

Funding

NSF-STC Biology with X-ray Lasers (NSF-1231306)