GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A<sub>2A</sub> Adenosine Receptor
Category
Published on
Type
journal-article
Author
Anna Shiriaeva and Daejin Park and Gyudong Kim and Yoonji Lee and Xiyan Hou and Dnyandev B. Jarhad and Gibae Kim and Jinha Yu and Young Eum Hyun and Woomi Kim and Zhan-Guo Gao and Kenneth A. Jacobson and Gye Won Han and Raymond C. Stevens and Lak Shin Jeong and Sun Choi and Vadim Cherezov
Citation
Shiriaeva, A., Park, D., Kim, G., Lee, Y., Hou, X., Jarhad, D. B., Kim, G., Yu, J., Hyun, Y. E., Kim, W., Gao, Z.-G., Jacobson, K. A., Han, G. W., Stevens, R. C., Jeong, L. S., Choi, S., & Cherezov, V. (2022). GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.2c00462
DOI
Funding
NSF-STC Biology with X-ray Lasers (NSF-1231306)