A Brief Atlas of Insulin
Category
Published on
Type
journal-article
Author
Hasan DeMirci and Esra Ayan
Citation
DeMirci, H., & Ayan, E. (2023). A Brief Atlas of Insulin. Current Diabetes Reviews, 19(6). https://doi.org/10.2174/1573399819666220610150342
Abstract
Abstract:
Insulin is an essential factor for mammalian organisms: a regulator of glucose metabolism
and other key signaling pathways. Insulin is also a multifunctional hormone whose absence
can cause many diseases. Recombinant insulin is widely used in the treatment of diabetes. Understanding
insulin, biosimilars, and biobetters from a holistic perspective will help pharmacologically
user-friendly molecules design and develop personalized medicine-oriented therapeutic strategies
for diabetes. Additionally, it helps to understand the underlying mechanism of other insulindependent
metabolic disorders. The purpose of this atlas is to review insulin from a biotechnological,
basic science, and clinical perspective, explain nearly all insulin-related disorders and their underlying
molecular mechanisms, explore exogenous/recombinant production strategies of patented
and research-level insulin/analogs, and highlight their mechanism of action from a structural perspective.
Combined with computational analysis, comparisons of insulin and analogs also provide
novel information about the structural dynamics of insulin.
