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De novo protein crystal structure determination from X-ray free-electron laser data

08 Jan 2014 | Publications | Contributor(s): J. E. Koglin, T. R. Barends, R. L. Shoeman, L. Foucar, I. Schlichting, S. Boutet, R. B. Doak, K. Nass, S. Botha, G. J. Williams, Mark Messerschmidt

The determination of protein crystal structures is hampered by the need for macroscopic crystals. X-ray free-electron lasers (FELs) provide extremely intense pulses of femtosecond duration, which …

https://www.bioxfel.org/resources/238

Protein structural ensembles are revealed by redefining X-ray electron density noise

06 Jan 2014 | Publications | Contributor(s): P. T. Lang, T. Alber, J. S. Fraser, James Holton

To increase the power of X-ray crystallography to determine not only the structures but also the motions of biomolecules, we developed methods to address two classic crystallographic problems: …

https://www.bioxfel.org/resources/282

Crystallographic data processing for free-electron laser sources

30 Jun 2013 | Publications | Contributor(s): N. A. Zatsepin, F. Stellato, T. A. White, A. Barty, R. A. Kirian, Henry Chapman, James Holton

A processing pipeline for diffraction data acquired using the `serial crystallography' methodology with a free-electron laser source is described with reference to the crystallographic analysis suite …

https://www.bioxfel.org/resources/236

Simultaneous femtosecond X-ray spectroscopy and diffraction of photosystem II at room temperature

25 Apr 2013 | Publications | Contributor(s): A. R. Fry, S. Gul, J. Sellberg, P. H. Zwart, G. Han, J. Hellmich, N. K. Sauter, D. Milathianaki, W. E. White, R. W. Grosse-Kunstleve, B. Lassalle-Kaiser, T. C. Weng, M. J. Bogan, R. G. Sierra, H. Laksmono, A. Miahnahri, S. Boutet, J. Messinger, P. Glatzel, D. W. Schafer, J. Hattne, N. Echols, D. Difiore, V. K. Yach, M. M. Seibert, R. Tran, A. Zouni, S. Koroidov, J. Yano, R. Alonso-Mori, G. J. Williams, J. Kern, P. D. Adams, D. Sokaras, A. Lampe, J. E. Koglin, C. Glockner, U. Bergmann, M. J. Latimer, R. J. Gildea, Mark Messerschmidt, Ranga Setlur

Intense femtosecond x-ray pulses produced at the Linac Coherent Light Source (LCLS) were used for simultaneous x-ray diffraction (XRD) and x-ray emission spectroscopy (XES) of microcrystals of …

https://www.bioxfel.org/resources/293

Crystallography: Sources of inspiration

31 Dec 2012 | Publications | Contributor(s): S. McSweeney, Petra Fromme

2014.

https://www.bioxfel.org/resources/237

Single mimivirus particles intercepted and imaged with an X-ray laser

02 Feb 2011 | Publications | Contributor(s): A. Barty, D. P. DePonte, G. Potdevin, B. Rudek, J. Schulz, M. Adolph, T. A. White, S. Bajt, N. Kimmel, C. Reich, F. R. Maia, M. Liang, B. Erk, J. Hajdu, L. Gumprecht, H. Graafsma, S. Stern, R. Hartmann, M. Bott, A. Martin, I. Schlichting, K. O. Hodgson, D. Rolles, G. Weidenspointner, C. Bostedt, S. Herrmann, R. Andritschke, T. Gorkhover, A. Aquila, H. Soltau, P. Holl, D. Odic, G. Hauser, M. Svenda, B. Nilsson, J. M. Claverie, L. Struder, R. L. Shoeman, C. D. Schroter, F. Krasniqi, M. J. Bogan, A. Rudenko, J. D. Bozek, L. Foucar, D. Starodub, H. Gorke, N. Coppola, S. Schorb, R. G. Sierra, V. Seltzer, J. Ullrich, M. Barthelmess, A. Homke, I. Andersson, D. Pietschner, G. Schaller, C. Abergel, T. Ekeberg, S. Boutet, H. Hirsemann, O. Jonsson, C. Y. Hampton, F. Schopper, M. M. Seibert, B. Iwan, J. Krzywinski, L. Lomb, A. A. Miahnahri, S. W. Epp, R. Kirian, C. Caleman, D. Westphal, M. Hantke, A. Rocker, J. Andreasson, K. U. Kuhnel, D. Rupp, G. Williams, S. Marchesini, R. B. Doak, Henry Chapman, Matthias Frank, Petra Fromme, Stefan Hau-Riege, Mark S. Hunter, Mark Messerschmidt, Marius Schmidt, John Spence, Uwe Weierstall

X-ray lasers offer new capabilities in understanding the structure of biological systems, complex materials and matter under extreme conditions. Very short and extremely bright, coherent X-ray …

https://www.bioxfel.org/resources/294

Reconstruction from a single diffraction pattern of azimuthally projected electron density of molecules aligned parallel to a single axis

31 Dec 2009 | Publications | Contributor(s): V. L. Shneerson, D. Starodub, Dilano Saldin, John Spence

Diffraction from the individual molecules of a molecular beam, aligned parallel to a single axis by a strong electric field or other means, has been proposed as a means of structure determination of …

https://www.bioxfel.org/resources/286