Protein structural ensembles are revealed by redefining X-ray electron density noise
06 Jan 2014 | Publications | Contributor(s): T. Alber, J. S. Fraser, P. T. Lang, James Holton
To increase the power of X-ray crystallography to determine not only the structures but also the motions of biomolecules, we developed methods to address two classic crystallographic problems: …
https://www.bioxfel.org/resources/282
Serial femtosecond crystallography of G protein-coupled receptors
19 Dec 2013 | Publications | Contributor(s): W. Liu, R. C. Stevens, M. Caffrey, D. Wang, R. A. Kirian, S. Boutet, C. Wang, I. Grotjohann, K. R. Beyerlein, G. W. Han, A. Barty, T. A. White, D. Wacker, S. Basu, C. Gati, M. M. Seibert, V. Katritch, K. N. Rendek, G. J. Williams, S. T. Shah, N. A. Zatsepin, J. E. Koglin, Henry Chapman, Vadim Cherezov, Petra Fromme, James Holton, Christopher Kupitz, Applications Manager, Mark Messerschmidt, Garrett Charles Nelson, John Spence, Uwe Weierstall
X-ray crystallography of G protein-coupled receptors and other membrane proteins is hampered by difficulties associated with growing sufficiently large crystals that withstand radiation damage and …
https://www.bioxfel.org/resources/290
Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex
31 Dec 2011 | Publications | Contributor(s): D. A. Calderwood, A. L. Stiegler, T. J. Boggon, Tom Grant, Joseph Luft, Edward Snell
The heterotrimeric protein complex containing the integrin linked kinase (ILK), parvin, and PINCH proteins, termed the IPP complex, is an essential component of focal adhesions, where it interacts …
https://www.bioxfel.org/resources/283
