De novo protein crystal structure determination from X-ray free-electron laser data
08 Jan 2014 | Publications | Contributor(s): T. R. Barends, J. E. Koglin, R. L. Shoeman, L. Foucar, S. Boutet, I. Schlichting, R. B. Doak, K. Nass, G. J. Williams, S. Botha, Mark Messerschmidt
The determination of protein crystal structures is hampered by the need for macroscopic crystals. X-ray free-electron lasers (FELs) provide extremely intense pulses of femtosecond duration, which …
https://www.bioxfel.org/resources/De-novo-protein-crystal-structure
Protein structural ensembles are revealed by redefining X-ray electron density noise
06 Jan 2014 | Publications | Contributor(s): T. Alber, J. S. Fraser, P. T. Lang, James Holton
To increase the power of X-ray crystallography to determine not only the structures but also the motions of biomolecules, we developed methods to address two classic crystallographic problems: …
https://www.bioxfel.org/resources/Protein-structural-ensembles-are-revealed
High-resolution protein structure determination by serial femtosecond crystallography
19 Jul 2012 | Publications | Contributor(s): T. A. White, H. T. Philipp, P. A. Montanez, D. Arnlund, M. Liang, S. Boutet, G. Haller, N. A. Zatsepin, C. Kenney, L. Redecke, J. Pines, R. Herbst, A. Barty, L. C. Johansson, I. Schlichting, D. Schafer, M. W. Tate, S. M. Gruner, R. Neutze, G. Katona, N. van Bakel, M. J. Bogan, F. Stellato, C. Caleman, L. Lomb, J. Morse, R. B. Doak, T. R. Barends, A. Aquila, K. Nass, P. Hart, D. P. DePonte, M. M. Seibert, S. Kassemeyer, R. L. Shoeman, G. J. Williams, N. Timneanu, C. Y. Hampton, M. Hromalik, J. Steinbrener, W. Ghonsalves, D. Wang, A. V. Martin, L. J. Koerner, J. Defever, R. A. Kirian, Henry Chapman, Petra Fromme, Mark S. Hunter, Christopher Kupitz, Mark Messerschmidt, John Spence, Uwe Weierstall
Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding …
https://www.bioxfel.org/resources/High-resolution-protein-structure-determination-by
