• Organization
    Arizona State University

  • Employment Status
    University / College Faculty

  • Telephone
    1 480 727 6444

  • Address(s)
    Arizona State University, Physics Department
    Center for Biological Physics, PSF 246
    Tempe, AZ 85287-1504

  • Biography

    Nadia Zatsepin was an Assistant Professor (Research) at Arizona State University and Head of XFEL data analysis in BioXFEL from 2013 to 2019, when she moved to La Trobe University, Australia.

    Her research focus is on the application and development of serial femtosecond crystallography (SFX) at X-ray free electron lasers (XFELs), and serial millisecond (snapshot) crystallography at synchrotron and compact X-ray sources for macromolecular structure determination and the study of their dynamics.

    She is interested in XFEL radiation damage, particularly its role in SFX data accuracy for anomalous phasing and calculation of time-resolved electron densities, and novel phasing algorithms exploiting unique beam parameters of large and compact XFELs. With support form NSF through award #1565180, the Zatsepin lab is developing algorithms and software for serial crystallography and XFEL solution scattering data collection, analysis and simulations.

    In the BioXFEL STC, Dr. Zatsepin leads serial crystallography data analysis, organized numerous SFX data analysis workshops, is part of the BioXFEL Education and Diversity Committee and led the Association of BioXFEL Young Scientists (ABYS) from 2014 to 2016.

    Dr. Zatsepin was principal investigator on 4, and co-PI or collaborator on more than 100, XFEL experiments. BioXFEL project highlights include establishing high-viscosity SFX as a robust technique for room-temperature high-resolution structure determination for G-protein coupled receptors and other large membrane proteins, the first atomic-resolution, pump-probe SFX study of femtosecond-scale structural dynamics, the first time-resolved SFX structures during ligand-binding with large conformational changes in crystallo, and the first demonstration of capturing real-time enzyme catalysis in microcrystals using mix-and-inject SFX.

    Dr. Zatsepin completed a Bachelor of Science (Hons), majoring in physics and mathematics in 2005, and a Ph.D. in physics in 2011 from Monash University, Australia. Her PhD work applied triple-axis diffractometry to study high resolution X-ray diffraction of large ensembles of nanoparticles using reciprocal space mapping combined with coherent diffractive imaging.

    Zatsepin lab website:

    Our software and scripts:


    Publication list:

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