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    University of California-San Francisco

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    James Fraser is an Assistant Professor in the Department of Bioengineering and Therapeutic Sciences at the University of California at San Francisco and the California Institute for Quantitative Biosciences (QB3). Dr. Fraser completed his PhD with Tom Alber at UC Berkeley, where he studied protein structure and dynamics. There, he developed biophysical methods to characterize protein side chain flexibility and applied these techniques to study connections between conformational dynamics and enzymatic catalysis. Prior to starting his independent career at UCSF, he was an EMBO Short Term Fellow in Dan Tawfik’s lab at the Weizmann Institute. Dr. Fraser is a recipient of the NIH Early Independence Award, a Pew Scholar Award, and a Searle Scholar Award. He is the author of the problems and solutions manual for the physical chemistry textbook “The Molecules of Life” (Kuriyan, Konforti, and Wemmer – Garland Science) Research in Dr. Fraser’s lab focuses on how protein conformational ensembles respond to perturbations such as temperature, ligand binding, and mutation. The lab develops new data collection capabilities (with a focus on ambient temperature data collection and diffuse scattering) and creates new multiconfomer representations of protein structure and dynamics. Within the BioXFEL center, Dr. Fraser’s group is interested in novel electron density analyses of time resolved data and studying the differences in radiation damage between synchrotron and XFEL data sets.

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