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The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state

By M. Gertrude Gutierrez, Jacob Deyell, Kate L. White, Lucia C. Dalle Ore, Vadim Cherezov1, Raymond C. Stevens, Noah Malmstadt

1. Bridge Institute - University of Southern California

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Category

BioXFEL Publications

Published on

Type

journal-article

Author

M. Gertrude Gutierrez and Jacob Deyell and Kate L. White and Lucia C. Dalle Ore and Vadim Cherezov and Raymond C. Stevens and Noah Malmstadt

Citation

Gutierrez, M.G. et al., 2019. The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state. Chemical Communications, 55(40), pp.5724–5727. Available at: http://dx.doi.org/10.1039/c8cc10130b.

Abstract

As cholesterol fraction increases, ligand-bound receptor occupies more vesicle surface area, demonstrating co-localization with the cholesterol-rich phase.

DOI

http://dx.doi.org/10.1039/c8cc10130b