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Megahertz single-particle imaging at the European XFEL

By Egor Sobolev, Sergei Zolotarev, Klaus Giewekemeyer, Johan Bielecki, Kenta Okamoto, Hemanth K. N. Reddy, Jakob Andreasson, Kartik Ayyer, Imrich Barak, Sadia Bari, Anton Barty, Richard Bean, Sergey Bobkov, Henry Chapman1, Grzegorz Chojnowski, Benedikt J. Daurer, Katerina Dörner, Tomas Ekeberg, Leonie Flückiger, Oxana Galzitskaya, Luca Gelisio, Steffen Hauf, Brenda Hogue2, Daniel A. Horke, Ahmad Hosseinizadeh3, Vyacheslav Ilyin, Chulho Jung, Chan Kim, Yoonhee Kim, Richard Kirian1, Henry Kirkwood, Olena Kulyk, Jochen Küpper, Romain Letrun, N. Duane Loh, Kristina Lorenzen, Marc Messerschmidt2, Kerstin Mühlig, Abbas Ourmazd4, Natascha Raab, Andrei V. Rode, Max Rose, Adam Round, Takushi Sato, Robin Schubert, Peter Schwander4, Jonas A. Sellberg, Marcin Sikorski, Alessandro Silenzi, Changyong Song, John Spence2, Stephan Stern, Jolanta Sztuk-Dambietz, Anthon Teslyuk, Nicusor Timneanu, Martin Trebbin5, Charlotte Uetrecht, Britta Weinhausen, Garth J. Williams, P. Lourdu Xavier, Chen Xu, Ivan A. Vartanyants, Victor S. Lamzin, Adrian Mancuso, Filipe R. N. C. Maia

1. Center for Free-Electron Laser Science 2. Arizona State University 3. University of Wisconsin - Milwaukee 4. University of Wisconsin-Milwaukee 5. University at Buffalo

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Category

BioXFEL Publications

Published on

Type

journal-article

Author

Egor Sobolev and Sergei Zolotarev and Klaus Giewekemeyer and Johan Bielecki and Kenta Okamoto and Hemanth K. N. Reddy and Jakob Andreasson and Kartik Ayyer and Imrich Barak and Sadia Bari and Anton Barty and Richard Bean and Sergey Bobkov and Henry N. Chapman and Grzegorz Chojnowski and Benedikt J. Daurer and Katerina Dörner and Tomas Ekeberg and Leonie Flückiger and Oxana Galzitskaya and Luca Gelisio and Steffen Hauf and Brenda G. Hogue and Daniel A. Horke and Ahmad Hosseinizadeh and Vyacheslav Ilyin and Chulho Jung and Chan Kim and Yoonhee Kim and Richard A. Kirian and Henry Kirkwood and Olena Kulyk and Jochen Küpper and Romain Letrun and N. Duane Loh and Kristina Lorenzen and Marc Messerschmidt and Kerstin Mühlig and Abbas Ourmazd and Natascha Raab and Andrei V. Rode and Max Rose and Adam Round and Takushi Sato and Robin Schubert and Peter Schwander and Jonas A. Sellberg and Marcin Sikorski and Alessandro Silenzi and Changyong Song and John C. H. Spence and Stephan Stern and Jolanta Sztuk-Dambietz and Anthon Teslyuk and Nicusor Timneanu and Martin Trebbin and Charlotte Uetrecht and Britta Weinhausen and Garth J. Williams and P. Lourdu Xavier and Chen Xu and Ivan A. Vartanyants and Victor S. Lamzin and Adrian Mancuso and Filipe R. N. C. Maia

Citation

Sobolev, E. et al., 2020. Megahertz single-particle imaging at the European XFEL. Communications Physics, 3(1). Available at: http://dx.doi.org/10.1038/s42005-020-0362-y.

Abstract

AbstractThe emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL is expected to provide 27,000 pulses per second, over two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The results obtained pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.

DOI

http://dx.doi.org/10.1038/s42005-020-0362-y

Funding

NSF-STC Biology with X-ray Lasers (NSF-1231306)