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Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The “Undoing” of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network

By Shenshen Hu, Adam R. Offenbacher, Erin M. Thompson, Christine L. Gee, Jarett Wilcoxen, Cody A. M. Carr, Daniil M. Prigozhin, Vanessa Yang, Tom Alber, R. David Britt, James Fraser1, Judith P. Klinman

1. University of California-San Francisco

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Category

BioXFEL Publications

Published on

Type

journal-article

Author

Shenshen Hu and Adam R. Offenbacher and Erin M. Thompson and Christine L. Gee and Jarett Wilcoxen and Cody A. M. Carr and Daniil M. Prigozhin and Vanessa Yang and Tom Alber and R. David Britt and James S. Fraser and Judith P. Klinman

Citation

Hu, S. et al., 2019. Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The “Undoing” of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network. Journal of the American Chemical Society, 141(4), pp.1555–1567. Available at: http://dx.doi.org/10.1021/jacs.8b10992.

DOI

http://dx.doi.org/10.1021/jacs.8b10992

Funding

NSF-STC Biology with X-ray Lasers (NSF-1231306)