A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

By David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, Alicia L. Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Bjoern Meyer, Ferdinand Roesch, Thomas Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ying Shi, Ziyang Zhang, Wenqi Shen, Ilsa T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J. P. Mathy, Tina Perica, Kala Bharath Pilla, Sai J. Ganesan, Daniel J. Saltzberg, Ramachandran Rakesh, Xi Liu, Sara B. Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, Jose Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, YongFeng Liu, Stephanie A. Wankowicz, Markus Bohn, Maliheh Safari, Fatima S. Ugur, Cassandra Koh, Nastaran Sadat Savar, Quang Dinh Tran, Djoshkun Shengjuler, Sabrina J. Fletcher, Michael C. O’Neal, Yiming Cai, Jason C. J. Chang, David J. Broadhurst, Saker Klippsten, Phillip P. Sharp, Nicole A. Wenzell, Duygu Kuzuoglu-Ozturk, Hao-Yuan Wang, Raphael Trenker, Janet M. Young, Devin A. Cavero, Joseph Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Robert Stroud1, Alan D. Frankel, Oren S. Rosenberg, Kliment A. Verba, David A. Agard, Melanie Ott, Michael Emerman, Natalia Jura, Mark Von Zastrow, Eric Verdin, Alan Ashworth, Olivier Schwartz, Christophe D’Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, Danica G. Fujimori, Trey Ideker, Charles S. Craik, Stephen N. Floor, James Fraser2, John D. Gross, Andrej Sali, Bryan L. Roth, Davide Ruggero, Jack Taunton, Tanja Kortemme, Pedro Beltrao, Marco Vignuzzi, Adolfo García-Sastre, Kevan M. Shokat, Brian K. Shoichet, Nevan J. Krogan

1. University of California San Francisco 2. University of California-San Francisco

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journal-article

Author

David E. Gordon and Gwendolyn M. Jang and Mehdi Bouhaddou and Jiewei Xu and Kirsten Obernier and Kris M. White and Matthew J. O’Meara and Veronica V. Rezelj and Jeffrey Z. Guo and Danielle L. Swaney and Tia A. Tummino and Ruth Hüttenhain and Robyn M. Kaake and Alicia L. Richards and Beril Tutuncuoglu and Helene Foussard and Jyoti Batra and Kelsey Haas and Maya Modak and Minkyu Kim and Paige Haas and Benjamin J. Polacco and Hannes Braberg and Jacqueline M. Fabius and Manon Eckhardt and Margaret Soucheray and Melanie J. Bennett and Merve Cakir and Michael J. McGregor and Qiongyu Li and Bjoern Meyer and Ferdinand Roesch and Thomas Vallet and Alice Mac Kain and Lisa Miorin and Elena Moreno and Zun Zar Chi Naing and Yuan Zhou and Shiming Peng and Ying Shi and Ziyang Zhang and Wenqi Shen and Ilsa T. Kirby and James E. Melnyk and John S. Chorba and Kevin Lou and Shizhong A. Dai and Inigo Barrio-Hernandez and Danish Memon and Claudia Hernandez-Armenta and Jiankun Lyu and Christopher J. P. Mathy and Tina Perica and Kala Bharath Pilla and Sai J. Ganesan and Daniel J. Saltzberg and Ramachandran Rakesh and Xi Liu and Sara B. Rosenthal and Lorenzo Calviello and Srivats Venkataramanan and Jose Liboy-Lugo and Yizhu Lin and Xi-Ping Huang and YongFeng Liu and Stephanie A. Wankowicz and Markus Bohn and Maliheh Safari and Fatima S. Ugur and Cassandra Koh and Nastaran Sadat Savar and Quang Dinh Tran and Djoshkun Shengjuler and Sabrina J. Fletcher and Michael C. O’Neal and Yiming Cai and Jason C. J. Chang and David J. Broadhurst and Saker Klippsten and Phillip P. Sharp and Nicole A. Wenzell and Duygu Kuzuoglu-Ozturk and Hao-Yuan Wang and Raphael Trenker and Janet M. Young and Devin A. Cavero and Joseph Hiatt and Theodore L. Roth and Ujjwal Rathore and Advait Subramanian and Julia Noack and Mathieu Hubert and Robert M. Stroud and Alan D. Frankel and Oren S. Rosenberg and Kliment A. Verba and David A. Agard and Melanie Ott and Michael Emerman and Natalia Jura and Mark von Zastrow and Eric Verdin and Alan Ashworth and Olivier Schwartz and Christophe d’Enfert and Shaeri Mukherjee and Matt Jacobson and Harmit S. Malik and Danica G. Fujimori and Trey Ideker and Charles S. Craik and Stephen N. Floor and James S. Fraser and John D. Gross and Andrej Sali and Bryan L. Roth and Davide Ruggero and Jack Taunton and Tanja Kortemme and Pedro Beltrao and Marco Vignuzzi and Adolfo García-Sastre and Kevan M. Shokat and Brian K. Shoichet and Nevan J. Krogan

Citation

Gordon, D.E. et al., 2020. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature, 583(7816), pp.459–468. Available at: http://dx.doi.org/10.1038/s41586-020-2286-9.

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