Search
Results (page 1 of 1)
-
BioXFEL collaborator Henry Chapman receives 2017 Roentgen Medal
News 11 Apr 2017
DESY scientist Henry Chapman has been awarded the Roentgen Medal by the city of Remscheid.… Henry Chapman, a Leading Scientist at DESY and professor at the University of Hamburg, has been awarded the Medal in recognition of his pioneering work on the application of X-ray lasers for determining the structure of biological…
-
NSF BioXFEL STC Postdoctoral Research Award granted to Andrea Katz
News 21 Mar 2019
The BioXFEL Center is proud to announce the recipient of the 2019 Postdoctoral Research Award, Andrea Katz. Andrea Katz received her Bachelor's degree in Physics and Astronomy from Trinity University in 2011.… She came to Cornell's Applied Physics department for graduate studies and joined Dr.… Here, Andrea…
-
News 12 Sep 2017
Scientists who make movies of molecules in motion have a new high-speed camera to shoot with. The €1.2-billion (US$1.4-billion) European X-ray Free Electron Laser (XFEL) will start running its first experiments in September near Hamburg, Germany. The European XFEL fires powerful X-rays in bursts of a few hundred femtoseconds: so short that, like…
-
Heterogeneity in M. tuberculosis β-lactamase inhibition by Sulbactam
News 8 Sep 2023
In a paper just published in Nature Communications, a team of BioXFEL researchers and collaborators used mix-and-inject serial crystallography (MISC) to analyze the reaction of the β-lactamase BlaC from tuberculosis bacteria with the suicide inhibitor sulbactam (SUB).… In this study, Tek Malla, a graduate student from Marius…
-
Job Opening: Research Specialist
News 24 Mar 2017
Arizona State University is currently seeking a research specialist. This position in experimental biophysics would assist scientists in collecting experimental data at the Linac Coherent Light Source (LCLS) X-ray laser near Stanford University, as part of the BioXFEL project https://www.bioxfel.org/. The job is based at ASU in Tempe, but…
-
BioXFEL Members Take Part in Sample Delivery Research
News 7 Aug 2018
A team of researchers, led by scientists from DESY, has demonstrated the successful use of a new type of liquid jet at high pulse repetition rates at FLASH.… Furthermore, the researchers conducted the first crystal diffraction experiments using X-ray pulse repetition rates of about a million pulses per second (MHz). X-ray…
-
Electron beam exposes crystal details down to hydrogen atoms
News 17 Jan 2017
A new algorithm created by Czech and French researchers allows 3D electron diffraction patterns to reveal nanocrystal structures down to the positions of individual hydrogen atoms. Researchers believe its uses could range from studying pharmaceuticals to catalysis and beyond. X-ray crystallography, in which the diffraction pattern of x-rays…
-
Timothy Stachowski Wins Linus Pauling Poster Prize
News 8 Aug 2019
Timothy Stachowski, a University at Buffalo Ph.D. candidate studying in the Snell Group at HWI, was awarded one of the Linus Pauling Poster Prizes at the 2019 American Crystallographic Association (ACA) meeting.… The international meeting focused on X-ray crystallography, one of HWI’s strongest methods in structural biology, was…
-
News 25 Mar 2021
Many organisms use sunlight to fuel cellular functions. But exactly how does this conversion of solar energy into chemical energy unfold? In a recent experiment, an international team of scientists, including several research groups from the BioXFEL Science and Technology Center, used time-resolved serial femtosecond crystallography (TR-SFX)…
-
Researchers capture membrane protein folding for first time in 3D and at single-atom level
News 3 Jan 2017
Membrane proteins are popular drug targets, as they are exposed to the environment surrounding the cell. Capturing their movements in video, the authors say, is potentially a revolutionary step forward in drug development.… Lead author Eriko Nango of Kyoto University explains that, whereas conventional X-ray crystallography only…
-
Serial millisecond crystallography of membrane
News 6 Jun 2017
Crystal structure determination of biological macromolecules using the novel technique of serial femtosecond crystallography (SFX) is severely limited by the scarcity of X-ray free-electron laser (XFEL) sources.… Owing to the longer exposure times that are needed at synchrotrons, serial data collection is termed serial…
-
BioXFEL Scientist, Dilano Saldin, passes away
News 24 Mar 2020
BioXFEL scientist Dilano Saldin, Distinguished Professor of Physics of the University of Wisconsin-Milwaukee and Fellow of the American Physical Society, passed away on March 9, 2020 after a long illness. He will be greatly missed by his family, friends, and the scientific community. Below is his obituary. Remembering Dilano Saldin For four…
-
Photosynthesis seen in a new light by rapid X-ray pulses
News 12 Nov 2019
In a new study led by Petra Fromme and Nadia Zatsepin at the Biodesign Center for Applied Structural Discovery, the School of Molecular Sciences and the Department of Physics at Arizona State University, researchers investigated the structure of Photosystem I (PSI) with ultrashort X-ray pulses at the European X-ray Free Electron Laser (EuXFEL)…
-
SLAC's Electron Hub Gets New 'Metro Map' for World's Most Powerful X-Ray Laser
News 7 Jul 2017
The central hub for powerful electron beams at the Department of Energy’s SLAC National Accelerator Laboratory is getting a makeover to prepare for the installation of LCLS-II – a major upgrade to the Linac Coherent Light Source (LCLS), the world’s first hard X-ray free-electron laser.… The hub, called the Beam Switch…
-
News 6 Apr 2017
Phytochromes are a family of photoreceptors that control light responses of plants, fungi and bacteria. A sequence of structural changes, which is not yet fully understood, leads to activation of an output domain.… Here we report the room temperature crystal structure of the chromophore-binding domains of the Deinococcus…
-
BioXFEL Members Explore Antibiotic Inactivation by a β-Lactamase
News 10 Sep 2018
Antibiotic resistance is an imminent threat to human health. Tuberculosis is the number one killer among infectious diseases. Bacteria that cause tuberculosis are difficult to treat because they are often antibiotic resistant. One of the causes of antibiotic resistance are β-lactamases which broadly inactivate β-lactam antibiotics such as…
-
Listen in on X-ray laser science
News 17 Aug 2018
The European X-ray Free-Electron Laser recently came on-line as the biggest and brightest source of X-rays on planet Earth. Those brilliant X-ray beams will allow chemists to do groundbreaking research on enzymes, solar-cell materials, and more. But with great science comes great responsibility. In our latest Stereo Chemistry podcast, C&EN…
-
BioXFEL Researcher Alexandra Ros Receives Innovation Award
News 2 Nov 2018
BioXFEL researcher, Alexandra Ros of Arizona State University, has received the Federation of Analytical Chemistry and Spectroscopy Societies Innovation Award for her paper and presentation, “Electrically Triggered Water-in-Oil Droplets for Serial Femtosecond Crystallography.… The award is given to the most innovative research…
-
BioXFEL Postdoctoral Fellowship Award
News 1 Jul 2021
Sabine Botha is a Postdoctoral Research Scholar in the group of Prof. John Spence at Arizona State University. She completed her undergraduate education and masters program at the University of Oxford (UK) in Engineering Science, specializing in Biomedical and Information Engineering.… After spending 2 years on sample injection…
-
Structural enzymology using X-ray free electron lasers
News 9 Mar 2017
Mix-and-inject serial crystallography (MISC) is a technique designed to image enzyme catalyzed reactions in which small protein crystals are mixed with a substrate just prior to being probed by an X-ray pulse.… It provides (i) room temperature structures at near atomic resolution, (ii) time resolution ranging from…
-
Dynamics and Kinetics in Structural Biology
News 21 Nov 2023
Understand the latest experimental tools in structured biology with this pioneering work by Keith Moffat and Eaton E.… Structural biology seeks to understand the chemical mechanisms and functions of biological molecules based on their atomic structures.… Dynamics and Kinetics in Structural Biology: Unravelling…
-
News 5 Jul 2017
Riboswitches are structurally dynamic RNA molecules, undergoing changes in shape as they perform their regulatory functions.… Thus far, structures have been obtained for the aptamer domains, but the motions caused by ligand binding have been tricky to observe by crystallography: crystals typically freeze molecules in one shape,…
-
Few-fs resolution of a photoactive protein traversing a conical intersection
News 4 Nov 2021
The structural dynamics of a molecule are determined by the underlying potential energy landscape.… Posited almost a century ago, conical intersections remain the subject of intense scientific interest. In biology, they have a pivotal role in vision, photosynthesis and DNA stability6. Accurate theoretical methods for examining…
-
News 25 Oct 2022
Nicole Terranova has a career background in secondary education. She taught biology in California for 17 years, assisted in creating her school district’s Next Generation Science Standards curriculum, developed social-emotional course content and student leadership curriculum content and activities while heading school events and student…
-
XFEL Pulses Demonstrate How Plants Perceive Light
News 7 Apr 2020
A team of scientists from Sweden, Finland, Japan and the United States led by University of Gothenburg researcher Sebastian Westenhoff and BioXFEL member Marius Schmidt from the University of Wisconsin-Milwaukee have shown, for the first time with time-resolved X-ray structures, how photoreceptors in plants respond to light.……
-
European XFEL Call for Proposals Dec. 11th
News 1 Nov 2019
The European X-Ray Free-Electron Laser Facility (European XFEL, https://www.xfel.eu) encourages the scientific community worldwide to submit proposals for User Experiments via the User Portal to the European XFEL (UPEX) until Wednesday, 11 December 2019 16:00 (local Hamburg/Schenefeld time - CE … Call for Proposals User…
-
News 2 Dec 2019
The European XFEL marks in a new age of protein movie-making that enables enzymes involved in disease to be observed in real time.… To study the swiftness of biology – the protein chemistry behind every life function – scientists have need to see molecules changing and interacting in unimaginably rapid time increments –…
-
Structural enzymology using X-ray free electron lasers
News 29 Aug 2017
Mix-and-inject serial crystallography (MISC) is a technique designed to image enzyme catalyzed reactions in which small protein crystals are mixed with a substrate just prior to being probed by an X-ray pulse.… It provides (i) room temperature structures at near atomic resolution, (ii) time resolution ranging from microseconds to…
-
Nora Berrah Named 2018 AAAS Fellow
News 13 Dec 2018
Professor Nora Berrah of the Department of Physics in the College of Liberal Arts and Sciences at University of Connecticut has been named a 2018 Fellow of the American Association for the Advancement of Science (AAAS).… Berrah, who was head of the physics department from 2014-2018, has been recognized for her distinguished…
-
Scientists Catch Snapshot of Photosynthesis
News 16 Jan 2017
A mystery that has perplexed scientists for centuries may soon be unraveling. Researchers at the Department of Energy’s SLAC National Accelerator Laboratory have captured for the first time how a protein complex—photosystem II—harvests energy from sunlight and uses it to split water into hydrogen and oxygen, a process that generates the…
-
Real-time molecular scale observation of crystal formation
News 12 Jan 2017
How molecules in solution form crystal nuclei, which then grow into large crystals, is a poorly understood phenomenon.… However, a non-classical mechanism suggests the formation of an amorphous dense phase that reorders to form stable crystal nuclei.… Here, using polyoxometallates, we show that the formation of…
-
News 25 Sep 2018
Structure Biologist (f/m/d) in the field of X-ray Crystallography Deutsches Elektronen-Synchrotron DESY - DESY - Helmholtz Association … Hamburg, Germany Posted about 1 month ago. Expires on September 26, 2018 Workgroup: FS-CFEL-1 Area of research: Scientific / postdoctoral posts Job Description: … DESY…
-
Shanghai team develops 'world's brightest VUV free-electron laser'
News 2 Feb 2017
Scientists completing a new free-electron laser (FEL) in China say that the facility now delivers the world’s brightest source of light in the vacuum ultraviolet (VUV) spectral region, yielding a tool with unprecedented scientific utility.… The Dalian Coherent Light Source (DCLS) is said to be the only high-gain FEL user facility…
-
A Bright Future for Serial Femtosecond Crystallography with XFELs
News 10 Aug 2017
BioXFEL scientist Vadim Cherezov and his colleagues released a new publication to CellPress: X-ray free electron lasers (XFELs) have the potential to revolutionize macromolecular structural biology due to the unique combination of spatial coherence, extreme peak brilliance, and short duration of X-ray pulses. A recently emerged serial femtosecond…
-
Stella Lisova - Maestro of the Liquid Jet
News 6 Mar 2019
Most of us in BioXFEL owe the success of our work at LCLS and other XFELs to Stella's remarkable skills. The precision grinding and manufacturing she undertakes to produce nozzles for our liquid jets has enabled much of the static structure determination and practically all of the time-resolved protein crystallography we do at XFELs since she…
-
Call for Papers on "Novel Structural Studies of Coronavirus Proteins"
News 26 Mar 2021
This Special Issue, “Novel Structural Studies of Coronavirus Proteins”, will gather both research and review articles from experts in the field with the ultimate goal of creating an international platform that provides with rich and reference information on the latest advances and exciting discoveries in the field of X-ray…
-
XFEL data analysis for structural biology
News 28 Feb 2017
X-ray Free Electron Lasers (XFELs) have advanced research in structure biology, by exploiting their ultra-short and bright X-ray pulses. The resulting “diffraction before destruction” experimental approach allows data collection to outrun radiation damage, a crucial factor that has often limited resolution in the structure determination of…
-
Three-dimensional-printed gas dynamic virtual nozzles for x-ray laser sample delivery
News 2 Mar 2017
Reliable sample delivery is essential to biological imaging using X-ray Free Electron Lasers (XFELs).… However, many important aspects of GDVN functionality have yet to be thoroughly understood and/or refined due to fabrication limitations.… This technique allows rapid prototyping of a wide range of different…
-
Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers
News 31 May 2017
X-ray crystallography at X-ray free-electron laser sources is a powerful method for studying macromolecules at biologically relevant temperatures. Moreover, when combined with complementary techniques like X-ray emission spectroscopy, both global structures and chemical properties of metalloenzymes can be obtained concurrently, providing insights…
-
Students displaced by Hurricane Maria at HWI
News 27 Jul 2018
In September of 2017, Hurricane Maria hit Puerto Rico with 175 mph winds, cutting the island in half and unleashing torrents of rain and devastation.… Natalia Crespo was an undergrad majoring in Industrial Biotechnology at the University of Puerto Rico when Maria hit.… “Classes got canceled a few days before…
-
Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography
News 27 Jun 2017
BioXFEL researchers in collaboration with others established a procedure for serial femtosecond crystallography (SFX) in lipidic cubic phase (LCP) for protein structure determination at X-ray free-electron lasers (XFELs).… LCP is a liquid-crystalline mesophase composed of lipids and water. It provides a membrane-mimicking…
-
News 25 Mar 2021
Phytochromes are the molecular eyes of plants and bacteria that regulate cellular response to light, an essential environmental signal. Upon light absorption, the phytochromes change their structures substantially from a conformation that absorbs in the red-light called Pr to another conformation that absorbs in the far-red light called Pfr,…
-
Researchers Develop New Way To See Proteins In Motion
News 10 Jan 2017
A new imaging technique to see proteins live in motion has been developed.… Given that subtle motions govern protein functions that take place on nano time scales of trillionths of a second, the study offers great potential in knowing how proteins work.… The study's senior author was Rama Ranganathan,…
-
XFEL structure of melatonin receptor aids discovery of potential sleep disorder drugs
News 2 Mar 2020
A recent study published in Nature involving a multi-institutional collaboration with BioXFEL researchers has produced novel drug candidates that may help with various sleep disorders.… Melatonin discovery may help adjust biological clock Article originally published at UB News. Read original article here. Like breathing or…
-
BioXFEL researchers make major advances in determination of gestational age
News 23 Jun 2020
An international group of researchers led by data scientists at the University of Wisconsin-Milwaukee have applied a machine learning technique they developed to substantially reduce the uncertainty in gestational age estimation.… Knowing the gestational age of a baby is key for optimal pregnancy management and in order to know…
-
Hao Hu - BioXFEL Beamline Scientist
News 8 Aug 2019
After completing a Masters degree in Biomaterials at Sichuan University, China in 2013 and a Masters degree in Biomedical Engineering at ASU in 2016, Hao Hu joined the Spence & Weierstall lab at ASU to develop microfluidics devices for sample delivery.… She has been working primarily on viscous injectors, supporting many…
-
Single-shot determination of focused FEL wave fields using iterative phase retrieval
News 3 Aug 2017
BioXFEL scientist Marc Messerschmidt, along with his colleagues, published a research article in OSA publishing. Summary: Determining fluctuations in focus properties is essential for many experiments at Self-Amplified-Spontaneous-Emission (SASE) based Free-Electron-Lasers (FELs), in particular for imaging single non-crystalline biological…
-
European XFEL Virtual User Information Meeting - 7th Call for Proposals
News 19 Nov 2020
European XFEL Virtual User Information Meeting - 7th Call for Proposals A virtual information meeting will be hosted by the European XFEL User Organization Executive Committee (UOEC) and held on 25 November 2020 17:30-19:30 (Hamburg/Schenefeld local time - CET) … The event will specifically address our 7th Call…
-
BioXFEL researchers publish first melatonin receptor structures
News 8 May 2019
An international team, including BioXFEL researchers, used an X-ray laser at the Department of Energy’s SLAC National Accelerator Laboratory to create the first detailed maps of two melatonin receptors that tell our bodies when to go to sleep or wake up, and guide other biological processes.… A better understanding of how they…
-
U.S. Crystal Growing Competition celebrates 5th anniversary
News 3 Oct 2018
The contest — founded by a UB chemist — reaches thousands of children around the country each year … In 2014, University at Buffalo crystallographer Jason Benedict had an idea: What better way to share his love of science and crystals than to start a nationwide contest in which kids can grow their own?… This…
-
BioXFEL ASU team among first user groups at Europe’s brightest light source
News 31 Oct 2017
A team of BioXFEL ASU scientists led by Professor and STC Member Alexandra Ros in the School of Molecular Sciences and the Biodesign Center for Applied Structural Discovery, has been just the second user group to conduct experiments at the brand new European X-ray free electron laser facility (EuXFEL) in Hamburg, Germany.……
-
Filming Antibiotic Resistance in Slow-Motion
News 13 Sep 2021
Using the X-ray laser European XFEL an international team of researchers has successfully filmed a reaction step that is important for the development of antibiotic resistance.… The molecular film captures the very rapid reaction of the enzyme beta-lactamase from tuberculosis bacteria with the cephalosporin antibiotic ceftriaxone…
-
NSF BioXFEL STC Postdoctoral Research Award granted to Benjamin Stauch and Ahmad Hosseinizadeh
News 30 Mar 2017
The BioXFEL Center is proud to announce the recipients of the Postdoctoral Research Award, Benjamin Stauch and Ahmad Hosseinizadeh.… Stauch is a Postdoctoral Research Associate in the group of Prof. Vadim Cherezov at the Bridge Institute of the University of Southern California in Los Angeles. He received his Master’s degree…
-
BioXFEL research published in Nature Methods enables seeing inside particles in solution
News 29 Jan 2018
New research published today in Nature Methods by BioXFEL researcher Tom Grant opens up new avenues for studying the structures of particles floating in solution. Typically, molecular structures are determined using a technique known as crystallography, where molecules are chemically induced to align next to each other in a large 3D…
-
XFELs Open A New Era in Structural Chemical Biology
News 22 Jun 2017
X-ray crystallography, the workhorse of structural biology, has been revolutionized by the advent of serial femtosecond crystallography using X-ray free electron lasers. Here, the fast pace and history of discoveries are discussed together with current challenges and the method's great potential to make new structural discoveries, such as the…
-
News 5 Sep 2019
Some of the world’s most accomplished scientific minds will converge on Arizona State University’s Tempe campus on November 6, 7 and 8 to explore new methods that make it possible to observe molecules in action. Illustrating the adage, "seeing is believing," the conference, “Functional dynamics – visualizing molecules in action,” will…
-
UWM researchers create first 3D movie of virus in action
News 14 Aug 2017
A research collaboration led by the University of Wisconsin-Milwaukee has for the first time created a three-dimensional movie showing a virus preparing to infect a healthy cell.… The research has the potential to fundamentally advance our understanding of how biological processes inside the cell work.… The feat…
-
News 10 Jan 2023
Click here for Conference Agenda Click here for Welcome Packet The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its 10th Annual International Conference May 16 - 18, 2023. The "From Time-Resolved Structure Factor Amplitudes to Structure and…
-
News 25 Sep 2018
Srd Div. Director [Senior/ Distinguished Staff Scientist] Link to job posting Job Requisition #: 3370 Classification Title: Staff Scientist- Senior Location: Menlo Park, CA (HQ) # of openings: 1 Position Summary LCLS SCIENCE RESEARCH AND DEVELOPMENT (SRD) DIVISION LEADER: … The Linac Coherent Light Source (LCLS) is…
-
Job opening - Post Doc in THz Biomolecular Optics at University at Buffalo
News 20 Feb 2018
DOE funded postdoc position for the study of photosynthesis proteins and enzymes using terahertz light.… The position involves instrumentation development, sample preparation and characterization.… PhD in experimental physics, biophysics, structural biology, chemistry or biochemistry Record of publications…
-
NSF awards $22.5 million to capture biology at the atomic level using X-ray lasers
News 26 Sep 2018
A research consortium led by the University at Buffalo has been awarded $22.… BioXFEL is revolutionizing bioimaging through collaborations with academia and industry, including Google Brain … By Ellen Goldbaum Original Article Here BioXFEL, an NSF Science and Technology Center and UB’s first such center,…
-
Earliest molecular events of vision revealed
News 23 Mar 2023
A large international team lead by Valerie Paneels and Gebhard Schertler revealed the molecular mechanism of light receptor activation in the eyes of vertebrae animals by time-resolved serial femtosecond crystallography (TR-SFX).… BioXFEL researchers Schmidt and Stojković were invited to write a News and Views article summarizing…
