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Marius Schmidt is using physical methods to investigate biological molecules. He is concentrating mainly on static and time-resolved macromolecular crystallography to investigate the structure, dynamics and kinetics of proteins.… Schmidt is also developing new, sophisticated software for the analysis of the time-resolved…
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Groups
The Kornberg lab's general interest in the BioXFEL Center is to explore the use of the nanocrystals and single particle analysis to study transcription and transcription regulator complexes. The Kornberg lab has two immediate projects they will embark on via the BioXFEL Center. The first project is a serial femtosecond crystallography project on…
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Groups
Lois Pollack's research program has two distinct themes. The first theme is instrumentation: the development of experimental tools that enable novel, time-resolved studies of proteins, DNA or RNA.… Her group has developed and applied tools that report dynamic shape changes as these large molecules assume ('fold' to) their…
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Groups
Research in Dr. Fraser’s lab focuses on how protein conformational ensembles respond to perturbations such as temperature, ligand binding, and mutation. The lab develops new data collection capabilities (with a focus on ambient temperature data collection and diffuse scattering) and creates new multiconfomer representations of protein structure…
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Groups
Dr. Frank's lab is currently working on developing and demonstrating techniques for high-resolution, dynamical imaging of biomolecules and biological nanoparticles with X-ray free-electron lasers, such as the Linac Coherent Light Source at SLAC.… As part of the BioXFEL Center, Dr. Frank, is a leader in the…
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Groups
The John Spence Group will focus on development of new single-particle sample-delivery systems for viruses and macromolecules, which aim to improve the hit rate from its current value of about 1% in gas-phase injectors, which are free of water background.… These include use expectation maximization for partial reflections and…



