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Structural biology in the time of COVID-19: perspectives on methods and milestones
BioXFEL Publications 22 Apr 2021 Contributor(s): Miranda Lynch, Edward Snell, Sarah EJ Bowman
http://dx.doi.org/10.1107/s2052252521003948 The global COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has wreaked unprecedented havoc on global society, in terms of a huge loss of life and burden of morbidity, economic upheaval and social disruption.… Structural biology has been at the…
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Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography
BioXFEL Publications 18 Sep 2023 Contributor(s): Iris Diane Young, James Holton, James Fraser, Michael Thompson
http://dx.doi.org/10.1038/s41557-023-01329-4 AbstractUnderstanding and controlling protein motion at atomic resolution is a hallmark challenge for structural biologists and protein engineers because conformational dynamics are essential for complex functions such as enzyme catalysis and allosteric regulation. Time-resolved crystallography offers a…
