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De novo protein crystal structure determination from X-ray free-electron laser data
08 Jan 2014 | Publications | Contributor(s): I. Schlichting, S. Boutet, R. B. Doak, K. Nass, S. Botha, G. J. Williams, J. E. Koglin, T. R. Barends, R. L. Shoeman, L. Foucar, Mark Messerschmidt
The determination of protein crystal structures is hampered by the need for macroscopic crystals. X-ray free-electron lasers (FELs) provide extremely intense pulses of femtosecond duration, which …
https://www.bioxfel.org/resources/De-novo-protein-crystal-structure
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Serial femtosecond crystallography of G protein-coupled receptors
19 Dec 2013 | Publications | Contributor(s): S. Boutet, M. Caffrey, D. Wang, R. A. Kirian, T. A. White, C. Wang, I. Grotjohann, K. R. Beyerlein, G. W. Han, S. Basu, A. Barty, V. Katritch, D. Wacker, S. T. Shah, C. Gati, M. M. Seibert, K. N. Rendek, W. Liu, G. J. Williams, R. C. Stevens, N. A. Zatsepin, J. E. Koglin, Henry Chapman, Vadim Cherezov, Petra Fromme, James Holton, Christopher Kupitz, Applications Manager, Mark Messerschmidt, Garrett Charles Nelson, John Spence, Uwe Weierstall
X-ray crystallography of G protein-coupled receptors and other membrane proteins is hampered by difficulties associated with growing sufficiently large crystals that withstand radiation damage and …
https://www.bioxfel.org/resources/Serial-femtosecond-crystallography-of-G
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Crystallographic data processing for free-electron laser sources
30 Jun 2013 | Publications | Contributor(s): F. Stellato, T. A. White, A. Barty, R. A. Kirian, N. A. Zatsepin, Henry Chapman, James Holton
A processing pipeline for diffraction data acquired using the `serial crystallography' methodology with a free-electron laser source is described with reference to the crystallographic analysis suite …
https://www.bioxfel.org/resources/Crystallographic-data-processing-for-free-electron
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Crystallography: Sources of inspiration
31 Dec 2012 | Publications | Contributor(s): S. McSweeney, Petra Fromme
2014.
https://www.bioxfel.org/resources/Crystallography:-Sources-of-inspiration
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X-ray lasers for structural and dynamic biology
30 Sep 2012 | Publications | Contributor(s): Henry Chapman, John Spence, Uwe Weierstall
Research opportunities and techniques are reviewed for the application of hard x-ray pulsed free-electron lasers (XFEL) to structural biology. These include the imaging of protein nanocrystals, …
https://www.bioxfel.org/resources/X-ray-lasers-for-structural-and
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High-resolution protein structure determination by serial femtosecond crystallography
19 Jul 2012 | Publications | Contributor(s): L. J. Koerner, A. Barty, T. A. White, R. A. Kirian, I. Schlichting, D. Schafer, P. A. Montanez, G. Katona, M. Liang, S. Boutet, L. Redecke, C. Caleman, R. Herbst, J. Morse, N. A. Zatsepin, F. Stellato, M. W. Tate, D. P. DePonte, L. C. Johansson, A. Aquila, S. M. Gruner, N. van Bakel, G. J. Williams, M. J. Bogan, C. Y. Hampton, R. Neutze, J. Steinbrener, L. Lomb, A. V. Martin, T. R. Barends, R. B. Doak, J. Defever, D. Wang, P. Hart, H. T. Philipp, M. M. Seibert, D. Arnlund, K. Nass, S. Kassemeyer, M. Hromalik, C. Kenney, W. Ghonsalves, R. L. Shoeman, J. Pines, N. Timneanu, G. Haller, Henry Chapman, Petra Fromme, Mark S. Hunter, Christopher Kupitz, Mark Messerschmidt, John Spence, Uwe Weierstall
Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding …
https://www.bioxfel.org/resources/High-resolution-protein-structure-determination-by
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Reconstructing an icosahedral virus from single-particle diffraction experiments
28 Aug 2011 | Publications | Contributor(s): H. C. Poon, CMS Manager, Dilano Saldin, Marius Schmidt, Peter Schwander, Miraj Uddin
The first experimental data from single-particle scattering experiments from free electron lasers (FELs) are now becoming available. The first such experiments are being performed on relatively …
https://www.bioxfel.org/resources/Reconstructing-an-icosahedral-virus-from
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Structure-factor analysis of femtosecond microdiffraction patterns from protein nanocrystals
28 Feb 2011 | Publications | Contributor(s): A. Barty, F. R. Maia, R. A. Kirian, A. Aquila, X. Wang, A. V. Martin, L. Lomb, T. A. White, Henry Chapman, Petra Fromme, James Holton, Mark S. Hunter, Marius Schmidt, John Spence
A complete set of structure factors has been extracted from hundreds of thousands of femtosecond single-shot X-ray microdiffraction patterns taken from randomly oriented nanocrystals. The method of …
https://www.bioxfel.org/resources/Structure-factor-analysis-of-femtosecond-microdiffraction
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Femtosecond X-ray protein nanocrystallography
02 Feb 2011 | Publications | Contributor(s): G. Schaller, A. Barty, M. Adolph, S. Bajt, D. Rupp, I. Grotjohann, C. Bostedt, T. A. White, J. Krzywinski, D. P. DePonte, N. Timneanu, H. Soltau, B. Erk, M. M. Seibert, S. Stern, L. Gumprecht, G. Hauser, R. Hartmann, T. R. Barends, H. Gorke, A. Rocker, M. Bott, S. Herrmann, K. Nass, F. Krasniqi, R. Andritschke, J. Andreasson, C. D. Schroter, R. Neutze, J. Ullrich, D. Rolles, P. Holl, I. Andersson, B. Rudek, G. Potdevin, A. Aquila, L. Struder, J. Hajdu, C. Y. Hampton, N. Kimmel, X. Wang, H. Hirsemann, A. V. Martin, M. Liang, S. Schorb, L. Foucar, F. Schopper, R. G. Sierra, T. Gorkhover, G. Weidenspointner, A. Homke, M. Barthelmess, S. Boutet, D. Starodub, R. A. Kirian, I. Schlichting, C. Caleman, R. L. Shoeman, J. Schulz, D. Pietschner, O. Jonsson, B. Nilsson, M. Svenda, S. W. Epp, G. J. Williams, L. Lomb, H. Graafsma, A. Rudenko, M. J. Bogan, S. Marchesini, K. U. Kuhnel, F. R. Maia, R. B. Doak, J. D. Bozek, C. Reich, N. Coppola, Henry Chapman, Matthias Frank, Petra Fromme, Stefan Hau-Riege, James Holton, Mark S. Hunter, Mark Messerschmidt, Marius Schmidt, John Spence, Uwe Weierstall
X-ray crystallography provides the vast majority of macromolecular structures, but the success of the method relies on growing crystals of sufficient size. In conventional measurements, the …
https://www.bioxfel.org/resources/Femtosecond-X-ray-protein-nanocrystallography
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Single mimivirus particles intercepted and imaged with an X-ray laser
02 Feb 2011 | Publications | Contributor(s): F. R. Maia, A. Aquila, L. Foucar, R. Hartmann, J. Hajdu, D. Odic, N. Coppola, H. Graafsma, B. Nilsson, M. J. Bogan, S. Stern, I. Schlichting, C. D. Schroter, T. Gorkhover, G. Weidenspointner, A. Rudenko, M. Barthelmess, S. Herrmann, D. Starodub, R. Andritschke, G. Hauser, A. Homke, L. Lomb, R. L. Shoeman, J. M. Claverie, D. Pietschner, O. Jonsson, H. Soltau, C. Abergel, M. M. Seibert, R. G. Sierra, J. D. Bozek, C. Y. Hampton, V. Seltzer, H. Gorke, B. Iwan, M. Hantke, S. Schorb, F. Krasniqi, A. A. Miahnahri, K. U. Kuhnel, I. Andersson, C. Caleman, T. Ekeberg, G. Schaller, A. Rocker, M. Adolph, S. Boutet, J. Ullrich, D. Rupp, S. W. Epp, F. Schopper, A. Barty, L. Gumprecht, R. Kirian, J. Krzywinski, D. P. DePonte, N. Kimmel, H. Hirsemann, B. Rudek, M. Liang, R. B. Doak, J. Andreasson, C. Reich, G. Williams, B. Erk, M. Bott, S. Marchesini, D. Westphal, K. O. Hodgson, T. A. White, G. Potdevin, A. Martin, L. Struder, S. Bajt, J. Schulz, D. Rolles, P. Holl, C. Bostedt, M. Svenda, Henry Chapman, Matthias Frank, Petra Fromme, Stefan Hau-Riege, Mark S. Hunter, Mark Messerschmidt, Marius Schmidt, John Spence, Uwe Weierstall
X-ray lasers offer new capabilities in understanding the structure of biological systems, complex materials and matter under extreme conditions. Very short and extremely bright, coherent X-ray …
https://www.bioxfel.org/resources/Single-mimivirus-particles-intercepted-and
