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A National Science Foundation Science and Technology Center
The BioXFEL National Science Foundation Science and Technology Center is pleased to announce that it will be hosting its fourth annual international conference in Las Vegas, NV January 10th - 12th, 2017.
Buffalo News article features BioXFEL Director Ed Lattman describing the “Apollo effect” caused by BioXFEL and the potential impact on increasing student participation in STEM areas locally.
Here we present a new analytical approach capable of determining the free-energy landscape and the continuous trajectories of molecular machines from a large number of snapshots obtained by cryogenic electron microscopy. We demonstrate this approach in the context of experimental cryogenic electron microscope images of a large ensemble of nontranslating ribosomes purified from yeast cells.
The BioXFEL Center will focus on developing new X-ray bioimaging techniques — including an advanced form of X-ray crystallography called serial femtosecond crystallography — to analyze a vast array of new molecular targets for drug discovery.