2015 Single Particle Imaging Workshop

By Russell Fung

University of Wisconsin-Milwaukee



Published on


How do you make a movie of a single particle jiggling and wiggling with atomic resolution and ultra-fast temporal resolution? How do you calculate the energy landscape or the kinetics/dynamics of a sequence of conformational changes? What do you do with millions and millions of snapshots, each for a random orientational and/or conformational state, noisy and with artifacts? How can I use symmetry to my advantage? We will answer all these questions and more.

SPEAKERS:   Peter Schwander, Ali Dashti, Ahmad Hosseinizadeh, Marius Schmidt and Dilano Saldin. 

Topics:       Manifold Embedding – From Single-Particle Snapshots to Movies of Molecular Machines and Energy Landscapes

                   Structure Based Protein Dynamics 

                   Finding the Structures of Randomly Oriented Particles: Method of Angular Correlations.


In This Workshop

  1. Manifold Embedding

    07 Oct 2015 | Teaching Materials | Contributor(s): Peter Schwander

    From single particle snapshots to movies of molecular machines and energy landscapes.

  2. Energy Landscapes

    07 Oct 2015 | Teaching Materials | Contributor(s): Ali Dashti

    Energy landscapes and continuous conformational mapping of molecular machines.

  3. 3D Single Particle Structure Recovery

    07 Oct 2015 | Teaching Materials | Contributor(s): Ahmad Hosseinizadeh

    Dr. Ahmad Hosseinizadeh discuss different pathways to recovering the structure of single particles from XFEL snapshots.

  4. Angular Momentum Decomposition

    07 Oct 2015 | Teaching Materials | Contributor(s): Dilano Saldin

    Dr. Dilano Saldin discusses using angular momentum decomposition in the analysis of single and multi-particle imaging with XFELs.