• New Publication in PNAS Discusses Conformational Movies and Energy Landscapes

    Here we present a new analytical approach capable of determining the free-energy landscape and the continuous trajectories of molecular machines from a large number of snapshots obtained by cryogenic electron microscopy. We demonstrate this approach in the context of experimental cryogenic electron microscope images of a large ensemble of nontranslating ribosomes purified from yeast cells.

  • NSF establishes BioXFEL Science and Technology Center with a $25 million award

    The BioXFEL Center will focus on developing new X-ray bioimaging techniques — including an advanced form of X-ray crystallography called serial femtosecond crystallography — to analyze a vast array of new molecular targets for drug discovery.