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  1. Time-Resolved Macromolecular Crystallography at Modern X-Ray Sources

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    01 Jun 2017 | BioXFEL Publications | Contributor(s): Marius Schmidt

    http://dx.doi.org/10.1007/978-1-4939-7000-1_11 book-chapter NSF-STC Biology with X-ray Lasers (NSF-1231306) Schmidt, M., 2017. Time-Resolved Macromolecular Crystallography at Modern X-Ray Sources. Protein Crystallography, pp.273–294. Available at: http://dx.doi.org/10.1007/978-1-4939-7000-1_11. …

  2. Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation

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    24 May 2017 | BioXFEL Publications | Contributor(s): Jose M. Martin-Garcia, Chelsie E Conrad, Garrett Charles Nelson, Natasha Stander, Nadia Zatsepin, James D Zook, Lan Zhu, James Geiger, Eugene Chun, David Kissick, Mark C. Hilgart, Craig Ogata, Andrii Ishchenko, Nirupa Nagaratnam, Shatabdi Roy-Chowdhury, Jesse David Coe, GANESH SUBRAMANIAN, Alexander Schaffer, Daniel James, Gihan Ketwala, Nagarajan Venugopalan, Shenglan Xu, Stephen Corcoran, Dale Ferguson, Uwe Weierstall, John Spence, Vadim Cherezov, Petra Fromme, Robert F. Fischetti, Wei Liu

    http://dx.doi.org/10.1107/s205225251700570x Crystal structure determination of biological macromolecules using the novel technique of serial femtosecond crystallography (SFX) is severely limited by the scarcity of X-ray free-electron laser (XFEL) sources. However, recent and future upgrades render …

  3. Structure of the full-length glucagon class B G-protein-coupled receptor

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    17 May 2017 | BioXFEL Publications | Contributor(s): Haonan Zhang, Anna Qiao, Dehua Yang, Linlin Yang, Antao Dai, Chris De Graaf, Steffen Reedtz-Runge, Venkatasubramanian Dharmarajan, Hui Zhang, Gye Won Han, Thomas D. Grant, Raymond G. Sierra, Uwe Weierstall, Garrett Charles Nelson, Wei Liu, Yanhong Wu, Limin Ma, Xiaoqing Cai, Guangyao Lin, Xiaoai Wu, Zhi Geng, Yuhui Dong, Gaojie Song, Patrick R. Griffin, Jesper Lau, Vadim Cherezov, Huaiyu Yang, Michael A. Hanson, Raymond C. Stevens, Qiang Zhao, Hualiang Jiang, Ming-Wei Wang, Beili Wu

    http://dx.doi.org/10.1038/nature22363 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Zhang, Haonan et al., 2017. Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. Available at: http://dx.doi.org/10.1038/nature22363. Haonan Zhang and Anna Qiao and …

  4. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand

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    17 May 2017 | BioXFEL Publications | Contributor(s): Xianjun Zhang, Fei Zhao, Yiran Wu, Jun Yang, Gye Won Han, Suwen Zhao, Andrii Ishchenko, Lintao Ye, Xi Lin, Kang Ding, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Cornelius Gati, Garrett Charles Nelson, Mark S. Hunter, Michael A. Hanson, Vadim Cherezov, Raymond C. Stevens, Wenfu Tan, Houchao Tao, Fei Xu

    http://dx.doi.org/10.1038/ncomms15383 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Zhang, X. et al., 2017. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nature Communications, 8, p.15383. Available at: …

  5. Peripheral Blood Biomarkers Associated With Toxicity and Treatment Characteristics After 131 I- Metaiodobenzylguanidine Therapy in Patients With Neuroblastoma

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    15 May 2017 | BioXFEL Publications | Contributor(s): Kevin Campbell, Erin E. Karski, Aleksandra Olow, David A. Edmondson, Ayano C. Kohlgruber, Matthew Coleman, Daphne A. Haas-Kogan, Katherine K. Matthay, Steven G. DuBois

    http://dx.doi.org/10.1016/j.ijrobp.2017.05.008 journal-article Campbell, K. et al., 2017. Peripheral Blood Biomarkers Associated With Toxicity and Treatment Characteristics After 131 I- Metaiodobenzylguanidine Therapy in Patients With Neuroblastoma. International Journal of Radiation …

  6. Chemically Stable Lipids for Membrane Protein Crystallization

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    12 May 2017 | BioXFEL Publications | Contributor(s): Andrii Ishchenko, Lingling Peng, Egor Zinovev, Alexey Vlasov, Sung Chang Lee, Alexander Kuklin, Alexey Mishin, Valentin Borshchevskiy, Qinghai Zhang, Vadim Cherezov

    http://dx.doi.org/10.1021/acs.cgd.7b00458 journal-article Ishchenko, A. et al., 2017. Chemically Stable Lipids for Membrane Protein Crystallization. Crystal Growth & Design. Available at: http://dx.doi.org/10.1021/acs.cgd.7b00458. Andrii Ishchenko and Lingling Peng and Egor Zinovev and Alexey …

  7. XFELs for structure and dynamics in biology

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    10 May 2017 | BioXFEL Publications | Contributor(s): J. C. H. Spence

    http://dx.doi.org/10.1107/s2052252517005760 The development and application of the free-electron X-ray laser (XFEL) to structure and dynamics in biology since its inception in 2009 are reviewed. The research opportunities which result from the ability to outrun most radiation-damage effects are …

  8. Proposal Writing Workshop Agenda

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    08 May 2017 | Downloads | Contributor(s): Bill Bauer

    …

  9. Re-directing bacterial microcompartment systems to enhance recombinant expression of lysis protein E from bacteriophage ϕX174 in Escherichia coli

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    25 Apr 2017 | BioXFEL Publications | Contributor(s): Mimi C. Yung, Feliza A. Bourguet, Timothy S. Carpenter, Matthew Coleman

    http://dx.doi.org/10.1186/s12934-017-0685-x journal-article Yung, M.C. et al., 2017. Re-directing bacterial microcompartment systems to enhance recombinant expression of lysis protein E from bacteriophage ϕX174 in Escherichia coli. Microbial Cell Factories, 16(1). Available at: …

  10. Laser control over the ultrafast Coulomb explosion of N22+ after Auger decay: A quantum-dynamics investigation

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    24 Apr 2017 | BioXFEL Publications | Contributor(s): Athiya Mahmud Hanna, Oriol Vendrell, Abbas Ourmazd, Robin Santra

    http://dx.doi.org/10.1103/physreva.95.043419 journal-article Hanna, A.M. et al., 2017. Laser control over the ultrafast Coulomb explosion of N22+ after Auger decay: A quantum-dynamics investigation. Physical Review A, 95(4). Available at: http://dx.doi.org/10.1103/physreva.95.043419. Athiya …

  11. X-Ray Lasers in Biology

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    24 Apr 2017 | BioXFEL Publications | Contributor(s): John Spence

    http://dx.doi.org/10.1016/bs.aiep.2017.01.008 book-chapter NSF-STC Biology with X-ray Lasers (NSF-1231306) Spence, J.C.H., 2017. X-Ray Lasers in Biology. Advances in Imaging and Electron Physics, pp.103–152. Available at: http://dx.doi.org/10.1016/bs.aiep.2017.01.008. John C.H. Spence

  12. Split-Second Reactions

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    24 Apr 2017 | BioXFEL Publications | Contributor(s): Petra Fromme, John Spence

    http://dx.doi.org/10.1038/scientificamerican0517-62 journal-article Fromme, P. & Spence, J.C.H., 2017. Split-Second Reactions. Scientific American, 316(5), pp.62–67. Available at: http://dx.doi.org/10.1038/scientificamerican0517-62. Petra Fromme and John C. H. Spence

  13. A multi-model approach to assessing local and global cryo-EM map quality

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    20 Apr 2017 | BioXFEL Publications | Contributor(s): Mark A Herzik, James Fraser, Gabriel C Lander

    http://dx.doi.org/10.1101/128561 There does not currently exist a standardized indicator of how well a cryo-EM-derived model represents the density from which it was generated. We present a straightforward methodology that utilizes freely available tools to generate a suite of independent models …

  14. Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin

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    13 Apr 2017 | BioXFEL Publications | Contributor(s): Justin T. Biel, Michael Thompson, Christian N. Cunningham, Jacob E. Corn, James Fraser

    http://dx.doi.org/10.1016/j.str.2017.03.009 journal-article Biel, J.T. et al., 2017. Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin. Structure, 25(5), pp.739–749.e3. Available at: http://dx.doi.org/10.1016/j.str.2017.03.009. …

  15. Diffraction data of core-shell nanoparticles from an X-ray free electron laser

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    11 Apr 2017 | BioXFEL Publications | Contributor(s): Xuanxuan Li, Chun-Ya Chiu, Hsiang-Ju Wang, Stephan Kassemeyer, Sabine Botha, Robert L. Shoeman, Robert M Lawrence, Christopher Kupitz, Richard Kirian, Daniel James, Dingjie Wang, Garrett Charles Nelson, Marc Messerschmidt, Sébastien Boutet, Garth J. Williams, Elisabeth Hartmann, Aliakbar Jafarpour, Lutz M. Foucar, Anton Barty, Henry Chapman, Mengning Liang, Andreas Menzel, Fenglin Wang, Shibom Basu, Raimund Fromme, R. Bruce Doak, Petra Fromme, Uwe Weierstall, Michael H. Huang, John Spence, Ilme Schlichting, Brenda Hogue, Haiguang Liu

    http://dx.doi.org/10.1038/sdata.2017.48 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Li, X. et al., 2017. Diffraction data of core-shell nanoparticles from an X-ray free electron laser. Scientific Data, 4, p.170048. Available at: http://dx.doi.org/10.1038/sdata.2017.48. …

  16. Experimental strategies for imaging bioparticles with femtosecond hard X-ray pulses

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    07 Apr 2017 | BioXFEL Publications | Contributor(s): Benedikt J. Daurer, Kenta Okamoto, Johan Bielecki, Filipe R. N. C. Maia, Kerstin Mühlig, M. Marvin Seibert, Max F. Hantke, Carl Nettelblad, W. Henry Benner, Martin Svenda, Nicuşor Tîmneanu, Tomas Ekeberg, N. Duane Loh, Alberto Pietrini, Alessandro Zani, Asawari D. Rath, Daniel Westphal, Richard Kirian, Salah Awel, Max Oliver Wiedorn, Gijs Van Der Schot, Gunilla H. Carlsson, Dirk Hasse, Jonas A. Sellberg, Anton Barty, Jakob Andreasson, Sébastien Boutet, Garth Williams, Jason Koglin, Inger Andersson, Janos Hajdu, Daniel S. D. Larsson

    http://dx.doi.org/10.1107/s2052252517003591 This study explores the capabilities of the Coherent X-ray Imaging Instrument at the Linac Coherent Light Source to image small biological samples. The weak signal from small samples puts a significant demand on the experiment. AerosolizedOmono River …

  17. Structural basis for selectivity and diversity in angiotensin II receptors

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    04 Apr 2017 | BioXFEL Publications | Contributor(s): Haitao Zhang, Gye Won Han, Alexander Batyuk, Andrii Ishchenko, Kate L. White, Nilkanth N Patel, Anastasiia Sadybekov, Beata Zamlynny, Michael T. Rudd, Kaspar Hollenstein, Alexandra Tolstikova, Thomas A. White, Mark S. Hunter, Uwe Weierstall, Wei Liu, Kerim Babaoglu, Eric L. Moore, Ryan D. Katz, Jennifer M. Shipman, Margarita Garcia-Calvo, Sujata Sharma, Payal Sheth, Stephen M. Soisson, Raymond C. Stevens, Vsevolod Katritch, Vadim Cherezov

    http://dx.doi.org/10.1038/nature22035 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Zhang, H. et al., 2017. Structural basis for selectivity and diversity in angiotensin II receptors. Nature, 544(7650), pp.327–332. Available at: http://dx.doi.org/10.1038/nature22035. Haitao …

  18. Chromatin-remodeling for transcription

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    17 Mar 2017 | BioXFEL Publications | Contributor(s): Yahli Lorch, Roger Kornberg

    Abstract The nucleosome serves as a general gene repressor, preventing all initiation of transcription except that which is brought about by specific positive regulatory mechanisms. The positive mechanisms begin with chromatin-remodeling by complexes that slide, disrupt, or otherwise …

  19. Double-flow focused liquid injector for efficient serial femtosecond crystallography

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    16 Mar 2017 | BioXFEL Publications | Contributor(s): Dominik Oberthuer, Juraj Knoška, Max Oliver Wiedorn, Kenneth R. Beyerlein, David Bushnell, Elena G. Kovaleva, Michael Heymann, Lars Gumprecht, Richard Kirian, Anton Barty, Valerio Mariani, Aleksandra Tolstikova, Luigi Adriano, Salah Awel, Miriam Barthelmess, Katerina Dörner, P. Lourdu Xavier, Oleksandr Yefanov, Daniel R. James, Garrett Charles Nelson, Dingjie Wang, George Douglas Calvey, Yujie Chen, Andrea Schmidt, Michael Szczepek, Stefan Frielingsdorf, Oliver Lenz, Edward Snell, Philip J. Robinson, Božidar Šarler, Grega Belšak, Marjan Maček, Fabian Wilde, Andrew Aquila, Sébastien Boutet, Mengning Liang, Mark S. Hunter, Patrick Scheerer, John D. Lipscomb, Uwe Weierstall, Roger Kornberg, John Spence, Lois Pollack, Henry Chapman, Saša Bajt

    http://dx.doi.org/10.1038/srep44628 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Oberthuer, D. et al., 2017. Double-flow focused liquid injector for efficient serial femtosecond crystallography. Scientific Reports, 7, p.44628. Available at: http://dx.doi.org/10.1038/srep44628. …

  20. Moving in the Right Direction: Protein Vibrational Steering Function

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    14 Mar 2017 | BioXFEL Publications | Contributor(s): Katherine A. Niessen, Mengyang Xu, Alessandro Paciaroni, Andrea Orecchini, Edward Snell, Andrea Markelz

    journal-article http://dx.doi.org/10.1016/j.bpj.2016.12.049 Niessen, K.A. et al., 2017. Moving in the Right Direction: Protein Vibrational Steering Function. Biophysical Journal, 112(5), pp.933–942. Available at: http://dx.doi.org/10.1016/j.bpj.2016.12.049. Katherine A. Niessen and Mengyang Xu …

  21. Synthesis of two fluorescent GTPγS molecules and their biological relevance

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    10 Mar 2017 | BioXFEL Publications | Contributor(s): Denise J. Trans, Ruoli Bai, J. Bennet Addison, Ruiwu Liu, Ernest Hamel, Matthew Coleman, Paul T. Henderson

    http://dx.doi.org/10.1080/15257770.2016.1231320 journal-article Trans, D.J. et al., 2017. Synthesis of two fluorescent GTPγS molecules and their biological relevance. Nucleosides, Nucleotides and Nucleic Acids, 36(6), pp.379–391. Available at: http://dx.doi.org/10.1080/15257770.2016.1231320. …

  22. Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

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    02 Mar 2017 | BioXFEL Publications | Contributor(s): Franklin D Fuller, Sheraz Gul, Ruchira Chatterjee, E Sethe Burgie, Iris Diane Young, Hugo Lebrette, Vivek Srinivas, Aaron S Brewster, Tara Michels-Clark, Jonathan Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J Pollock, Miao Zhang, Claudiu A Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell Miller, Muhamed Amin, Sergey Koroidov, Christian G Roessler, Marc Allaire, Raymond G Sierra, Peter T Docker, James M Glownia, Silke Nelson, Jason E Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K Boal, J Martin Bollinger, Carsten Krebs, Martin Högbom, George Phillips, Richard D Vierstra, Nicholas K Sauter, Allen M Orville, Jan Kern, Vittal K Yachandra, Junko Yano

    journal-article http://dx.doi.org/10.1038/nmeth.4195 NSF-STC Biology with X-ray Lasers (NSF-1231306) Fuller, F.D. et al., 2017. Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers. Nature Methods, 14(4), pp.443–449. Available at: …

  23. Ondrej Krivanek's early scientific research

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    01 Mar 2017 | BioXFEL Publications | Contributor(s): John Spence

    http://dx.doi.org/10.1016/j.ultramic.2016.12.006 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Spence, J.C.H., 2017. Ondrej Krivanek’s early scientific research. Ultramicroscopy, 180, pp.8–13. Available at: http://dx.doi.org/10.1016/j.ultramic.2016.12.006. John C.H. Spence

  24. Serial crystallography at synchrotrons and X-ray lasers

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    23 Feb 2017 | BioXFEL Publications | Contributor(s): Jörg Standfuss, John Spence

    http://dx.doi.org/10.1107/s2052252517001877 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Standfuss, J. & Spence, J., 2017. Serial crystallography at synchrotrons and X-ray lasers. IUCrJ, 4(2), pp.100–101. Available at: http://dx.doi.org/10.1107/s2052252517001877. Jörg …

  25. An Engineered TGF-β Monomer that Functions as a Dominant Negative to Block TGF-β Signaling

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    22 Feb 2017 | BioXFEL Publications | Contributor(s): Sun Kyung Kim, Lindsey Barron, Cynthia S. Hinck, Elyse M. Petrunak, Kristin E. Cano, Avinash Thangirala, Brian Iskra, Molly Brothers, Machell Vonberg, Belinda Leal, Blair Richter, Ravindra Kodali, Alexander B. Taylor, Shoucheng Du, Christopher Barnes, Traian Sulea, Guillermo Calero, P. John Hart, Matthew J. Hart, Borries Demeler, Andrew P. Hinck

    journal-article http://dx.doi.org/10.1074/jbc.m116.768754 Kim, S.K. et al., 2017. An Engineered TGF-β Monomer that Functions as a Dominant Negative to Block TGF-β Signaling. Journal of Biological Chemistry, p.jbc.M116.768754. Available at: http://dx.doi.org/10.1074/jbc.m116.768754. Sun Kyung …

  26. Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptide

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    22 Feb 2017 | BioXFEL Publications | Contributor(s): Arpan Deb, William A. Johnson, Alexander P. Kline, Boston J. Scott, Lydia R. Meador, Dustin Srinivas, Jose M. Martin-Garcia, Katerina Dörner, Chad R. Borges, Rajeev Misra, Brenda Hogue, Petra Fromme, Tsafrir S. Mor

    http://dx.doi.org/10.1371/journal.pone.0172529 journal-article Deb, A. et al., 2017. Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptide M. Schindler, ed. PLOS ONE, 12(2), p.e0172529. Available at: …

  27. Mechanism of Human Apohemoglobin Unfolding

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    21 Feb 2017 | BioXFEL Publications | Contributor(s): Premila P. Samuel, William C. Ou, George Phillips, John S. Olson

    http://dx.doi.org/10.1021/acs.biochem.6b01235 journal-article Samuel, P.P. et al., 2017. Mechanism of Human Apohemoglobin Unfolding. Biochemistry, 56(10), pp.1444–1459. Available at: http://dx.doi.org/10.1021/acs.biochem.6b01235. Premila P. Samuel and William C. Ou and George N. Phillips and …

  28. A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay

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    21 Feb 2017 | BioXFEL Publications | Contributor(s): Hou-Fu Guo, Eun Jeong Cho, Ashwini K. Devkota, Yulong Chen, William Russell, George Phillips, Mitsuo Yamauchi, Kevin N. Dalby, Jonathan M. Kurie

    journal-article http://dx.doi.org/10.1016/j.abb.2017.02.003 Guo, H.-F. et al., 2017. A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay. Archives of Biochemistry and Biophysics, 618, pp.45–51. Available at: http://dx.doi.org/10.1016/j.abb.2017.02.003. …

  29. The impact of base stacking on the conformations and electrostatics of single-stranded DNA

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    17 Feb 2017 | BioXFEL Publications | Contributor(s): Alex Plumridge, Steve P. Meisburger, Kurt Andresen, Lois Pollack

    http://dx.doi.org/10.1093/nar/gkx140 journal-article Plumridge, A. et al., 2017. The impact of base stacking on the conformations and electrostatics of single-stranded DNA. Nucleic Acids Research. Available at: http://dx.doi.org/10.1093/nar/gkx140. Alex Plumridge and Steve P. Meisburger and Kurt …

  30. Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser

    0.0 out of 5 stars 

    15 Feb 2017 | BioXFEL Publications | Contributor(s): Cornelius Gati, Dominik Oberthuer, Oleksandr Yefanov, Richard D. Bunker, Francesco Stellato, Elaine Chiu, Shin-Mei Yeh, Andrew Aquila, Shibom Basu, Richard Bean, Kenneth R. Beyerlein, Sabine Botha, Sébastien Boutet, Daniel P. DePonte, R. Bruce Doak, Raimund Fromme, Lorenzo Galli, Ingo Grotjohann, Daniel R. James, Christopher Kupitz, Lukas Lomb, Marc Messerschmidt, Karol Nass, Kimberly Rendek, Robert L. Shoeman, Dingjie Wang, Uwe Weierstall, Thomas A. White, Garth J. Williams, Nadia Zatsepin, Petra Fromme, John Spence, Kenneth N. Goldie, Johannes A. Jehle, Peter Metcalf, Anton Barty, Henry Chapman

    journal-article http://dx.doi.org/10.1073/pnas.1609243114 NSF-STC Biology with X-ray Lasers (NSF-1231306) Gati, C. et al., 2017. Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser. Proceedings of the National Academy of Sciences, …

  31. Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED

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    13 Feb 2017 | BioXFEL Publications | Contributor(s): M Jason De La Cruz, Johan Hattne, Dan Shi, Paul Seidler, Jose Rodriguez, Francis E Reyes, Michael R Sawaya, Duilio Cascio, Simon C Weiss, Sun Kyung Kim, Cynthia S Hinck, Andrew P Hinck, Guillermo Calero, David Eisenberg, Tamir Gonen

    journal-article http://dx.doi.org/10.1038/nmeth.4178 NSF-STC Biology with X-ray Lasers (NSF-1231306) De la Cruz, M.J. et al., 2017. Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nature Methods, 14(4), pp.399–402. Available at: …

  32. Structure and specificity of a permissive bacterial C-prenyltransferase

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    06 Feb 2017 | BioXFEL Publications | Contributor(s): Sherif I Elshahawi, Hongnan Cao, Khaled A Shaaban, Larissa V Ponomareva, Thangaiah Subramanian, Mark L Farman, H Peter Spielmann, George Phillips, Jon S Thorson, Shanteri Singh

    journal-article http://dx.doi.org/10.1038/nchembio.2285 Elshahawi, S.I. et al., 2017. Structure and specificity of a permissive bacterial C-prenyltransferase. Nature Chemical Biology, 13(4), pp.366–368. Available at: http://dx.doi.org/10.1038/nchembio.2285. Sherif I Elshahawi and Hongnan Cao …

  33. Retinal oxidative stress at the onset of diabetes determined by synchrotron FTIR widefield imaging: towards diabetes pathogenesis

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    06 Feb 2017 | BioXFEL Publications | Contributor(s): Ebrahim Aboualizadeh, Mahsa Ranji, Christine M. Sorenson, Reyhaneh Sepehr, Nader Sheibani, Carol J. Hirschmugl

    A mechanistic understanding of oxidative damage in the retina and the significance of photoreceptors at the onset of diabetic retinopathy are reported. journal-article http://dx.doi.org/10.1039/c6an02603f Aboualizadeh, E. et al., 2017. Retinal oxidative stress at the onset of diabetes determined …

  34. Model Comparison to Identify Structural Heterogeneity in Protein X-Ray Crystallography

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    04 Feb 2017 | BioXFEL Publications | Contributor(s): Nathan S. Babcock, David A. Sivak, Daniel Keedy, James Fraser

    http://dx.doi.org/10.1016/j.bpj.2016.11.2628 journal-article Babcock, N.S. et al., 2017. Model Comparison to Identify Structural Heterogeneity in Protein X-Ray Crystallography. Biophysical Journal, 112(3), p.486a. Available at: http://dx.doi.org/10.1016/j.bpj.2016.11.2628. Nathan S. Babcock and …

  35. Role of the MT1 and MT2 melatonin receptors in mediating depressive- and anxiety-like behaviors in C3H/HeN mice

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    03 Feb 2017 | BioXFEL Publications | Contributor(s): J. Liu, S. J. Clough, M. L. Dubocovich

    http://dx.doi.org/10.1111/gbb.12369 journal-article Liu, J., Clough, S.J. & Dubocovich, M.L., 2017. Role of the MT1 and MT2 melatonin receptors in mediating depressive- and anxiety-like behaviors in C3H/HeN mice. Genes, Brain and Behavior, 16(5), pp.546–553. Available at: …

  36. A short history of structure based research on the photocycle of photoactive yellow protein

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    31 Jan 2017 | BioXFEL Publications | Contributor(s): Marius Schmidt

    journal-article http://dx.doi.org/10.1063/1.4974172 NSF-STC Biology with X-ray Lasers (NSF-1231306) Schmidt, M., 2017. A short history of structure based research on the photocycle of photoactive yellow protein. Structural Dynamics, 4(3), p.032201. Available at: …

  37. Chromatin potentiates transcription

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    30 Jan 2017 | BioXFEL Publications | Contributor(s): Shigeki Nagai, Ralph E. Davis, Pierre Jean Mattei, Kyle Patrick Eagen, Roger Kornberg

    journal-article http://dx.doi.org/10.1073/pnas.1620312114 Nagai, S. et al., 2017. Chromatin potentiates transcription. Proceedings of the National Academy of Sciences, 114(7), pp.1536–1541. Available at: http://dx.doi.org/10.1073/pnas.1620312114. Shigeki Nagai and Ralph E. Davis and Pierre Jean …

  38. Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization

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    30 Jan 2017 | BioXFEL Publications | Contributor(s): Madison B. Adolph, Anjuman Ara, Yuqing Feng, Cristina J. Wittkopp, Michael Emerman, James Fraser, Linda Chelico

    journal-article http://dx.doi.org/10.1093/nar/gkx066 Adolph, M.B. et al., 2017. Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization. Nucleic Acids Research, 45(6), pp.3378–3394. Available at: http://dx.doi.org/10.1093/nar/gkx066. …

  39. Spermine Condenses DNA, but Not RNA Duplexes

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    10 Jan 2017 | BioXFEL Publications | Contributor(s): Andrea Katz, Igor S. Tolokh, Suzette A. Pabit, Nathan Baker, Alexey V. Onufriev, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2016.11.018 journal-article Katz, A.M. et al., 2017. Spermine Condenses DNA, but Not RNA Duplexes. Biophysical Journal, 112(1), pp.22–30. Available at: http://dx.doi.org/10.1016/j.bpj.2016.11.018. Andrea M. Katz and Igor S. Tolokh and Suzette A. Pabit and Nathan …

  40. OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation

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    09 Jan 2017 | BioXFEL Publications | Contributor(s): Ryan R. Hughes, Khaled A. Shaaban, Jianjun Zhang, Hongnan Cao, George Phillips, Jon S. Thorson

    http://dx.doi.org/10.1002/cbic.201600676 journal-article Hughes, R.R. et al., 2017. OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation. ChemBioChem, 18(4), pp.363–367. Available at: http://dx.doi.org/10.1002/cbic.201600676. Ryan R. Hughes and Khaled A. Shaaban and Jianjun …

  41. Asymmetric unwrapping of nucleosomal DNA propagates asymmetric opening and dissociation of the histone core

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    27 Dec 2016 | BioXFEL Publications | Contributor(s): Yujie Chen, Joshua M. Tokuda, Traci Topping, Steve P. Meisburger, Suzette A. Pabit, Lisa M. Gloss, Lois Pollack

    http://dx.doi.org/10.1073/pnas.1611118114 journal-article Chen, Y. et al., 2016. Asymmetric unwrapping of nucleosomal DNA propagates asymmetric opening and dissociation of the histone core. Proceedings of the National Academy of Sciences, 114(2), pp.334–339. Available at: …

  42. Carbamate Insecticides Target Human Melatonin Receptors

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    27 Dec 2016 | BioXFEL Publications | Contributor(s): Marina Popovska-Gorevski, Margarita L. Dubocovich, Rajendram V. Rajnarayanan

    http://dx.doi.org/10.1021/acs.chemrestox.6b00301 journal-article Popovska-Gorevski, M., Dubocovich, M.L. & Rajnarayanan, R.V., 2017. Carbamate Insecticides Target Human Melatonin Receptors. Chemical Research in Toxicology, 30(2), pp.574–582. Available at: …

  43. Conformational variation of proteins at room temperature is not dominated by radiation damage

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    21 Dec 2016 | BioXFEL Publications | Contributor(s): Silvia Russi, Ana González, Lillian R. Kenner, Daniel A. Keedy, James Fraser, Henry Van Den Bedem

    Protein crystallography data collection at synchrotrons is routinely carried out at cryogenic temperatures to mitigate radiation damage. Although damage still takes place at 100 K and below, the immobilization of free radicals increases the lifetime of the crystals by approximately 100-fold. …

  44. LCLS Beam-time Schedules

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    20 Dec 2016 | Downloads

    All Schedules on LCLS Website LCLS Run 15 Schedule (June 2017 - Nov 2017)LCLS Run 14 Schedule (Aug 2016 - Dec 2016)LCLS Run 13 Schedule (Mar 2016 - Aug 2016)LCLS Run 12 Schedule (Oct 2015 - Mar 2016)LCLS Run 11 Schedule (Mar 2015 - Aug 2015)LCLS Run 10 Schedule (Oct 2014 - Mar 2015)

  45. Structural enzymology using X-ray free electron lasers

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    15 Dec 2016 | BioXFEL Publications | Contributor(s): Christopher Kupitz, Jose L. Olmos, Mark Holl, Lee Tremblay, Kanupriya Pande, Suraj Pandey, Dominik Oberthür, Mark S. Hunter, Mengning Liang, Andrew Aquila, Jason Tenboer, George Douglas Calvey, Andrea Katz, Yujie Chen, Max Oliver Wiedorn, Juraj Knoska, Alke Meents, Valerio Majriani, Tyler Norwood, Ishwor Poudyal, Thomas Grant, Mitchell Miller, Weijun Xu, Aleksandra Tolstikova, Andrew Morgan, Markus Metz, Jose M. Martin-Garcia, James D Zook, Shatabdi Roy-Chowdhury, Jesse David Coe, Nirupa Nagaratnam, Domingo Meza, Raimund Fromme, Shibom Basu, Matthias Frank, Thomas White, Anton Barty, Sasa Bajt, Oleksandr Yefanov, Henry Chapman, Nadia Zatsepin, Garrett Charles Nelson, Uwe Weierstall, John Spence, Peter Schwander, Lois Pollack, Petra Fromme, Abbas Ourmazd, George Phillips, Marius Schmidt

    http://dx.doi.org/10.1063/1.4972069 Christopher Kupitz and Jose L. Olmos and Mark Holl and Lee Tremblay and Kanupriya Pande and Suraj Pandey and Dominik Oberthür and Mark Hunter and Mengning Liang and Andrew Aquila and Jason Tenboer and George Calvey and Andrea Katz and Yujie Chen and Max O. …

  46. Visualizing single-stranded nucleic acids in solution

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    13 Dec 2016 | BioXFEL Publications | Contributor(s): Alex Plumridge, Steve P. Meisburger, Lois Pollack

    http://dx.doi.org/10.1093/nar/gkw1297 journal-article Plumridge, A., Meisburger, S.P. & Pollack, L., 2016. Visualizing single-stranded nucleic acids in solution. Nucleic Acids Research, p.gkw1297. Available at: http://dx.doi.org/10.1093/nar/gkw1297. Alex Plumridge and Steve P. Meisburger and …

  47. Continuous Separation of DNA Molecules by Size Using Insulator-Based Dielectrophoresis

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    12 Dec 2016 | BioXFEL Publications | Contributor(s): Paul V. Jones, Gabriel L. Salmon, Alexandra Ros

    journal-article http://dx.doi.org/10.1021/acs.analchem.6b03369 Jones, P.V., Salmon, G.L. & Ros, A., 2017. Continuous Separation of DNA Molecules by Size Using Insulator-Based Dielectrophoresis. Analytical Chemistry, 89(3), pp.1531–1539. Available at: …

  48. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

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    06 Dec 2016 | BioXFEL Publications | Contributor(s): Yi Zheng, Ling Qin, Natalia V. Ortiz Zacarías, Henk De Vries, Gye Won Han, Martin Gustavsson, Marta Dabros, Chunxia Zhao, Robert J. Cherney, Percy Carter, Dean Stamos, Ruben Abagyan, Vadim Cherezov, Raymond C. Stevens, Adriaan P. IJzerman, Laura H. Heitman, Andrew Tebben, Irina Kufareva, Tracy M. Handel

    http://dx.doi.org/10.1038/nature20605 journal-article Zheng, Y. et al., 2016. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature, 540(7633), pp.458–461. Available at: http://dx.doi.org/10.1038/nature20605. Yi Zheng and Ling Qin and Natalia V. Ortiz …

  49. Lecture Series

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    01 Dec 2016 | Teaching Materials

    BioXFEL Lecture Series videos are kept here.

  50. Journal Club Seminars

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    01 Dec 2016 | Teaching Materials

    Videos of all past Journal Clubs 

  51. Editorial overview: Biophysical and molecular biological methods

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    28 Nov 2016 | BioXFEL Publications | Contributor(s): Petra Fromme, Andrej Sali

    http://dx.doi.org/10.1016/j.sbi.2016.11.015 journal-article Fromme, P. & Sali, A., 2016. Editorial overview: Biophysical and molecular biological methods. Current Opinion in Structural Biology, 40, pp.ix–xi. Available at: http://dx.doi.org/10.1016/j.sbi.2016.11.015. Petra Fromme and Andrej Sali

  52. Structure of photosystem II and substrate binding at room temperature

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    18 Nov 2016 | BioXFEL Publications | Contributor(s): Iris Diane Young, Mohamed Ibrahim, Ruchira Chatterjee, Sheraz Gul, Franklin D. Fuller, Sergey Koroidov, Aaron S. Brewster, Rosalie Tran, Roberto Alonso-Mori, Thomas Kroll, Tara Michels-Clark, Hartawan Laksmono, Raymond G. Sierra, Claudiu A. Stan, Rana Hussein, Miao Zhang, Lacey Douthit, Markus Kubin, Casper De Lichtenberg, Long Vo Pham, Håkan Nilsson, Mun Hon Cheah, Dmitriy Shevela, Claudio Saracini, Mackenzie A. Bean, Ina Seuffert, Dimosthenis Sokaras, Tsu-Chien Weng, Ernest Pastor, Clemens Weninger, Thomas Fransson, Louise Lassalle, Philipp Bräuer, Pierre Aller, Peter T. Docker, Babak Andi, Allen M. Orville, James M. Glownia, Silke Nelson, Marcin Sikorski, Diling Zhu, Mark S. Hunter, Thomas J. Lane, Andy Aquila, Jason E. Koglin, Joseph Robinson, Mengning Liang, Sébastien Boutet, Artem Y. Lyubimov, Monarin Uervirojnangkoorn, Nigel W. Moriarty, Dorothee Liebschner, Pavel V. Afonine, David G. Waterman, Gwyndaf Evans, Philippe Wernet, Holger Dobbek, William I. Weis, Axel T. Brunger, Petrus H. Zwart, Paul D. Adams, Athina Zouni, Johannes Messinger, Uwe Bergmann, Nicholas K. Sauter, Jan Kern, Vittal K. Yachandra, Junko Yano

    http://dx.doi.org/10.1038/nature20161 Iris D. Young and Mohamed Ibrahim and Ruchira Chatterjee and Sheraz Gul and Franklin D. Fuller and Sergey Koroidov and Aaron S. Brewster and Rosalie Tran and Roberto Alonso-Mori and Thomas Kroll and Tara Michels-Clark and Hartawan Laksmono and Raymond G. Sierra …

  53. Simulations of single-pulse Laue diffraction from proteins with radiation from synchrotron and XFEL sources

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    15 Nov 2016 | BioXFEL Publications | Contributor(s): Victoria Kabanova, Marius Schmidt, Friedrich Schotte, Marco Cammarata, Michael Wulff

    http://dx.doi.org/10.1107/s2053273316097898 journal-article Kabanova, V. et al., 2016. Simulations of single-pulse Laue diffraction from proteins with radiation from synchrotron and XFEL sources. Acta Crystallographica Section A Foundations and Advances, 72(a1), pp.s142–s142. Available at: …

  54. Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography

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    15 Nov 2016 | BioXFEL Publications | Contributor(s): Przemyslaw Nogly, Valerie Panneels, Garrett Charles Nelson, Cornelius Gati, Tetsunari Kimura, Christopher Milne, Despina Milathianaki, Minoru Kubo, Wenting Wu, Chelsie E Conrad, Jesse David Coe, Richard Bean, Yun Zhao, Petra Bath, Robert Dods, Rajiv Harimoorthy, Kenneth Beyerlein, Jan Rheinberger, Daniel James, Daniel DePonte, Chufeng Li, Leonardo Sala, Garth Williams, Mark S. Hunter, Jason E. Koglin, Peter Berntsen, Eriko Nango, So Iwata, Henry Chapman, Petra Fromme, Matthias Frank, Rafael Abela, Sébastien Boutet, Anton Barty, Thomas A. White, Uwe Weierstall, John Spence, Richard Neutze, Gebhard F.X. Schertler, Jörg Standfuss

    http://dx.doi.org/10.1107/s2053273316099368 Przemyslaw Nogly and Valerie Panneels and Garrett Nelson and Cornelius Gati and Tetsunari Kimura and Christopher Milne and Despina Milathianaki and Minoru Kubo and Wenting Wu and Chelsie Conrad and Jesse Coe and Richard Bean and Yun Zhao and Petra Bath …

  55. The use of haptic interfaces and web services in crystallography: an application for a `screen to beam' interface

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    11 Nov 2016 | BioXFEL Publications | Contributor(s): Andrew E. Bruno, Alexei S. Soares, Robin L. Owen, Edward Snell

    http://dx.doi.org/10.1107/s160057671601431x Haptic interfaces have become common in consumer electronics. They enable easy interaction and information entry without the use of a mouse or keyboard. The work presented here illustrates the application of a haptic interface to crystallization screening …

  56. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

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    11 Nov 2016 | BioXFEL Publications | Contributor(s): J. R. Stagno, Y. Liu, Y. R. Bhandari, C. E. Conrad, S. Panja, M. Swain, L. Fan, G. Nelson, C. Li, D. R. Wendel, T. A. White, J. D. Coe, M. O. Wiedorn, J. Knoska, D. Oberthuer, R. A. Tuckey, P. Yu, M. Dyba, S. G. Tarasov, U. Weierstall, T. D. Grant, C. D. Schwieters, J. Zhang, A. R. Ferré-D’Amaré, P. Fromme, D. E. Draper, M. Liang, M. S. Hunter, S. Boutet, K. Tan, X. Zuo, X. Ji, A. Barty, N. A. Zatsepin, H. N. Chapman, J. C. H. Spence, S. A. Woodson, Y.-X. Wang

    http://dx.doi.org/10.1038/nature20599 J. R. Stagno and Y. Liu and Y. R. Bhandari and C. E. Conrad and S. Panja and M. Swain and L. Fan and G. Nelson and C. Li and D. R. Wendel and T. A. White and J. D. Coe and M. O. Wiedorn and J. Knoska and D. Oberthuer and R. A. Tuckey and P. Yu and M. Dyba and …

  57. Development of a photophoretic optical guide for femtosecond x-ray diffractive imaging of aerosolized nanoparticles (Conference Presentation)

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    10 Nov 2016 | BioXFEL Publications | Contributor(s): Richard Kirian, Salah Awel, Max Oliver Wiedorn, Daniel Horke, Nils Roth, Niko O. Eckerskorn, Jochen Küpper, Henry Chapman, Andrei V. Rode

    http://dx.doi.org/10.1117/12.2239171 Richard A. Kirian and Salah Awel and Max Wiedorn and Daniel Horke and Nils Roth and Niko O. Eckerskorn and Jochen Küpper and Henry N. Chapman and Andrei V. Rode Kirian, R.A. et al., 2016. Development of a photophoretic optical guide for femtosecond x-ray …

  58. 4th BioXFEL Conference

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    04 Nov 2016 | Downloads

    …

  59. Selenium single-wavelength anomalous diffraction de novo phasing using an X-ray-free electron laser

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    04 Nov 2016 | BioXFEL Publications | Contributor(s): Mark S. Hunter, Chun Hong Yoon, Hasan Demirci, Raymond G. Sierra, E. Han Dao, Radman Ahmadi, Fulya Aksit, Andrew L. Aquila, Halilibrahim Ciftci, Serge Guillet, Matt J. Hayes, Thomas J. Lane, Meng Liang, Ulf Lundström, Jason E. Koglin, Paul Mgbam, Yashas Rao, Lindsey Zhang, Soichi Wakatsuki, James Holton, Sébastien Boutet

    http://dx.doi.org/10.1038/ncomms13388 Mark S. Hunter and Chun Hong Yoon and Hasan DeMirci and Raymond G. Sierra and E. Han Dao and Radman Ahmadi and Fulya Aksit and Andrew L. Aquila and Halilibrahim Ciftci and Serge Guillet and Matt J. Hayes and Thomas J. Lane and Meng Liang and Ulf Lundström and …

  60. Advanced Transmission Electron Microscopy

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    25 Oct 2016 | BioXFEL Publications | Contributor(s): Jian Min Zuo, John Spence

    http://dx.doi.org/10.1007/978-1-4939-6607-3 book Zuo, J.M. & Spence, J.C.H., 2017. Advanced Transmission Electron Microscopy. Available at: http://dx.doi.org/10.1007/978-1-4939-6607-3. Jian Min Zuo and John C.H. Spence

  61. XFEL Game - Windows Download

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    25 Oct 2016 | Downloads | Contributor(s): fiacre

    Windows Version

  62. The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography

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    19 Oct 2016 | BioXFEL Publications | Contributor(s): Petra Edlund, Heikki Takala, Elin Claesson, Léocadie Henry, Robert Dods, Heli Lehtivuori, Matthijs Panman, Kanupriya Pande, Thomas White, Takanori Nakane, Oskar Berntsson, Emil Gustavsson, Petra Båth, Vaibhav Modi, Shatabdi Roy-Chowdhury, James D Zook, Peter Berntsen, Suraj Pandey, Ishwor Poudyal, Jason Tenboer, Christopher Kupitz, Anton Barty, Petra Fromme, Jake D. Koralek, Tomoyuki Tanaka, John Spence, Mengning Liang, Mark S. Hunter, Sebastien Boutet, Eriko Nango, Keith Moffat, Gerrit Groenhof, Janne Ihalainen, Emina A. Stojković, Marius Schmidt, Sebastian Westenhoff

    http://dx.doi.org/10.1038/srep35279 Petra Edlund and Heikki Takala and Elin Claesson and Léocadie Henry and Robert Dods and Heli Lehtivuori and Matthijs Panman and Kanupriya Pande and Thomas White and Takanori Nakane and Oskar Berntsson and Emil Gustavsson and Petra Båth and Vaibhav Modi and …

  63. Flexibility and design: conformational heterogeneity along the evolutionary trajectory of a redesigned ubiquitin

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    19 Oct 2016 | BioXFEL Publications | Contributor(s): Justin T Biel, Michael Thompson, Christian N Cunningham, Jacob E Corn, James Fraser

    http://dx.doi.org/10.1101/081646 Although protein design has been used to introduce new functions, designed variants generally only function as well as natural proteins after rounds of laboratory evolution. One possibility for this pattern is that designed mutants frequently sample nonfunctional …

  64. Learned motivation drives circadian physiology in the absence of the master circadian clock

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    12 Oct 2016 | BioXFEL Publications | Contributor(s): Oliver Rawashdeh, Shannon J. Clough, Randall L. Hudson, Margarita L. Dubocovich

    http://dx.doi.org/10.1096/fj.201600926r journal-article Rawashdeh, O. et al., 2017. Learned motivation drives circadian physiology in the absence of the master circadian clock. The FASEB Journal, 31(1), pp.388–399. Available at: http://dx.doi.org/10.1096/fj.201600926r. Oliver Rawashdeh and …

  65. Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex

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    12 Oct 2016 | BioXFEL Publications | Contributor(s): Artem Y Lyubimov, Monarin Uervirojnangkoorn, Oliver B Zeldin, Qiangjun Zhou, Minglei Zhao, Aaron S Brewster, Tara Michels-Clark, James Holton, Nicholas K Sauter, William I Weis, Axel T Brunger

    X-ray free electron lasers (XFELs) reduce the effects of radiation damage on macromolecular diffraction data and thereby extend the limiting resolution. Previously, we adapted classical post-refinement techniques to XFEL diffraction data to produce accurate diffraction data sets from a limited …

  66. Successful Strategies to Determine High-Resolution Structures of GPCRs

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    11 Oct 2016 | BioXFEL Publications | Contributor(s): Jin Xiang, Eugene Chun, Chang Liu, Liang Jing, Zina Al-Sahouri, Lan Zhu, Wei Liu

    journal-article http://dx.doi.org/10.1016/j.tips.2016.09.009 NSF-STC Biology with X-ray Lasers (NSF-1231306) Xiang, J. et al., 2016. Successful Strategies to Determine High-Resolution Structures of GPCRs. Trends in Pharmacological Sciences, 37(12), pp.1055–1069. Available at: …

  67. Reconstruction of an object from diffraction intensities averaged over multiple object clusters

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    29 Sep 2016 | BioXFEL Publications | Contributor(s): J P J Chen, R D Arnal, A J Morgan, R J Bean, K R Beyerlein, H N Chapman, P J Bones, R P Millane, R A Kirian

    http://dx.doi.org/10.1088/2040-8978/18/11/114003 J P J Chen and R D Arnal and A J Morgan and R J Bean and K R Beyerlein and H N Chapman and P J Bones and R P Millane and R A Kirian Chen, J.P.J. et al., 2016. Reconstruction of an object from diffraction intensities averaged over multiple object …

  68. De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure

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    27 Sep 2016 | BioXFEL Publications | Contributor(s): Jacques-Philippe Colletier, Michael R. Sawaya, Mari Gingery, Jose A. Rodriguez, Duilio Cascio, Aaron S. Brewster, Tara Michels-Clark, Robert H. Hice, Nicolas Coquelle, Sébastien Boutet, Garth J. Williams, Marc Messerschmidt, Daniel P. DePonte, Raymond G. Sierra, Hartawan Laksmono, Jason E. Koglin, Mark S. Hunter, Hyun-Woo Park, Monarin Uervirojnangkoorn, Dennis K. Bideshi, Axel T. Brunger, Brian A. Federici, Nicholas K. Sauter, David S. Eisenberg

    http://dx.doi.org/10.1038/nature19825 Jacques-Philippe Colletier and Michael R. Sawaya and Mari Gingery and Jose A. Rodriguez and Duilio Cascio and Aaron S. Brewster and Tara Michels-Clark and Robert H. Hice and Nicolas Coquelle and Sébastien Boutet and Garth J. Williams and Marc Messerschmidt and …

  69. Angular correlations of photons from solution diffraction at a free-electron laser encode molecular structure

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    26 Sep 2016 | BioXFEL Publications | Contributor(s): Derek Mendez, Herschel Watkins, Shenglan Qiao, Kevin S. Raines, Thomas J. Lane, Gundolf Schenk, Garrett Charles Nelson, GANESH SUBRAMANIAN, Kensuke Tono, Yasumasa Joti, Makina Yabashi, Daniel Ratner, Sebastian Doniach

    During X-ray exposure of a molecular solution, photons scattered from the same molecule are correlated. If molecular motion is insignificant during exposure, then differences in momentum transfer between correlated photons are direct measurements of the molecular structure. In conventional small- …

  70. Native phasing of x-ray free-electron laser data for a G protein-coupled receptor

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    23 Sep 2016 | BioXFEL Publications | Contributor(s): Alexander Batyuk, Lorenzo Galli, Andrii Ishchenko, Gye Won Han, Cornelius Gati, Petr A. Popov, Ming-Yue Lee, Benjamin Stauch, Thomas A. White, Anton Barty, Andrew Aquila, Mark S. Hunter, Mengning Liang, Sébastien Boutet, Mengchen Pu, Zhi-jie Liu, Garrett Charles Nelson, Daniel James, Chufeng Li, Yun Zhao, John Spence, Wei Liu, Petra Fromme, Vsevolod Katritch, Uwe Weierstall, Raymond C. Stevens, Vadim Cherezov

    http://dx.doi.org/10.1126/sciadv.1600292 Alexander Batyuk and Lorenzo Galli and Andrii Ishchenko and Gye Won Han and Cornelius Gati and Petr A. Popov and Ming-Yue Lee and Benjamin Stauch and Thomas A. White and Anton Barty and Andrew Aquila and Mark S. Hunter and Mengning Liang and Sébastien …

  71. Spectral Hole Burning in Cyanobacterial Photosystem I with P700 in Oxidized and Neutral States

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    23 Sep 2016 | BioXFEL Publications | Contributor(s): Nicoleta Herascu, Mark S. Hunter, Golia Shafiei, Mehdi Najafi, T. Wade Johnson, Petra Fromme, Valter Zazubovich

    http://dx.doi.org/10.1021/acs.jpcb.6b07803 Nicoleta Herascu and Mark S. Hunter and Golia Shafiei and Mehdi Najafi and T. Wade Johnson and Petra Fromme and Valter Zazubovich Herascu, N. et al., 2016. Spectral Hole Burning in Cyanobacterial Photosystem I with P700 in Oxidized and Neutral States. The …

  72. Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography

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    20 Sep 2016 | BioXFEL Publications | Contributor(s): Andrii Ishchenko, Vadim Cherezov, Wei Liu

    http://dx.doi.org/10.3791/54463 Andrii Ishchenko and Vadim Cherezov and Wei Liu Ishchenko, A., Cherezov, V. & Liu, W., 2016. Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography. Journal of Visualized Experiments, (115). Available at: …

  73. Crystallographic Methods of Structural Biology

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    18 Sep 2016 | Courses | Contributor(s): Robert H Blessing, Edward Snell

    The goal of the course is that students acquire sufficient knowledge and understanding of the basic principles of biomolecular crystal structure analysis that they will be able to comfortably, and with interest and insight, read and comprehend the articles in Volume F of the International Tables …

  74. Establishing nonlinearity thresholds with ultraintense X-ray pulses

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    13 Sep 2016 | BioXFEL Publications | Contributor(s): Jakub Szlachetko, Joanna Hoszowska, Jean-Claude Dousse, Maarten Nachtegaal, Wojciech Błachucki, Yves Kayser, Jacinto Sà, Marc Messerschmidt, Sebastien Boutet, Garth J. Williams, Christian David, Grigory Smolentsev, Jeroen A. Van Bokhoven, Bruce D. Patterson, Thomas J. Penfold, Gregor Knopp, Marek Pajek, Rafael Abela, Christopher J. Milne

    http://dx.doi.org/10.1038/srep33292 Jakub Szlachetko and Joanna Hoszowska and Jean-Claude Dousse and Maarten Nachtegaal and Wojciech Błachucki and Yves Kayser and Jacinto Sà and Marc Messerschmidt and Sebastien Boutet and Garth J. Williams and Christian David and Grigory Smolentsev and Jeroen A. …

  75. X-ray laser-induced electron dynamics observed by femtosecond diffraction from nanocrystals of Buckminsterfullerene

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    09 Sep 2016 | BioXFEL Publications | Contributor(s): Brian Abbey, Ruben A. Dilanian, Connie Darmanin, Rebecca A. Ryan, Corey T. Putkunz, Andrew V. Martin, David Wood, Victor Streltsov, Michael W. M. Jones, Naylyn Gaffney, Felix Hofmann, Garth J. Williams, Sébastien Boutet, Marc Messerschmidt, M. Marvin Seibert, Sophie Williams, Evan Curwood, Eugeniu Balaur, Andrew G. Peele, Keith A. Nugent, Harry M. Quiney

    http://dx.doi.org/10.1126/sciadv.1601186 Brian Abbey and Ruben A. Dilanian and Connie Darmanin and Rebecca A. Ryan and Corey T. Putkunz and Andrew V. Martin and David Wood and Victor Streltsov and Michael W. M. Jones and Naylyn Gaffney and Felix Hofmann and Garth J. Williams and Sébastien Boutet …

  76. Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex

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    09 Sep 2016 | BioXFEL Publications | Contributor(s): Philip J. Robinson, Michael J. Trnka, David Bushnell, Ralph E. Davis, Pierre-Jean Mattei, Alma L. Burlingame, Roger Kornberg

    http://dx.doi.org/10.1016/j.cell.2016.08.050 Philip J. Robinson and Michael J. Trnka and David A. Bushnell and Ralph E. Davis and Pierre-Jean Mattei and Alma L. Burlingame and Roger D. Kornberg Robinson, P.J. et al., 2016. Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex. …

  77. Ghost imaging with x rays

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    07 Sep 2016 | BioXFEL Publications | Contributor(s): Dilano Saldin

    journal-article http://dx.doi.org/10.1103/physics.9.103 Saldin, D., 2016. Ghost imaging with x rays. Physics, 9. Available at: http://dx.doi.org/10.1103/physics.9.103. Dilano Saldin

  78. Frontiers of free-electron laser science II

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    06 Sep 2016 | BioXFEL Publications | Contributor(s): Roger Falcone, Michael Dunne, Henry Chapman, Makina Yabashi, Kiyoshi Ueda

    http://dx.doi.org/10.1088/0953-4075/49/18/180201 journal-article Falcone, R. et al., 2016. Frontiers of free-electron laser science II. Journal of Physics B: Atomic, Molecular and Optical Physics, 49(18), p.180201. Available at: http://dx.doi.org/10.1088/0953-4075/49/18/180201. Roger Falcone and …

  79. Mixing injector enables time-resolved crystallography with high hit rate at X-ray free electron lasers

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    29 Aug 2016 | BioXFEL Publications | Contributor(s): George Douglas Calvey, Andrea Katz, Chris B. Schaffer, Lois Pollack

    http://dx.doi.org/10.1063/1.4961971 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Calvey, G.D. et al., 2016. Mixing injector enables time-resolved crystallography with high hit rate at X-ray free electron lasers. Structural Dynamics, 3(5), p.054301. Available at: …

  80. The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction

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    29 Aug 2016 | BioXFEL Publications | Contributor(s): Ying Wu, Xiaohong Zhou, Christopher Barnes, Maria DeLucia, Aina E Cohen, Angela M Gronenborn, Jinwoo Ahn, Guillermo Calero

    journal-article http://dx.doi.org/10.1038/nsmb.3284 NSF-STC Biology with X-ray Lasers (NSF-1231306) Wu, Y. et al., 2016. The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction. Nature Structural & Molecular Biology, 23(10), pp.933–940. Available …

  81. Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 inStreptomyces globisporus

    0.0 out of 5 stars 

    25 Aug 2016 | BioXFEL Publications | Contributor(s): Chin-Yuan Chang, Jeremy R. Lohman, Hongnan Cao, Kemin Tan, Jeffrey D. Rudolf, Ming Ma, Weijun Xu, Craig A. Bingman, Ragothaman M. Yennamalli, Lance Bigelow, Gyorgy Babnigg, Xiaohui Yan, Andrzej Joachimiak, George Phillips, Ben Shen

    http://dx.doi.org/10.1021/acs.biochem.6b00713 Chin-Yuan Chang and Jeremy R. Lohman and Hongnan Cao and Kemin Tan and Jeffrey D. Rudolf and Ming Ma and Weijun Xu and Craig A. Bingman and Ragothaman M. Yennamalli and Lance Bigelow and Gyorgy Babnigg and Xiaohui Yan and Andrzej Joachimiak and George …

  82. Electron Crystallography, Charge-Density Mapping and Nanodiffraction

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    24 Aug 2016 | BioXFEL Publications | Contributor(s): John Spence

    book-chapter http://dx.doi.org/10.1007/978-3-319-26651-0_5 Spence, J., 2016. Electron Crystallography, Charge-Density Mapping and Nanodiffraction. Transmission Electron Microscopy, pp.145–166. Available at: http://dx.doi.org/10.1007/978-3-319-26651-0_5. John Spence

  83. Serial Femtosecond Crystallography of Membrane Proteins

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    23 Aug 2016 | BioXFEL Publications | Contributor(s): Lan Zhu, Uwe Weierstall, Vadim Cherezov, Wei Liu

    book-chapter http://dx.doi.org/10.1007/978-3-319-35072-1_11 NSF-STC Biology with X-ray Lasers (NSF-1231306) Zhu, L. et al., 2016. Serial Femtosecond Crystallography of Membrane Proteins. The Next Generation in Membrane Protein Structure Determination, pp.151–160. Available at: …

  84. Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography

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    22 Aug 2016 | BioXFEL Publications | Contributor(s): Przemyslaw Nogly, Valerie Panneels, Garrett Charles Nelson, Cornelius Gati, Tetsunari Kimura, Christopher Milne, Despina Milathianaki, Minoru Kubo, Wenting Wu, Chelsie E Conrad, Jesse David Coe, Richard Bean, Yun Zhao, Petra Båth, Robert Dods, Rajiv Harimoorthy, Kenneth R. Beyerlein, Jan Rheinberger, Daniel James, Daniel DePonte, Chufeng Li, Leonardo Sala, Garth J. Williams, Mark S. Hunter, Jason E. Koglin, Peter Berntsen, Eriko Nango, So Iwata, Henry Chapman, Petra Fromme, Matthias Frank, Rafael Abela, Sébastien Boutet, Anton Barty, Thomas A. White, Uwe Weierstall, John Spence, Richard Neutze, Gebhard F.X. Schertler, Jörg Standfuss

    http://dx.doi.org/10.1038/ncomms12314 Przemyslaw Nogly and Valerie Panneels and Garrett Nelson and Cornelius Gati and Tetsunari Kimura and Christopher Milne and Despina Milathianaki and Minoru Kubo and Wenting Wu and Chelsie Conrad and Jesse Coe and Richard Bean and Yun Zhao and Petra Båth and …

  85. An Introduction to X-Ray Diffraction Physics

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    10 Aug 2016 | Teaching Materials | Contributor(s): Blessing

    These notes present basic principles of the physics that underlies X-ray analysis of the atomic structure of matter. In particular, classical electromagnetic wave theory of X-ray scattering by electrons and atoms is described as background for subsequent study of X-ray diffraction methods for …

  86. Structure of the ent -Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase

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    04 Aug 2016 | BioXFEL Publications | Contributor(s): Jeffrey D. Rudolf, Liao-Bin Dong, Hongnan Cao, Catherine Hatzos-Skintges, Jerzy Osipiuk, Michael Endres, Chin-Yuan Chang, Ming Ma, Gyorgy Babnigg, Andrzej Joachimiak, George Phillips, Ben Shen

    http://dx.doi.org/10.1021/jacs.6b04317 Jeffrey D. Rudolf and Liao-Bin Dong and Hongnan Cao and Catherine Hatzos-Skintges and Jerzy Osipiuk and Michael Endres and Chin-Yuan Chang and Ming Ma and Gyorgy Babnigg and Andrzej Joachimiak and George N. Phillips and Ben Shen Rudolf, J.D. et al., 2016. …

  87. Enhanced hydrogenation activity and diastereomeric interactions of methyl pyruvate co-adsorbed with R-1-(1-naphthyl)ethylamine on Pd(111)

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    04 Aug 2016 | BioXFEL Publications | Contributor(s): Mausumi Mahapatra, Luke Burkholder, Michael Garvey, Yun Bai, Dilano Saldin, Wilfred T. Tysoe

    http://dx.doi.org/10.1038/ncomms12380 Mausumi Mahapatra and Luke Burkholder and Michael Garvey and Yun Bai and Dilano K. Saldin and Wilfred T. Tysoe Mahapatra, M. et al., 2016. Enhanced hydrogenation activity and diastereomeric interactions of methyl pyruvate co-adsorbed with …

  88. Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5′-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form

    0.0 out of 5 stars 

    02 Aug 2016 | BioXFEL Publications | Contributor(s): Ming Yan, Srinivas Chakravarthy, Joshua M. Tokuda, Lois Pollack, Gregory D. Bowman, Young-Sam Lee

    journal-article http://dx.doi.org/10.1021/acs.biochem.6b00658 Yan, M. et al., 2016. Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5′-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form. Biochemistry, 55(33), pp.4731–4736. Available at: …

  89. Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source

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    29 Jul 2016 | BioXFEL Publications | Contributor(s): Anna Munke, Jakob Andreasson, Andrew Aquila, Salah Awel, Kartik Ayyer, Anton Barty, Richard J. Bean, Peter Berntsen, Johan Bielecki, Sébastien Boutet, Maximilian Bucher, Henry Chapman, Benedikt J. Daurer, Hasan Demirci, Veit Elser, Petra Fromme, Janos Hajdu, Max F. Hantke, Akifumi Higashiura, Brenda Hogue, Ahmad Hosseinizadeh, Yoonhee Kim, Richard Kirian, Hemanth K.N. Reddy, Ti-Yen Lan, Daniel S.D. Larsson, Haiguang Liu, N. Duane Loh, Filipe R.N.C. Maia, Adrian P. Mancuso, Kerstin Mühlig, Atsushi Nakagawa, Daewoong Nam, Garrett Charles Nelson, Carl Nettelblad, Kenta Okamoto, Abbas Ourmazd, Max Rose, Gijs Van Der Schot, Peter Schwander, M. Marvin Seibert, Jonas A. Sellberg, Raymond G. Sierra, Changyong Song, Martin Svenda, Nicusor Timneanu, Ivan A. Vartanyants, Daniel Westphal, Max Oliver Wiedorn, Garth J. Williams, Paulraj Lourdu Xavier, Chun Hong Yoon, James D Zook

    http://dx.doi.org/10.1038/sdata.2016.64 Anna Munke and Jakob Andreasson and Andrew Aquila and Salah Awel and Kartik Ayyer and Anton Barty and Richard J. Bean and Peter Berntsen and Johan Bielecki and Sébastien Boutet and Maximilian Bucher and Henry N. Chapman and Benedikt J. Daurer and Hasan …

  90. A data set from flash X-ray imaging of carboxysomes

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    29 Jul 2016 | BioXFEL Publications | Contributor(s): Max F. Hantke, Dirk Hasse, Tomas Ekeberg, Katja John, Martin Svenda, Duane Loh, Andrew V. Martin, Nicusor Timneanu, Daniel S.D. Larsson, Gijs Van Der Schot, Gunilla H. Carlsson, Margareta Ingelman, Jakob Andreasson, Daniel Westphal, Bianca Iwan, Charlotte Uetrecht, Johan Bielecki, Mengning Liang, Francesco Stellato, Daniel P. DePonte, Sadia Bari, Robert Hartmann, Nils Kimmel, Richard Kirian, M. Marvin Seibert, Kerstin Mühlig, Sebastian Schorb, Ken Ferguson, Christoph Bostedt, Sebastian Carron, John D. Bozek, Daniel Rolles, Artem Rudenko, Lutz Foucar, Sascha W. Epp, Henry Chapman, Anton Barty, Inger Andersson, Janos Hajdu, Filipe R.N.C. Maia

    http://dx.doi.org/10.1038/sdata.2016.61 Max F. Hantke and Dirk Hasse and Tomas Ekeberg and Katja John and Martin Svenda and Duane Loh and Andrew V. Martin and Nicusor Timneanu and Daniel S.D. Larsson and Gijs van der Schot and Gunilla H. Carlsson and Margareta Ingelman and Jakob Andreasson and …

  91. Single-shot diffraction data from the Mimivirus particle using an X-ray free-electron laser

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    29 Jul 2016 | BioXFEL Publications | Contributor(s): Tomas Ekeberg, Martin Svenda, M. Marvin Seibert, Chantal Abergel, Filipe R.N.C. Maia, Virginie Seltzer, Daniel P. DePonte, Andrew Aquila, Jakob Andreasson, Bianca Iwan, Olof Jönsson, Daniel Westphal, Duško Odić, Inger Andersson, Anton Barty, Meng Liang, Andrew V. Martin, Lars Gumprecht, Holger Fleckenstein, Saša Bajt, Miriam Barthelmess, Nicola Coppola, Jean-Michel Claverie, N. Duane Loh, Christoph Bostedt, John D. Bozek, Jacek Krzywinski, Marc Messerschmidt, Michael J. Bogan, Christina Y. Hampton, Raymond G. Sierra, Matthias Frank, Robert L. Shoeman, Lukas Lomb, Lutz Foucar, Sascha W. Epp, Daniel Rolles, Artem Rudenko, Robert Hartmann, Andreas Hartmann, Nils Kimmel, Peter Holl, Georg Weidenspointner, Benedikt Rudek, Benjamin Erk, Stephan Kassemeyer, Ilme Schlichting, Lothar Strüder, Joachim Ullrich, Carlo Schmidt, Faton Krasniqi, Günter Hauser, Christian Reich, Heike Soltau, Sebastian Schorb, Helmut Hirsemann, Cornelia Wunderer, Heinz Graafsma, Henry Chapman, Janos Hajdu

    http://dx.doi.org/10.1038/sdata.2016.60 Tomas Ekeberg and Martin Svenda and M. Marvin Seibert and Chantal Abergel and Filipe R.N.C. Maia and Virginie Seltzer and Daniel P. DePonte and Andrew Aquila and Jakob Andreasson and Bianca Iwan and Olof Jönsson and Daniel Westphal and Duško Odić and Inger …

  92. Open data set of live cyanobacterial cells imaged using an X-ray laser

    0.0 out of 5 stars 

    29 Jul 2016 | BioXFEL Publications | Contributor(s): Gijs Van Der Schot, Martin Svenda, Filipe R.N.C. Maia, Max F. Hantke, Daniel P. DePonte, M. Marvin Seibert, Andrew Aquila, Joachim Schulz, Richard Kirian, Mengning Liang, Francesco Stellato, Sadia Bari, Bianca Iwan, Jakob Andreasson, Nicusor Timneanu, Johan Bielecki, Daniel Westphal, Francisca Nunes De Almeida, Duško Odić, Dirk Hasse, Gunilla H. Carlsson, Daniel S.D. Larsson, Anton Barty, Andrew V. Martin, Sebastian Schorb, Christoph Bostedt, John D. Bozek, Sebastian Carron, Ken Ferguson, Daniel Rolles, Artem Rudenko, Sascha W. Epp, Lutz Foucar, Benedikt Rudek, Benjamin Erk, Robert Hartmann, Nils Kimmel, Peter Holl, Lars Englert, N. Duane Loh, Henry Chapman, Inger Andersson, Janos Hajdu, Tomas Ekeberg

    http://dx.doi.org/10.1038/sdata.2016.58 Gijs van der Schot and Martin Svenda and Filipe R.N.C. Maia and Max F. Hantke and Daniel P. DePonte and M. Marvin Seibert and Andrew Aquila and Joachim Schulz and Richard A. Kirian and Mengning Liang and Francesco Stellato and Sadia Bari and Bianca Iwan and …

  93. Serial femtosecond crystallography datasets from G protein-coupled receptors

    0.0 out of 5 stars 

    29 Jul 2016 | BioXFEL Publications | Contributor(s): Thomas A. White, Anton Barty, Wei Liu, Andrii Ishchenko, Haitao Zhang, Cornelius Gati, Nadia Zatsepin, Shibom Basu, Dominik Oberthür, Markus Metz, Kenneth R. Beyerlein, Chun Hong Yoon, Oleksandr M. Yefanov, Daniel James, Dingjie Wang, Marc Messerschmidt, Jason E. Koglin, Sébastien Boutet, Uwe Weierstall, Vadim Cherezov

    http://dx.doi.org/10.1038/sdata.2016.57 Thomas A. White and Anton Barty and Wei Liu and Andrii Ishchenko and Haitao Zhang and Cornelius Gati and Nadia A. Zatsepin and Shibom Basu and Dominik Oberthür and Markus Metz and Kenneth R. Beyerlein and Chun Hong Yoon and Oleksandr M. Yefanov and Daniel …

  94. Full inactivation of alphaviruses in single particle and crystallized forms

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    26 Jul 2016 | BioXFEL Publications | Contributor(s): Robert M Lawrence, James D Zook, Brenda Hogue

    http://dx.doi.org/10.1016/j.jviromet.2016.07.020 Robert M. Lawrence and James D. Zook and Brenda G. Hogue Lawrence, R.M., Zook, J.D. & Hogue, B.G., 2016. Full inactivation of alphaviruses in single particle and crystallized forms. Journal of Virological Methods, 236, pp.237–244. Available at: …

  95. XFEL data analysis for structural biology

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    21 Jul 2016 | BioXFEL Publications | Contributor(s): Haiguang Liu, John Spence

    http://dx.doi.org/10.1007/s40484-016-0076-z Haiguang Liu and John C. H. Spence Liu, H. & Spence, J.C.H., 2016. XFEL data analysis for structural biology. Quantitative Biology, 4(3), pp.159–176. Available at: http://dx.doi.org/10.1007/s40484-016-0076-z. NSF-STC Biology with X-ray Lasers …

  96. Improving the efficiency of molecular replacement by utilizing a new iterative transform phasing algorithm

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    15 Jul 2016 | BioXFEL Publications | Contributor(s): Hongxing He, Hengrui Fang, Mitchell Miller, George Phillips, Wu-Pei Su

    An iterative transform method proposed previously for direct phasing of high-solvent-content protein crystals is employed for enhancing the molecular-replacement (MR) algorithm in protein crystallography. Target structures that are resistant to conventional MR due to insufficient similarity between …

  97. Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027

    0.0 out of 5 stars 

    13 Jul 2016 | BioXFEL Publications | Contributor(s): Tingting Huang, Chin-Yuan Chang, Jeremy R Lohman, Jeffrey D Rudolf, Youngchang Kim, Changsoo Chang, Dong Yang, Ming Ma, Xiaohui Yan, Ivana Crnovcic, Lance Bigelow, Shonda Clancy, Craig A Bingman, Ragothaman M Yennamalli, Gyorgy Babnigg, Andrzej Joachimiak, George Phillips, Ben Shen

    http://dx.doi.org/10.1038/ja.2016.88 Tingting Huang and Chin-Yuan Chang and Jeremy R Lohman and Jeffrey D Rudolf and Youngchang Kim and Changsoo Chang and Dong Yang and Ming Ma and Xiaohui Yan and Ivana Crnovcic and Lance Bigelow and Shonda Clancy and Craig A Bingman and Ragothaman M Yennamalli and …

  98. Opposing Effects of Multivalent Ions on the Flexibility of DNA and RNA

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    06 Jul 2016 | BioXFEL Publications | Contributor(s): Aleksander V. Drozdetski, Igor S. Tolokh, Lois Pollack, Nathan Baker, Alexey V. Onufriev

    http://dx.doi.org/10.1103/physrevlett.117.028101 journal-article Drozdetski, A.V. et al., 2016. Opposing Effects of Multivalent Ions on the Flexibility of DNA and RNA. Physical Review Letters, 117(2). Available at: http://dx.doi.org/10.1103/physrevlett.117.028101. Aleksander V. Drozdetski and …

  99. Special issue on imaging the dynamic structure of matter

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    30 Jun 2016 | BioXFEL Publications | Contributor(s): Heinrich Schwoerer, Henry Chapman, Bradley J Siwick, R J Dwayne Miller

    http://dx.doi.org/10.1088/0953-4075/49/15/150201 journal-article Schwoerer, H. et al., 2016. Special issue on imaging the dynamic structure of matter. Journal of Physics B: Atomic, Molecular and Optical Physics, 49(15), p.150201. Available at: http://dx.doi.org/10.1088/0953-4075/49/15/150201. …

  100. Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways

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    28 Jun 2016 | BioXFEL Publications | Contributor(s): Tyler D. Huber, Fengbin Wang, Shanteri Singh, Brooke R. Johnson, Jianjun Zhang, Manjula Sunkara, Steven G. Van Lanen, Andrew J. Morris, George Phillips, Jon S. Thorson

    http://dx.doi.org/10.1021/acschembio.6b00348 journal-article Huber, T.D. et al., 2016. Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways. ACS Chemical Biology, 11(9), pp.2484–2491. Available at: http://dx.doi.org/10.1021/acschembio.6b00348. Tyler D. Huber and …