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  1. FreeDam – A Webtool for Free-Electron Laser-Induced Damage in Femtosecond X-ray Crystallography

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    21 Feb 2018 | BioXFEL Publications | Contributor(s): H. Olof Jönsson, Christofer Östlin, Howard A. Scott, Henry Chapman, Steve J. Aplin, Nicuşor Tîmneanu, Carl Caleman

    http://dx.doi.org/10.1016/j.hedp.2018.02.004 journal-article Jönsson, H.O. et al., 2018. FreeDam – A Webtool for Free-Electron Laser-Induced Damage in Femtosecond X-ray Crystallography. High Energy Density Physics. Available at: http://dx.doi.org/10.1016/j.hedp.2018.02.004. H. Olof Jönsson …

  2. Femtosecond X-ray Fourier holography imaging of free-flying nanoparticles

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    16 Feb 2018 | BioXFEL Publications | Contributor(s): Tais Gorkhover, Anatoli Ulmer, Ken Ferguson, Max Bucher, Filipe R. N. C. Maia, Johan Bielecki, Tomas Ekeberg, Max F. Hantke, Benedikt J. Daurer, Carl Nettelblad, Jakob Andreasson, Anton Barty, Petr Bruza, Sebastian Carron, Dirk Hasse, Jacek Krzywinski, Daniel S. D. Larsson, Andrew Morgan, Kerstin Mühlig, Maria Müller, Kenta Okamoto, Alberto Pietrini, Daniela Rupp, Mario Sauppe, Gijs Van Der Schot, Marvin Seibert, Jonas A. Sellberg, Martin Svenda, Michelle Swiggers, Nicusor Timneanu, Daniel Westphal, Garth Williams, Alessandro Zani, Henry Chapman, Gyula Faigel, Thomas Möller, Janos Hajdu, Christoph Bostedt

    http://dx.doi.org/10.1038/s41566-018-0110-y journal-article Gorkhover, T. et al., 2018. Femtosecond X-ray Fourier holography imaging of free-flying nanoparticles. Nature Photonics, 12(3), pp.150–153. Available at: http://dx.doi.org/10.1038/s41566-018-0110-y. Tais Gorkhover and Anatoli Ulmer …

  3. Bringing diffuse X-ray scattering into focus

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    15 Feb 2018 | BioXFEL Publications | Contributor(s): Michael E Wall, Alexander M Wolff, James Fraser

    http://dx.doi.org/10.1016/j.sbi.2018.01.009 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Wall, M.E., Wolff, A.M. & Fraser, J.S., 2018. Bringing diffuse X-ray scattering into focus. Current Opinion in Structural Biology, 50, pp.109–116. Available at: …

  4. Structure of the 30S ribosomal decoding complex at ambient temperature

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    12 Feb 2018 | BioXFEL Publications | Contributor(s): E. Han Dao, Frederic Poitevin, Raymond G. Sierra, Cornelius Gati, Yashas Rao, Halil Ibrahim Ciftci, Fulya Akşit, Alex McGurk, Trevor Obrinski, Paul Mgbam, Brandon Hayes, Casper De Lichtenberg, Fatima Pardo-Avila, Nicholas Corsepius, Lindsey Zhang, Matt Seaberg, Mark S. Hunter, Mengling Liang, Jason E. Koglin, Soichi Wakatsuki, Hasan Demirci

    http://dx.doi.org/10.1101/262972 The ribosome translates nucleotide sequences of messenger RNA to proteins through selection of cognate transfer RNA according to the genetic code. To date, structural studies of ribosomal decoding complexes yielding high-resolution data have predominantly relied on …

  5. How 2'- O -Methylation in mRNA Disrupts tRNA Decoding during Translation Elongation

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    06 Feb 2018 | BioXFEL Publications | Contributor(s): Junhong Choi, Gabriele Indrisiunaite, Hasan Demirci, Ka-Weng Ieong, Jinfan Wang, Alexey Petrov, Arjun Prabhakar, Gideon Rechavi, Dan Dominissini, Chuan He, Måns Ehrenberg, Joseph D. Puglisi

    http://dx.doi.org/10.1016/j.bpj.2017.11.3237 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Choi, J. et al., 2018. How 2’- O -Methylation in mRNA Disrupts tRNA Decoding during Translation Elongation. Biophysical Journal, 114(3), p.592a. Available at: …

  6. A Graphene-Based Microfluidic Platform for Electrocrystallization and In Situ X-ray Diffraction

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    02 Feb 2018 | BioXFEL Publications | Contributor(s): Shuo Sui, Yuxi Wang, Christos Dimitrakopoulos, Sarah Perry

    http://dx.doi.org/10.3390/cryst8020076 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Sui, S. et al., 2018. A Graphene-Based Microfluidic Platform for Electrocrystallization and In Situ X-ray Diffraction. Crystals, 8(2), p.76. Available at: http://dx.doi.org/10.3390/cryst8020076. …

  7. Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography

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    01 Feb 2018 | BioXFEL Publications | Contributor(s): Dan Bi Lee, Jong-Min Kim, Jong Hyeon Seok, Ji-Hye Lee, Jae Deok Jo, Ji Young Mun, Chelsie E Conrad, Jesse David Coe, Garrett Charles Nelson, Brenda Hogue, Thomas A. White, Nadia Zatsepin, Uwe Weierstall, Anton Barty, Henry Chapman, Petra Fromme, John Spence, Mi Sook Chung, Chang-Hyun Oh, Kyung Hyun Kim

    http://dx.doi.org/10.1038/s41598-018-20899-9 journal-article Lee, D.B. et al., 2018. Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography. Scientific Reports, 8(1). Available at: http://dx.doi.org/10.1038/s41598-018-20899-9. Dan Bi Lee …

  8. Ab initio electron density determination directly from solution scattering data

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    29 Jan 2018 | BioXFEL Publications | Contributor(s): Thomas D Grant

    http://dx.doi.org/10.1038/nmeth.4581 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Grant, T.D., 2018. Ab initio electron density determination directly from solution scattering data. Nature Methods. Available at: http://dx.doi.org/10.1038/nmeth.4581. Thomas D Grant

  9. Femtosecond X-ray diffraction from an aerosolized beam of protein nanocrystals

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    26 Jan 2018 | BioXFEL Publications | Contributor(s): Salah Awel, Richard Kirian, Max Oliver Wiedorn, Kenneth R. Beyerlein, Nils Roth, Daniel A. Horke, Dominik Oberthür, Juraj Knoska, Valerio Mariani, Andrew Morgan, Luigi Adriano, Alexandra Tolstikova, P. Lourdu Xavier, Oleksandr Yefanov, Andrew Aquila, Anton Barty, Shatabdi Roy-Chowdhury, Mark S. Hunter, Daniel James, Joseph S. Robinson, Uwe Weierstall, Andrei V. Rode, Saša Bajt, Jochen Küpper, Henry Chapman

    http://dx.doi.org/10.1107/s1600576717018131 High-resolution Bragg diffraction from aerosolized single granulovirus nanocrystals using an X-ray free-electron laser is demonstrated. The outer dimensions of the in-vacuum aerosol injector components are identical to conventional liquid-microjet nozzles …

  10. qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps

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    26 Jan 2018 | BioXFEL Publications | Contributor(s): Gydo CP Van Zundert, Brandi M Hudson, Daniel A Keedy, Rasmus Fonseca, Amelie Heliou, Pooja Suresh, Kenneth Borrelli, Tyler Day, James Fraser, Henry Van Den Bedem

    http://dx.doi.org/10.1101/253419 Proteins and ligands sample a conformational ensemble that governs molecular recognition, activity, and dissociation. In structure-based drug design, access to this conformational ensemble is critical to understand the balance between entropy and enthalpy in lead …

  11. Transferring the entatic-state principle to copper photochemistry

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    15 Jan 2018 | BioXFEL Publications | Contributor(s): B. Dicke, A. Hoffmann, J. Stanek, M. S. Rampp, B. Grimm-Lebsanft, F. Biebl, D. Rukser, B. Maerz, D. Göries, M. Naumova, M. Biednov, G. Neuber, A. Wetzel, S. M. Hofmann, P. Roedig, A. Meents, J. Bielecki, J. Andreasson, K. R. Beyerlein, H. N. Chapman, C. Bressler, W. Zinth, M. Rübhausen, S. Herres-Pawlis

    http://dx.doi.org/10.1038/nchem.2916 journal-article Dicke, B. et al., 2018. Transferring the entatic-state principle to copper photochemistry. Nature Chemistry. Available at: http://dx.doi.org/10.1038/nchem.2916. B. Dicke and A. Hoffmann and J. Stanek and M. S. Rampp and B. Grimm-Lebsanft and …

  12. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

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    04 Jan 2018 | BioXFEL Publications | Contributor(s): Tao Che, Susruta Majumdar, Saheem A. Zaidi, Pauline Ondachi, John D. McCorvy, Sheng Wang, Philip D. Mosier, Rajendra Uprety, Eyal Vardy, Brian E. Krumm, Gye Won Han, Ming-Yue Lee, Els Pardon, Jan Steyaert, Xi-Ping Huang, Ryan T. Strachan, Alexandra R. Tribo, Gavril W. Pasternak, F. Ivy Carroll, Raymond C. Stevens, Vadim Cherezov, Vsevolod Katritch, Daniel Wacker, Bryan L. Roth

    http://dx.doi.org/10.1016/j.cell.2017.12.011 journal-article Che, T. et al., 2018. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell, 172(1-2), pp.55–67.e15. Available at: http://dx.doi.org/10.1016/j.cell.2017.12.011. Tao Che and Susruta Majumdar and Saheem …

  13. High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions

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    04 Jan 2018 | BioXFEL Publications | Contributor(s): Jana Broecker, Takefumi Morizumi, Wei-Lin Ou, Viviane Klingel, Anling Kuo, David J Kissick, Andrii Ishchenko, Ming-Yue Lee, Shenglan Xu, Oleg Makarov, Vadim Cherezov, Craig M Ogata, Oliver P Ernst

    http://dx.doi.org/10.1038/nprot.2017.135 journal-article Broecker, J. et al., 2018. High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions. Nature Protocols, 13(2), pp.260–292. Available at: …

  14. Thermal x-ray diffraction and near-field phase contrast imaging

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    27 Dec 2017 | BioXFEL Publications | Contributor(s): Zheng Li, Anton Classen, Tao Peng, Nikita Medvedev, Fenglin Wang, Henry Chapman, Yanhua Shih

    http://dx.doi.org/10.1209/0295-5075/120/16003 journal-article Li, Z. et al., 2017. Thermal x-ray diffraction and near-field phase contrast imaging. EPL (Europhysics Letters), 120(1), p.16003. Available at: http://dx.doi.org/10.1209/0295-5075/120/16003. Zheng Li and Anton Classen and Tao Peng and …

  15. Resolution extension by image summing in serial femtosecond crystallography of two-dimensional membrane-protein crystals

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    22 Dec 2017 | BioXFEL Publications | Contributor(s): Cecilia M. Casadei, Ching-Ju Tsai, Anton Barty, Mark S. Hunter, Nadia Zatsepin, Celestino Padeste, Guido Capitani, W. Henry Benner, Sébastien Boutet, Stefan Hau-Riege, Christopher Kupitz, Marc Messerschmidt, John I. Ogren, Tom Pardini, Kenneth J. Rothschild, Leonardo Sala, Brent W. Segelke, Garth J. Williams, James E. Evans, Xiao-Dan Li, Matthew Coleman, Bill Pedrini, Matthias Frank

    http://dx.doi.org/10.1107/s2052252517017043 Previous proof-of-concept measurements on single-layer two-dimensional membrane-protein crystals performed at X-ray free-electron lasers (FELs) have demonstrated that the collection of meaningful diffraction patterns, which is not possible at synchrotrons …

  16. Resolution extension by image summing in serial femtosecond crystallography of two-dimensional membrane-protein crystals

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    22 Dec 2017 | BioXFEL Publications | Contributor(s): Cecilia M. Casadei, Ching-Ju Tsai, Anton Barty, Mark S. Hunter, Nadia Zatsepin, Celestino Padeste, Guido Capitani, W. Henry Benner, Sébastien Boutet, Stefan Hau-Riege, Christopher Kupitz, Marc Messerschmidt, John I. Ogren, Tom Pardini, Kenneth J. Rothschild, Leonardo Sala, Brent W. Segelke, Garth J. Williams, James E. Evans, Xiao-Dan Li, Matthew Coleman, Bill Pedrini, Matthias Frank

    http://dx.doi.org/10.1107/s2052252517017043/ec5006sup1.pdf component Casadei, C.M. et al., 2018. Resolution extension by image summing in serial femtosecond crystallography of two-dimensional membrane-protein crystals. Available at: http://dx.doi.org/10.1107/s2052252517017043/ec5006sup1.pdf. …

  17. Small-angle X-ray and neutron scattering demonstrates that cell-free expression produces properly formed disc-shaped nanolipoprotein particles

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    20 Dec 2017 | BioXFEL Publications | Contributor(s): Thomas E. Cleveland, Wei He, Angela C. Evans, Nicholas O. Fischer, Edmond Y. Lau, Matthew Coleman, Paul Butler

    http://dx.doi.org/10.1002/pro.3365 journal-article Cleveland, T.E. et al., 2017. Small-angle X-ray and neutron scattering demonstrates that cell-free expression produces properly formed disc-shaped nanolipoprotein particles. Protein Science. Available at: http://dx.doi.org/10.1002/pro.3365. …

  18. Time-resolved mixing-jet X-ray free-electron laser crystallography experiments

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    19 Dec 2017 | BioXFEL Publications | Contributor(s): Dominik Oberthuer, Juraj Knoška, Max Oliver Wiedorn, Saša Bajt, Henry Chapman

    http://dx.doi.org/10.1107/s2053273317087393 journal-article Oberthuer, D. et al., 2017. Time-resolved mixing-jet X-ray free-electron laser crystallography experiments. Acta Crystallographica Section A Foundations and Advances, 73(a2), pp.C835–C835. Available at: …

  19. Picosecond to microsecond TR-XAS: intermediates in the photolysis of methylcobalamin

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    19 Dec 2017 | BioXFEL Publications | Contributor(s): GANESH SUBRAMANIAN, Gerdenis Kodis, Andrew Chizmeshya, Qingyu Kong, Xiaoyi Zhang, Uwe Weierstall, John Spence

    http://dx.doi.org/10.1107/s2053273317084455 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Subramanian, G. et al., 2017. Picosecond to microsecond TR-XAS: intermediates in the photolysis of methylcobalamin. Acta Crystallographica Section A Foundations and Advances, 73(a2), …

  20. Mechanism and X-ray damage: beware of artefacts in xylose isomerase

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    19 Dec 2017 | BioXFEL Publications | Contributor(s): Helena Taberman, Charles S. Bury, Kristin A. Sutton, Edward Snell, Elspeth F. Garman

    http://dx.doi.org/10.1107/s205327331709341x journal-article Taberman, H. et al., 2017. Mechanism and X-ray damage: beware of artefacts in xylose isomerase. Acta Crystallographica Section A Foundations and Advances, 73(a2), pp.C232–C232. Available at: …

  21. Monochromatic and polychromatic serial crystallography at the Advanced Photon Source

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    19 Dec 2017 | BioXFEL Publications | Contributor(s): R. F. Fischetti, J. Martin-Garcia, N. Zatsepin, N. Stander, L. Zhu, G. Subramanian, G. Nelson, J. Coe, N. Nagaratnam, S. Roy-Chowdury, D. Kissick, A. Ishchenko, C. Conrad, G. Ketawala, D. James, J. Zook, C. Ogata, N. Venugopalan, S. Xu, A. Meents, V. Srajer, R. Henning, H. Chapman, J. Spence, U. Weierstall, V. Cherezov, P. Fromme, W. Liu

    http://dx.doi.org/10.1107/s0108767317096404 journal-article Fischetti, R.F. et al., 2017. Monochromatic and polychromatic serial crystallography at the Advanced Photon Source. Acta Crystallographica Section A Foundations and Advances, 73(a1), pp.a368–a369. Available at: …

  22. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

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    19 Dec 2017 | BioXFEL Publications | Contributor(s): J. R. Stagno, Y. Liu, Y. R. Bhandari, C. E. Conrad, S. Panja, M. Swain, L. Fan, G. Nelson, C. Li, D. R. Wendel, T. A. White, J. D. Coe, M. O. Wiedorn, J. Knoska, D. Oberthuer, R. A. Tuckey, P. Yu, M. Dyba, S. G. Tarasov, U. Weierstall, T. D. Grant, C. D. Schwieters, J. Zhang, A. R. Ferré-D'Amaré, P. Fromme, D. E. Draper, M. Liang, M. S. Hunter, S. Boutet, K. Tan, X. Zuo, X. Ji, A. Barty, N. A. Zatsepin, H. N. Chapman, J. C. H. Spence, S. A. Woodson, Y.-X. Wang

    http://dx.doi.org/10.1107/s0108767317099081 journal-article Stagno, J.R. et al., 2017. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Acta Crystallographica Section A Foundations and Advances, 73(a1), pp.a92–a92. Available at: …

  23. Low-background pink-beam serial crystallography

    0.0 out of 5 stars 

    19 Dec 2017 | BioXFEL Publications | Contributor(s): A. Meents, M. O. Wiedorn, V. Srajer, R. Henning, I. Sarrou, J. Bergtholdt, M. Barthelmess, P. Reinke, D. Dierksmeyer, A. Tolstikova, S. Schaible, M. Messerschmidt, C. M. Ogata, D. J. Kissick, M. Taft, D. Manstein, J. Lieske, D. Oberthuer, R. F. Fischetti, H. N. Chapman

    http://dx.doi.org/10.1107/s0108767317096052 journal-article Meents, A. et al., 2017. Low-background pink-beam serial crystallography. Acta Crystallographica Section A Foundations and Advances, 73(a1), pp.a405–a405. Available at: http://dx.doi.org/10.1107/s0108767317096052. A. Meents and M. O. …

  24. Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser

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    19 Dec 2017 | BioXFEL Publications | Contributor(s): Cornelius Gati, Dominik Oberthuer, Oleksandr Yefanov, Richard D. Bunker, Peter Metcalf, Anton Barty, Henry Chapman

    http://dx.doi.org/10.1107/s0108767317097124 journal-article Gati, C. et al., 2017. Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser. Acta Crystallographica Section A Foundations and Advances, 73(a1), pp.a292–a293. Available at: …

  25. Phase-retrieval algorithms for direct phasing of coherent nanocrystal diffraction

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    19 Dec 2017 | BioXFEL Publications | Contributor(s): Joe Chen, Richard Kirian

    http://dx.doi.org/10.1107/s0108767317097653 journal-article Chen, J.P.J. & Kirian, R.A., 2017. Phase-retrieval algorithms for direct phasing of coherent nanocrystal diffraction. Acta Crystallographica Section A Foundations and Advances, 73(a1), pp.a239–a239. Available at: …

  26. XFEL structures of the influenza M2 proton channel at 1.4 Å: room-temperature water networks and insights into proton conduction

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    19 Dec 2017 | BioXFEL Publications | Contributor(s): Jessica L. Thomaston, Rahel Woldeyes, Takanori Nakane, Kotaro Koiwai, Ayumi Yamashita, Tomoyuki Tanaka, Toshi Arima, Jun Kobayashi, Tetsuya Masuda, Mamoru Suzuki, Michihiro Sugahara, Rie Tanaka, Eriko Nango, So Iwata, Fumiaki Yumoto, James Fraser, William F. DeGrado

    http://dx.doi.org/10.1107/s0108767317099603 journal-article Thomaston, J.L. et al., 2017. XFEL structures of the influenza M2 proton channel at 1.4 Å: room-temperature water networks and insights into proton conduction. Acta Crystallographica Section A Foundations and Advances, 73(a1), …

  27. The influence of promiscuous metals on metalloprotein structure: complementary techniques to separate the good, the bad and the ugly

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    19 Dec 2017 | BioXFEL Publications | Contributor(s): Edward Snell, M. Elizabeth Snell, Oliver B. Zeldin, Geoffrey W. Grime, Elspeth F. Garman

    http://dx.doi.org/10.1107/s0108767317097677 journal-article Snell, E.H. et al., 2017. The influence of promiscuous metals on metalloprotein structure: complementary techniques to separate the good, the bad and the ugly. Acta Crystallographica Section A Foundations and Advances, 73(a1), …

  28. Structural changes of tailless bacteriophage ΦX174 during penetration of bacterial cell walls

    0.0 out of 5 stars 

    11 Dec 2017 | BioXFEL Publications | Contributor(s): Yingyuan Sun, Aaron P. Roznowski, Joshua M. Tokuda, Thomas Klose, Alexander Mauney, Lois Pollack, Bentley A. Fane, Michael G. Rossmann

    http://dx.doi.org/10.1073/pnas.1716614114 journal-article Sun, Y. et al., 2017. Structural changes of tailless bacteriophage ΦX174 during penetration of bacterial cell walls. Proceedings of the National Academy of Sciences, p.201716614. Available at: http://dx.doi.org/10.1073/pnas.1716614114. …

  29. 5th BioXFEL International Conference

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    04 Dec 2017 | Downloads

    …

  30. EuXFEL Workshop

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    30 Nov 2017 | Downloads

    …

  31. Publisher's Note: “Enzyme transient state kinetics in crystal and solution from the perspective of a time-resolved crystallographer” [Struct. Dyn. 1, 024701 (2014)]

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    28 Nov 2017 | BioXFEL Publications | Contributor(s): Marius Schmidt, Dilano Saldin

    http://dx.doi.org/10.1063/1.5016802 journal-article Schmidt, M. & Saldin, D.K., 2017. Publisher’s Note: “Enzyme transient state kinetics in crystal and solution from the perspective of a time-resolved crystallographer” [Struct. Dyn. 1, 024701 (2014)]. Structural Dynamics, 4(6), p.069901. …

  32. New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering

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    14 Nov 2017 | BioXFEL Publications | Contributor(s): Daniel A Keedy, Zachary B Hill, Justin T Biel, Emily Kang, T. Justin Rettenmaier, Jose Brandao-Neto, Nicholas M Pearce, Frank Von Delft, James A. Wells, James Fraser

    http://dx.doi.org/10.1101/218966 Allostery is an inherent feature of proteins and provides alternative routes to regulating function. Small-molecule allosteric inhibitors are often desirable; however, it remains challenging to identify surface sites in proteins which can bind small molecules and …

  33. Single-Walled Carbon Nanotubes Probed with Insulator-Based Dielectrophoresis

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    13 Nov 2017 | BioXFEL Publications | Contributor(s): Mohammad Towshif Rabbani, Christoph F. Schmidt, Alexandra Ros

    http://dx.doi.org/10.1021/acs.analchem.7b03105 journal-article Rabbani, M.T., Schmidt, C.F. & Ros, A., 2017. Single-Walled Carbon Nanotubes Probed with Insulator-Based Dielectrophoresis. Analytical Chemistry, 89(24), pp.13235–13244. Available at: http://dx.doi.org/10.1021/acs.analchem.7b03105. …

  34. A peak-finding algorithm based on robust statistical analysis in serial crystallography

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    03 Nov 2017 | BioXFEL Publications | Contributor(s): Marjan Hadian-Jazi, Marc Messerschmidt, Connie Darmanin, Klaus Giewekemeyer, Adrian P. Mancuso, Brian Abbey

    http://dx.doi.org/10.1107/s1600576717014340 The recent development of serial crystallography at synchrotron and X-ray free-electron laser (XFEL) sources is producing crystallographic datasets of ever increasing volume. The size of these datasets is such that fast and efficient analysis presents a …

  35. Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril

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    01 Nov 2017 | BioXFEL Publications | Contributor(s): Cody Hoop, Jie Zhu, Ana Nunes, David Case, Jean Baum

    http://dx.doi.org/10.3390/biom7040076 journal-article Hoop, C. et al., 2017. Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril. Biomolecules, 7(4), p.76. Available at: http://dx.doi.org/10.3390/biom7040076. Cody Hoop and Jie Zhu and Ana Nunes and …

  36. Pink-beam serial crystallography

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    30 Oct 2017 | BioXFEL Publications | Contributor(s): A. Meents, M. O. Wiedorn, V. Srajer, R. Henning, I. Sarrou, J. Bergtholdt, M. Barthelmess, P. Y. A. Reinke, D. Dierksmeyer, A. Tolstikova, S. Schaible, M. Messerschmidt, C. M. Ogata, D. J. Kissick, M. H. Taft, D. J. Manstein, J. Lieske, D. Oberthuer, R. F. Fischetti, H. N. Chapman

    http://dx.doi.org/10.1038/s41467-017-01417-3 journal-article Meents, A. et al., 2017. Pink-beam serial crystallography. Nature Communications, 8(1). Available at: http://dx.doi.org/10.1038/s41467-017-01417-3. A. Meents and M. O. Wiedorn and V. Srajer and R. Henning and I. Sarrou and J. …

  37. Performance of silicon drift detectors at LCLS

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    25 Oct 2017 | BioXFEL Publications | Contributor(s): G. Blaj, C. J. Kenney, S. Boutet, G. Carini, M. Chollet, G. Dakovski, G. Haller, P. Hart, S. Herrmann, J. Koglin, M. Messerschmidt, S. Nelson, J. Pines, S. Song, J. Thayer, A. Tomada, G. Williams

    http://dx.doi.org/10.1109/nssmic.2016.8069827 proceedings-article Blaj, G. et al., 2016. Performance of silicon drift detectors at LCLS. 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD). Available at: …

  38. Corrigendum: Diffraction data of core-shell nanoparticles from an X-ray free electron laser

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    24 Oct 2017 | BioXFEL Publications | Contributor(s): Xuanxuan Li, Chun-Ya Chiu, Hsiang-Ju Wang, Stephan Kassemeyer, Sabine Botha, Robert L Shoeman, Robert M Lawrence, Christopher Kupitz, Richard Kirian, Daniel James, Dingjie Wang, Garrett Charles Nelson, Marc Messerschmidt, Sébastien Boutet, Garth J Williams, Elisabeth Hartmann, Aliakbar Jafarpour, Lutz M Foucar, Anton Barty, Henry Chapman, Mengning Liang, Andreas Menzel, Fenglin Wang, Shibom Basu, Raimund Fromme, R.Bruce Doak, Petra Fromme, Uwe Weierstall, Michael H Huang, John Spence, Ilme Schlichting, Brenda Hogue, Haiguang Liu

    http://dx.doi.org/10.1038/sdata.2017.154 journal-article Li, X. et al., 2017. Corrigendum: Diffraction data of core-shell nanoparticles from an X-ray free electron laser. Scientific Data, 4, p.170154. Available at: http://dx.doi.org/10.1038/sdata.2017.154. Xuanxuan Li and Chun-Ya Chiu and …

  39. Analysis of XFEL serial diffraction data from individual crystalline fibrils

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    20 Oct 2017 | BioXFEL Publications | Contributor(s): David H. Wojtas, Kartik Ayyer, Mengning Liang, Estelle Mossou, Filippo Romoli, Carolin Seuring, Kenneth R. Beyerlein, Richard J. Bean, Andrew J. Morgan, Dominik Oberthuer, Holger Fleckenstein, Michael Heymann, Cornelius Gati, Oleksandr Yefanov, Miriam Barthelmess, Eirini Ornithopoulou, Lorenzo Galli, P. Lourdu Xavier, Wai Li Ling, Matthias Frank, Chun Hong Yoon, Thomas A. White, Saša Bajt, Anna Mitraki, Sebastien Boutet, Andrew Aquila, Anton Barty, V. Trevor Forsyth, Henry Chapman, Rick P. Millane

    http://dx.doi.org/10.1107/s2052252517014324 Serial diffraction data collected at the Linac Coherent Light Source from crystalline amyloid fibrils delivered in a liquid jet show that the fibrils are well oriented in the jet. At low fibril concentrations, diffraction patterns are recorded from single …

  40. FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death

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    16 Oct 2017 | BioXFEL Publications | Contributor(s): Duan-Zhuo Li, Shun-Fang Liu, Lan Zhu, Yu-Xing Wang, Yi-Xiang Chen, Jie Liu, Gang Hu, Xin Yu, Jian Li, Jin Zhang, Zhi-Xiang Wu, Han Lu, Wei Liu, Bin Liu

    http://dx.doi.org/10.18632/oncotarget.21843 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Li, D.-Z. et al., 2017. FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death. Oncotarget, 8(57). Available at: http://dx.doi.org/10.18632/oncotarget.21843. …

  41. Post-sample aperture for low background diffraction experiments at X-ray free-electron lasers

    0.0 out of 5 stars 

    16 Oct 2017 | BioXFEL Publications | Contributor(s): Max Oliver Wiedorn, Salah Awel, Andrew J. Morgan, Miriam Barthelmess, Richard Bean, Kenneth R. Beyerlein, Leonard M. G. Chavas, Niko Eckerskorn, Holger Fleckenstein, Michael Heymann, Daniel A. Horke, Juraj Knoška, Valerio Mariani, Dominik Oberthür, Nils Roth, Oleksandr Yefanov, Anton Barty, Saša Bajt, Jochen Küpper, Andrei V. Rode, Richard Kirian, Henry Chapman

    http://dx.doi.org/10.1107/s1600577517011961 The success of diffraction experiments from weakly scattering samples strongly depends on achieving an optimal signal-to-noise ratio. This is particularly important in single-particle imaging experiments where diffraction signals are typically very weak …

  42. Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

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    13 Oct 2017 | BioXFEL Publications | Contributor(s): Jose Olmos, Suraj Pandey, Jose M. Martin-Garcia, George Douglas Calvey, Andrea Katz, Juray Knoska, Christopher Kupitz, Mark S. Hunter, Mengning Liang, Dominik Oberthuer, Oleksandr Yefanov, Max Oliver Wiedorn, Michael Heymann, Mark Holl, Kanupriya Pande, Anton Barty, Mitchell Miller, Stephan Stern, Shatabdi Roy-Chowdhury, Jesse David Coe, Nirupa Nagaratnam, James D Zook, Jacob Christopher Verburgt, Tyler Norwood, Ishwor Poudyal, David Xu, Jason Koglin, Matt Seaberg, Yun Zhao, Sasa Bajt, Thomas Grant, Valerio Mariani, Garrett Charles Nelson, GANESH SUBRAMANIAN, Euiyoung Bae, Raimund Fromme, Russel Fung, Peter Schwander, Matthias Frank, Thomas White, Uwe Weierstall, Nadia Zatsepin, John Spence, Petra Fromme, Henry Chapman, Lois Pollack, Lee Tremblay, Abbas Ourmazd, George Phillips, Marius Schmidt

    http://dx.doi.org/10.1101/202432 Ever since the first atomic structure of an enzyme was solved, the discovery of the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal for the understanding of the molecular processes that drive life on earth. Despite a large number …

  43. Correlations in Scattered X-Ray Laser Pulses Reveal Nanoscale Structural Features of Viruses

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    12 Oct 2017 | BioXFEL Publications | Contributor(s): Ruslan P. Kurta, Jeffrey J. Donatelli, Chun Hong Yoon, Peter Berntsen, Johan Bielecki, Benedikt J. Daurer, Hasan Demirci, Petra Fromme, Max Felix Hantke, Filipe R. N. C. Maia, Anna Munke, Carl Nettelblad, Kanupriya Pande, Hemanth K. N. Reddy, Jonas A. Sellberg, Raymond G. Sierra, Martin Svenda, Gijs Van Der Schot, Ivan A. Vartanyants, Garth J. Williams, P. Lourdu Xavier, Andrew Aquila, Peter H. Zwart, Adrian P. Mancuso

    http://dx.doi.org/10.1103/physrevlett.119.158102 journal-article Kurta, R.P. et al., 2017. Correlations in Scattered X-Ray Laser Pulses Reveal Nanoscale Structural Features of Viruses. Physical Review Letters, 119(15). Available at: http://dx.doi.org/10.1103/physrevlett.119.158102. Ruslan P. …

  44. Optimal Pulse Processing, Pile-Up Decomposition, and Applications of Silicon Drift Detectors at LCLS

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    11 Oct 2017 | BioXFEL Publications | Contributor(s): G. Blaj, C. J. Kenney, A. Dragone, G. Carini, S. Herrmann, P. Hart, A. Tomada, J. Koglin, G. Haller, S. Boutet, M. Messerschmidt, G. Williams, M. Chollet, G. Dakovski, S. Nelson, J. Pines, S. Song, J. Thayer

    http://dx.doi.org/10.1109/tns.2017.2762281 journal-article Blaj, G. et al., 2017. Optimal Pulse Processing, Pile-Up Decomposition, and Applications of Silicon Drift Detectors at LCLS. IEEE Transactions on Nuclear Science, 64(11), pp.2854–2868. Available at: …

  45. Mix-and-diffuse serial synchrotron crystallography

    0.0 out of 5 stars 

    09 Oct 2017 | BioXFEL Publications | Contributor(s): Kenneth R. Beyerlein, Dennis Dierksmeyer, Valerio Mariani, Manuela Kuhn, Iosifina Sarrou, Angelica Ottaviano, Salah Awel, Juraj Knoska, Silje Fuglerud, Olof Jönsson, Stephan Stern, Max Oliver Wiedorn, Oleksandr Yefanov, Luigi Adriano, Richard Bean, Anja Burkhardt, Pontus Fischer, Michael Heymann, Daniel A. Horke, Katharina E. J. Jungnickel, Elena Kovaleva, Olga Lorbeer, Markus Metz, Jan Meyer, Andrew Morgan, Kanupriya Pande, Saravanan Panneerselvam, Carolin Seuring, Aleksandra Tolstikova, Julia Lieske, Steve Aplin, Manfred Roessle, Thomas A. White, Henry Chapman, Alke Meents, Dominik Oberthuer

    http://dx.doi.org/10.1107/s2052252517013124 Unravelling the interaction of biological macromolecules with ligands and substrates at high spatial and temporal resolution remains a major challenge in structural biology. The development of serial crystallography methods at X-ray free-electron lasers …

  46. Nanocrystallography measurements of early stage synthetic malaria pigment

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    28 Sep 2017 | BioXFEL Publications | Contributor(s): Ruben A. Dilanian, Victor Streltsov, Hannah D. Coughlan, Harry M. Quiney, Andrew V. Martin, Nectarios Klonis, Con Dogovski, Sébastien Boutet, Marc Messerschmidt, Garth J. Williams, Sophie Williams, Nicholas W. Phillips, Keith A. Nugent, Leann Tilley, Brian Abbey

    http://dx.doi.org/10.1107/s1600576717012663 The recent availability of extremely intense, femtosecond X-ray free-electron laser (XFEL) sources has spurred the development of serial femtosecond nanocrystallography (SFX). Here, SFX is used to analyze nanoscale crystals of β-hematin, the synthetic …

  47. Merging single-shot XFEL diffraction data from inorganic nanoparticles: a new approach to size and orientation determination

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    22 Sep 2017 | BioXFEL Publications | Contributor(s): Xuanxuan Li, John Spence, Brenda Hogue, Haiguang Liu

    http://dx.doi.org/10.1107/s2052252517012398 X-ray free-electron lasers (XFELs) provide new opportunities for structure determination of biomolecules, viruses and nanomaterials. With unprecedented peak brilliance and ultra-short pulse duration, XFELs can tolerate higher X-ray doses by exploiting the …

  48. Structure determination based on continuous diffraction from macromolecular crystals

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    14 Sep 2017 | BioXFEL Publications | Contributor(s): Henry Chapman, Petra Fromme

    http://dx.doi.org/10.1016/j.sbi.2017.07.008 journal-article Chapman, H.N. & Fromme, P., 2017. Structure determination based on continuous diffraction from macromolecular crystals. Current Opinion in Structural Biology, 45, pp.170–177. Available at: http://dx.doi.org/10.1016/j.sbi.2017.07.008. …

  49. Phase retrieval in the presence of multiplicative noise

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    06 Sep 2017 | BioXFEL Publications | Contributor(s): Joe Chen, Richard Kirian

    http://dx.doi.org/10.1117/12.2275182 proceedings-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Chen, J.P.J. & Kirian, R.A., 2017. Phase retrieval in the presence of multiplicative noise J. J. Dolne & R. P. Millane, eds. Unconventional and Indirect Imaging, Image Reconstruction, and …

  50. Rescue of Conformational Dynamics in Enzyme Catalysis by Directed Evolution

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    06 Sep 2017 | BioXFEL Publications | Contributor(s): Renee Otten, Lin Liu, Lillian R. Kenner, Michael W. Clarkson, David Mavor, Dan S. Tawfik, Dorothee Kern, James Fraser

    http://dx.doi.org/10.1101/185009 Rational design and directed evolution have proved to be successful approaches to increase catalytic efficiencies of both natural and artificial enzymes. However, a comprehensive understanding of how evolution shapes the energy landscape of catalysis remains a …

  51. XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction

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    23 Aug 2017 | BioXFEL Publications | Contributor(s): Jessica L. Thomaston, Rahel Woldeyes, Takanori Nakane, Ayumi Yamashita, Tomoyuki Tanaka, Kotaro Koiwai, Aaron S. Brewster, Benjamin A. Barad, Yujie Chen, Thomas Lemmin, Monarin Uervirojnangkoorn, Toshi Arima, Jun Kobayashi, Tetsuya Masuda, Mamoru Suzuki, Michihiro Sugahara, Nicholas K. Sauter, Rie Tanaka, Osamu Nureki, Kensuke Tono, Yasumasa Joti, Eriko Nango, So Iwata, Fumiaki Yumoto, James Fraser, William F. DeGrado

    http://dx.doi.org/10.1073/pnas.1705624114 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Thomaston, J.L. et al., 2017. XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction. Proceedings of the National Academy of …

  52. Conformational landscape of a virus by single-particle X-ray scattering

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    14 Aug 2017 | BioXFEL Publications | Contributor(s): Ahmad Hosseinizadeh, Ghoncheh Mashayekhi, Jeremy Copperman, Peter Schwander, Ali Dashti, Reyhaneh Sepehr, Russell Fung, Marius Schmidt, Chun Hong Yoon, Brenda Hogue, Garth J Williams, Andrew Aquila, Abbas Ourmazd

    http://dx.doi.org/10.1038/nmeth.4395 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Hosseinizadeh, A. et al., 2017. Conformational landscape of a virus by single-particle X-ray scattering. Nature Methods. Available at: http://dx.doi.org/10.1038/nmeth.4395. Ahmad Hosseinizadeh and …

  53. Incoherent Diffractive Imaging via Intensity Correlations of Hard X Rays

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    31 Jul 2017 | BioXFEL Publications | Contributor(s): Anton Classen, Kartik Ayyer, Henry Chapman, Ralf Röhlsberger, Joachim Von Zanthier

    http://dx.doi.org/10.1103/physrevlett.119.053401 journal-article Classen, A. et al., 2017. Incoherent Diffractive Imaging via Intensity Correlations of Hard X Rays. Physical Review Letters, 119(5). Available at: http://dx.doi.org/10.1103/physrevlett.119.053401. Anton Classen and Kartik Ayyer and …

  54. Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases

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    31 Jul 2017 | BioXFEL Publications | Contributor(s): Timothy M. Acker, Jonathan E. Gable, Markus-Frederik Bohn, Priyadarshini Jaishankar, Michael Thompson, James Fraser, Adam R. Renslo, Charles S. Craik

    http://dx.doi.org/10.1021/jacs.7b04030 journal-article Acker, T.M. et al., 2017. Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases. Journal of the American Chemical Society. Available at: …

  55. Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors

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    27 Jul 2017 | BioXFEL Publications | Contributor(s): X. Edward Zhou, Yuanzheng He, Parker W. De Waal, Xiang Gao, Yanyong Kang, Ned Van Eps, Yanting Yin, Kuntal Pal, Devrishi Goswami, Thomas A. White, Anton Barty, Naomi R. Latorraca, Henry Chapman, Wayne L. Hubbell, Ron O. Dror, Raymond C. Stevens, Vadim Cherezov, Vsevolod V. Gurevich, Patrick R. Griffin, Oliver P. Ernst, Karsten Melcher, H. Eric Xu

    http://dx.doi.org/10.1016/j.cell.2017.07.002 journal-article Zhou, X.E. et al., 2017. Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. Cell, 170(3), pp.457–469.e13. Available at: http://dx.doi.org/10.1016/j.cell.2017.07.002. X. Edward Zhou and …

  56. Cell-free production of a functional oligomeric form of aChlamydiamajor outer-membrane protein (MOMP) for vaccine development

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    24 Jul 2017 | BioXFEL Publications | Contributor(s): Wei He, Martina Felderman, Angela C. Evans, Jia Geng, David Homan, Feliza Bourguet, Nicholas O. Fischer, Yuanpei Li, Kit S. Lam, Aleksandr Noy, Li Xing, R. Holland Cheng, Amy Rasley, Craig D. Blanchette, Kurt Kamrud, Nathaniel Wang, Heather Gouvis, Todd C. Peterson, Bolyn Hubby, Matthew Coleman

    http://dx.doi.org/10.1074/jbc.m117.784561 journal-article He, W. et al., 2017. Cell-free production of a functional oligomeric form of aChlamydiamajor outer-membrane protein (MOMP) for vaccine development. Journal of Biological Chemistry, 292(36), pp.15121–15132. Available at: …

  57. Development of a ceramic injection molding process for liquid jet nozzles to be applied for X-ray free-electron lasers

    0.0 out of 5 stars 

    24 Jul 2017 | BioXFEL Publications | Contributor(s): Volker Piotter, Alexander Klein, Klaus Plewa, Kenneth R. Beyerlein, Henry Chapman, Saša Bajt

    http://dx.doi.org/10.1007/s00542-017-3493-7 journal-article Piotter, V. et al., 2017. Development of a ceramic injection molding process for liquid jet nozzles to be applied for X-ray free-electron lasers. Microsystem Technologies. Available at: http://dx.doi.org/10.1007/s00542-017-3493-7. …

  58. A Bright Future for Serial Femtosecond Crystallography with XFELs

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    18 Jul 2017 | BioXFEL Publications | Contributor(s): Linda C. Johansson, Benjamin Stauch, Andrii Ishchenko, Vadim Cherezov

    http://dx.doi.org/10.1016/j.tibs.2017.06.007 journal-article Johansson, L.C. et al., 2017. A Bright Future for Serial Femtosecond Crystallography with XFELs. Trends in Biochemical Sciences. Available at: http://dx.doi.org/10.1016/j.tibs.2017.06.007. Linda C. Johansson and Benjamin Stauch and …

  59. Single-shot determination of focused FEL wave fields using iterative phase retrieval

    0.0 out of 5 stars 

    18 Jul 2017 | BioXFEL Publications | Contributor(s): Masoud Mehrjoo, Klaus Giewekemeyer, Patrik Vagovič, Stephan Stern, Richard Bean, Marc Messerschmidt, Barbara Keitel, Elke Plönjes, Marion Kuhlmann, Tobias Mey, Evgeny A. Schneidmiller, Mikhail V. Yurkov, Torsten Limberg, Adrian P. Mancuso

    http://dx.doi.org/10.1364/oe.25.017892 journal-article Mehrjoo, M. et al., 2017. Single-shot determination of focused FEL wave fields using iterative phase retrieval. Optics Express, 25(15), p.17892. Available at: http://dx.doi.org/10.1364/oe.25.017892. Masoud Mehrjoo and Klaus Giewekemeyer and …

  60. Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

    0.0 out of 5 stars 

    17 Jul 2017 | BioXFEL Publications | Contributor(s): Andrii Ishchenko, Daniel Wacker, Mili Kapoor, Ai Zhang, Gye Won Han, Shibom Basu, Nilkanth N Patel, Marc Messerschmidt, Uwe Weierstall, Wei Liu, Vsevolod Katritch, Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov

    http://dx.doi.org/10.1073/pnas.1700891114 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Ishchenko, A. et al., 2017. Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody. Proceedings of the National Academy of Sciences, …

  61. Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature

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    11 Jul 2017 | BioXFEL Publications | Contributor(s): Izumi Ishigami, Nadia Zatsepin, Masahide Hikita, Chelsie E Conrad, Garrett Charles Nelson, Jesse David Coe, Shibom Basu, Thomas D. Grant, Matthew H. Seaberg, Raymond G. Sierra, Mark S. Hunter, Petra Fromme, Raimund Fromme, Syun-Ru Yeh, Denis L. Rousseau

    http://dx.doi.org/10.1073/pnas.1705628114 Cytochromecoxidase (CcO), the terminal enzyme in the electron transfer chain, translocates protons across the inner mitochondrial membrane by harnessing the free energy generated by the reduction of oxygen to water. Several redox-coupled proton …

  62. FELIX: an algorithm for indexing multiple crystallites in X-ray free-electron laser snapshot diffraction images

    0.0 out of 5 stars 

    07 Jul 2017 | BioXFEL Publications | Contributor(s): Kenneth R. Beyerlein, Thomas A. White, Oleksandr Yefanov, Cornelius Gati, Ivan G. Kazantsev, Nicolai Fog-Gade Nielsen, Peter M. Larsen, Henry Chapman, Søren Schmidt

    http://dx.doi.org/10.1107/s1600576717007506 A novel algorithm for indexing multiple crystals in snapshot X-ray diffraction images, especially suited for serial crystallography data, is presented. The algorithm, FELIX, utilizes a generalized parametrization of the Rodrigues–Frank space, in which …

  63. Continuous diffraction of molecules and disordered molecular crystals

    0.0 out of 5 stars 

    07 Jul 2017 | BioXFEL Publications | Contributor(s): Henry Chapman, Oleksandr M. Yefanov, Kartik Ayyer, Thomas A. White, Anton Barty, Andrew Morgan, Valerio Mariani, Dominik Oberthuer, Kanupriya Pande

    http://dx.doi.org/10.1107/s160057671700749x The intensities of far-field diffraction patterns of orientationally aligned molecules obey Wilson statistics, whether those molecules are in isolation (giving rise to a continuous diffraction pattern) or arranged in a crystal (giving rise to Bragg …

  64. Watching proteins function with time-resolved x-ray crystallography

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    03 Jul 2017 | BioXFEL Publications | Contributor(s): Vukica Šrajer, Marius Schmidt

    http://dx.doi.org/10.1088/1361-6463/aa7d32 journal-article Šrajer, V. & Schmidt, M., 2017. Watching proteins function with time-resolved x-ray crystallography. Journal of Physics D: Applied Physics, 50(37), p.373001. Available at: http://dx.doi.org/10.1088/1361-6463/aa7d32. Vukica Šrajer and …

  65. How Cubic Can Ice Be?

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    28 Jun 2017 | BioXFEL Publications | Contributor(s): Andrew J. Amaya, Harshad Pathak, Viraj P. Modak, Hartawan Laksmono, N. Duane Loh, Jonas A. Sellberg, Raymond G. Sierra, Trevor A. McQueen, Matt J. Hayes, Garth J. Williams, Marc Messerschmidt, Sébastien Boutet, Michael J. Bogan, Anders Nilsson, Claudiu A. Stan, Barbara E. Wyslouzil

    http://dx.doi.org/10.1021/acs.jpclett.7b01142 journal-article Amaya, A.J. et al., 2017. How Cubic Can Ice Be? The Journal of Physical Chemistry Letters, pp.3216–3222. Available at: http://dx.doi.org/10.1021/acs.jpclett.7b01142. Andrew J. Amaya and Harshad Pathak and Viraj P. Modak and Hartawan …

  66. Coherent soft X-ray diffraction imaging of coliphage PR772 at the Linac coherent light source

    0.0 out of 5 stars 

    27 Jun 2017 | BioXFEL Publications | Contributor(s): Hemanth K.N. Reddy, Chun Hong Yoon, Andrew Aquila, Salah Awel, Kartik Ayyer, Anton Barty, Peter Berntsen, Johan Bielecki, Sergey Bobkov, Maximilian Bucher, Gabriella A. Carini, Sebastian Carron, Henry Chapman, Benedikt Daurer, Hasan Demirci, Tomas Ekeberg, Petra Fromme, Janos Hajdu, Max Felix Hanke, Philip Hart, Brenda Hogue, Ahmad Hosseinizadeh, Yoonhee Kim, Richard Kirian, Ruslan P. Kurta, Daniel S.D. Larsson, N. Duane Loh, Filipe R.N.C. Maia, Adrian P. Mancuso, Kerstin Mühlig, Anna Munke, Daewoong Nam, Carl Nettelblad, Abbas Ourmazd, Max Rose, Peter Schwander, Marvin Seibert, Jonas A. Sellberg, Changyong Song, John Spence, Martin Svenda, Gijs Van Der Schot, Ivan A. Vartanyants, Garth J. Williams, P. Lourdu Xavier

    http://dx.doi.org/10.1038/sdata.2017.79 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Reddy, H.K.N. et al., 2017. Coherent soft X-ray diffraction imaging of coliphage PR772 at the Linac coherent light source. Scientific Data, 4, p.170079. Available at: …

  67. Algorithm for Reconstruction of 3D Images of Nanorice Particles from Diffraction Patterns of Two Particles in Independent Random Orientations with an X-ray Laser

    0.0 out of 5 stars 

    23 Jun 2017 | BioXFEL Publications | Contributor(s): Sung Soon Kim, Sandi Wibowo, Dilano Saldin

    http://dx.doi.org/10.3390/app7070646 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Kim, S., Wibowo, S. & Saldin, D., 2017. Algorithm for Reconstruction of 3D Images of Nanorice Particles from Diffraction Patterns of Two Particles in Independent Random Orientations with an X-ray …

  68. Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase

    0.0 out of 5 stars 

    22 Jun 2017 | BioXFEL Publications | Contributor(s): Pius S. Padayatti, Josephine H. Leung, Paween Mahinthichaichan, Emad Tajkhorshid, Andrii Ishchenko, Vadim Cherezov, S. Michael Soltis, J. Baz Jackson, C. David Stout, Robert B. Gennis, Qinghai Zhang

    http://dx.doi.org/10.1016/j.str.2017.05.022 journal-article Padayatti, P.S. et al., 2017. Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase. Structure, 25(7), pp.1111–1119.e3. Available at: http://dx.doi.org/10.1016/j.str.2017.05.022. Pius S. …

  69. Non-thermal damage to lead tungstate induced by intense short-wavelength laser radiation (Conference Presentation)

    0.0 out of 5 stars 

    21 Jun 2017 | BioXFEL Publications | Contributor(s): Vojtech Vozda, Pavel Boháček, Tomáš Burian, Jaromir Chalupský, Vera Hájková, Libor Juha, Ludek Vyšín, Jérôme Gaudin, Philip A. Heimann, Stefan Hau-Riege, Marek Jurek, Dorota Klinger, Jacek Krzywinski, Marc Messerschmidt, Stefan P. Moeller, Robert Nagler, Jerzy B. Pelka, Michael Rowen, William F. Schlotter, Michele L. Swiggers, Harald Sinn, Ryszard Sobierajski, Kai Tiedtke, Sven Toleikis, Thomas Tschentscher, Joshua J. Turner, Hubertus Wabnitz, Art J. Nelson, Maria V. Kozlova, Sam M. Vinko, Thomas Whitcher, Thomas Dzelzainis, Oldrich Renner, Karel Saksl, Roland R. Fäustlin, Ali R. Khorsand, Marta Fajardo, Bianca S. Iwan, Jakob Andreasson, Janos Hajdu, Nicusor Timneanu, Justin S. Wark, David Riley, Richard W. Lee, Mitsuru Nagasono, Makina Yabashi

    http://dx.doi.org/10.1117/12.2270944 proceedings-article Vozda, V. et al., 2017. Non-thermal damage to lead tungstate induced by intense short-wavelength laser radiation (Conference Presentation) L. Juha, S. Bajt, & R. Soufli, eds. Damage to VUV, EUV, and X-ray Optics VI. Available at: …

  70. Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography

    0.0 out of 5 stars 

    21 Jun 2017 | BioXFEL Publications | Contributor(s): Dominik Oberthuer, Juraj Knoška, Max Oliver Wiedorn, Kenneth R. Beyerlein, David Bushnell, Elena G. Kovaleva, Michael Heymann, Lars Gumprecht, Richard Kirian, Anton Barty, Valerio Mariani, Aleksandra Tolstikova, Luigi Adriano, Salah Awel, Miriam Barthelmess, Katerina Dörner, P. Lourdu Xavier, Oleksandr Yefanov, Daniel R. James, Garrett Charles Nelson, Dingjie Wang, George Douglas Calvey, Yujie Chen, Andrea Schmidt, Michael Szczepek, Stefan Frielingsdorf, Oliver Lenz, Edward Snell, Philip J. Robinson, Božidar Šarler, Grega Belšak, Marjan Maček, Fabian Wilde, Andrew Aquila, Sébastien Boutet, Mengning Liang, Mark S. Hunter, Patrick Scheerer, John D. Lipscomb, Uwe Weierstall, Roger Kornberg, John Spence, Lois Pollack, Henry Chapman, Saša Bajt

    http://dx.doi.org/10.1038/srep46846 journal-article Oberthuer, D. et al., 2017. Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography. Scientific Reports, 7, p.46846. Available at: http://dx.doi.org/10.1038/srep46846. Dominik Oberthuer and Juraj …

  71. Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

    0.0 out of 5 stars 

    21 Jun 2017 | BioXFEL Publications | Contributor(s): Yi Zheng, Gye Won Han, Ruben Abagyan, Beili Wu, Raymond C. Stevens, Vadim Cherezov, Irina Kufareva, Tracy M. Handel

    http://dx.doi.org/10.1016/j.immuni.2017.05.002 journal-article Zheng, Y. et al., 2017. Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. Immunity, 46(6), pp.1005–1017.e5. Available at: …

  72. Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system

    0.0 out of 5 stars 

    06 Jun 2017 | BioXFEL Publications | Contributor(s): Tiffany M. Scharadin, Wei He, Yianni Yiannakou, Alexey A. Tomilov, Matthew Saldana, Gino A. Cortopassi, Kermit L. Carraway, Matthew Coleman, Paul T. Henderson

    http://dx.doi.org/10.1371/journal.pone.0177761 journal-article Scharadin, T.M. et al., 2017. Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system L. Buday, ed. PLOS ONE, 12(6), p.e0177761. Available at: …

  73. Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser

    0.0 out of 5 stars 

    02 Jun 2017 | BioXFEL Publications | Contributor(s): David Popp, N. Duane Loh, Habiba Zorgati, Umesh Ghoshdastider, Lu Ting Liow, Magdalena I. Ivanova, Mårten Larsson, Daniel P. DePonte, Richard Bean, Kenneth R. Beyerlein, Cornelius Gati, Dominik Oberthuer, David Arnlund, Gisela Brändén, Peter Berntsen, Duilio Cascio, Leonard M. G. Chavas, Joe Chen, Ke Ding, Holger Fleckenstein, Lars Gumprecht, Rajiv Harimoorthy, Estelle Mossou, Michael R. Sawaya, Aaron S. Brewster, Johan Hattne, Nicholas K. Sauter, Marvin Seibert, Carolin Seuring, Francesco Stellato, Thomas Tilp, David S. Eisenberg, Marc Messerschmidt, Garth J. Williams, Jason E. Koglin, Lee Makowski, Rick P. Millane, Trevor Forsyth, Sébastien Boutet, Thomas A. White, Anton Barty, Henry Chapman, Swaine L. Chen, Mengning Liang, Richard Neutze, Robert C. Robinson

    http://dx.doi.org/10.1002/cm.21378 journal-article Popp, D. et al., 2017. Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser. Cytoskeleton. Available at: http://dx.doi.org/10.1002/cm.21378. David Popp and N. Duane Loh and Habiba Zorgati and Umesh …

  74. Outrunning damage: Electrons vs X-rays—timescales and mechanisms

    0.0 out of 5 stars 

    01 Jun 2017 | BioXFEL Publications | Contributor(s): John Spence

    http://dx.doi.org/10.1063/1.4984606 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Spence, J.C.H., 2017. Outrunning damage: Electrons vs X-rays—timescales and mechanisms. Structural Dynamics, 4(4), p.044027. Available at: http://dx.doi.org/10.1063/1.4984606. John C. …

  75. Crystallization of Membrane Proteins: An Overview

    0.0 out of 5 stars 

    01 Jun 2017 | BioXFEL Publications | Contributor(s): Andrii Ishchenko, Enrique E. Abola, Vadim Cherezov

    http://dx.doi.org/10.1007/978-1-4939-7000-1_5 book-chapter Ishchenko, A., Abola, E.E. & Cherezov, V., 2017. Crystallization of Membrane Proteins: An Overview. Protein Crystallography, pp.117–141. Available at: http://dx.doi.org/10.1007/978-1-4939-7000-1_5. Andrii Ishchenko and Enrique E. Abola …

  76. Time-Resolved Macromolecular Crystallography at Modern X-Ray Sources

    0.0 out of 5 stars 

    01 Jun 2017 | BioXFEL Publications | Contributor(s): Marius Schmidt

    http://dx.doi.org/10.1007/978-1-4939-7000-1_11 book-chapter NSF-STC Biology with X-ray Lasers (NSF-1231306) Schmidt, M., 2017. Time-Resolved Macromolecular Crystallography at Modern X-Ray Sources. Protein Crystallography, pp.273–294. Available at: http://dx.doi.org/10.1007/978-1-4939-7000-1_11. …

  77. Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation

    0.0 out of 5 stars 

    24 May 2017 | BioXFEL Publications | Contributor(s): Jose M. Martin-Garcia, Chelsie E Conrad, Garrett Charles Nelson, Natasha Stander, Nadia Zatsepin, James D Zook, Lan Zhu, James Geiger, Eugene Chun, David Kissick, Mark C. Hilgart, Craig Ogata, Andrii Ishchenko, Nirupa Nagaratnam, Shatabdi Roy-Chowdhury, Jesse David Coe, GANESH SUBRAMANIAN, Alexander Schaffer, Daniel James, Gihan Ketwala, Nagarajan Venugopalan, Shenglan Xu, Stephen Corcoran, Dale Ferguson, Uwe Weierstall, John Spence, Vadim Cherezov, Petra Fromme, Robert F. Fischetti, Wei Liu

    http://dx.doi.org/10.1107/s205225251700570x Crystal structure determination of biological macromolecules using the novel technique of serial femtosecond crystallography (SFX) is severely limited by the scarcity of X-ray free-electron laser (XFEL) sources. However, recent and future upgrades render …

  78. Structure of the full-length glucagon class B G-protein-coupled receptor

    0.0 out of 5 stars 

    17 May 2017 | BioXFEL Publications | Contributor(s): Haonan Zhang, Anna Qiao, Dehua Yang, Linlin Yang, Antao Dai, Chris De Graaf, Steffen Reedtz-Runge, Venkatasubramanian Dharmarajan, Hui Zhang, Gye Won Han, Thomas D. Grant, Raymond G. Sierra, Uwe Weierstall, Garrett Charles Nelson, Wei Liu, Yanhong Wu, Limin Ma, Xiaoqing Cai, Guangyao Lin, Xiaoai Wu, Zhi Geng, Yuhui Dong, Gaojie Song, Patrick R. Griffin, Jesper Lau, Vadim Cherezov, Huaiyu Yang, Michael A. Hanson, Raymond C. Stevens, Qiang Zhao, Hualiang Jiang, Ming-Wei Wang, Beili Wu

    http://dx.doi.org/10.1038/nature22363 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Zhang, Haonan et al., 2017. Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. Available at: http://dx.doi.org/10.1038/nature22363. Haonan Zhang and Anna Qiao and …

  79. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand

    0.0 out of 5 stars 

    17 May 2017 | BioXFEL Publications | Contributor(s): Xianjun Zhang, Fei Zhao, Yiran Wu, Jun Yang, Gye Won Han, Suwen Zhao, Andrii Ishchenko, Lintao Ye, Xi Lin, Kang Ding, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Cornelius Gati, Garrett Charles Nelson, Mark S. Hunter, Michael A. Hanson, Vadim Cherezov, Raymond C. Stevens, Wenfu Tan, Houchao Tao, Fei Xu

    http://dx.doi.org/10.1038/ncomms15383 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Zhang, X. et al., 2017. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nature Communications, 8, p.15383. Available at: …

  80. Peripheral Blood Biomarkers Associated With Toxicity and Treatment Characteristics After 131 I- Metaiodobenzylguanidine Therapy in Patients With Neuroblastoma

    0.0 out of 5 stars 

    15 May 2017 | BioXFEL Publications | Contributor(s): Kevin Campbell, Erin E. Karski, Aleksandra Olow, David A. Edmondson, Ayano C. Kohlgruber, Matthew Coleman, Daphne A. Haas-Kogan, Katherine K. Matthay, Steven G. DuBois

    http://dx.doi.org/10.1016/j.ijrobp.2017.05.008 journal-article Campbell, K. et al., 2017. Peripheral Blood Biomarkers Associated With Toxicity and Treatment Characteristics After 131 I- Metaiodobenzylguanidine Therapy in Patients With Neuroblastoma. International Journal of Radiation …

  81. Chemically Stable Lipids for Membrane Protein Crystallization

    0.0 out of 5 stars 

    12 May 2017 | BioXFEL Publications | Contributor(s): Andrii Ishchenko, Lingling Peng, Egor Zinovev, Alexey Vlasov, Sung Chang Lee, Alexander Kuklin, Alexey Mishin, Valentin Borshchevskiy, Qinghai Zhang, Vadim Cherezov

    http://dx.doi.org/10.1021/acs.cgd.7b00458 journal-article Ishchenko, A. et al., 2017. Chemically Stable Lipids for Membrane Protein Crystallization. Crystal Growth & Design. Available at: http://dx.doi.org/10.1021/acs.cgd.7b00458. Andrii Ishchenko and Lingling Peng and Egor Zinovev and Alexey …

  82. XFELs for structure and dynamics in biology

    0.0 out of 5 stars 

    10 May 2017 | BioXFEL Publications | Contributor(s): J. C. H. Spence

    http://dx.doi.org/10.1107/s2052252517005760 The development and application of the free-electron X-ray laser (XFEL) to structure and dynamics in biology since its inception in 2009 are reviewed. The research opportunities which result from the ability to outrun most radiation-damage effects are …

  83. Proposal Writing Workshop Agenda

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    08 May 2017 | Downloads | Contributor(s): Bill Bauer

    …

  84. Re-directing bacterial microcompartment systems to enhance recombinant expression of lysis protein E from bacteriophage ϕX174 in Escherichia coli

    0.0 out of 5 stars 

    25 Apr 2017 | BioXFEL Publications | Contributor(s): Mimi C. Yung, Feliza A. Bourguet, Timothy S. Carpenter, Matthew Coleman

    http://dx.doi.org/10.1186/s12934-017-0685-x journal-article Yung, M.C. et al., 2017. Re-directing bacterial microcompartment systems to enhance recombinant expression of lysis protein E from bacteriophage ϕX174 in Escherichia coli. Microbial Cell Factories, 16(1). Available at: …

  85. Laser control over the ultrafast Coulomb explosion of N22+ after Auger decay: A quantum-dynamics investigation

    0.0 out of 5 stars 

    24 Apr 2017 | BioXFEL Publications | Contributor(s): Athiya Mahmud Hanna, Oriol Vendrell, Abbas Ourmazd, Robin Santra

    http://dx.doi.org/10.1103/physreva.95.043419 journal-article Hanna, A.M. et al., 2017. Laser control over the ultrafast Coulomb explosion of N22+ after Auger decay: A quantum-dynamics investigation. Physical Review A, 95(4). Available at: http://dx.doi.org/10.1103/physreva.95.043419. Athiya …

  86. X-Ray Lasers in Biology

    0.0 out of 5 stars 

    24 Apr 2017 | BioXFEL Publications | Contributor(s): John Spence

    http://dx.doi.org/10.1016/bs.aiep.2017.01.008 book-chapter NSF-STC Biology with X-ray Lasers (NSF-1231306) Spence, J.C.H., 2017. X-Ray Lasers in Biology. Advances in Imaging and Electron Physics, pp.103–152. Available at: http://dx.doi.org/10.1016/bs.aiep.2017.01.008. John C.H. Spence

  87. Split-Second Reactions

    0.0 out of 5 stars 

    24 Apr 2017 | BioXFEL Publications | Contributor(s): Petra Fromme, John Spence

    http://dx.doi.org/10.1038/scientificamerican0517-62 journal-article Fromme, P. & Spence, J.C.H., 2017. Split-Second Reactions. Scientific American, 316(5), pp.62–67. Available at: http://dx.doi.org/10.1038/scientificamerican0517-62. Petra Fromme and John C. H. Spence

  88. A multi-model approach to assessing local and global cryo-EM map quality

    0.0 out of 5 stars 

    20 Apr 2017 | BioXFEL Publications | Contributor(s): Mark A Herzik, James Fraser, Gabriel C Lander

    http://dx.doi.org/10.1101/128561 There does not currently exist a standardized indicator of how well a cryo-EM-derived model represents the density from which it was generated. We present a straightforward methodology that utilizes freely available tools to generate a suite of independent models …

  89. Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin

    0.0 out of 5 stars 

    13 Apr 2017 | BioXFEL Publications | Contributor(s): Justin T. Biel, Michael Thompson, Christian N. Cunningham, Jacob E. Corn, James Fraser

    http://dx.doi.org/10.1016/j.str.2017.03.009 journal-article Biel, J.T. et al., 2017. Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin. Structure, 25(5), pp.739–749.e3. Available at: http://dx.doi.org/10.1016/j.str.2017.03.009. …

  90. Diffraction data of core-shell nanoparticles from an X-ray free electron laser

    0.0 out of 5 stars 

    11 Apr 2017 | BioXFEL Publications | Contributor(s): Xuanxuan Li, Chun-Ya Chiu, Hsiang-Ju Wang, Stephan Kassemeyer, Sabine Botha, Robert L. Shoeman, Robert M Lawrence, Christopher Kupitz, Richard Kirian, Daniel James, Dingjie Wang, Garrett Charles Nelson, Marc Messerschmidt, Sébastien Boutet, Garth J. Williams, Elisabeth Hartmann, Aliakbar Jafarpour, Lutz M. Foucar, Anton Barty, Henry Chapman, Mengning Liang, Andreas Menzel, Fenglin Wang, Shibom Basu, Raimund Fromme, R. Bruce Doak, Petra Fromme, Uwe Weierstall, Michael H. Huang, John Spence, Ilme Schlichting, Brenda Hogue, Haiguang Liu

    http://dx.doi.org/10.1038/sdata.2017.48 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Li, X. et al., 2017. Diffraction data of core-shell nanoparticles from an X-ray free electron laser. Scientific Data, 4, p.170048. Available at: http://dx.doi.org/10.1038/sdata.2017.48. …

  91. Experimental strategies for imaging bioparticles with femtosecond hard X-ray pulses

    0.0 out of 5 stars 

    07 Apr 2017 | BioXFEL Publications | Contributor(s): Benedikt J. Daurer, Kenta Okamoto, Johan Bielecki, Filipe R. N. C. Maia, Kerstin Mühlig, M. Marvin Seibert, Max F. Hantke, Carl Nettelblad, W. Henry Benner, Martin Svenda, Nicuşor Tîmneanu, Tomas Ekeberg, N. Duane Loh, Alberto Pietrini, Alessandro Zani, Asawari D. Rath, Daniel Westphal, Richard Kirian, Salah Awel, Max Oliver Wiedorn, Gijs Van Der Schot, Gunilla H. Carlsson, Dirk Hasse, Jonas A. Sellberg, Anton Barty, Jakob Andreasson, Sébastien Boutet, Garth Williams, Jason Koglin, Inger Andersson, Janos Hajdu, Daniel S. D. Larsson

    http://dx.doi.org/10.1107/s2052252517003591 This study explores the capabilities of the Coherent X-ray Imaging Instrument at the Linac Coherent Light Source to image small biological samples. The weak signal from small samples puts a significant demand on the experiment. AerosolizedOmono River …

  92. Structural basis for selectivity and diversity in angiotensin II receptors

    0.0 out of 5 stars 

    04 Apr 2017 | BioXFEL Publications | Contributor(s): Haitao Zhang, Gye Won Han, Alexander Batyuk, Andrii Ishchenko, Kate L. White, Nilkanth N Patel, Anastasiia Sadybekov, Beata Zamlynny, Michael T. Rudd, Kaspar Hollenstein, Alexandra Tolstikova, Thomas A. White, Mark S. Hunter, Uwe Weierstall, Wei Liu, Kerim Babaoglu, Eric L. Moore, Ryan D. Katz, Jennifer M. Shipman, Margarita Garcia-Calvo, Sujata Sharma, Payal Sheth, Stephen M. Soisson, Raymond C. Stevens, Vsevolod Katritch, Vadim Cherezov

    http://dx.doi.org/10.1038/nature22035 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Zhang, H. et al., 2017. Structural basis for selectivity and diversity in angiotensin II receptors. Nature, 544(7650), pp.327–332. Available at: http://dx.doi.org/10.1038/nature22035. Haitao …

  93. Chromatin-remodeling for transcription

    0.0 out of 5 stars 

    17 Mar 2017 | BioXFEL Publications | Contributor(s): Yahli Lorch, Roger Kornberg

    Abstract The nucleosome serves as a general gene repressor, preventing all initiation of transcription except that which is brought about by specific positive regulatory mechanisms. The positive mechanisms begin with chromatin-remodeling by complexes that slide, disrupt, or otherwise …

  94. Double-flow focused liquid injector for efficient serial femtosecond crystallography

    0.0 out of 5 stars 

    16 Mar 2017 | BioXFEL Publications | Contributor(s): Dominik Oberthuer, Juraj Knoška, Max Oliver Wiedorn, Kenneth R. Beyerlein, David Bushnell, Elena G. Kovaleva, Michael Heymann, Lars Gumprecht, Richard Kirian, Anton Barty, Valerio Mariani, Aleksandra Tolstikova, Luigi Adriano, Salah Awel, Miriam Barthelmess, Katerina Dörner, P. Lourdu Xavier, Oleksandr Yefanov, Daniel R. James, Garrett Charles Nelson, Dingjie Wang, George Douglas Calvey, Yujie Chen, Andrea Schmidt, Michael Szczepek, Stefan Frielingsdorf, Oliver Lenz, Edward Snell, Philip J. Robinson, Božidar Šarler, Grega Belšak, Marjan Maček, Fabian Wilde, Andrew Aquila, Sébastien Boutet, Mengning Liang, Mark S. Hunter, Patrick Scheerer, John D. Lipscomb, Uwe Weierstall, Roger Kornberg, John Spence, Lois Pollack, Henry Chapman, Saša Bajt

    http://dx.doi.org/10.1038/srep44628 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Oberthuer, D. et al., 2017. Double-flow focused liquid injector for efficient serial femtosecond crystallography. Scientific Reports, 7, p.44628. Available at: http://dx.doi.org/10.1038/srep44628. …

  95. Moving in the Right Direction: Protein Vibrational Steering Function

    0.0 out of 5 stars 

    14 Mar 2017 | BioXFEL Publications | Contributor(s): Katherine A. Niessen, Mengyang Xu, Alessandro Paciaroni, Andrea Orecchini, Edward Snell, Andrea Markelz

    journal-article http://dx.doi.org/10.1016/j.bpj.2016.12.049 Niessen, K.A. et al., 2017. Moving in the Right Direction: Protein Vibrational Steering Function. Biophysical Journal, 112(5), pp.933–942. Available at: http://dx.doi.org/10.1016/j.bpj.2016.12.049. Katherine A. Niessen and Mengyang Xu …

  96. Synthesis of two fluorescent GTPγS molecules and their biological relevance

    0.0 out of 5 stars 

    10 Mar 2017 | BioXFEL Publications | Contributor(s): Denise J. Trans, Ruoli Bai, J. Bennet Addison, Ruiwu Liu, Ernest Hamel, Matthew Coleman, Paul T. Henderson

    http://dx.doi.org/10.1080/15257770.2016.1231320 journal-article Trans, D.J. et al., 2017. Synthesis of two fluorescent GTPγS molecules and their biological relevance. Nucleosides, Nucleotides and Nucleic Acids, 36(6), pp.379–391. Available at: http://dx.doi.org/10.1080/15257770.2016.1231320. …

  97. Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

    0.0 out of 5 stars 

    02 Mar 2017 | BioXFEL Publications | Contributor(s): Franklin D Fuller, Sheraz Gul, Ruchira Chatterjee, E Sethe Burgie, Iris Diane Young, Hugo Lebrette, Vivek Srinivas, Aaron S Brewster, Tara Michels-Clark, Jonathan Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J Pollock, Miao Zhang, Claudiu A Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell Miller, Muhamed Amin, Sergey Koroidov, Christian G Roessler, Marc Allaire, Raymond G Sierra, Peter T Docker, James M Glownia, Silke Nelson, Jason E Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K Boal, J Martin Bollinger, Carsten Krebs, Martin Högbom, George Phillips, Richard D Vierstra, Nicholas K Sauter, Allen M Orville, Jan Kern, Vittal K Yachandra, Junko Yano

    journal-article http://dx.doi.org/10.1038/nmeth.4195 NSF-STC Biology with X-ray Lasers (NSF-1231306) Fuller, F.D. et al., 2017. Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers. Nature Methods, 14(4), pp.443–449. Available at: …

  98. Ondrej Krivanek's early scientific research

    0.0 out of 5 stars 

    01 Mar 2017 | BioXFEL Publications | Contributor(s): John Spence

    http://dx.doi.org/10.1016/j.ultramic.2016.12.006 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Spence, J.C.H., 2017. Ondrej Krivanek’s early scientific research. Ultramicroscopy, 180, pp.8–13. Available at: http://dx.doi.org/10.1016/j.ultramic.2016.12.006. John C.H. Spence

  99. Serial crystallography at synchrotrons and X-ray lasers

    0.0 out of 5 stars 

    23 Feb 2017 | BioXFEL Publications | Contributor(s): Jörg Standfuss, John Spence

    http://dx.doi.org/10.1107/s2052252517001877 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Standfuss, J. & Spence, J., 2017. Serial crystallography at synchrotrons and X-ray lasers. IUCrJ, 4(2), pp.100–101. Available at: http://dx.doi.org/10.1107/s2052252517001877. Jörg …

  100. An Engineered TGF-β Monomer that Functions as a Dominant Negative to Block TGF-β Signaling

    0.0 out of 5 stars 

    22 Feb 2017 | BioXFEL Publications | Contributor(s): Sun Kyung Kim, Lindsey Barron, Cynthia S. Hinck, Elyse M. Petrunak, Kristin E. Cano, Avinash Thangirala, Brian Iskra, Molly Brothers, Machell Vonberg, Belinda Leal, Blair Richter, Ravindra Kodali, Alexander B. Taylor, Shoucheng Du, Christopher Barnes, Traian Sulea, Guillermo Calero, P. John Hart, Matthew J. Hart, Borries Demeler, Andrew P. Hinck

    journal-article http://dx.doi.org/10.1074/jbc.m116.768754 Kim, S.K. et al., 2017. An Engineered TGF-β Monomer that Functions as a Dominant Negative to Block TGF-β Signaling. Journal of Biological Chemistry, p.jbc.M116.768754. Available at: http://dx.doi.org/10.1074/jbc.m116.768754. Sun Kyung …