Resources: All

Finding a resource

Use the sorting or filtering options to sort results and/or narrow down the list of resources.

Use the 'Search' to find specific resources by title or description.

Search for Courses
  1. Machine learning deciphers structural features of RNA duplexes measured with solution X-ray scattering

    11 Aug 2020 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Lois Pollack

    http://dx.doi.org/10.1107/s2052252520008830 Macromolecular structures can be determined from solution X-ray scattering. Small-angle X-ray scattering (SAXS) provides global structural information on length scales of 10s to 100s of Ångstroms, and many algorithms are available to convert SAXS data …

  2. Diffusion in multilayers, studied by quantitative chemical mapping at the atomic level

    18 Jun 2020 | BioXFEL Publications | Contributor(s): Y. Kim, A. Ourmazd

    http://dx.doi.org/10.1017/s0424820100174904 Using chemical lattice imaging in combination with vector pattern recognition, we study diffusion and interdiffusion at single interfaces in mulilayered semiconductors quantitatively with atomic plane resolution. 20 periods of 50Å C-doped GaAs/50Å …

  3. Pyridine-2,6-Dithiocarboxylic Acid and Its Metal Complexes: New Inhibitors of New Delhi Metallo β-Lactamase-1

    02 Jun 2020 | BioXFEL Publications | Contributor(s): Chris S. Thomas, Doug R. Braun, Jose Luis Olmos, Scott R. Rajski, George Phillips, David Andes, Tim S. Bugni

    http://dx.doi.org/10.3390/md18060295 Keywords: NDM-1 inhibitors; marine-derived Streptomyces sp.; carbapenem-resistant Enterobacteriaceae; metal chelators journal-article Thomas, C.S. et al., 2020. Pyridine-2,6-Dithiocarboxylic Acid and Its Metal Complexes: New Inhibitors of New Delhi Metallo …

  4. Carbon nanotube dielectrophoresis: Theory and applications

    31 May 2020 | BioXFEL Publications | Contributor(s): Mohammad Towshif Rabbani, Mukul Sonker, Alexandra Ros

    http://dx.doi.org/10.1002/elps.202000049 journal-article Rabbani, M.T., Sonker, M. & Ros, A., 2020. Carbon nanotube dielectrophoresis: Theory and applications. ELECTROPHORESIS. Available at: http://dx.doi.org/10.1002/elps.202000049. Mohammad Towshif Rabbani and Mukul Sonker and Alexandra Ros

  5. Megahertz single-particle imaging at the European XFEL

    29 May 2020 | BioXFEL Publications | Contributor(s): Egor Sobolev, Sergei Zolotarev, Klaus Giewekemeyer, Johan Bielecki, Kenta Okamoto, Hemanth K. N. Reddy, Jakob Andreasson, Kartik Ayyer, Imrich Barak, Sadia Bari, Anton Barty, Richard Bean, Sergey Bobkov, Henry Chapman, Grzegorz Chojnowski, Benedikt J. Daurer, Katerina Dörner, Tomas Ekeberg, Leonie Flückiger, Oxana Galzitskaya, Luca Gelisio, Steffen Hauf, Brenda Hogue, Daniel A. Horke, Ahmad Hosseinizadeh, Vyacheslav Ilyin, Chulho Jung, Chan Kim, Yoonhee Kim, Richard Kirian, Henry Kirkwood, Olena Kulyk, Jochen Küpper, Romain Letrun, N. Duane Loh, Kristina Lorenzen, Marc Messerschmidt, Kerstin Mühlig, Abbas Ourmazd, Natascha Raab, Andrei V. Rode, Max Rose, Adam Round, Takushi Sato, Robin Schubert, Peter Schwander, Jonas A. Sellberg, Marcin Sikorski, Alessandro Silenzi, Changyong Song, John Spence, Stephan Stern, Jolanta Sztuk-Dambietz, Anthon Teslyuk, Nicusor Timneanu, Martin Trebbin, Charlotte Uetrecht, Britta Weinhausen, Garth J. Williams, P. Lourdu Xavier, Chen Xu, Ivan A. Vartanyants, Victor S. Lamzin, Adrian Mancuso, Filipe R. N. C. Maia

    http://dx.doi.org/10.1038/s42005-020-0362-y journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Sobolev, E. et al., 2020. Megahertz single-particle imaging at the European XFEL. Communications Physics, 3(1). Available at: http://dx.doi.org/10.1038/s42005-020-0362-y. Egor Sobolev and …

  6. Targeted DNA sequencing analysis to reveal genetic diversity and androgen-receptor alteration in advanced EGFR mutant lung adenocarcinoma.

    25 May 2020 | BioXFEL Publications | Contributor(s): Wei Wu, Ross A. Okimoto, Collin Michael Blakely, James Fraser, Trever G. Bivona

    http://dx.doi.org/10.1200/jco.2020.38.15_suppl.9526 9526 Background: Lung cancer remains the leading cause of death from cancer around the world. Several oncogenic drivers have been identified from large cancer genome projects focused mainly on profiling early-stage lung cancers. Targeted …

  7. Length-Selective Dielectrophoretic Manipulation of Single-Walled Carbon Nanotubes

    25 May 2020 | BioXFEL Publications | Contributor(s): Mohammad T. Rabbani, Christoph F. Schmidt, Alexandra Ros

    http://dx.doi.org/10.1021/acs.analchem.0c00794 journal-article Rabbani, M.T., Schmidt, C.F. & Ros, A., 2020. Length-Selective Dielectrophoretic Manipulation of Single-Walled Carbon Nanotubes. Analytical Chemistry. Available at: http://dx.doi.org/10.1021/acs.analchem.0c00794. Mohammad T. Rabbani …

  8. Science in the age of machine learning

    21 May 2020 | BioXFEL Publications | Contributor(s): Abbas Ourmazd

    http://dx.doi.org/10.1038/s42254-020-0191-7 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Ourmazd, A., 2020. Science in the age of machine learning. Nature Reviews Physics. Available at: http://dx.doi.org/10.1038/s42254-020-0191-7. Abbas Ourmazd

  9. Prochlorococcus phage ferredoxin: Structural characterization and electron transfer to cyanobacterial sulfite reductases

    20 May 2020 | BioXFEL Publications | Contributor(s): Ian J. Campbell, Jose Luis Olmos, Weijun Xu, Dimithree Kahanda, Joshua T Atkinson, Othneil Noble Sparks, Mitchell Miller, George Phillips, George N. Bennett, Jonathan J. Silberg

    http://dx.doi.org/10.1074/jbc.ra120.013501 Marine cyanobacteria are infected by phages whose genomes encode ferredoxin (Fd) electron carriers. These Fds are thought to redirect the energy harvested from light to phage-encoded oxidoreductases that enhance viral fitness, but it is  unclear how the …

  10. Imaging of Objects by Coherent Diffraction of X-Ray Free-Electron Laser Pulses

    04 May 2020 | BioXFEL Publications | Contributor(s): Richard Kirian, Henry Chapman

    http://dx.doi.org/10.1007/978-3-030-23201-6_27 book-chapter Kirian, R.A. & Chapman, H.N., 2020. Imaging of Objects by Coherent Diffraction of X-Ray Free-Electron Laser Pulses. Synchrotron Light Sources and Free-Electron Lasers, pp.1337–1397. Available at: …

  11. The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser

    30 Mar 2020 | BioXFEL Publications | Contributor(s): Elin Claesson, Weixiao Yuan Wahlgren, Heikki Takala, Suraj Pandey, Leticia Castillon, Valentyna Kuznetsova, Léocadie Henry, Matthijs Panman, Melissa Carrillo, Joachim Kübel, Rahul Nanekar, Linnéa Isaksson, Amke Nimmrich, Andrea Cellini, Dmitry Morozov, Michał Maj, Moona Kurttila, Robert William Bosman, Eriko Nango, Rie Tanaka, Tomoyuki Tanaka, Luo Fangjia, So Iwata, Shigeki Owada, Keith Moffat, Gerrit Groenhof, Emina A Stojković, Janne A Ihalainen, Marius Schmidt, Sebastian Westenhoff

    http://dx.doi.org/10.7554/elife.53514 Phytochrome proteins control the growth, reproduction, and photosynthesis of plants, fungi, and bacteria. Light is detected by a bilin cofactor, but it remains elusive how this leads to activation of the protein through structural changes. We present serial …

  12. Propagation of Conformational Coordinates Across Angular Space in Mapping the Continuum of States from Cryo-EM Data by Manifold Embedding

    24 Mar 2020 | BioXFEL Publications | Contributor(s): Suvrajit Maji, Hstau Liao, Ali Dashti, Ghoncheh Mashayekhi, Abbas Ourmazd, Joachim Frank

    http://dx.doi.org/10.1021/acs.jcim.9b01115 journal-article Maji, S. et al., 2020. Propagation of Conformational Coordinates Across Angular Space in Mapping the Continuum of States from Cryo-EM Data by Manifold Embedding. Journal of Chemical Information and Modeling. Available at: …

  13. Using Machine Learning to Achieve Accurate Estimates of Fetal Gestational Age and Personalized Predictions of Fetal Growth

    24 Mar 2020 | BioXFEL Publications | Contributor(s): Russell Fung, Jose Villar, Ali Dashti, Leila Cheikh Ismail, Eleonora Staines-Urias, Eric O. Ohuma, Laurent J. Salomon, Cesar G. Victora, Fernando C. Barros, Ann Lambert, Maria Carvalho, Yasmin A. Jaffer, Alison J. Noble, Michael G. Gravett, Manorama Purwar, Ruyan Pang, Enrico Bertino, Shama Munim, Aung Myat Min, Rose McGready, Shane A. Norris, Zulfiqar A Bhutta, Stephen H. Kennedy, Aris T. Papageorghiou, Abbas Ourmazd, International Fetal And Newborn Gro Group

    http://dx.doi.org/10.2139/ssrn.3471997 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Fung, R. et al., 2019. Using Machine Learning to Achieve Accurate Estimates of Fetal Gestational Age and Personalized Predictions of Fetal Growth. SSRN Electronic Journal. Available at: …

  14. Single-particle imaging by x-ray free-electron lasers—How many snapshots are needed?

    20 Mar 2020 | BioXFEL Publications | Contributor(s): I. Poudyal, M. Schmidt, P. Schwander

    http://dx.doi.org/10.1063/1.5144516 journal-article Poudyal, I., Schmidt, M. & Schwander, P., 2020. Single-particle imaging by x-ray free-electron lasers—How many snapshots are needed? Structural Dynamics, 7(2), p.024102. Available at: http://dx.doi.org/10.1063/1.5144516. I. Poudyal and M. …

  15. XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia

    09 Mar 2020 | BioXFEL Publications | Contributor(s): James D Zook, Mrinal Shekhar, Debra Hansen, Chelsie E Conrad, Thomas Grant, Chitrak Gupta, Thomas White, Anton Barty, Shibom Basu, Yun Zhao, Nadia Zatsepin, Andrii Ishchenko, Alex Batyuk, Cornelius Gati, Chufeng Li, Lorenzo Galli, Jesse David Coe, Mark S. Hunter, Meng Liang, Uwe Weierstall, Garret Nelson, Daniel James, Benjamin Stauch, Felicia Craciunescu, Darren Gary Thifault, Wei Liu, Vadim Cherezov, Abhishek Singharoy, Petra Fromme

    http://dx.doi.org/10.1016/j.str.2020.02.005 journal-article Zook, J. et al., 2020. XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia. Structure. Available at: http://dx.doi.org/10.1016/j.str.2020.02.005. James Zook and Mrinal Shekhar …

  16. Lucina pectinata oxyhemoglobin (II-III) heterodimer pH susceptibility

    07 Mar 2020 | BioXFEL Publications | Contributor(s): Darya Marchany-Rivera, Clyde A. Smith, Josiris D. Rodriguez-Perez, Juan J Lopez-Garriga

    http://dx.doi.org/10.1016/j.jinorgbio.2020.111055 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Marchany-Rivera, D. et al., 2020. Lucina pectinata oxyhemoglobin (II-III) heterodimer pH susceptibility. Journal of Inorganic Biochemistry, 207, p.111055. Available at: …

  17. Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

    25 Feb 2020 | BioXFEL Publications | Contributor(s): Alexander M. Wolff, Iris Diane Young, Raymond G. Sierra, Aaron S. Brewster, Michael W. Martynowycz, Eriko Nango, Michihiro Sugahara, Takanori Nakane, Kazutaka Ito, Andrew Aquila, Asmit Bhowmick, Justin T. Biel, Sergio Carbajo, Aina E. Cohen, Saul Cortez, Ana Gonzalez, Tomoya Hino, Dohyun Im, Jake D. Koralek, Minoru Kubo, Tomas Lazarou, Takashi Nomura, Shigeki Owada, Avi J. Samelson, Tomoyuki Tanaka, Rie Tanaka, Erin M. Thompson, Henry Van Den Bedem, Rahel Woldeyes, Fumiaki Yumoto, Wei Zhao, Kensuke Tono, Sebastien Boutet, So Iwata, Tamir Gonen, Nicholas K. Sauter, James Fraser, Michael Thompson

    http://dx.doi.org/10.1107/s205225252000072x Innovative new crystallographic methods are facilitating structural studies from ever smaller crystals of biological macromolecules. In particular, serial X-ray crystallography and microcrystal electron diffraction (MicroED) have emerged as useful methods …

  18. Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes

    24 Feb 2020 | BioXFEL Publications | Contributor(s): Tyler D. Huber, Jonathan Clinger, Yang Liu, Weijun Xu, Mitchell Miller, George Phillips, Jon S. Thorson

    http://dx.doi.org/10.1021/acschembio.9b00943 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Huber, T.D. et al., 2020. Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes. ACS Chemical Biology, 15(3), pp.695–705. Available at: …

  19. Serial Crystallography: Preface

    24 Feb 2020 | BioXFEL Publications | Contributor(s): John Spence

    http://dx.doi.org/10.3390/cryst10020135 The history of serial crystallography (SC) has its origins in the earliest attempts to merge data from several crystals. This preface provides an overview of some recent work, with a survey of the rapid advances made over the past decade in both sample …

  20. Reaction Initiation in Enzyme Crystals by Diffusion of Substrate

    14 Feb 2020 | BioXFEL Publications | Contributor(s): Marius Schmidt

    http://dx.doi.org/10.3390/cryst10020116 Ever since the first structure of an enzyme, lysozyme, was solved, scientists have been eager to explore how these molecules perform their catalytic function. There has been an overwhelmingly large body of publications that report the X-ray structures of …

  21. Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

    10 Feb 2020 | BioXFEL Publications | Contributor(s): Reed M. Stein, Hye Jin Kang, John D. McCorvy, Grant C. Glatfelter, Anthony J. Jones, Tao Che, Samuel Slocum, Xi-Ping Huang, Olena Savych, Yurii S. Moroz, Benjamin Stauch, Linda C. Johansson, Vadim Cherezov, Terry Kenakin, John J. Irwin, Brian K. Shoichet, Bryan L. Roth, Margarita L. Dubocovich

    http://dx.doi.org/10.1038/s41586-020-2027-0 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Stein, R.M. et al., 2020. Virtual discovery of melatonin receptor ligands to modulate circadian rhythms. Nature. Available at: http://dx.doi.org/10.1038/s41586-020-2027-0. Reed M. Stein and …

  22. Convolutional Neural Networks Bridge Molecular Models and Solution X-ray Scattering Experiments

    07 Feb 2020 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2019.11.1706 poster Chen, Y.-L. & Pollack, L., 2020. Convolutional Neural Networks Bridge Molecular Models and Solution X-ray Scattering Experiments. Biophysical Journal, 118(3), p.301a. Available at: http://dx.doi.org/10.1016/j.bpj.2019.11.1706. Yen-Lin Chen and …

  23. Discovering Design Principles to Re-Engineer Functional RNA Elements

    07 Feb 2020 | BioXFEL Publications | Contributor(s): Alex Plumridge, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2019.11.556 poster Plumridge, A. & Pollack, L., 2020. Discovering Design Principles to Re-Engineer Functional RNA Elements. Biophysical Journal, 118(3), p.70a. Available at: http://dx.doi.org/10.1016/j.bpj.2019.11.556. Alex Plumridge and Lois Pollack

  24. Probing Mg2+-Mediated RNA-RNA Interactions in the Presence of Metabolites

    07 Feb 2020 | BioXFEL Publications | Contributor(s): Derrick R. Lin, Suzette A. Pabit, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2019.11.551 poster Lin, D.R., Pabit, S.A. & Pollack, L., 2020. Probing Mg2+-Mediated RNA-RNA Interactions in the Presence of Metabolites. Biophysical Journal, 118(3), p.69a. Available at: http://dx.doi.org/10.1016/j.bpj.2019.11.551. Derrick R. Lin and Suzette A. …

  25. Quantitative Analysis of Salt-Induced RNA Duplex Variations by Wide-Angle X-ray Scattering (WAXS)

    07 Feb 2020 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2019.11.548 poster Chen, Y.-L. & Pollack, L., 2020. Quantitative Analysis of Salt-Induced RNA Duplex Variations by Wide-Angle X-ray Scattering (WAXS). Biophysical Journal, 118(3), p.68a. Available at: http://dx.doi.org/10.1016/j.bpj.2019.11.548. Yen-Lin Chen and …

  26. DNA Sequence and Histone Core Composition Determine the Unwrapping Pathways in Nucleosomes

    07 Feb 2020 | BioXFEL Publications | Contributor(s): Alex Mauney, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2019.11.2706 poster Mauney, A. & Pollack, L., 2020. DNA Sequence and Histone Core Composition Determine the Unwrapping Pathways in Nucleosomes. Biophysical Journal, 118(3), p.489a. Available at: http://dx.doi.org/10.1016/j.bpj.2019.11.2706. Alex Mauney and Lois …

  27. Evidence that Primary Microrna Bends in the Presence of DGCR8 Seen using Both Saxs and FRET Measurements

    07 Feb 2020 | BioXFEL Publications | Contributor(s): Suzette A. Pabit, Yen-Lin Chen, Grace A. Usher, Erik C. Cook, Lois Pollack, Scott A. Showalter

    http://dx.doi.org/10.1016/j.bpj.2019.11.1318 poster Pabit, S.A. et al., 2020. Evidence that Primary Microrna Bends in the Presence of DGCR8 Seen using Both Saxs and FRET Measurements. Biophysical Journal, 118(3), p.222a. Available at: http://dx.doi.org/10.1016/j.bpj.2019.11.1318. Suzette A. …

  28. Synthesis and structural studies of 16‐ferrocenemethyl‐estra‐1,3,5(10)‐triene‐3,17β‐diol and its interaction with human serum albumin by fluorescence spectroscopy and in silico docking approaches

    06 Feb 2020 | BioXFEL Publications | Contributor(s): José A. Carmona‐Negrón, José M. Liboy‐Lugo, Alberto Santana, Enrique Meléndez

    http://dx.doi.org/10.1002/aoc.5483 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Carmona‐Negrón, J.A. et al., 2020. Synthesis and structural studies of 16‐ferrocenemethyl‐estra‐1,3,5(10)‐triene‐3,17β‐diol and its interaction with human serum albumin by …

  29. In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors

    30 Jan 2020 | BioXFEL Publications | Contributor(s): Karol Nass, Lars Redecke, M. Perbandt, O. Yefanov, M. Klinge, R. Koopmann, F. Stellato, A. Gabdulkhakov, R. Schönherr, D. Rehders, J. M. Lahey-Rudolph, A. Aquila, A. Barty, S. Basu, R. B. Doak, R. Duden, M. Frank, R. Fromme, S. Kassemeyer, G. Katona, R. Kirian, H. Liu, I. Majoul, J. M. Martin-Garcia, M. Messerschmidt, R. L. Shoeman, U. Weierstall, S. Westenhoff, T. A. White, G. J. Williams, C. H. Yoon, N. Zatsepin, P. Fromme, M. Duszenko, H. N. Chapman, C. Betzel

    http://dx.doi.org/10.1038/s41467-020-14484-w journal-article Nass, K. et al., 2020. In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors. Nature Communications, 11(1). Available at: http://dx.doi.org/10.1038/s41467-020-14484-w. Karol …

  30. Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit

    14 Jan 2020 | BioXFEL Publications | Contributor(s): Vanja Stojković, Alexander G Myasnikov, Iris Diane Young, Adam Frost, James Fraser, Danica Galonić Fujimori

    http://dx.doi.org/10.1093/nar/gkaa037 Abstract Post-transcriptional ribosomal RNA (rRNA) modifications are present in all organisms, but their exact functional roles and positions are yet to be fully characterized. Modified nucleotides have been implicated in the stabilization of RNA …

  31. Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates

    12 Jan 2020 | BioXFEL Publications | Contributor(s): Benjamin A. Barad, Lin Liu, Roberto E. Diaz, Ralp Basilio, Steven J. Van Dyken, Richard M. Locksley, James Fraser

    http://dx.doi.org/10.1002/pro.3822 journal-article Barad, B.A. et al., 2020. Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates. Protein Science. Available at: http://dx.doi.org/10.1002/pro.3822. Benjamin A. Barad and Lin Liu and Roberto E. Diaz …

  32. Structural knowledge or X-ray damage? Dose-dependent case studies on xylose isomerase revealing structural perturbations

    03 Jan 2020 | BioXFEL Publications | Contributor(s): Edward Snell, Helena Taberman, Charles S. Bury, Mark J. Van Der Woerd, Elspeth F. Garman

    http://dx.doi.org/10.1107/s010876731909771x poster NSF-STC Biology with X-ray Lasers (NSF-1231306) Snell, E.H. et al., 1999. Structural knowledge or X-ray damage? Dose-dependent case studies on xylose isomerase revealing structural perturbations. Acta Crystallographica Section A Foundations and …

  33. Ribosomal protein L11 selectively stabilizes a tertiary structure of the GTPase Center rRNA domain

    23 Dec 2019 | BioXFEL Publications | Contributor(s): Robb Welty, Michael Rau, Suzette Pabit, Mark S. Dunstan, Graeme L. Conn, Lois Pollack, Kathleen B. Hall

    http://dx.doi.org/10.1016/j.jmb.2019.12.010 journal-article Welty, R. et al., 2019. Ribosomal protein L11 selectively stabilizes a tertiary structure of the GTPase Center rRNA domain. Journal of Molecular Biology. Available at: http://dx.doi.org/10.1016/j.jmb.2019.12.010. Robb Welty and Michael …

  34. 7th Annual BioXFEL International Conference

    23 Dec 2019 | Downloads

  35. Liquid-like and rigid-body motions in molecular-dynamics simulations of a crystalline protein

    18 Dec 2019 | BioXFEL Publications | Contributor(s): David C. Wych, James Fraser, David L. Mobley, Michael E. Wall

    http://dx.doi.org/10.1063/1.5132692 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Wych, D.C. et al., 2019. Liquid-like and rigid-body motions in molecular-dynamics simulations of a crystalline protein. Structural Dynamics, 6(6), p.064704. Available at: …

  36. Low-signal limit of X-ray single particle diffractive imaging

    12 Dec 2019 | BioXFEL Publications | Contributor(s): Kartik Ayyer, Andrew J. Morgan, Andrew Aquila, Hasan Demirci, Brenda Hogue, Richard Kirian, P. Lourdu Xavier, Chun Hong Yoon, Henry Chapman, Anton Barty

    http://dx.doi.org/10.1364/oe.27.037816 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Ayyer, K. et al., 2019. Low-signal limit of X-ray single particle diffractive imaging. Optics Express, 27(26), p.37816. Available at: http://dx.doi.org/10.1364/oe.27.037816. Kartik Ayyer and …

  37. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

    06 Dec 2019 | BioXFEL Publications | Contributor(s): Anastasiia Gusach, Aleksandra Luginina, Egor Marin, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Andrii Ishchenko, Petr Popov, Nilkanth N Patel, Taku Fujimoto, Toru Maruyama, Benjamin Stauch, Margarita Ergasheva, Daria Romanovskaia, Anastasiia Stepko, Kirill Kovalev, Mikhail Shevtsov, Valentin Gordeliy, Gye Won Han, Vsevolod Katritch, Valentin Borshchevskiy, Philippe Sarret, Alexey Mishin, Vadim Cherezov

    http://dx.doi.org/10.1038/s41467-019-13348-2 journal-article Gusach, A. et al., 2019. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nature Communications, 10(1). Available at: http://dx.doi.org/10.1038/s41467-019-13348-2. Anastasiia Gusach and …

  38. Visualizing Disordered Single-Stranded RNA: Connecting Sequence, Structure, and Electrostatics

    05 Dec 2019 | BioXFEL Publications | Contributor(s): Alex Plumridge, Kurt Andresen, Lois Pollack

    http://dx.doi.org/10.1021/jacs.9b04461 journal-article Plumridge, A., Andresen, K. & Pollack, L., 2019. Visualizing Disordered Single-Stranded RNA: Connecting Sequence, Structure, and Electrostatics. Journal of the American Chemical Society. Available at: http://dx.doi.org/10.1021/jacs.9b04461. …

  39. High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application

    03 Dec 2019 | BioXFEL Publications | Contributor(s): Geoffrey W. Grime, Oliver B. Zeldin, Mary E. Snell, Edward D. Lowe, John F. Hunt, Gaetano T. Montelione, Liang Tong, Edward Snell, Elspeth F. Garman

    http://dx.doi.org/10.1021/jacs.9b09186 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Grime, G.W. et al., 2019. High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application. Journal of the American Chemical …

  40. Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

    27 Nov 2019 | BioXFEL Publications | Contributor(s): Tobias Claff, Jing Yu, Véronique Blais, Nilkanth N Patel, Charlotte Martin, Lijie Wu, Gye Won Han, Brian J. Holleran, Olivier Van Der Poorten, Kate L. White, Michael A. Hanson, Philippe Sarret, Louis Gendron, Vadim Cherezov, Vsevolod Katritch, Steven Ballet, Zhi-Jie Liu, Christa E. Müller, Raymond C. Stevens

    http://dx.doi.org/10.1126/sciadv.aax9115 Selective activation of the δ-opioid receptor (DOP) has great potential for the treatment of chronic pain, benefitting from ancillary anxiolytic and antidepressant-like effects. Moreover, DOP agonists show reduced adverse effects as compared to μ-opioid …

  41. Computational design of a modular protein sense-response system

    25 Nov 2019 | BioXFEL Publications | Contributor(s): Anum A. Glasgow, Yao-Ming Huang, Daniel J. Mandell, Michael Thompson, Ryan Ritterson, Amanda L. Loshbaugh, Jenna Pellegrino, Cody Krivacic, Roland A. Pache, Kyle A. Barlow, Noah Ollikainen, Deborah Jeon, Mark J. S. Kelly, James Fraser, Tanja Kortemme

    http://dx.doi.org/10.1126/science.aax8780 Sensing and responding to signals is a fundamental ability of living systems, but despite substantial progress in the computational design of new protein structures, there is no general approach for engineering arbitrary new protein sensors. Here, we …

  42. Time-resolved serial femtosecond crystallography at the European XFEL

    18 Nov 2019 | BioXFEL Publications | Contributor(s): Suraj Pandey, Richard Bean, Tokushi Sato, Ishwor Poudyal, Johan Bielecki, Jorvani Cruz Villarreal, Oleksandr Yefanov, Valerio Mariani, Thomas A. White, Christopher Kupitz, Mark S. Hunter, Mohamed H. Abdellatif, Saša Bajt, Valerii Bondar, Austin Echelmeier, Diandra Doppler, Moritz Emons, Matthias Frank, Raimund Fromme, Yaroslav Gevorkov, Gabriele Giovanetti, Man Jiang, Daihyun Kim, Yoonhee Kim, Henry Kirkwood, Anna Klimovskaia, Juraj Knoska, Faisal Hammad Mekky Koua, Romain Letrun, Stella Lisova, Luis Maia, Victoria Mazalova, Domingo Meza, Thomas Michelat, Abbas Ourmazd, Guido Palmer, Marco Ramilli, Robin Schubert, Peter Schwander, Alessandro Silenzi, Jolanta Sztuk-Dambietz, Alexandra Tolstikova, Henry Chapman, Alexandra Ros, Anton Barty, Petra Fromme, Adrian P. Mancuso, Marius Schmidt

    http://dx.doi.org/10.1038/s41592-019-0628-z journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Pandey, S. et al., 2019. Time-resolved serial femtosecond crystallography at the European XFEL. Nature Methods. Available at: http://dx.doi.org/10.1038/s41592-019-0628-z. Suraj Pandey and …

  43. Structural Insights into Melatonin Receptors

    06 Nov 2019 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda C. Johansson, Vadim Cherezov

    http://dx.doi.org/10.1111/febs.15128 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Stauch, B., Johansson, L.C. & Cherezov, V., 2019. Structural Insights into Melatonin Receptors. The FEBS Journal. Available at: http://dx.doi.org/10.1111/febs.15128. Benjamin Stauch and Linda C. …

  44. Membrane protein megahertz crystallography at the European XFEL

    04 Nov 2019 | BioXFEL Publications | Contributor(s): Chris Gisriel, Jesse David Coe, Romain Letrun, Oleksandr M. Yefanov, Cesar Luna-Chavez, Natasha Stander, Stella Lisova, Valerio Mariani, Manuela Kuhn, Steve Aplin, Thomas D. Grant, Katerina Dörner, Tokushi Sato, Austin Echelmeier, Jorvani Cruz Villarreal, Mark S. Hunter, Max Oliver Wiedorn, Juraj Knoska, Victoria Mazalova, Shatabdi Roy-Chowdhury, Jay-How Yang, Alex Jones, Richard Bean, Johan Bielecki, Yoonhee Kim, Grant Mills, Britta Weinhausen, Jose D. Meza, Nasser Al-Qudami, Saša Bajt, Gerrit Brehm, Sabine Botha, Djelloul Boukhelef, Sandor Brockhauser, Barry D. Bruce, Matthew Coleman, Cyril Danilevski, Erin Discianno, Zachary Dobson, Hans Fangohr, Jose M. Martin-Garcia, Yaroslav Gevorkov, Steffen Hauf, Ahmad Hosseinizadeh, Friederike Januschek, Gihan Kaushylal Ketawala, Christopher Kupitz, Luis Maia, Maurizio Manetti, Marc Messerschmidt, Thomas Michelat, Jyotirmoy Mondal, Abbas Ourmazd, Gianpietro Previtali, Iosifina Sarrou, Silvan Schön, Peter Schwander, Megan Shelby, Alessandro Silenzi, Jolanta Sztuk-Dambietz, Janusz Szuba, Monica Turcato, Thomas A. White, Krzysztof Wrona, Chen Xu, Mohamed H. Abdellatif, James D Zook, John Spence, Henry Chapman, Anton Barty, Richard Kirian, Matthias Frank, Alexandra Ros, Marius Schmidt, Raimund Fromme, Adrian P. Mancuso, Petra Fromme, Nadia Zatsepin

    http://dx.doi.org/10.1038/s41467-019-12955-3 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Gisriel, C. et al., 2019. Membrane protein megahertz crystallography at the European XFEL. Nature Communications, 10(1). Available at: http://dx.doi.org/10.1038/s41467-019-12955-3. Chris …

  45. Toward G protein-coupled receptor structure-based drug design using X-ray lasers

    24 Oct 2019 | BioXFEL Publications | Contributor(s): Andrii Ishchenko, Benjamin Stauch, Gye Won Han, Alexander Batyuk, Anna Shiriaeva, Chufeng Li, Nadia Zatsepin, Uwe Weierstall, Wei Liu, Eriko Nango, Takanori Nakane, Rie Tanaka, Kensuke Tono, Yasumasa Joti, So Iwata, Isabel Moraes, Cornelius Gati, Vadim Cherezov

    http://dx.doi.org/10.1107/s2052252519013137 Rational structure-based drug design (SBDD) relies on the availability of a large number of co-crystal structures to map the ligand-binding pocket of the target protein and use this information for lead-compound optimization via an iterative process. …

  46. Salt Dependence of A-Form RNA Duplexes: Structures and Implications

    23 Oct 2019 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Lois Pollack

    http://dx.doi.org/10.1021/acs.jpcb.9b07502 journal-article Chen, Y.-L. & Pollack, L., 2019. Salt Dependence of A-Form RNA Duplexes: Structures and Implications. The Journal of Physical Chemistry B. Available at: http://dx.doi.org/10.1021/acs.jpcb.9b07502. Yen-Lin Chen and Lois Pollack

  47. Correction to: Spatiotemporal Pattern Extraction by Spectral Analysis of Vector-Valued Observables

    23 Oct 2019 | BioXFEL Publications | Contributor(s): Dimitrios Giannakis, Abbas Ourmazd, Joanna Slawinska, Zhizhen Zhao

    http://dx.doi.org/10.1007/s00332-019-09586-9 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Giannakis, D. et al., 2019. Correction to: Spatiotemporal Pattern Extraction by Spectral Analysis of Vector-Valued Observables. Journal of Nonlinear Science. Available at: …

  48. Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

    09 Oct 2019 | BioXFEL Publications | Contributor(s): Aleksandra Luginina, Anastasiia Gusach, Egor Marin, Alexey Mishin, Rebecca Brouillette, Petr Popov, Anna Shiriaeva, Élie Besserer-Offroy, Jean-Michel Longpré, Elizaveta Lyapina, Andrii Ishchenko, Nilkanth N Patel, Vitaly Polovinkin, Nadezhda Safronova, Andrey Bogorodskiy, Evelina Edelweiss, Hao Hu, Uwe Weierstall, Wei Liu, Alexander Batyuk, Valentin Gordeliy, Gye Won Han, Philippe Sarret, Vsevolod Katritch, Valentin Borshchevskiy, Vadim Cherezov

    http://dx.doi.org/10.1126/sciadv.aax2518 The G protein–coupled cysteinyl leukotriene receptor CysLT1R mediates inflammatory processes and plays a major role in numerous disorders, including asthma, allergic rhinitis, cardiovascular disease, and cancer. Selective CysLT1R antagonists are widely …

  49. Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme

    16 Sep 2019 | BioXFEL Publications | Contributor(s): Michael Thompson, Benjamin A. Barad, Alexander M. Wolff, Hyun Sun Cho, Friedrich Schotte, Daniel M. C. Schwarz, Philip Anfinrud, James Fraser

    http://dx.doi.org/10.1038/s41557-019-0329-3 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Thompson, M.C. et al., 2019. Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme. Nature Chemistry, 11(11), pp.1058–1066. Available at: …

  50. 3D printed droplet generation devices for serial femtosecond crystallography enabled by surface coating

    29 Aug 2019 | BioXFEL Publications | Contributor(s): Austin Echelmeier, Daihyun Kim, Jorvani Cruz Villarreal, Jesse David Coe, Sebastian E Quintana, Gerrit Brehm, Ana Egatz-Gomez, Reza Nazari, Raymond G. Sierra, Jason E. Koglin, Alexander Batyuk, Mark S. Hunter, Sébastien Boutet, Nadia Zatsepin, Richard Kirian, Thomas D. Grant, Petra Fromme, Alexandra Ros

    http://dx.doi.org/10.1107/s1600576719010343 The role of surface wetting properties and their impact on the performance of 3D printed microfluidic droplet generation devices for serial femtosecond crystallography (SFX) are reported. SFX is a novel crystallography method enabling structure …

  51. Reconstruction of Objects from Their Averaged Finite Crystal Diffraction Intensity

    26 Aug 2019 | BioXFEL Publications | Contributor(s): J. P. J. Chen, K. E. Schmidt, R. A. Kirian, J. J. Donatelli

    http://dx.doi.org/10.1109/icip.2019.8804468 proceedings-article Chen, J.P.J. et al., 2019. Reconstruction of Objects from Their Averaged Finite Crystal Diffraction Intensity. 2019 IEEE International Conference on Image Processing (ICIP). Available at: http://dx.doi.org/10.1109/icip.2019.8804468. …

  52. A Remarkable Return On Investment In Fundamental Research: 40 Years of Basic Energy Sciences at the Department of Energy

    02 Aug 2019 | BioXFEL Publications | Contributor(s): Persis Drell, Dawn A. Bonnell, Jingguang Chen, Sue Clark, Beatriz Roldan Cuenya, Helmut Dosch, Cynthia Friend, Yan Gao, Sharon Hammes-Schiffer, Marc Kastner, Bruce Kay, Stephen R. Leone, Despina Louca, Monica Olvera De La Cruz, Abbas Ourmazd, Philippe Piot, Ian Robertson, Anthony Rollett, Frances Ross, Gary Rubloff, Maria Santore, Esther S. Takeuchi, John Tranquada, Stephen Wasserman

    http://dx.doi.org/10.2172/1545686 report Drell, P. et al., 2018. A Remarkable Return On Investment In Fundamental Research: 40 Years of Basic Energy Sciences at the Department of Energy. Available at: http://dx.doi.org/10.2172/1545686. Persis Drell and Dawn A. Bonnell and Jingguang Chen and Sue …

  53. Electric Triggering for Enhanced Control of Droplet Generation

    01 Jul 2019 | BioXFEL Publications | Contributor(s): Daihyun Kim, Austin Echelmeier, Jorvani Cruz Villarreal, Sahir Ilyas Gandhi, Sebastian E Quintana, Ana Egatz-Gomez, Alexandra Ros

    http://dx.doi.org/10.1021/acs.analchem.9b01449 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Kim, D. et al., 2019. Electric Triggering for Enhanced Control of Droplet Generation. Analytical Chemistry, 91(15), pp.9792–9799. Available at: …

  54. Microfluidic sample delivery for serial crystallography using XFELs

    27 Jun 2019 | BioXFEL Publications | Contributor(s): Austin Echelmeier, Mukul Sonker, Alexandra Ros

    http://dx.doi.org/10.1007/s00216-019-01977-x journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Echelmeier, A., Sonker, M. & Ros, A., 2019. Microfluidic sample delivery for serial crystallography using XFELs. Analytical and Bioanalytical Chemistry, 411(25), pp.6535–6547. Available …

  55. Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both

    24 Jun 2019 | BioXFEL Publications | Contributor(s): Helena Taberman, Charles S. Bury, Mark J. Van Der Woerd, Edward Snell, Elspeth F. Garman

    http://dx.doi.org/10.1107/s1600577519005599 Xylose isomerase (XI) is an industrially important metalloprotein studied for decades. Its reaction mechanism has been postulated to involve movement of the catalytic metal cofactor to several different conformations. Here, a dose-dependent approach was …

  56. Coherent diffractive imaging of microtubules using an X-ray laser

    13 Jun 2019 | BioXFEL Publications | Contributor(s): Gisela Brändén, Greger Hammarin, Rajiv Harimoorthy, Alexander Johansson, David Arnlund, Erik Malmerberg, Anton Barty, Stefan Tångefjord, Peter Berntsen, Daniel P. DePonte, Carolin Seuring, Thomas A. White, Francesco Stellato, Richard Bean, Kenneth R. Beyerlein, Leonard M. G. Chavas, Holger Fleckenstein, Cornelius Gati, Umesh Ghoshdastider, Lars Gumprecht, Dominik Oberthür, David Popp, Marvin Seibert, Thomas Tilp, Marc Messerschmidt, Garth J. Williams, N. Duane Loh, Henry Chapman, Peter Zwart, Mengning Liang, Sébastien Boutet, Robert C. Robinson, Richard Neutze

    http://dx.doi.org/10.1038/s41467-019-10448-x journal-article Brändén, G. et al., 2019. Coherent diffractive imaging of microtubules using an X-ray laser. Nature Communications, 10(1). Available at: http://dx.doi.org/10.1038/s41467-019-10448-x. Gisela Brändén and Greger Hammarin and Rajiv …

  57. 7th Annual BioXFEL International Conference

    23 May 2019 | Downloads

  58. Spatial characterization of FLASH2 pulses: current status and future plan (Conference Presentation)

    14 May 2019 | BioXFEL Publications | Contributor(s): Masoud Mehrjoo, Elke Plönjes, Barbara Keitel, Marion Kuhlmann, Mabel Ruiz-Lopez, Thomas Wodzinski, Klaus Giewekemeyer, Patrik Vagovic, Yoonhee Kim, Mohammadreza Banjafar, Marc Messerschmidt, Tomáš Burian

    http://dx.doi.org/10.1117/12.2523254 proceedings-article Mehrjoo, M. et al., 2019. Spatial characterization of FLASH2 pulses: current status and future plan (Conference Presentation) T. Tschentscher et al., eds. X-Ray Free-Electron Lasers: Advances in Source Development and Instrumentation V. …

  59. Spatiotemporal Pattern Extraction by Spectral Analysis of Vector-Valued Observables

    13 May 2019 | BioXFEL Publications | Contributor(s): Dimitrios Giannakis, Abbas Ourmazd, Joanna Slawinska, Zhizhen Zhao

    http://dx.doi.org/10.1007/s00332-019-09548-1 journal-article Giannakis, D. et al., 2019. Spatiotemporal Pattern Extraction by Spectral Analysis of Vector-Valued Observables. Journal of Nonlinear Science. Available at: http://dx.doi.org/10.1007/s00332-019-09548-1. Dimitrios Giannakis and Abbas …

  60. Abstract P6-19-01: Evaluation of multiple transcriptomic gene risk signatures in male breast cancer

    11 May 2019 | BioXFEL Publications | Contributor(s): J Bayani, C Poncet, CQ Yao, C Crozier, N Anouk, T Piper, C Cunningham, M Sobol, S Aebi, K Benstead, O Bogler, L Dal Lago, J Fraser, FH Hilbers, I Hedenfalk, L Korde, B Linderholm, J Martens, L Middleton, M Murray, C Kelly, C Nilsson, M Nowaczyk, S Peeters, A Peric, P Porter, C Schröder, IT Rubio, KJ Ruddy, C Van Asperen, D Van Den Weyngaert, C Van Deurzen, E Van Leeuwen-Stok, J Vermeij, E Winer, PC Boutros, SH Giordano, F Cardoso, JM Bartlett

    http://dx.doi.org/10.1158/1538-7445.sabcs18-p6-19-01 proceedings-article Bayani, J. et al., 2019. Abstract P6-19-01: Evaluation of multiple transcriptomic gene risk signatures in male breast cancer. Poster Session Abstracts. Available at: http://dx.doi.org/10.1158/1538-7445.sabcs18-p6-19-01. J …

  61. Microfluidic Mixing Injector Holder Enables Routine Structural Enzymology Measurements with Mix-and-Inject Serial Crystallography Using X-ray Free Electron Lasers

    07 May 2019 | BioXFEL Publications | Contributor(s): George Douglas Calvey, Andrea Katz, Lois Pollack

    http://dx.doi.org/10.1021/acs.analchem.9b00311 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Calvey, G.D., Katz, A.M. & Pollack, L., 2019. Microfluidic Mixing Injector Holder Enables Routine Structural Enzymology Measurements with Mix-and-Inject Serial Crystallography Using X-ray …

  62. Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor

    02 May 2019 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda C. Johansson, John D. McCorvy, Nilkanth N Patel, Gye Won Han, Xi-Ping Huang, Cornelius Gati, Alexander Batyuk, Samuel T. Slocum, Andrii Ishchenko, Wolfgang Brehm, Thomas A. White, Nairie Michaelian, Caleb Alexander Madsen, Lan Zhu, Thomas D. Grant, Jessica M. Grandner, Anna Shiriaeva, Reid H. J. Olsen, Alexandra R. Tribo, Saïd Yous, Raymond C. Stevens, Uwe Weierstall, Vsevolod Katritch, Bryan L. Roth, Wei Liu, Vadim Cherezov

    http://dx.doi.org/10.1038/s41586-019-1209-0 journal-article Stauch, B. et al., 2019. Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature, 569(7756), pp.E6–E6. Available at: http://dx.doi.org/10.1038/s41586-019-1209-0. Benjamin Stauch and …

  63. The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state

    30 Apr 2019 | BioXFEL Publications | Contributor(s): M. Gertrude Gutierrez, Jacob Deyell, Kate L. White, Lucia C. Dalle Ore, Vadim Cherezov, Raymond C. Stevens, Noah Malmstadt

    http://dx.doi.org/10.1039/c8cc10130b As cholesterol fraction increases, ligand-bound receptor occupies more vesicle surface area, demonstrating co-localization with the cholesterol-rich phase. journal-article Gutierrez, M.G. et al., 2019. The lipid phase preference of the adenosine A2A receptor …

  64. Structural basis of ligand recognition at the human MT1 melatonin receptor

    24 Apr 2019 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda C. Johansson, John D. McCorvy, Nilkanth N Patel, Gye Won Han, Xi-Ping Huang, Cornelius Gati, Alexander Batyuk, Samuel T. Slocum, Andrii Ishchenko, Wolfgang Brehm, Thomas A. White, Nairie Michaelian, Caleb Alexander Madsen, Lan Zhu, Thomas D. Grant, Jessica M. Grandner, Anna Shiriaeva, Reid H. J. Olsen, Alexandra R. Tribo, Saïd Yous, Raymond C. Stevens, Uwe Weierstall, Vsevolod Katritch, Bryan L. Roth, Wei Liu, Vadim Cherezov

    http://dx.doi.org/10.1038/s41586-019-1141-3 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Stauch, B. et al., 2019. Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature. Available at: http://dx.doi.org/10.1038/s41586-019-1141-3. Benjamin Stauch and …

  65. XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

    24 Apr 2019 | BioXFEL Publications | Contributor(s): Linda C. Johansson, Benjamin Stauch, John D. McCorvy, Gye Won Han, Nilkanth N Patel, Xi-Ping Huang, Alexander Batyuk, Cornelius Gati, Samuel T. Slocum, Chufeng Li, Jessica M. Grandner, Shuming Hao, Reid H. J. Olsen, Alexandra R. Tribo, Sahba Zaare, Lan Zhu, Nadia Zatsepin, Uwe Weierstall, Saïd Yous, Raymond C. Stevens, Wei Liu, Bryan L. Roth, Vsevolod Katritch, Vadim Cherezov

    http://dx.doi.org/10.1038/s41586-019-1144-0 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Johansson, L.C. et al., 2019. XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity. Nature. Available at: http://dx.doi.org/10.1038/s41586-019-1144-0. …

  66. The Single Particles, Clusters and Biomolecules and Serial Femtosecond Crystallography instrument of the European XFEL: initial installation

    12 Apr 2019 | BioXFEL Publications | Contributor(s): Adrian P. Mancuso, Andrew Aquila, Lewis Batchelor, Richard J. Bean, Johan Bielecki, Gannon Borchers, Katerina Doerner, Klaus Giewekemeyer, Rita Graceffa, Oliver D. Kelsey, Yoonhee Kim, Henry J. Kirkwood, Alexis Legrand, Romain Letrun, Bradley Manning, Luis Lopez Morillo, Marc Messerschmidt, Grant Mills, Steffen Raabe, Nadja Reimers, Adam Round, Tokushi Sato, Joachim Schulz, Cedric Signe Takem, Marcin Sikorski, Stephan Stern, Prasad Thute, Patrik Vagovič, Britta Weinhausen, Thomas Tschentscher

    http://dx.doi.org/10.1107/s1600577519003308 The European X-ray Free-Electron Laser (FEL) became the first operational high-repetition-rate hard X-ray FEL with first lasing in May 2017. Biological structure determination has already benefitted from the unique properties and capabilities of X-ray …

  67. High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source

    04 Apr 2019 | BioXFEL Publications | Contributor(s): Jose M. Martin-Garcia, Lan Zhu, Derek Mendez, Ming-Yue Lee, Eugene Chun, Chufeng Li, Hao Hu, GANESH SUBRAMANIAN, David Kissick, Craig Ogata, Robert Henning, Andrii Ishchenko, Zachary Dobson, Shangji Zhang, Uwe Weierstall, John Spence, Petra Fromme, Nadia Zatsepin, Robert F. Fischetti, Vadim Cherezov, Wei Liu

    http://dx.doi.org/10.1107/s205225251900263x Since the first successful serial crystallography (SX) experiment at a synchrotron radiation source, the popularity of this approach has continued to grow showing that third-generation synchrotrons can be viable alternatives to scarce X-ray free-electron …

  68. DENSS: Ab Initio Electron Density Maps from Biological SAXS Data

    20 Mar 2019 | Seminars | Contributor(s): Thomas Grant

    Small angle scattering is an experimental technique used to analyze the molecular structures of a wide variety of biological and non-biological samples in solution. In contrast to X-ray crystallography and cryo-electron microscopy, where 3D electron density maps are calculated, available methods …

  69. Protein and RNA dynamical fingerprinting

    04 Mar 2019 | BioXFEL Publications | Contributor(s): Katherine A. Niessen, Mengyang Xu, Deepu K. George, Michael C. Chen, Adrian R. Ferré-D’Amaré, Edward Snell, Vivian Cody, James Pace, Marius Schmidt, Andrea Markelz

    http://dx.doi.org/10.1038/s41467-019-08926-3 journal-article Niessen, K.A. et al., 2019. Protein and RNA dynamical fingerprinting. Nature Communications, 10(1). Available at: http://dx.doi.org/10.1038/s41467-019-08926-3. Katherine A. Niessen and Mengyang Xu and Deepu K. George and Michael C. …

  70. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data

    01 Mar 2019 | BioXFEL Publications | Contributor(s): Yingchen Shi, Ke Yin, Xuecheng Tai, Hasan Demirci, Ahmad Hosseinizadeh, Brenda Hogue, Haoyuan Li, Abbas Ourmazd, Peter Schwander, Ivan A. Vartanyants, Chun Hong Yoon, Andrew Aquila, Haiguang Liu

    http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.pdf component Shi, Y. et al., 2019. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data. Available at: http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.pdf. Yingchen Shi and Ke Yin and …

  71. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data

    01 Mar 2019 | BioXFEL Publications | Contributor(s): Yingchen Shi, Ke Yin, Xuecheng Tai, Hasan Demirci, Ahmad Hosseinizadeh, Brenda Hogue, Haoyuan Li, Abbas Ourmazd, Peter Schwander, Ivan A. Vartanyants, Chun Hong Yoon, Andrew Aquila, Haiguang Liu

    http://dx.doi.org/10.1107/s2052252519001854 Using X-ray free-electron lasers (XFELs), it is possible to determine three-dimensional structures of nanoscale particles using single-particle imaging methods. Classification algorithms are needed to sort out the single-particle diffraction patterns from …

  72. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data

    01 Mar 2019 | BioXFEL Publications | Contributor(s): Yingchen Shi, Ke Yin, Xuecheng Tai, Hasan Demirci, Ahmad Hosseinizadeh, Brenda Hogue, Haoyuan Li, Abbas Ourmazd, Peter Schwander, Ivan A. Vartanyants, Chun Hong Yoon, Andrew Aquila, Haiguang Liu

    http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.docx component Shi, Y. et al., 2019. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data. Available at: http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.docx. Yingchen Shi and Ke Yin and …

  73. Shape transform phasing of edgy nanocrystals

    28 Feb 2019 | BioXFEL Publications | Contributor(s): J. P. J. Chen, J. J. Donatelli, K. E. Schmidt, R. A. Kirian

    http://dx.doi.org/10.1107/s205327331900113x Diffraction patterns from small protein crystals illuminated by highly coherent X-rays often contain measurable interference signals between Bragg peaks. This coherent `shape transform' signal introduces enough additional information to allow the …

  74. Following Folding Pathways of Common Riboswitch Motifs with Time-Resolved Single-Molecule FRET

    15 Feb 2019 | BioXFEL Publications | Contributor(s): Alex Plumridge, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.1931 poster Plumridge, A. & Pollack, L., 2019. Following Folding Pathways of Common Riboswitch Motifs with Time-Resolved Single-Molecule FRET. Biophysical Journal, 116(3), p.355a. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.1931. Alex Plumridge …

  75. Time-Resolved Contrast Variation SAXS for Studying RNA-Protein Interactions

    15 Feb 2019 | BioXFEL Publications | Contributor(s): Suzette A. Pabit, Andrea Katz, George Douglas Calvey, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.1733 poster Pabit, S.A. et al., 2019. Time-Resolved Contrast Variation SAXS for Studying RNA-Protein Interactions. Biophysical Journal, 116(3), p.319a–320a. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.1733. Suzette A. Pabit and Andrea M. Katz …

  76. DNA Sequence and Histone Core Composition Control the Unwrapping of DNA from Nucleosome Core Particles

    15 Feb 2019 | BioXFEL Publications | Contributor(s): Alex Mauney, Joshua Tokuda, Yujie Chen, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.1179 poster Mauney, A. et al., 2019. DNA Sequence and Histone Core Composition Control the Unwrapping of DNA from Nucleosome Core Particles. Biophysical Journal, 116(3), p.214a. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.1179. Alex Mauney and …

  77. Separation Phenomena in Tailored Micro- and Nanofluidic Environments

    30 Jan 2019 | BioXFEL Publications | Contributor(s): Mukul Sonker, Daihyun Kim, Ana Egatz-Gomez, Alexandra Ros

    http://dx.doi.org/10.1146/annurev-anchem-061417-125758 journal-article Sonker, M. et al., 2019. Separation Phenomena in Tailored Micro- and Nanofluidic Environments. Annual Review of Analytical Chemistry, 12(1). Available at: http://dx.doi.org/10.1146/annurev-anchem-061417-125758. Mukul Sonker …

  78. Cysteine modification can gate non-equilibrium conformational dynamics during enzyme catalysis: Supplemental Information

    19 Jan 2019 | BioXFEL Publications | Contributor(s): Medhanjali DasGupta, Dominik Budday, Peter Madzelan, Javier Seravalli, Brandon Hayes, Raymond G. Sierra, Roberto Alonso-Mori, Aaron S. Brewster, Nicholas K. Sauter, Gregory A. Applegate, Virendra Tiwari, David B. Berkowitz, Michael Thompson, James Fraser, Michael E. Wall, Henry Van Den Bedem, Mark A. Wilson

    http://dx.doi.org/10.1101/524751 Post-translational modification of cysteine residues can regulate protein function and is essential for catalysis by cysteine-dependent enzymes. Covalent modifications neutralize charge on the reactive cysteine thiolate anion and thus alter the active site …

  79. Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The “Undoing” of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network

    15 Jan 2019 | BioXFEL Publications | Contributor(s): Shenshen Hu, Adam R. Offenbacher, Erin M. Thompson, Christine L. Gee, Jarett Wilcoxen, Cody A. M. Carr, Daniil M. Prigozhin, Vanessa Yang, Tom Alber, R. David Britt, James Fraser, Judith P. Klinman

    http://dx.doi.org/10.1021/jacs.8b10992 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Hu, S. et al., 2019. Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The “Undoing” of Precise Substrate Positioning Relative to Metal Cofactor and an …

  80. The Catalytic Cycle of Water Oxidation in Crystallized Photosystem II Complexes: Performance and Requirements for Formation of Intermediates

    04 Jan 2019 | BioXFEL Publications | Contributor(s): Gennady Ananyev, Shatabdi Roy-Chowdhury, Colin Gates, Petra Fromme, G. Charles Dismukes

    http://dx.doi.org/10.1021/acscatal.8b04513 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Ananyev, G. et al., 2019. The Catalytic Cycle of Water Oxidation in Crystallized Photosystem II Complexes: Performance and Requirements for Formation of Intermediates. ACS Catalysis, …

  81. SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response

    02 Jan 2019 | BioXFEL Publications | Contributor(s): Shi-chun Du, Lan Zhu, Yu-xing Wang, Jie Liu, Die Zhang, Yu-lu Chen, Qing Peng, Wei Liu, Bin Liu

    http://dx.doi.org/10.1186/s12935-018-0722-9 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Du, S. et al., 2019. SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response. Cancer Cell International, 19(1). Available at: …

  82. Phasing Serial Crystallography Data

    27 Dec 2018 | BioXFEL Publications | Contributor(s): Richard Kirian, Joe Chen, John Spence

    http://dx.doi.org/10.1007/978-3-030-00551-1_8 book-chapter NSF-STC Biology with X-ray Lasers (NSF-1231306) Kirian, R.A., Chen, J.P.J. & Spence, J.C.H., 2018. Phasing Serial Crystallography Data. X-ray Free Electron Lasers, pp.235–252. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1_8. …

  83. Advances in Structure Determination of G Protein-Coupled Receptors by SFX

    27 Dec 2018 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda Johansson, Andrii Ishchenko, Gye Won Han, Alexander Batyuk, Vadim Cherezov

    http://dx.doi.org/10.1007/978-3-030-00551-1_10 book-chapter Stauch, B. et al., 2018. Advances in Structure Determination of G Protein-Coupled Receptors by SFX. X-ray Free Electron Lasers, pp.301–329. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1_10. Benjamin Stauch and Linda …

  84. Small Is Beautiful: Growth and Detection of Nanocrystals

    27 Dec 2018 | BioXFEL Publications | Contributor(s): Jesse David Coe, Alexandra Ros

    http://dx.doi.org/10.1007/978-3-030-00551-1_3 book-chapter Coe, J. & Ros, A., 2018. Small Is Beautiful: Growth and Detection of Nanocrystals. X-ray Free Electron Lasers, pp.59–85. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1_3. Jesse Coe and Alexandra Ros

  85. X-ray Free Electron Lasers

    27 Dec 2018 | BioXFEL Publications

    http://dx.doi.org/10.1007/978-3-030-00551-1 book Boutet, S., Fromme, P. & Hunter, M.S. eds., 2018. X-ray Free Electron Lasers. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1.

  86. Ab initio phasing of the diffraction of crystals with translational disorder

    20 Dec 2018 | BioXFEL Publications | Contributor(s): Andrew J. Morgan, Kartik Ayyer, Anton Barty, Joe Chen, Tomas Ekeberg, Dominik Oberthuer, Thomas A. White, Oleksandr Yefanov, Henry Chapman

    http://dx.doi.org/10.1107/s2053273318015395 To date X-ray protein crystallography is the most successful technique available for the determination of high-resolution 3D structures of biological molecules and their complexes. In X-ray protein crystallography the structure of a protein is refined …

  87. X-ray Emission Spectroscopy at X-ray Free Electron Lasers: Limits to Observation of the Classical Spectroscopic Response for Electronic Structure Analysis

    19 Dec 2018 | BioXFEL Publications | Contributor(s): Scott C. Jensen, Brendan Sullivan, Daniel A. Hartzler, Jose Meza Aguilar, Salah Awel, Saša Bajt, Shibom Basu, Richard Bean, Henry Chapman, Chelsie E Conrad, Matthias Frank, Raimund Fromme, Jose M. Martin-Garcia, Thomas D. Grant, Michael Heymann, Mark S. Hunter, Gihan Kaushylal Ketawala, Richard Kirian, Juraj Knoska, Christopher Kupitz, Xuanxuan Li, Mengning Liang, Stella Lisova, Valerio Mariani, Victoria Mazalova, Marc Messerschmidt, Michael Moran, Garrett Charles Nelson, Dominik Oberthür, Alex Schaffer, Raymond G. Sierra, Natalie Vaughn, Uwe Weierstall, Max Oliver Wiedorn, P. Lourdu Xavier, Jay-How Yang, Oleksandr Yefanov, Nadia Zatsepin, Andrew Aquila, Petra Fromme, Sébastien Boutet, Gerald T. Seidler, Yulia Pushkar

    http://dx.doi.org/10.1021/acs.jpclett.8b03595 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Jensen, S.C. et al., 2019. X-ray Emission Spectroscopy at X-ray Free Electron Lasers: Limits to Observation of the Classical Spectroscopic Response for Electronic Structure Analysis. The …

  88. SPIND: a reference-based auto-indexing algorithm for sparse serial crystallography data

    10 Dec 2018 | BioXFEL Publications | Contributor(s): Chufeng Li, Xuanxuan Li, Richard Kirian, John Spence, Haiguang Liu, Nadia Zatsepin

    http://dx.doi.org/10.1107/s2052252518014951 SPIND (sparse-pattern indexing) is an auto-indexing algorithm for sparse snapshot diffraction patterns (`stills') that requires the positions of only five Bragg peaks in a single pattern, when provided with unit-cell parameters. The …

  89. Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor

    29 Nov 2018 | BioXFEL Publications | Contributor(s): Martin Audet, Kate L. White, Billy Breton, Barbara Zarzycka, Gye Won Han, Yan Lu, Cornelius Gati, Alexander Batyuk, Petr Popov, Jeffrey Velasquez, David Manahan, Hao Hu, Uwe Weierstall, Wei Liu, Wenqing Shui, Vsevolod Katritch, Vadim Cherezov, Michael A. Hanson, Raymond C. Stevens

    http://dx.doi.org/10.1038/s41589-018-0160-y journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Audet, M. et al., 2018. Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor. Nature Chemical Biology, 15(1), pp.11–17. Available at: …

  90. Dielectrophoresis: From molecular to micrometer scale analytes

    27 Nov 2018 | BioXFEL Publications | Contributor(s): Daihyun Kim, Mukul Sonker, Alexandra Ros

    http://dx.doi.org/10.1021/acs.analchem.8b05454 journal-article Kim, D., Sonker, M. & Ros, A., 2018. Dielectrophoresis: From molecular to micrometer scale analytes. Analytical Chemistry. Available at: http://dx.doi.org/10.1021/acs.analchem.8b05454. Daihyun Kim and Mukul Sonker and Alexandra Ros

  91. Synthesis, structure, docking and cytotoxic studies of ferrocene–hormone conjugates for hormone-dependent breast cancer application

    22 Nov 2018 | BioXFEL Publications | Contributor(s): José A. Carmona-Negrón, Alberto Santana, Arnold L. Rheingold, Enrique Meléndez

    http://dx.doi.org/10.1039/c8dt01856a Ferrocene–estrogen conjugates can be recognized by ERα, suggesting that estrogens could serve as vectors to target specifically breast cancer cell lines. journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Carmona-Negrón, J.A. et al., 2019. …

  92. Conformations of an RNA Helix-Junction-Helix Construct revealed by SAXS Refinement of MD Simulations

    22 Nov 2018 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Tongsik Lee, Ron Elber, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.020 journal-article Chen, Y.-L. et al., 2018. Conformations of an RNA Helix-Junction-Helix Construct revealed by SAXS Refinement of MD Simulations. Biophysical Journal. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.020. Yen-Lin Chen and Tongsik Lee …

  93. Temperature-Jump Solution X-ray Scattering Reveals Distinct Motions in a Dynamic Enzyme:

    22 Nov 2018 | BioXFEL Publications | Contributor(s): Michael Thompson, Benjamin A Barad, Alexander M Wolff, Hyun Sun Cho, Friedrich Schotte, Daniel M.C. Schwarz, Philip Anfinrud, James Fraser

    http://dx.doi.org/10.1101/476432 Correlated motions of proteins and their bound solvent molecules are critical to function, but these features are difficult to resolve using traditional structure determination techniques. Time-resolved methods hold promise for addressing this challenge but have …

  94. qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps

    20 Nov 2018 | BioXFEL Publications | Contributor(s): Gydo C. P. Van Zundert, Brandi M. Hudson, Saulo H. P. De Oliveira, Daniel A. Keedy, Rasmus Fonseca, Amelie Heliou, Pooja Suresh, Kenneth Borrelli, Tyler Day, James Fraser, Henry Van Den Bedem

    http://dx.doi.org/10.1021/acs.jmedchem.8b01292 journal-article Van Zundert, G. et al., 2018. qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps. Journal of Medicinal Chemistry. Available at: …

  95. Structure-factor amplitude reconstruction from serial femtosecond crystallography of two-dimensional membrane-protein crystals

    12 Nov 2018 | BioXFEL Publications | Contributor(s): Cecilia M. Casadei, Karol Nass, Anton Barty, Mark S. Hunter, Celestino Padeste, Ching-Ju Tsai, Sébastien Boutet, Marc Messerschmidt, Leonardo Sala, Garth J. Williams, Dmitry Ozerov, Matthew Coleman, Xiao-Dan Li, Matthias Frank, Bill Pedrini

    http://dx.doi.org/10.1107/s2052252518014641 Serial femtosecond crystallography of two-dimensional membrane-protein crystals at X-ray free-electron lasers has the potential to address the dynamics of functionally relevant large-scale motions, which can be sterically hindered in three-dimensional …

  96. Serial Femtosecond Crystallography at Megahertz pulse rates

    09 Oct 2018 | BioXFEL Publications | Contributor(s): M.O. Wiedorn, D. Oberthuer, A. Barty, H.N. Chapman

    http://dx.doi.org/10.2210/pdb6ftr/pdb component NSF-STC Biology with X-ray Lasers (NSF-1231306) Wiedorn, M.O. et al., 2018. Serial Femtosecond Crystallography at Megahertz pulse rates. Available at: http://dx.doi.org/10.2210/pdb6ftr/pdb. M.O. Wiedorn and D. Oberthuer and A. Barty and H.N. Chapman

  97. How the Conformations of an Internal Junction Contribute to Fold an RNA Domain

    04 Oct 2018 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Julie L. Sutton, Lois Pollack

    http://dx.doi.org/10.1021/acs.jpcb.8b07262 journal-article Chen, Y.-L., Sutton, J.L. & Pollack, L., 2018. How the Conformations of an Internal Junction Contribute to Fold an RNA Domain. The Journal of Physical Chemistry B. Available at: http://dx.doi.org/10.1021/acs.jpcb.8b07262. Yen-Lin Chen …

  98. Free-electron laser data for multiple-particle fluctuation scattering analysis

    02 Oct 2018 | BioXFEL Publications | Contributor(s): Kanupriya Pande, Jeffrey J. Donatelli, Erik Malmerberg, Lutz Foucar, Billy K. Poon, Markus Sutter, Sabine Botha, Shibom Basu, R. Bruce Doak, Katerina Dörner, Sascha W. Epp, Lars Englert, Raimund Fromme, Elisabeth Hartmann, Robert Hartmann, Guenter Hauser, Johan Hattne, Ahmad Hosseinizadeh, Stephan Kassemeyer, Lukas Lomb, Sebastian F. Carron Montero, Andreas Menzel, Daniel Rolles, Artem Rudenko, Marvin M. Seibert, Raymond George Sierra, Peter Schwander, Abbas Ourmazd, Petra Fromme, Nicholas K. Sauter, Michael Bogan, John Bozek, Christoph Bostedt, Ilme Schlichting, Cheryl A. Kerfeld, Petrus H. Zwart

    http://dx.doi.org/10.1038/sdata.2018.201 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Pande, K. et al., 2018. Free-electron laser data for multiple-particle fluctuation scattering analysis. Scientific Data, 5, p.180201. Available at: http://dx.doi.org/10.1038/sdata.2018.201. …

  99. Divalent ions tune the kinetics of a bacterial GTPase center rRNA folding transition from secondary to tertiary structure

    25 Sep 2018 | BioXFEL Publications | Contributor(s): Robb Welty, Suzette A. Pabit, Andrea Katz, George Douglas Calvey, Lois Pollack, Kathleen B. Hall

    http://dx.doi.org/10.1261/rna.068361.118 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Welty, R. et al., 2018. Divalent ions tune the kinetics of a bacterial GTPase center rRNA folding transition from secondary to tertiary structure. RNA, 24(12), pp.1828–1838. Available at: …

  100. Single-particle imaging without symmetry constraints at an X-ray free-electron laser

    21 Sep 2018 | BioXFEL Publications | Contributor(s): Max Rose, Sergey Bobkov, Kartik Ayyer, Ruslan P. Kurta, Dmitry Dzhigaev, Young Yong Kim, Andrew J. Morgan, Chun Hong Yoon, Daniel Westphal, Johan Bielecki, Jonas A. Sellberg, Garth Williams, Filipe R.N.C. Maia, Olexander M. Yefanov, Vyacheslav Ilyin, Adrian P. Mancuso, Henry Chapman, Brenda Hogue, Andrew Aquila, Anton Barty, Ivan A. Vartanyants

    http://dx.doi.org/10.1107/s205225251801120x/it5017sup9.mp4 component Rose, M. et al., 2018. Single-particle imaging without symmetry constraints at an X-ray free-electron laser. Available at: http://dx.doi.org/10.1107/s205225251801120x/it5017sup9.mp4. Max Rose and Sergey Bobkov and Kartik Ayyer …