Search
Filter results
- All Categories 292
- Content 96
- Events 75
- Groups 2
- Knowledge Base 7
- Members 11
- Resources 96
- Wiki 5
Results (page 1 of 3)
-
Generalized Born Implicit Solvent Models for Biomolecules
BioXFEL Publications 12 Mar 2019 Contributor(s): David Case
http://dx.doi.org/10.1146/annurev-biophys-052118-115325 It would often be useful in computer simulations to use an implicit description of solvation effects, instead of explicitly representing the individual solvent molecules. Continuum dielectric models often work well in describing the thermodynamic aspects of aqueous solvation and can be very…
-
Registration 25 Mar 2010
Sorry, but login names cannot be changed.
-
Wiki 22 May 2014
Includes are standard wiki pages whose content is designed to be transcluded (embedded) inside other pages. Any wiki page may be an include. To include content from another wiki page, use the following syntax:For example, say you had a page named '''Welcome''' with the following content:… Hello! Welcome to the wiki.And then you…
-
John Spence at 4th International Conference on Ultrafast Structural Dynamics
Events 5 Dec 2017
Dec 05 2017
The 4th International Conference on Ultrafast Structural Dynamics will be held in Trieste, Italy December 5-7, 2017.… ICUSD is a platform for discussing the latest methodological, theoretical and scientific developments aimed at understanding real-time structural changes in materials science, chemistry and…
-
Teaching Materials 7 Oct 2015
VIEW WORKSHOP SERIES Dr. Ali Dashti discuss energy landscapes and continuous conformational mapping of molecular machines.
-
Wiki 22 May 2014
Wiki Page Names … Wiki page names commonly use the !… Within wiki text, any word in !CamelCase automatically becomes a hyperlink to the wiki page with that name.… !CamelCase page names must follow these rules:… # The name must consist of '''alphabetic characters…
-
2nd International BioXFEL Conference Logo
Downloads 11 Jul 2014 Contributor(s): Tom Grant
Transparent background logo for 2nd BioXFEL Conference
-
Events 9 Nov 2022
Nov 09 2022
For 20 years, the Annual Biomedical Research Conference for Minority Students (ABRCMS) – recipient of the 2019 AIMBE Excellence in STEM Education Award – has been the go-to conference for underrepresented community college, undergraduate and post-baccalaureate students in science, technology, engineering and mathematics.……
-
Moving in the Right Direction: Protein Vibrational Steering Function
News 18 May 2017
Nearly all protein functions require structural change, such as enzymes clamping onto substrates, and ion channels opening and closing.… Calculations have indicated protein vibrations enable structural change.… By using the novel technique of anisotropic terahertz microscopy, we find that there is a dramatic…
-
Tips 25 Mar 2010
Have some interesting results from a simulation that you'd like someone else to see? Share the session! Enter one or more login names in the form beneath the tool session and click on the Share button.… Just as you would click a link to resume a tool session, they can click the link and access your session. Many people can…
-
Groups
Dr. Snell's research group uses complementary techniques to extract structural and dynamic information from biological macromolecules. This research includes the development of crystallization methodology and the resulting analysis with an emphasis on high-energy light sources.
-
Members
BioXFEL, in collaboration with SLAC at Stanford University, has been instrumental in the continuation of my studies towards my doctorate. With their support I was able to relocate to Stanford after the destruction of Hurricane Maria and advance my research project. During this year I was also able to participate in their protein workshop and the…
-
BioXFEL Publications 3 Aug 2019 Contributor(s): Abbas Ourmazd
http://dx.doi.org/10.2172/1545686 report Drell, P. et al., 2018. A Remarkable Return On Investment In Fundamental Research: 40 Years of Basic Energy Sciences at the Department of Energy.
-
Events 5 Sep 2021
Sep 05 2021
PAL-XFEL Call for R&D beamtime Proposals Information for R&D beamtimePAL-XFEL operates the R&D beamtime program independent from general user beamtime. It is opened for the experiments that meet the following criteria. Establishing new experimental techniques or instruments at PAL-XFEL Proving critical performance of PAL-XFEL New users…
-
Energy landscapes from cryo-EM snapshots: a benchmarking study
BioXFEL Publications 25 Jan 2023 Contributor(s): Raison Dsouza, Ghoncheh Mashayekhi, Roshanak Etemadpour, Peter Schwander, Abbas Ourmazd
http://dx.doi.org/10.1038/s41598-023-28401-w AbstractBiomolecules undergo continuous conformational motions, a subset of which are functionally relevant. Understanding, and ultimately controlling biomolecular function are predicated on the ability to map continuous conformational motions, and identify the functionally relevant conformational…
-
News 5 Sep 2019
Some of the world’s most accomplished scientific minds will converge on Arizona State University’s Tempe campus on November 6, 7 and 8 to explore new methods that make it possible to observe molecules in action. Illustrating the adage, "seeing is believing," the conference, “Functional dynamics – visualizing molecules in action,” will…
-
2015 BioXFEL International Conference Invited Speakers Abstracts
Downloads 17 Dec 2014
This is a compilation of the abstracts of the Invited Speakers of the 2015 BioXFEL Conference in Ponce, Puerto Rico.
-
2021 Conference Registration Scholarship Deadline
Events 31 Dec 2020
Dec 31 2020
2021 Conference Registration Scholarship … The Annual International BioXFEL conference will be held virtually in 2021.… This award will waive all fees associated with both the conference and associated workshop series.… Eligibility All applicants must be enrolled in an undergraduate or…
-
2020 Conference Poster Presentation
Events 24 Jan 2020
Jan 24 2020
Presented a poster at the 7th Annual BioXFEL conference
-
Members
Abbas Ourmazd, Ph.D., is currently Distinguished Professor of Physics and Electrical Engineering at the University of Wisconsin-Milwaukee. His current interests include the structure of biological assemblies, such as viruses and proteins, and the dynamics of molecular machines, such as the ribosome. Dr. Ourmazd has held leadership positions on…
-
2nd International BioXFEL Conference Detailed Agenda
Downloads 5 Dec 2014 Contributor(s): Tom Grant
This is a detailed agenda for the 2nd International BioXFEL Conference to be held in Ponce, Puerto Rico in January 2015.
-
Call for Applications: 2019 Panofsky Fellowship at the SLAC
News 19 Oct 2018
The Panofsky Fellowship honors SLAC National Accelerator Laboratory’s founder and first Director, Wolfgang K.… Panofsky. It is intended to recognize exceptional and promising young scientists who would most benefit from the unique opportunity to conduct their research at SLAC National Accelerator Laboratory. 2019 Panofsky…
-
Single-femtosecond atomic-resolution observation of a protein traversing a conical intersection
BioXFEL Publications 15 Nov 2020
http://dx.doi.org/10.1101/2020.11.13.382218 The structural dynamics of a molecule are determined by the underlying potential energy landscape.… Posited almost a century ago 1, conical intersections remain the subject of intense scientific investigation 2–4. In biology, they play a pivotal role in vision, photosynthesis, and DNA…
-
Groups
Marius Schmidt is using physical methods to investigate biological molecules. He is concentrating mainly on static and time-resolved macromolecular crystallography to investigate the structure, dynamics and kinetics of proteins. Dr. Schmidt is also developing new, sophisticated software for the analysis of the time-resolved (4-dimensional) X-ray…
-
BioXFEL Publications 10 Nov 2016 Contributor(s): Richard Kirian, Max Oliver Wiedorn, Henry Chapman
http://dx.doi.org/10.1117/12.2239171 Richard A. Kirian and Salah Awel and Max Wiedorn and Daniel Horke and Nils Roth and Niko O. Eckerskorn and Jochen Küpper and Henry N. Chapman and Andrei V. Rode Kirian, R.A. et al., 2016. Development of a photophoretic optical guide for femtosecond x-ray diffractive imaging of aerosolized nanoparticles…
-
Spatial characterization of FLASH2 pulses: current status and future plan (Conference Presentation)
BioXFEL Publications 14 May 2019 Contributor(s): Marc Messerschmidt
http://dx.doi.org/10.1117/12.2523254 proceedings-article Mehrjoo, M. et al., 2019. Spatial characterization of FLASH2 pulses: current status and future plan (Conference Presentation) T.
-
Protein energy landscapes determined by five-dimensional crystallography
Publications 1 Dec 2013 Contributor(s): Marius Schmidt
https://www.bioxfel.org/resources/Protein-energy-landscapes-determined-by
-
Members
Juan started his scientific career with BioXFEL. The summer internship of 2016 was his first research experience. He graduated from the University of Puerto Rico Mayaguez the following spring and was accepted into a postbacc program at Case Western University. This prepared his for graduate school and contributed to his acceptance into multiple…
-
From Static Structures to Continuous Conformational Changes on the Energy Landscapes
BioXFEL Publications 30 Jul 2020 Contributor(s): Ghoncheh Mashayekhi, Ali Dashti, Peter Schwander, Abbas Ourmazd
http://dx.doi.org/10.1017/s1431927620018723 journal-article Mashayekhi, G. et al., 2020. From Static Structures to Continuous Conformational Changes on the Energy Landscapes.
-
Registration 25 Mar 2010
We have an online form to change your password.
-
National Society of Black Physicists 2019 Conference
Events 14 Nov 2019
Nov 14 2019
The National Society of Black Physicists will be having the 2019 Conference on November 14- 17, 2019, in Providence, Rhode Island.… Promoting Professional Connections and Persistence in Physics." The NSBP conference is the largest academic meeting of minority physicists in the United States.… The Conference…
-
Applications DUE for 2019 Panofsky Fellowship at the SLAC
Events 30 Nov 2018
Nov 30 2018
2019 Panofsky Fellowship at the SLAC National Accelerator Laboratory (SLAC) Call for applications Deadline November 30, 2018 Fellowship for early-career research (experiment or theory) in a diverse range of fields related to the SLAC scientific mission: Accelerator science & advanced accelerator research Applied Energy…
-
Legal 2 May 2012
Edit this page and fill in contact information for your project, or unpublish it if you think it is unnecessary. The following text is just a suggestion for the policies that you may want to highlight, and your contact for legal issues. Policies Review 's Terms of Use, Privacy Policy or Abuse Policy. Legal Contacts Your…
-
Mediator structure and conformation change
BioXFEL Publications 10 Feb 2021 Contributor(s): Rayees Mattoo, David Bushnell, Roger Kornberg
http://dx.doi.org/10.1016/j.molcel.2021.01.022 journal-article Heqiao Zhang and Dong-Hua Chen and Rayees U.H. Mattoo and David A. Bushnell and Yannan Wang and Chao Yuan and Lin Wang and Chunnian Wang and Ralph E. Davis and Yan Nie and Roger D. Kornberg
-
Protein energy landscapes determined by five-dimensional crystallography
BioXFEL Publications 19 Nov 2013 Contributor(s): Marius Schmidt
Free-energy landscapes decisively determine the progress of enzymatically catalyzed reactions [Cornish-Bowden (2012),Fundamentals of Enzyme Kinetics, 4th ed.… Time-resolved macromolecular crystallography unifies transient-state kinetics with structure determination [Moffat (2001),Chem. Rev.101, 1569–1581; Schmidtet…
-
Legal 25 Mar 2010
What is Creative Commons? The Creative Commons (CC) enables copyright holders to grant some or all of their rights to the public while retaining others through a variety of licensing and contract schemes. prefers the Creative Commons 3.0 license, which is well suited to education and academic research. This license allows people to use your…
-
Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity
BioXFEL Publications 8 Mar 2022 Contributor(s): Ghoncheh Mashayekhi, Abbas Ourmazd
http://dx.doi.org/10.1016/j.crstbi.2022.02.001 journal-article Mashayekhi, G., Vant, J., Polavarapu, A., Ourmazd, A., & Singharoy, A. (2022). Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity.
-
Absolute pulse energy measurements of soft x-rays at the Linac Coherent Light Source
BioXFEL Publications 25 Aug 2014
journal-article http://dx.doi.org/10.1364/oe.22.021214 Tiedtke, K. et al., 2014. Absolute pulse energy measurements of soft x-rays at the Linac Coherent Light Source.
-
BioXFEL Publications 25 May 2014 Contributor(s): James Fraser
http://dx.doi.org/10.1038/nchem.1954 journal-article Fischer, M. et al., 2014. Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery.
-
Events 11 Feb 2019
Feb 11 2019
Attend 2019 BioXFEL Conference
-
BioXFEL Publications 13 Mar 2015 Contributor(s): Gebhard F.X. Schertler, Vadim Cherezov
http://dx.doi.org/10.1007/s00210-015-1111-8 Alexander Heifetz and Gebhard F. X. Schertler and Roland Seifert and Christopher G. Tate and Patrick M. Sexton and Vsevolod V. Gurevich and Daniel Fourmy and Vadim Cherezov and Fiona H. Marshall and R. Ian Storer and Isabel Moraes and Irina G. Tikhonova and Christofer S. Tautermann and Peter Hunt and Tom…
-
BPS2025 - Automated, efficient, and rigorous absolute binding free energy calculations
BioXFEL Publications 13 Feb 2025 Contributor(s): David Case
https://doi.org/10.1016/j.bpj.2024.11.1764 journal-article Ayoub, S., Luchko, T., Barton, M., & Case, D. A. (2025). BPS2025 - Automated, efficient, and rigorous absolute binding free energy calculations.
-
Deducing fast electron density changes in uncrystallized biomolecules
Teaching Materials 13 Oct 2015
We propose a method for deducing time-resolved structural changes in uncrystallized biomolecules in solution.… The experiment is somewhat like a pump–probe version of an experiment on small angle X-ray scattering, except that the data expected by the algorithm are not just the radial variation of the averaged intensities. The…
-
Thank You for Another Succesful BioXFEL Conference
News 31 Jan 2017
Thank You for Your Attendance and Sponsorship of the 4th BioXFEL Conference and Single Particle Sample Delivery Workshop … We would like to thank you for your attendance of the SP Workshop and 4th Annual Conference.… We’d also like to thank our vendors and sponsors: Rayonix, Formulatrix, Molecular…
-
Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser
Teaching Materials 13 Oct 2015
We describe a method to measure ultrafast protein structural changes using time-resolved wide-angle X-ray scattering at an X-ray free-electron laser.… This provides direct structural evidence for a 'protein quake': the hypothesis that proteins rapidly dissipate energy through quake-like structural motions.
-
7th Annual BioXFEL International Conference
Downloads 23 Dec 2019
-
7th Annual BioXFEL International Conference
Downloads 23 May 2019
-
BioXFEL Publications 27 Nov 2022 Contributor(s): Shatabdi Roy-Chowdhury, Petra Fromme
http://dx.doi.org/10.1007/s11120-022-00985-w journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Gates, C., Ananyev, G., Roy-Chowdhury, S., Fromme, P., & Dismukes, G. C. (2022). Regulation of light energy conversion between linear and cyclic electron flow within photosystem II controlled by the plastoquinone/quinol redox poise.
-
How directed evolution reshapes the energy landscape in an enzyme to boost catalysis
BioXFEL Publications 20 Nov 2020 Contributor(s): Shuo Sui, Sarah Perry
http://dx.doi.org/10.1126/science.abd3623 The advent of biocatalysts designed computationally and optimized by laboratory evolution provides an opportunity to explore molecular strategies for augmenting catalytic function. Applying a suite of NMR, crystallographic, and stopped-flow techniques to an enzyme designed for an elementary proton transfer…
-
Members
Since 2016, the Center has been key to my scientific growth, exposing me to different workshops and enriching scientific experiences. I have also had the opportunity to participate in the international BioXFEL conferences from 2016 through 2020 and present my research.
-
Events 26 Jul 2015
Jul 26 2015
-
8th BioXFEL International Conference
Downloads 9 Dec 2020
-
5th BioXFEL International Conference
Downloads 4 Dec 2017
-
3rd BioXFEL International Conference
Downloads 8 Sep 2015
-
Members
David Case is a world leader in computational biophysics, with pioneering contributions in molecular dynamics simulations of biomolecules (via the development of innovative computational methods and accurate force fields), the interpretation of NMR (linking spectral parameters with structure and dynamics), free energy estimations, and the structure…
-
Events 10 Jan 2017
Jan 10 2017
-
Events 26 Mar 2015
Mar 26 2015
-
From Protein Design to the Energy Landscape of a Cold Unfolding Protein
BioXFEL Publications 7 Feb 2022 Contributor(s): Surya V. S. R. K Pulavarti, shirley yuen, Jermel Griffin, Edward Snell, Thomas Szyperski
http://dx.doi.org/10.1021/acs.jpcb.1c10750 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Pulavarti, S. V. S. R. K., Maguire, J. B., Yuen, S., Harrison, J. S., Griffin, J., Premkumar, L., Esposito, E. A., Makhatadze, G. I., Garcia, A. E., Weiss, T. M., Snell, E. H., Kuhlman, B., & Szyperski, T. (2022). From Protein Design to the…
-
Teaching Materials 7 Oct 2015 Contributor(s): Peter Schwander
VIEW WORKSHOP SERIES Dr. Peter Schwander discuss how to proceed from single particle snapshots to movies of molecular machines and energy landscapes.
-
The 75th Annual Pittsburgh Diffraction Conference featuring BioXFEL Members
Events 19 Oct 2017
Oct 19 2017
BioXFEL members Thomas Grant (University at Buffalo) and Guillermo Calero (University of Pittsburgh) will be giving talks on "The Applications of Emerging Methods of Structural Biology" at the 75th Annual Pittsburgh Diffraction Conference.… Preceeding the PDS conference, a GSAS-II workshop will be held on Wednesday, October…
-
BioXFEL Publications 21 Jun 2017 Contributor(s): Stefan Hau-Riege, Marc Messerschmidt
http://dx.doi.org/10.1117/12.2270944 proceedings-article Vozda, V. et al., 2017. Non-thermal damage to lead tungstate induced by intense short-wavelength laser radiation (Conference Presentation) L.
-
Downloads 4 Nov 2016
-
External Conference & Professional Development Scholarship
Education 6 Apr 2018
The BioXFEL External Conference & Professional Development Travel Scholarship was created to support the continuing education of our BioXFEL Scholars.… This scholarship will support up to half of the travel expenses incurred for a relevant, educational or scientific workshop, conference or other training event within a maximum…
-
Diffraction methods in Structural Biology Gordon Research Conference
Events 24 Jul 2022
Jul 24 2022
Structural biology is entering a new era. Not just the virus and biomedicine, not just astounding breakthroughs in prediction, but new and complementary approaches are exploding onto the scene. It is time to imagine what could be achieved if there were no barriers to structural information and to contemplate how we will combine our diverse…
-
2021 Panofsky Fellowship Deadline
Events 2 Nov 2020
Nov 02 2020
2021 Panofsky Fellowship at the SLAC National Accelerator Laboratory (SLAC) Call for Applications – Deadline for submission is November 2, 2020 Fellowship for early-career research (experiment or theory) in a diverse range of fields related to the SLAC scientific mission: • Accelerator science & advanced accelerator research • Applied…
-
Downloads 24 Jul 2018 Contributor(s): Tom Grant
Please use this template for all BioXFEL-related posters. This version has been updated to reflect the current requirements for the 2019 Annual conference.
-
Uncategorised 17 Apr 2017
The BioXFELbb mailing list is a listserv created for the purpose of facilitating communication between members of the biological XFEL community regarding topics related to: - sample preparation/crystallization - sample delivery - software - general topics of interest related to biology with XFELs - announcements regarding…
-
BioXFEL collaborator Henry Chapman receives 2017 Roentgen Medal
News 11 Apr 2017
DESY scientist Henry Chapman has been awarded the Roentgen Medal by the city of Remscheid. The town in which Wilhelm Conrad Roentgen was born has been presenting this award annually since 1951 to individuals who have made outstanding contributions towards improving and advancing the use of the radiation discovered by Roentgen.
-
Downloads 7 Dec 2021
-
9th Annual International Conference
Published 20 Apr 2021
No details available at this time. Please check back later.
-
Biography 21 May 2013
Abbas Ourmazd University of Wisconsin-Milwaukee Department of Physics 1900 East Kenwood Boulevard Milwaukee, WI 53211 ourmazd@uwm.edu (414) 229-2610 Abbas Ourmazd, Ph.D., is currently Distinguished Professor of Physics and Electrical Engineering at the University of Wisconsin-Milwaukee. His current interests include the structure of biological…
-
Events 26 Jul 2015
Jul 26 2015
Click here for details
-
BioXFEL Scholars at Challenges in Structural Biology
Events 15 Oct 2017
Oct 15 2017
BioXFEL members Henry Chapman (Deutsches Elektronen-Synchrotron), James Fraser(University of California, San Francisco) and Guillermo Calero (University of Pittsburgh) have been invited to participate in the Challenges in Structural Biology Conference at Janelia Research Campus.
-
BioXFEL Publications 31 Aug 2023 Contributor(s): James Fraser
http://dx.doi.org/10.1371/journal.ppat.1011614 Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP-ribosylhydrolase activity and a possible drug target. To determine the role of Mac1 catalytic activity in viral replication, we generated…
-
Workshops 26 Aug 2014 Contributor(s): Tom Grant, Nadia Zatsepin
Video and interactive web presentations with PDF slides available for download. Description Serial crystallography is a rapidly growing field with a correspondingly rapidly growing user base. One of the main bottlenecks in serial crystallography is the ability to efficiently filter and analyze large datasets to arrive at accurate structure factors…
https://www.bioxfel.org/resources/2014-data-analysis-workshop
-
Vibrational Excitations and Low-Energy Electronic Structure of Epoxide-Decorated Graphene
BioXFEL Publications 18 Dec 2013
journal-article http://dx.doi.org/10.1021/jz4025386 Mattson, E.C. et al., 2014. Vibrational Excitations and Low-Energy Electronic Structure of Epoxide-Decorated Graphene.
-
News 25 Sep 2018
Srd Div. Director [Senior/ Distinguished Staff Scientist] Link to job posting Job Requisition #: 3370 Classification Title: Staff Scientist- Senior Location: Menlo Park, CA (HQ) # of openings: 1 Position Summary LCLS SCIENCE RESEARCH AND DEVELOPMENT (SRD) DIVISION LEADER: The Linac Coherent Light Source (LCLS) is an internationally…
-
Write Winning Grant Proposals Workshop
Events 27 Jan 2020
Jan 27 2020
Grant Writers' Seminars and Workshops (GWSW) and BioXFEL are hosting a one-day grant writing workshop prior to the 2020 BioXFEL Annual International Conference on Monday, January 27th.… Robertson, PhD from GWSW will present "Write Winning Grant Proposals" to attendees interested in learning more about submitting proposals to…
-
Ourmazd joins advisory committee of DOE
Knowledge Transfer 27 Apr 2017
Abbas Ourmazd, a UWM distinguished professor of physics, has been appointed to serve on the Basic Energy Sciences Advisory Committee (BESAC) of the U.… Department of Energy (DOE).… See original article here The 25-member committee has a substantial impact on national scientific programs, supporting more than…
-
Valence electron energy-loss spectroscopy study of ZrSiO4 and ZrO2
BioXFEL Publications 17 Jul 2013 Contributor(s): John Spence
journal-article http://dx.doi.org/10.1016/j.ultramic.2013.06.021 Jiang, N. & Spence, J.C.H., 2013. Valence electron energy-loss spectroscopy study of ZrSiO4 and ZrO2.
-
Publications 4 May 2012 Contributor(s): Lois Pollack
The results of more than a dozen single-molecule Forster resonance energy transfer (smFRET) experiments suggest that chemically unfolded polypeptides invariably collapse from an expanded random coil to more compact dimensions as the denaturant concentration is reduced.
https://www.bioxfel.org/resources/Small-angle-X-ray-scattering-and-single-molecule
-
BioXFEL CoPI Appointed to DOE Advisory Committee
News 27 Apr 2017
Abbas Ourmazd, a UWM distinguished professor of physics, has been appointed to serve on the Basic Energy Sciences Advisory Committee (BESAC) of the U.… Department of Energy (DOE).… See original article here The three divisions of Basic Energy Sciences are the largest, or among the largest, federally funded…
-
2015 Single Particle Imaging Workshop
Workshops 17 Aug 2015 Contributor(s): Russell Fung
How do you make a movie of a single particle jiggling and wiggling with atomic resolution and ultra-fast temporal resolution? How do you calculate the energy landscape or the kinetics/dynamics of a sequence of conformational changes?… How can I use symmetry to my advantage? We will answer all these questions and…
-
Events 22 Aug 2017
Aug 22 2017
BioXFEL member Belinda Pastrana will be giving a talk at the BIOProcessing Summit in Boston, MA. Her talk "Novel Approach towards the Evaluation of Critical Quality Attributes and Stability of Proteins" centers on therapeutic proteins. Therapeutic proteins are highly complex molecules; their CQAs require diverse bioanalytical techniques to…
-
BioXFEL STC 2nd Annual International Conference
Events 14 Jan 2015
Jan 14 2015
Sponsored in part by: On behalf of the National Science Foundation’s BioXFEL Science and Technology Center and Conference Co-chairs, Dr.… Abbas Ourmazd, we’d like to thank you for attending the January 2015 BioXFEL 2nd International Annual Conference in…
-
Uncategorised 3 Jul 2018
-
Members
Edward Snell, Ph.D., is a the President and Chief Executive Officer of the Hauptman-Woodward Medical Research Institute and faculty member at the University at Buffalo in the Department of Structural Biology. He is a board member on the International Organization for Biological Crystallization. He is the director of the BioXFEL Science and…
-
SACNAS Awards for BioXFEL Interns & Scholar
News 18 Oct 2018
BioXFEL interns (Rice Univ. Summer 2017) Jesus Valencia and Jessica Weng, and BioXFEL Scholar Joey Olmos (Rice Univ.PhD candidate), were awarded presentation awards for their “Outstanding Research Presentation,” at the 2018 National Diversity in STEM Conference in San Antonio, Texas.… Over 1000 participants attended the…
-
Reach Out Science Communication Competition
Events 6 Apr 2021
Apr 06 2021
Don’t miss the 2021 (virtual) Reach Out Science Slams! Who can tell the best science story in just 3-minutes? Follow along and cast your votes to find out! Early career researchers from around the country will be competing to see who can tell the best science story in just 3 minutes!
-
2021 Panofsky Fellowship Call for Applications
News 22 Sep 2020
2021 Panofsky Fellowship at the SLAC National Accelerator Laboratory (SLAC) Call for Applications – Deadline for submission is November 2, 2020 Fellowship for early-career research (experiment or theory) in a diverse range of fields related to the SLAC scientific mission: • Accelerator science & advanced accelerator…
https://www.bioxfel.org/2021-panofsky-fellowship-call-for-applications
-
Protein Production and Purification at UPR-RP
Events 16 Feb 2018
Feb 16 2018
BioXFEL Protein Production and Purification Workshop The NSF BioXFEL Science and Technology Center will be sponsoring a workshop on March 16th, 2018 for all interested UPR researchers. The full day course will cover the basics of the biochemistry, cloning, expression and purification of proteins. We will discuss the theory behind common…
-
BioXFEL Publications 5 Feb 2020 Contributor(s): Edward Snell
http://dx.doi.org/10.1107/s205225251901707x Transforming growth factor β-1 (TGFβ-1) is a secreted signalling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. The primary endogenous activity regulatory mechanism for TGFβ-1 is sequestration by its pro-peptide, latency-associated…
-
Crystal structure of the 4-hydroxybutyryl-CoA synthetase (ADP-forming) from nitrosopumilus maritimus
BioXFEL Publications 21 Oct 2024 Contributor(s): Hasan Demirci
https://doi.org/10.1038/s42003-024-06432-x AbstractThe 3-hydroxypropionate/4-hydroxybutyrate (3HP/4HB) cycle from ammonia-oxidizing Thaumarchaeota is currently considered the most energy-efficient aerobic carbon fixation pathway.… This enzyme reduces energy requirements on the cell, reflecting thaumarchaeal success in adapting to…
-
BioXFEL at USA Science & Engineering Festival
Events 5 Apr 2018
Apr 05 2018
The USA Science & Engineering Festival Expo, presented by Lockheed Martin, will take place on April 7-8, 2018 at the Walter E. Washington Convention Center in Washington, DC. The event is the nation’s largest celebration of science, technology, engineering and mathematics (STEM) featuring over 3,000 hands-on exhibits, 30 stage shows and…
-
Photonics Spring Workshop 2017 Registration Deadline 3/31
Events 31 Mar 2017
Mar 31 2017
The Paul Scherrer Institut is very happy to announce the Photonics Spring Workshop 2017. The workshop will focus on the SwissFEL Athos soft X-ray beamline and the SLS-2 upgrade project. We invite you to participate in this workshop that will be guided by science rather than machine design, focusing on the identification of grand challenges…
-
Postdoc position at Cornell University: Dynamic biophysical studies using XFELs
Opportunities 24 Jun 2020
We invite applications for a postdoctoral position in the Pollack Lab in the School of Applied and Engineering Physics at Cornell University. We are an interdisciplinary research group, known for the innovative application of x-ray scattering to study biological macromolecules. The goal of this project is to develop and apply new instruments for…
-
5th Annual BioXFEL International Conference
Events 13 Feb 2018
Feb 13 2018
The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its fifth annual international conference in New Orleans, LA February 13th - 15th, 2018.… Our annual External Advisors Meeting will be held Monday, Feb 12th. Conference Co-Chairs: … Dr. James…
-
Members
Dr. Molinaro has a dual B.S., in Biophysics and Chemistry from Wayne State University in Detroit, Michigan and a Ph.D., in Biophysical Chemistry from the University of California, Berkeley. Since the early 1990's, he has been strongly involved in education and has a familiarity with multiple educational technologies. From 1994 through 1999, Dr.…
-
Members
Lee Tremblay’s research in biophysics has focused on the structural and kinetic aspects of enzymatic action. In pursuit of the fundamental mechanistic forces behind enzymatic biochemistry, he has proposed experimental designs for the use of the unique features of the LCLS linear accelerator in California, which have the potential to provide…
-
Uncategorised 20 Oct 2021
The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its ninth annual international conference virtually February 8-10, 2021.… The annual International BioXFEL Conference brings together experts in a variety of fields (structural biology, physics, biochemistry, and…
