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  1. Microfluidic Mixing Injector Holder Enables Routine Structural Enzymology Measurements with Mix-and-Inject Serial Crystallography Using X-ray Free Electron Lasers

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    07 May 2019 | BioXFEL Publications | Contributor(s): George Douglas Calvey, Andrea Katz, Lois Pollack

    http://dx.doi.org/10.1021/acs.analchem.9b00311 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Calvey, G.D., Katz, A.M. & Pollack, L., 2019. Microfluidic Mixing Injector Holder Enables Routine Structural Enzymology Measurements with Mix-and-Inject Serial Crystallography Using X-ray …

  2. Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor

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    02 May 2019 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda C. Johansson, John D. McCorvy, Nilkanth N Patel, Gye Won Han, Xi-Ping Huang, Cornelius Gati, Alexander Batyuk, Samuel T. Slocum, Andrii Ishchenko, Wolfgang Brehm, Thomas A. White, Nairie Michaelian, Caleb Alexander Madsen, Lan Zhu, Thomas D. Grant, Jessica M. Grandner, Anna Shiriaeva, Reid H. J. Olsen, Alexandra R. Tribo, Saïd Yous, Raymond C. Stevens, Uwe Weierstall, Vsevolod Katritch, Bryan L. Roth, Wei Liu, Vadim Cherezov

    http://dx.doi.org/10.1038/s41586-019-1209-0 journal-article Stauch, B. et al., 2019. Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature, 569(7756), pp.E6–E6. Available at: http://dx.doi.org/10.1038/s41586-019-1209-0. Benjamin Stauch and …

  3. The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state

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    30 Apr 2019 | BioXFEL Publications | Contributor(s): M. Gertrude Gutierrez, Jacob Deyell, Kate L. White, Lucia C. Dalle Ore, Vadim Cherezov, Raymond C. Stevens, Noah Malmstadt

    http://dx.doi.org/10.1039/c8cc10130b As cholesterol fraction increases, ligand-bound receptor occupies more vesicle surface area, demonstrating co-localization with the cholesterol-rich phase. journal-article Gutierrez, M.G. et al., 2019. The lipid phase preference of the adenosine A2A receptor …

  4. Structural basis of ligand recognition at the human MT1 melatonin receptor

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    24 Apr 2019 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda C. Johansson, John D. McCorvy, Nilkanth N Patel, Gye Won Han, Xi-Ping Huang, Cornelius Gati, Alexander Batyuk, Samuel T. Slocum, Andrii Ishchenko, Wolfgang Brehm, Thomas A. White, Nairie Michaelian, Caleb Alexander Madsen, Lan Zhu, Thomas D. Grant, Jessica M. Grandner, Anna Shiriaeva, Reid H. J. Olsen, Alexandra R. Tribo, Saïd Yous, Raymond C. Stevens, Uwe Weierstall, Vsevolod Katritch, Bryan L. Roth, Wei Liu, Vadim Cherezov

    http://dx.doi.org/10.1038/s41586-019-1141-3 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Stauch, B. et al., 2019. Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature. Available at: http://dx.doi.org/10.1038/s41586-019-1141-3. Benjamin Stauch and …

  5. XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

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    24 Apr 2019 | BioXFEL Publications | Contributor(s): Linda C. Johansson, Benjamin Stauch, John D. McCorvy, Gye Won Han, Nilkanth N Patel, Xi-Ping Huang, Alexander Batyuk, Cornelius Gati, Samuel T. Slocum, Chufeng Li, Jessica M. Grandner, Shuming Hao, Reid H. J. Olsen, Alexandra R. Tribo, Sahba Zaare, Lan Zhu, Nadia Zatsepin, Uwe Weierstall, Saïd Yous, Raymond C. Stevens, Wei Liu, Bryan L. Roth, Vsevolod Katritch, Vadim Cherezov

    http://dx.doi.org/10.1038/s41586-019-1144-0 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Johansson, L.C. et al., 2019. XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity. Nature. Available at: http://dx.doi.org/10.1038/s41586-019-1144-0. …

  6. The Single Particles, Clusters and Biomolecules and Serial Femtosecond Crystallography instrument of the European XFEL: initial installation

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    12 Apr 2019 | BioXFEL Publications | Contributor(s): Adrian P. Mancuso, Andrew Aquila, Lewis Batchelor, Richard J. Bean, Johan Bielecki, Gannon Borchers, Katerina Doerner, Klaus Giewekemeyer, Rita Graceffa, Oliver D. Kelsey, Yoonhee Kim, Henry J. Kirkwood, Alexis Legrand, Romain Letrun, Bradley Manning, Luis Lopez Morillo, Marc Messerschmidt, Grant Mills, Steffen Raabe, Nadja Reimers, Adam Round, Tokushi Sato, Joachim Schulz, Cedric Signe Takem, Marcin Sikorski, Stephan Stern, Prasad Thute, Patrik Vagovič, Britta Weinhausen, Thomas Tschentscher

    http://dx.doi.org/10.1107/s1600577519003308 The European X-ray Free-Electron Laser (FEL) became the first operational high-repetition-rate hard X-ray FEL with first lasing in May 2017. Biological structure determination has already benefitted from the unique properties and capabilities of X-ray …

  7. High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source

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    04 Apr 2019 | BioXFEL Publications | Contributor(s): Jose M. Martin-Garcia, Lan Zhu, Derek Mendez, Ming-Yue Lee, Eugene Chun, Chufeng Li, Hao Hu, GANESH SUBRAMANIAN, David Kissick, Craig Ogata, Robert Henning, Andrii Ishchenko, Zachary Dobson, Shangji Zhang, Uwe Weierstall, John Spence, Petra Fromme, Nadia Zatsepin, Robert F. Fischetti, Vadim Cherezov, Wei Liu

    http://dx.doi.org/10.1107/s205225251900263x Since the first successful serial crystallography (SX) experiment at a synchrotron radiation source, the popularity of this approach has continued to grow showing that third-generation synchrotrons can be viable alternatives to scarce X-ray free-electron …

  8. Serial Femtosecond X-Ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature

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    04 Apr 2019 | BioXFEL Publications | Contributor(s): Halil I Ciftci, Raymond G Sierra, Chun Yoon, Zhen Su, Hiroshi Tateishi, Ryoko Koga, Koiwai Kotaro, Fumiaki Yumoto, Toshiya Senda, Mengling Liang, Soichi Wakatsuki, Masami Otsuka, Mikako Fujita, Hasan Demirci

    http://dx.doi.org/10.3390/ijms20071675 The Human immunodeficiency virus-1 (HIV-1) matrix (MA) domain is involved in the highly regulated assembly process of the virus particles that occur at the host cell’s plasma membrane. High-resolution structures of the MA domain determined using cryo X-ray …

  9. DENSS: Ab Initio Electron Density Maps from Biological SAXS Data

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    20 Mar 2019 | Seminars | Contributor(s): Thomas Grant

    Small angle scattering is an experimental technique used to analyze the molecular structures of a wide variety of biological and non-biological samples in solution. In contrast to X-ray crystallography and cryo-electron microscopy, where 3D electron density maps are calculated, available methods …

  10. Generalized Born Implicit Solvent Models for Biomolecules

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    11 Mar 2019 | BioXFEL Publications | Contributor(s): Alexey V. Onufriev, David Case

    http://dx.doi.org/10.1146/annurev-biophys-052118-115325 It would often be useful in computer simulations to use an implicit description of solvation effects, instead of explicitly representing the individual solvent molecules. Continuum dielectric models often work well in describing the …

  11. Protein and RNA dynamical fingerprinting

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    04 Mar 2019 | BioXFEL Publications | Contributor(s): Katherine A. Niessen, Mengyang Xu, Deepu K. George, Michael C. Chen, Adrian R. Ferré-D’Amaré, Edward Snell, Vivian Cody, James Pace, Marius Schmidt, Andrea Markelz

    http://dx.doi.org/10.1038/s41467-019-08926-3 journal-article Niessen, K.A. et al., 2019. Protein and RNA dynamical fingerprinting. Nature Communications, 10(1). Available at: http://dx.doi.org/10.1038/s41467-019-08926-3. Katherine A. Niessen and Mengyang Xu and Deepu K. George and Michael C. …

  12. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data

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    01 Mar 2019 | BioXFEL Publications

    http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.pdf component Shi, Y. et al., 2019. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data. Available at: http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.pdf. Yingchen Shi and Ke Yin and …

  13. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data

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    01 Mar 2019 | BioXFEL Publications | Contributor(s): Yingchen Shi, Ke Yin, Xuecheng Tai, Hasan Demirci, Ahmad Hosseinizadeh, Brenda Hogue, Haoyuan Li, Abbas Ourmazd, Peter Schwander, Ivan A. Vartanyants, Chun Hong Yoon, Andrew Aquila, Haiguang Liu

    http://dx.doi.org/10.1107/s2052252519001854 Using X-ray free-electron lasers (XFELs), it is possible to determine three-dimensional structures of nanoscale particles using single-particle imaging methods. Classification algorithms are needed to sort out the single-particle diffraction patterns from …

  14. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data

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    01 Mar 2019 | BioXFEL Publications

    http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.docx component Shi, Y. et al., 2019. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data. Available at: http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.docx. Yingchen Shi and Ke Yin and …

  15. Shape transform phasing of edgy nanocrystals

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    28 Feb 2019 | BioXFEL Publications | Contributor(s): J. P. J. Chen, J. J. Donatelli, K. E. Schmidt, R. A. Kirian

    http://dx.doi.org/10.1107/s205327331900113x Diffraction patterns from small protein crystals illuminated by highly coherent X-rays often contain measurable interference signals between Bragg peaks. This coherent `shape transform' signal introduces enough additional information to allow the …

  16. The Macromolecular Femtosecond Crystallography Instrument at the Linac Coherent Light Source

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    22 Feb 2019 | BioXFEL Publications | Contributor(s): Raymond G. Sierra, Alexander Batyuk, Zhibin Sun, Andrew Aquila, Mark S. Hunter, Thomas J. Lane, Mengning Liang, Chun Hong Yoon, Roberto Alonso-Mori, Rebecca Armenta, Jean-Charles Castagna, Michael Hollenbeck, Ted O. Osier, Matt Hayes, Jeff Aldrich, Robin Curtis, Jason E. Koglin, Theodore Rendahl, Evan Rodriguez, Sergio Carbajo, Serge Guillet, Rob Paul, Philip Hart, Kazutaka Nakahara, Gabriella Carini, Hasan Demirci, E. Han Dao, Brandon Hayes, Yashas P. Rao, Matthieu Chollet, Yiping Feng, Franklin D. Fuller, Christopher Kupitz, Takahiro Sato, Matthew H. Seaberg, Sanghoon Song, Tim B. Van Driel, Hasan Yavas, Diling Zhu, Aina E. Cohen, Soichi Wakatsuki, Sébastien Boutet

    http://dx.doi.org/10.1107/s1600577519001577 The Macromolecular Femtosecond Crystallography (MFX) instrument at the Linac Coherent Light Source (LCLS) is the seventh and newest instrument at the world's first hard X-ray free-electron laser. It was designed with a primary focus on structural biology, …

  17. Following Folding Pathways of Common Riboswitch Motifs with Time-Resolved Single-Molecule FRET

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    15 Feb 2019 | BioXFEL Publications | Contributor(s): Alex Plumridge, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.1931 poster Plumridge, A. & Pollack, L., 2019. Following Folding Pathways of Common Riboswitch Motifs with Time-Resolved Single-Molecule FRET. Biophysical Journal, 116(3), p.355a. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.1931. Alex Plumridge …

  18. Time-Resolved Contrast Variation SAXS for Studying RNA-Protein Interactions

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    15 Feb 2019 | BioXFEL Publications | Contributor(s): Suzette A. Pabit, Andrea Katz, George Douglas Calvey, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.1733 poster Pabit, S.A. et al., 2019. Time-Resolved Contrast Variation SAXS for Studying RNA-Protein Interactions. Biophysical Journal, 116(3), p.319a–320a. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.1733. Suzette A. Pabit and Andrea M. Katz …

  19. DNA Sequence and Histone Core Composition Control the Unwrapping of DNA from Nucleosome Core Particles

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    15 Feb 2019 | BioXFEL Publications | Contributor(s): Alex Mauney, Joshua Tokuda, Yujie Chen, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.1179 poster Mauney, A. et al., 2019. DNA Sequence and Histone Core Composition Control the Unwrapping of DNA from Nucleosome Core Particles. Biophysical Journal, 116(3), p.214a. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.1179. Alex Mauney and …

  20. Virus Dynamics Studied by Time-Resolved Small Angle X-Ray Scattering

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    15 Feb 2019 | BioXFEL Publications | Contributor(s): Josue San Emeterio, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.2321 journal-article San Emeterio, J., & Pollack, L. (2019). Virus Dynamics Studied by Time-Resolved Small Angle X-Ray Scattering. Biophysical Journal, 116(3), 431a. https://doi.org/10.1016/j.bpj.2018.11.2321 Josue San Emeterio and Lois Pollack

  21. A novel form of allosteric regulation in Bacillus subtilis ribonucleotide reductase revealed by SAXS and cryo-electron microscopy

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    05 Feb 2019 | BioXFEL Publications | Contributor(s): William C. Thomas, Frederick P. Brooks, Mackenzie J. Parker, David Case, Jason T. Kaelber, JoAnne Stubbe, James Chen, Nozomi Ando

    http://dx.doi.org/10.1107/s0108767318099142 journal-article Thomas, W. C., Brooks, F. P., Parker, M. J., Case, D. A., Kaelber, J. T., Stubbe, J., Chen, J., & Ando, N. (2018). A novel form of allosteric regulation in Bacillus subtilis ribonucleotide reductase revealed by SAXS and cryo-electron …

  22. Separation Phenomena in Tailored Micro- and Nanofluidic Environments

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    30 Jan 2019 | BioXFEL Publications | Contributor(s): Mukul Sonker, Daihyun Kim, Ana Egatz-Gomez, Alexandra Ros

    http://dx.doi.org/10.1146/annurev-anchem-061417-125758 journal-article Sonker, M. et al., 2019. Separation Phenomena in Tailored Micro- and Nanofluidic Environments. Annual Review of Analytical Chemistry, 12(1). Available at: http://dx.doi.org/10.1146/annurev-anchem-061417-125758. Mukul Sonker …

  23. Cysteine modification can gate non-equilibrium conformational dynamics during enzyme catalysis: Supplemental Information

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    19 Jan 2019 | BioXFEL Publications | Contributor(s): Medhanjali DasGupta, Dominik Budday, Peter Madzelan, Javier Seravalli, Brandon Hayes, Raymond G. Sierra, Roberto Alonso-Mori, Aaron S. Brewster, Nicholas K. Sauter, Gregory A. Applegate, Virendra Tiwari, David B. Berkowitz, Michael Thompson, James Fraser, Michael E. Wall, Henry Van Den Bedem, Mark A. Wilson

    http://dx.doi.org/10.1101/524751 Post-translational modification of cysteine residues can regulate protein function and is essential for catalysis by cysteine-dependent enzymes. Covalent modifications neutralize charge on the reactive cysteine thiolate anion and thus alter the active site …

  24. Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The “Undoing” of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network

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    15 Jan 2019 | BioXFEL Publications | Contributor(s): Shenshen Hu, Adam R. Offenbacher, Erin M. Thompson, Christine L. Gee, Jarett Wilcoxen, Cody A. M. Carr, Daniil M. Prigozhin, Vanessa Yang, Tom Alber, R. David Britt, James Fraser, Judith P. Klinman

    http://dx.doi.org/10.1021/jacs.8b10992 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Hu, S. et al., 2019. Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The “Undoing” of Precise Substrate Positioning Relative to Metal Cofactor and an …

  25. The Catalytic Cycle of Water Oxidation in Crystallized Photosystem II Complexes: Performance and Requirements for Formation of Intermediates

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    04 Jan 2019 | BioXFEL Publications | Contributor(s): Gennady Ananyev, Shatabdi Roy-Chowdhury, Colin Gates, Petra Fromme, G. Charles Dismukes

    http://dx.doi.org/10.1021/acscatal.8b04513 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Ananyev, G. et al., 2019. The Catalytic Cycle of Water Oxidation in Crystallized Photosystem II Complexes: Performance and Requirements for Formation of Intermediates. ACS Catalysis, …

  26. SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response

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    02 Jan 2019 | BioXFEL Publications | Contributor(s): Shi-chun Du, Lan Zhu, Yu-xing Wang, Jie Liu, Die Zhang, Yu-lu Chen, Qing Peng, Wei Liu, Bin Liu

    http://dx.doi.org/10.1186/s12935-018-0722-9 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Du, S. et al., 2019. SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response. Cancer Cell International, 19(1). Available at: …

  27. Phasing Serial Crystallography Data

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    27 Dec 2018 | BioXFEL Publications | Contributor(s): Richard Kirian, Joe Chen, John Spence

    http://dx.doi.org/10.1007/978-3-030-00551-1_8 book-chapter NSF-STC Biology with X-ray Lasers (NSF-1231306) Kirian, R.A., Chen, J.P.J. & Spence, J.C.H., 2018. Phasing Serial Crystallography Data. X-ray Free Electron Lasers, pp.235–252. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1_8. …

  28. Advances in Structure Determination of G Protein-Coupled Receptors by SFX

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    27 Dec 2018 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda Johansson, Andrii Ishchenko, Gye Won Han, Alexander Batyuk, Vadim Cherezov

    http://dx.doi.org/10.1007/978-3-030-00551-1_10 book-chapter Stauch, B. et al., 2018. Advances in Structure Determination of G Protein-Coupled Receptors by SFX. X-ray Free Electron Lasers, pp.301–329. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1_10. Benjamin Stauch and Linda …

  29. Small Is Beautiful: Growth and Detection of Nanocrystals

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    27 Dec 2018 | BioXFEL Publications | Contributor(s): Jesse David Coe, Alexandra Ros

    http://dx.doi.org/10.1007/978-3-030-00551-1_3 book-chapter Coe, J. & Ros, A., 2018. Small Is Beautiful: Growth and Detection of Nanocrystals. X-ray Free Electron Lasers, pp.59–85. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1_3. Jesse Coe and Alexandra Ros

  30. X-ray Free Electron Lasers

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    27 Dec 2018 | BioXFEL Publications

    http://dx.doi.org/10.1007/978-3-030-00551-1 book Boutet, S., Fromme, P. & Hunter, M.S. eds., 2018. X-ray Free Electron Lasers. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1.

  31. Ab initio phasing of the diffraction of crystals with translational disorder

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    20 Dec 2018 | BioXFEL Publications | Contributor(s): Andrew J. Morgan, Kartik Ayyer, Anton Barty, Joe Chen, Tomas Ekeberg, Dominik Oberthuer, Thomas A. White, Oleksandr Yefanov, Henry Chapman

    http://dx.doi.org/10.1107/s2053273318015395 To date X-ray protein crystallography is the most successful technique available for the determination of high-resolution 3D structures of biological molecules and their complexes. In X-ray protein crystallography the structure of a protein is refined …

  32. X-ray Emission Spectroscopy at X-ray Free Electron Lasers: Limits to Observation of the Classical Spectroscopic Response for Electronic Structure Analysis

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    19 Dec 2018 | BioXFEL Publications | Contributor(s): Scott C. Jensen, Brendan Sullivan, Daniel A. Hartzler, Jose Meza Aguilar, Salah Awel, Saša Bajt, Shibom Basu, Richard Bean, Henry Chapman, Chelsie E Conrad, Matthias Frank, Raimund Fromme, Jose M. Martin-Garcia, Thomas D. Grant, Michael Heymann, Mark S. Hunter, Gihan Kaushylal Ketawala, Richard Kirian, Juraj Knoska, Christopher Kupitz, Xuanxuan Li, Mengning Liang, Stella Lisova, Valerio Mariani, Victoria Mazalova, Marc Messerschmidt, Michael Moran, Garrett Charles Nelson, Dominik Oberthür, Alex Schaffer, Raymond G. Sierra, Natalie Vaughn, Uwe Weierstall, Max Oliver Wiedorn, P. Lourdu Xavier, Jay-How Yang, Oleksandr Yefanov, Nadia Zatsepin, Andrew Aquila, Petra Fromme, Sébastien Boutet, Gerald T. Seidler, Yulia Pushkar

    http://dx.doi.org/10.1021/acs.jpclett.8b03595 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Jensen, S.C. et al., 2019. X-ray Emission Spectroscopy at X-ray Free Electron Lasers: Limits to Observation of the Classical Spectroscopic Response for Electronic Structure Analysis. The …

  33. A generalized parametric divisor method for political apportionment

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    14 Dec 2018 | BioXFEL Publications | Contributor(s): Tatsuo Oyama, Nicholas G. Hall, Kazuhiro Kobayashi

    http://dx.doi.org/10.1111/itor.12622 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Oyama, T., Hall, N.G. & Kobayashi, K., 2018. A generalized parametric divisor method for political apportionment. International Transactions in Operational Research, 28(1), pp.327–355. Available …

  34. SPIND: a reference-based auto-indexing algorithm for sparse serial crystallography data

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    10 Dec 2018 | BioXFEL Publications | Contributor(s): Chufeng Li, Xuanxuan Li, Richard Kirian, John Spence, Haiguang Liu, Nadia Zatsepin

    http://dx.doi.org/10.1107/s2052252518014951 SPIND (sparse-pattern indexing) is an auto-indexing algorithm for sparse snapshot diffraction patterns (`stills') that requires the positions of only five Bragg peaks in a single pattern, when provided with unit-cell parameters. The …

  35. Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor

    0.0 out of 5 stars 

    29 Nov 2018 | BioXFEL Publications | Contributor(s): Martin Audet, Kate L. White, Billy Breton, Barbara Zarzycka, Gye Won Han, Yan Lu, Cornelius Gati, Alexander Batyuk, Petr Popov, Jeffrey Velasquez, David Manahan, Hao Hu, Uwe Weierstall, Wei Liu, Wenqing Shui, Vsevolod Katritch, Vadim Cherezov, Michael A. Hanson, Raymond C. Stevens

    http://dx.doi.org/10.1038/s41589-018-0160-y journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Audet, M. et al., 2018. Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor. Nature Chemical Biology, 15(1), pp.11–17. Available at: …

  36. Dielectrophoresis: From molecular to micrometer scale analytes

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    27 Nov 2018 | BioXFEL Publications | Contributor(s): Daihyun Kim, Mukul Sonker, Alexandra Ros

    http://dx.doi.org/10.1021/acs.analchem.8b05454 journal-article Kim, D., Sonker, M. & Ros, A., 2018. Dielectrophoresis: From molecular to micrometer scale analytes. Analytical Chemistry. Available at: http://dx.doi.org/10.1021/acs.analchem.8b05454. Daihyun Kim and Mukul Sonker and Alexandra Ros

  37. Synthesis, structure, docking and cytotoxic studies of ferrocene–hormone conjugates for hormone-dependent breast cancer application

    0.0 out of 5 stars 

    22 Nov 2018 | BioXFEL Publications | Contributor(s): José A. Carmona-Negrón, Alberto Santana, Arnold L. Rheingold, Enrique Meléndez

    http://dx.doi.org/10.1039/c8dt01856a Ferrocene–estrogen conjugates can be recognized by ERα, suggesting that estrogens could serve as vectors to target specifically breast cancer cell lines. journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Carmona-Negrón, J.A. et al., 2019. …

  38. Conformations of an RNA Helix-Junction-Helix Construct revealed by SAXS Refinement of MD Simulations

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    22 Nov 2018 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Tongsik Lee, Ron Elber, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.020 journal-article Chen, Y.-L. et al., 2018. Conformations of an RNA Helix-Junction-Helix Construct revealed by SAXS Refinement of MD Simulations. Biophysical Journal. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.020. Yen-Lin Chen and Tongsik Lee …

  39. Temperature-Jump Solution X-ray Scattering Reveals Distinct Motions in a Dynamic Enzyme:

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    22 Nov 2018 | BioXFEL Publications | Contributor(s): Michael Thompson, Benjamin A Barad, Alexander M Wolff, Hyun Sun Cho, Friedrich Schotte, Daniel M.C. Schwarz, Philip Anfinrud, James Fraser

    http://dx.doi.org/10.1101/476432 Correlated motions of proteins and their bound solvent molecules are critical to function, but these features are difficult to resolve using traditional structure determination techniques. Time-resolved methods hold promise for addressing this challenge but have …

  40. qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps

    0.0 out of 5 stars 

    20 Nov 2018 | BioXFEL Publications | Contributor(s): Gydo C. P. Van Zundert, Brandi M. Hudson, Saulo H. P. De Oliveira, Daniel A. Keedy, Rasmus Fonseca, Amelie Heliou, Pooja Suresh, Kenneth Borrelli, Tyler Day, James Fraser, Henry Van Den Bedem

    http://dx.doi.org/10.1021/acs.jmedchem.8b01292 journal-article Van Zundert, G. et al., 2018. qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps. Journal of Medicinal Chemistry. Available at: …

  41. Structure-factor amplitude reconstruction from serial femtosecond crystallography of two-dimensional membrane-protein crystals

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    12 Nov 2018 | BioXFEL Publications | Contributor(s): Cecilia M. Casadei, Karol Nass, Anton Barty, Mark S. Hunter, Celestino Padeste, Ching-Ju Tsai, Sébastien Boutet, Marc Messerschmidt, Leonardo Sala, Garth J. Williams, Dmitry Ozerov, Matthew Coleman, Xiao-Dan Li, Matthias Frank, Bill Pedrini

    http://dx.doi.org/10.1107/s2052252518014641 Serial femtosecond crystallography of two-dimensional membrane-protein crystals at X-ray free-electron lasers has the potential to address the dynamics of functionally relevant large-scale motions, which can be sterically hindered in three-dimensional …

  42. Cryptic binding sites become accessible through surface reconstruction of the type I collagen fibril

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    05 Nov 2018 | BioXFEL Publications | Contributor(s): Jie Zhu, Cody L. Hoop, David Case, Jean Baum

    http://dx.doi.org/10.1038/s41598-018-34616-z journal-article Zhu, J. et al., 2018. Cryptic binding sites become accessible through surface reconstruction of the type I collagen fibril. Scientific Reports, 8(1). Available at: http://dx.doi.org/10.1038/s41598-018-34616-z. Jie Zhu and Cody L. Hoop …

  43. Serial Femtosecond Crystallography at Megahertz pulse rates

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    09 Oct 2018 | BioXFEL Publications | Contributor(s): M.O. Wiedorn, D. Oberthuer, A. Barty, H.N. Chapman

    http://dx.doi.org/10.2210/pdb6ftr/pdb component NSF-STC Biology with X-ray Lasers (NSF-1231306) Wiedorn, M.O. et al., 2018. Serial Femtosecond Crystallography at Megahertz pulse rates. Available at: http://dx.doi.org/10.2210/pdb6ftr/pdb. M.O. Wiedorn and D. Oberthuer and A. Barty and H.N. Chapman

  44. How the Conformations of an Internal Junction Contribute to Fold an RNA Domain

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    04 Oct 2018 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Julie L. Sutton, Lois Pollack

    http://dx.doi.org/10.1021/acs.jpcb.8b07262 journal-article Chen, Y.-L., Sutton, J.L. & Pollack, L., 2018. How the Conformations of an Internal Junction Contribute to Fold an RNA Domain. The Journal of Physical Chemistry B. Available at: http://dx.doi.org/10.1021/acs.jpcb.8b07262. Yen-Lin Chen …

  45. Free-electron laser data for multiple-particle fluctuation scattering analysis

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    02 Oct 2018 | BioXFEL Publications | Contributor(s): Kanupriya Pande, Jeffrey J. Donatelli, Erik Malmerberg, Lutz Foucar, Billy K. Poon, Markus Sutter, Sabine Botha, Shibom Basu, R. Bruce Doak, Katerina Dörner, Sascha W. Epp, Lars Englert, Raimund Fromme, Elisabeth Hartmann, Robert Hartmann, Guenter Hauser, Johan Hattne, Ahmad Hosseinizadeh, Stephan Kassemeyer, Lukas Lomb, Sebastian F. Carron Montero, Andreas Menzel, Daniel Rolles, Artem Rudenko, Marvin M. Seibert, Raymond George Sierra, Peter Schwander, Abbas Ourmazd, Petra Fromme, Nicholas K. Sauter, Michael Bogan, John Bozek, Christoph Bostedt, Ilme Schlichting, Cheryl A. Kerfeld, Petrus H. Zwart

    http://dx.doi.org/10.1038/sdata.2018.201 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Pande, K. et al., 2018. Free-electron laser data for multiple-particle fluctuation scattering analysis. Scientific Data, 5, p.180201. Available at: http://dx.doi.org/10.1038/sdata.2018.201. …

  46. Divalent ions tune the kinetics of a bacterial GTPase center rRNA folding transition from secondary to tertiary structure

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    25 Sep 2018 | BioXFEL Publications | Contributor(s): Robb Welty, Suzette A. Pabit, Andrea Katz, George Douglas Calvey, Lois Pollack, Kathleen B. Hall

    http://dx.doi.org/10.1261/rna.068361.118 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Welty, R. et al., 2018. Divalent ions tune the kinetics of a bacterial GTPase center rRNA folding transition from secondary to tertiary structure. RNA, 24(12), pp.1828–1838. Available at: …

  47. Single-particle imaging without symmetry constraints at an X-ray free-electron laser

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    21 Sep 2018 | BioXFEL Publications | Contributor(s): Max Rose, Sergey Bobkov, Kartik Ayyer, Ruslan P. Kurta, Dmitry Dzhigaev, Young Yong Kim, Andrew J. Morgan, Chun Hong Yoon, Daniel Westphal, Johan Bielecki, Jonas A. Sellberg, Garth Williams, Filipe R.N.C. Maia, Olexander M. Yefanov, Vyacheslav Ilyin, Adrian P. Mancuso, Henry Chapman, Brenda Hogue, Andrew Aquila, Anton Barty, Ivan A. Vartanyants

    http://dx.doi.org/10.1107/s205225251801120x/it5017sup9.mp4 component Rose, M. et al., 2018. Single-particle imaging without symmetry constraints at an X-ray free-electron laser. Available at: http://dx.doi.org/10.1107/s205225251801120x/it5017sup9.mp4. Max Rose and Sergey Bobkov and Kartik Ayyer …

  48. Biological Small Angle Scattering

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    20 Sep 2018 | BioXFEL Publications | Contributor(s): Eaton E Lattman, Thomas D. Grant, Edward Snell

    http://dx.doi.org/10.1093/oso/9780199670871.001.0001 The technique of small angle solution scattering has been revolutionized in the last two decades. Exponential increases in computing power, parallel algorithm development, and the development of synchrotron, free-electron X-ray sources, and …

  49. Examples of Biological Small Angle Scattering

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    20 Sep 2018 | BioXFEL Publications | Contributor(s): Eaton E Lattman, Thomas D. Grant, Edward Snell

    http://dx.doi.org/10.1093/oso/9780199670871.003.0012 In this chapter we illustrate the biological applications of small angle scattering. We cover examples of contrast matching has been used in the neutron case and with SAXS,. time-resolved studies that have helped reveal mechanism and how SAXS or …

  50. Single-particle imaging without symmetry constraints at an X-ray free-electron laser

    0.0 out of 5 stars 

    18 Sep 2018 | BioXFEL Publications | Contributor(s): Max Rose, Sergey Bobkov, Kartik Ayyer, Ruslan P. Kurta, Dmitry Dzhigaev, Young Yong Kim, Andrew J. Morgan, Chun Hong Yoon, Daniel Westphal, Johan Bielecki, Jonas A. Sellberg, Garth Williams, Filipe R.N.C. Maia, Olexander M. Yefanov, Vyacheslav Ilyin, Adrian P. Mancuso, Henry Chapman, Brenda Hogue, Andrew Aquila, Anton Barty, Ivan A. Vartanyants

    http://dx.doi.org/10.1107/s205225251801120x The analysis of a single-particle imaging (SPI) experiment performed at the AMO beamline at LCLS as part of the SPI initiative is presented here. A workflow for the three-dimensional virus reconstruction of the PR772 bacteriophage from measured …

  51. Rayleigh-scattering microscopy for tracking and sizing nanoparticles in focused aerosol beams

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    11 Sep 2018 | BioXFEL Publications | Contributor(s): Max F. Hantke, Johan Bielecki, Olena Kulyk, Daniel Westphal, Daniel S. D. Larsson, Martin Svenda, Hemanth K. N. Reddy, Richard Kirian, Jakob Andreasson, Janos Hajdu, Filipe R. N. C. Maia

    http://dx.doi.org/10.1107/s2052252518010837 Ultra-bright femtosecond X-ray pulses generated by X-ray free-electron lasers (XFELs) can be used to image high-resolution structures without the need for crystallization. For this approach, aerosol injection has been a successful method to deliver …

  52. A New Approach to Signal Processing of Spatiotemporal Data

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    07 Sep 2018 | BioXFEL Publications | Contributor(s): Joanna Slawinska, Abbas Ourmazd, Dimitrios Giannakis

    http://dx.doi.org/10.1109/ssp.2018.8450704 proceedings-article Slawinska, J., Ourmazd, A. & Giannakis, D., 2018. A New Approach to Signal Processing of Spatiotemporal Data. 2018 IEEE Statistical Signal Processing Workshop (SSP). Available at: http://dx.doi.org/10.1109/ssp.2018.8450704. Joanna …

  53. The phase problem for two-dimensional crystals. II. Simulations

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    03 Sep 2018 | BioXFEL Publications | Contributor(s): Romain D. Arnal, Yun Zhao, Alok K. Mitra, John Spence, Rick P. Millane

    http://dx.doi.org/10.1107/s2053273318008707 Phasing of diffraction data from two-dimensional crystals using only minimal molecular envelope information is investigated by simulation. Two-dimensional crystals are an attractive target for studying membrane proteins using X-ray free-electron lasers, …

  54. Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway

    0.0 out of 5 stars 

    29 Aug 2018 | BioXFEL Publications | Contributor(s): Thibault Annaval, Lu Han, Jeffrey D. Rudolf, Guangbo Xie, Dong Yang, Chin-Yuan Chang, Ming Ma, Ivana Crnovcic, Mitchell Miller, Jayashree Soman, Weijun Xu, George Phillips, Ben Shen

    http://dx.doi.org/10.1021/acschembio.8b00673 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Annaval, T. et al., 2018. Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway. ACS Chemical Biology, …

  55. Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome

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    29 Aug 2018 | BioXFEL Publications | Contributor(s): Nicole C. Woitowich, Andrei S. Halavaty, Patricia Waltz, Christopher Kupitz, Joseph Valera, Gregory Tracy, Kevin D. Gallagher, Elin Claesson, Takanori Nakane, Suraj Pandey, Garrett Charles Nelson, Rie Tanaka, Eriko Nango, Eiichi Mizohata, Shigeki Owada, Kensure Tono, Yasumasa Joti, Angela C. Nugent, Hardik Patel, Ayesha Mapara, James Hopkins, Phu Duong, Dorina Bizhga, Svetlana E. Kovaleva, Rachael St. Peter, Cynthia N. Hernandez, Wesley B. Ozarowski, Shatabdi Roy-Chowdhuri, Jay-How Yang, Petra Edlund, Heikki Takala, Janne Ihalainen, Jennifer Brayshaw, Tyler Norwood, Ishwor Poudyal, Petra Fromme, John Spence, Keith Moffat, Sebastian Westenhoff, Marius Schmidt, Emina A. Stojković

    http://dx.doi.org/10.1107/s2052252518010631 Phytochromes are red-light photoreceptors that were first characterized in plants, with homologs in photosynthetic and non-photosynthetic bacteria known as bacteriophytochromes (BphPs). Upon absorption of light, BphPs interconvert between two states …

  56. Structure of the 30S ribosomal decoding complex at ambient temperature

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    23 Aug 2018 | BioXFEL Publications | Contributor(s): E. Han Dao, Frédéric Poitevin, Raymond G. Sierra, Cornelius Gati, Yashas Rao, Halil Ibrahim Ciftci, Fulya Akşit, Alex McGurk, Trevor Obrinski, Paul Mgbam, Brandon Hayes, Casper De Lichtenberg, Fatima Pardo-Avila, Nicholas Corsepius, Lindsey Zhang, Matthew H. Seaberg, Mark S. Hunter, Mengling Liang, Jason E. Koglin, Soichi Wakatsuki, Hasan Demirci

    http://dx.doi.org/10.1261/rna.067660.118 The ribosome translates nucleotide sequences of messenger RNA to proteins through selection of cognate transfer RNA according to the genetic code. To date, structural studies of ribosomal decoding complexes yielding high-resolution data have predominantly …

  57. Megahertz data collection from protein microcrystals at an X-ray free-electron laser

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    22 Aug 2018 | BioXFEL Publications | Contributor(s): Marie Luise Grünbein, Johan Bielecki, Alexander Gorel, Miriam Stricker, Richard Bean, Marco Cammarata, Katerina Dörner, Lars Fröhlich, Elisabeth Hartmann, Steffen Hauf, Mario Hilpert, Yoonhee Kim, Marco Kloos, Romain Letrun, Marc Messerschmidt, Grant Mills, Gabriela Nass Kovacs, Marco Ramilli, Christopher M. Roome, Tokushi Sato, Matthias Scholz, Michel Sliwa, Jolanta Sztuk-Dambietz, Martin Weik, Britta Weinhausen, Nasser Al-Qudami, Djelloul Boukhelef, Sandor Brockhauser, Wajid Ehsan, Moritz Emons, Sergey Esenov, Hans Fangohr, Alexander Kaukher, Thomas Kluyver, Max Lederer, Luis Maia, Maurizio Manetti, Thomas Michelat, Astrid Münnich, Florent Pallas, Guido Palmer, Gianpietro Previtali, Natascha Raab, Alessandro Silenzi, Janusz Szuba, Sandhya Venkatesan, Krzysztof Wrona, Jun Zhu, R. Bruce Doak, Robert L. Shoeman, Lutz Foucar, Jacques-Philippe Colletier, Adrian P. Mancuso, Thomas R. M. Barends, Claudiu A. Stan, Ilme Schlichting

    http://dx.doi.org/10.1038/s41467-018-05953-4 journal-article Grünbein, M.L. et al., 2018. Megahertz data collection from protein microcrystals at an X-ray free-electron laser. Nature Communications, 9(1). Available at: http://dx.doi.org/10.1038/s41467-018-05953-4. Marie Luise Grünbein and …

  58. Scanning Compton X-ray Microscopy

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    10 Aug 2018 | BioXFEL Publications | Contributor(s): Pablo Villanueva-Perez, Sasa Bajt, Henry Chapman

    http://dx.doi.org/10.1017/s1431927618013259 journal-article Villanueva-Perez, P., Bajt, S. & Chapman, H.N., 2018. Scanning Compton X-ray Microscopy. Microscopy and Microanalysis, 24(S2), pp.182–183. Available at: http://dx.doi.org/10.1017/s1431927618013259. Pablo Villanueva-Perez and Sasa Bajt …

  59. Characterization of High Numerical Aperture Multilayer Laue Lenses

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    10 Aug 2018 | BioXFEL Publications | Contributor(s): Kevin T. Murray, Andrew J. Morgan, Mauro Prasciolu, Istvan Mohacsi, Henry Chapman, Saša Bajt

    http://dx.doi.org/10.1017/s1431927618013740 journal-article Murray, K.T. et al., 2018. Characterization of High Numerical Aperture Multilayer Laue Lenses. Microscopy and Microanalysis, 24(S2), pp.282–283. Available at: http://dx.doi.org/10.1017/s1431927618013740. Kevin T. Murray and Andrew J. …

  60. Developments Towards Imaging Nanoscale Biology with XFELs: Some Recent Examples and a Glance to the Future

    0.0 out of 5 stars 

    10 Aug 2018 | BioXFEL Publications | Contributor(s): Adrian P. Mancuso, Andrew Aquila, Richard Bean, Johan Bielecki, Carsten Fortmann-Grote, Klaus Giewekemeyer, Yoonhee Kim, Ruslan Kurta, Romain Letrun, Masoud Mehrjoo, Marc Messerschmidt, Grant Mills, Adam Round, Tokushi Sato, Joachim Schulz, Marcin Sikorski, Stephan Stern, Patrik Vagovic, Thomas Tschentscher

    http://dx.doi.org/10.1017/s143192761801276x journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Mancuso, A.P. et al., 2018. Developments Towards Imaging Nanoscale Biology with XFELs: Some Recent Examples and a Glance to the Future. Microscopy and Microanalysis, 24(S2), pp.76–77. …

  61. De novo protein structure determination by heavy-atom soaking in lipidic cubic phase and SIRAS phasing using serial synchrotron crystallography

    0.0 out of 5 stars 

    08 Aug 2018 | BioXFEL Publications | Contributor(s): S. Botha, D. Baitan, K. E. J. Jungnickel, D. Oberthür, C. Schmidt, S. Stern, M. O. Wiedorn, M. Perbandt, H. N. Chapman, C. Betzel

    http://dx.doi.org/10.1107/s2052252518009223 During the past few years, serial crystallography methods have undergone continuous development and serial data collection has become well established at high-intensity synchrotron-radiation beamlines and XFEL radiation sources. However, the application …

  62. CAMP@FLASH: an end-station for imaging, electron- and ion-spectroscopy, and pump–probe experiments at the FLASH free-electron laser

    0.0 out of 5 stars 

    02 Aug 2018 | BioXFEL Publications | Contributor(s): Benjamin Erk, Jan P. Müller, Cédric Bomme, Rebecca Boll, Günter Brenner, Henry Chapman, Jonathan Correa, Stefan Düsterer, Siarhei Dziarzhytski, Stefan Eisebitt, Heinz Graafsma, Sören Grunewald, Lars Gumprecht, Robert Hartmann, Günter Hauser, Barbara Keitel, Clemens Von Korff Schmising, Marion Kuhlmann, Bastian Manschwetus, Laurent Mercadier, Erland Müller, Christopher Passow, Elke Plönjes, Daniel Ramm, Dimitrios Rompotis, Artem Rudenko, Daniela Rupp, Mario Sauppe, Frank Siewert, Dieter Schlosser, Lothar Strüder, Angad Swiderski, Simone Techert, Kai Tiedtke, Thomas Tilp, Rolf Treusch, Ilme Schlichting, Joachim Ullrich, Robert Moshammer, Thomas Möller, Daniel Rolles

    http://dx.doi.org/10.1107/s1600577518008585 The non-monochromatic beamline BL1 at the FLASH free-electron laser facility at DESY was upgraded with new transport and focusing optics, and a new permanent end-station, CAMP, was installed. This multi-purpose instrument is optimized for electron- and …

  63. Local DNA Sequence Controls Asymmetry of DNA Unwrapping from Nucleosome Core Particles

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    30 Jul 2018 | BioXFEL Publications | Contributor(s): Alexander W. Mauney, Joshua M. Tokuda, Lisa M. Gloss, Oscar Gonzalez, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.07.009 journal-article Mauney, A.W. et al., 2018. Local DNA Sequence Controls Asymmetry of DNA Unwrapping from Nucleosome Core Particles. Biophysical Journal. Available at: http://dx.doi.org/10.1016/j.bpj.2018.07.009. Alexander W. Mauney and Joshua M. Tokuda …

  64. Rapid sample delivery for megahertz serial crystallography at X-ray FELs

    0.0 out of 5 stars 

    27 Jul 2018 | BioXFEL Publications | Contributor(s): Max Oliver Wiedorn, Salah Awel, Andrew J. Morgan, Kartik Ayyer, Yaroslav Gevorkov, Holger Fleckenstein, Nils Roth, Luigi Adriano, Richard Bean, Kenneth R. Beyerlein, Joe Chen, Jesse David Coe, Francisco Cruz-Mazo, Tomas Ekeberg, Rita Graceffa, Michael Heymann, Daniel A. Horke, Juraj Knoška, Valerio Mariani, Reza Nazari, Dominik Oberthür, Amit K. Samanta, Raymond G. Sierra, Claudiu A. Stan, Oleksandr Yefanov, Dimitrios Rompotis, Jonathan Correa, Benjamin Erk, Rolf Treusch, Joachim Schulz, Brenda Hogue, Alfonso M. Gañán-Calvo, Petra Fromme, Jochen Küpper, Andrei V. Rode, Saša Bajt, Richard Kirian, Henry Chapman

    http://dx.doi.org/10.1107/s2052252518008369 Liquid microjets are a common means of delivering protein crystals to the focus of X-ray free-electron lasers (FELs) for serial femtosecond crystallography measurements. The high X-ray intensity in the focus initiates an explosion of the microjet and …

  65. BioXFEL Logos

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    25 Jul 2018 | Downloads | Contributor(s): Sean Kilcullen

    Three BioXFEL logos in PNG format

  66. BioXFEL PowerPoint Template

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    24 Jul 2018 | Downloads

    A PowerPoint template to be used for all BioXFEL presentations.

  67. BioXFEL Poster Template

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    23 Jul 2018 | Downloads

    Please use this template for all BioXFEL-related posters. This version has been updated to reflect the current requirements for the 2019 Annual conference.

  68. Solving protein structure from sparse serial microcrystal diffraction data at a storage-ring synchrotron source

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    20 Jul 2018 | BioXFEL Publications | Contributor(s): Ti-Yen Lan, Jennifer L. Wierman, Mark W. Tate, Hugh T. Philipp, Jose M. Martin-Garcia, Lan Zhu, David Kissick, Petra Fromme, Robert F. Fischetti, Wei Liu, Veit Elser, Sol M. Gruner

    http://dx.doi.org/10.1107/s205225251800903x In recent years, the success of serial femtosecond crystallography and the paucity of beamtime at X-ray free-electron lasers have motivated the development of serial microcrystallography experiments at storage-ring synchrotron sources. However, especially …

  69. Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature

    0.0 out of 5 stars 

    20 Jul 2018 | BioXFEL Publications | Contributor(s): Mary E O’Sullivan, Frédéric Poitevin, Raymond G Sierra, Cornelius Gati, E Han Dao, Yashas Rao, Fulya Aksit, Halilibrahim Ciftci, Nicholas Corsepius, Robert Greenhouse, Brandon Hayes, Mark S Hunter, Mengling Liang, Alex McGurk, Paul Mbgam, Trevor Obrinsky, Fátima Pardo-Avila, Matthew H Seaberg, Alan G Cheng, Anthony J Ricci, Hasan Demirci

    http://dx.doi.org/10.1093/nar/gky693 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) O’Sullivan, M.E. et al., 2018. Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature. Nucleic Acids Research, 46(18), pp.9793–9804. Available at: …

  70. Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature

    0.0 out of 5 stars 

    19 Jul 2018 | BioXFEL Publications | Contributor(s): Mary E. O'Sullivan, Frederic Poitevin, Raymond G. Sierra, Cornelius Gati, E. Han Dao, Yashas Rao, Fulya Aksit, Halilibrahim Ciftci, Nicholas Corsepius, Robert Greenhouse, Brandon Hayes, Mark S. Hunter, Mengling Liang, Alex McGurk, Paul Mbgam, Trevor Obrinsky, Fatima Pardo-Avila, Matt Seaberg, Alan G. Cheng, Anthony J. Ricci, Hasan Demirci

    http://dx.doi.org/10.1101/372144 The bacterial 30S ribosomal subunit is a primary antibiotic target. Despite decades of discovery, the mechanisms by which antibiotic binding induces ribosomal dysfunction are not fully understood. Ambient temperature crystallographic techniques allow more …

  71. Orientation and analysis of XFEL serial diffraction patterns from fibrous molecular assemblies

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    05 Jul 2018 | BioXFEL Publications | Contributor(s): David H. Wojtas, Kartik Ayyer, Mengning Liang, Estelle Mossou, Carolin Seuring, V. Trevor Forsyth, Henry Chapman, Rick P. Millane

    http://dx.doi.org/10.1109/ivcnz.2017.8402508 proceedings-article Wojtas, D.H. et al., 2017. Orientation and analysis of XFEL serial diffraction patterns from fibrous molecular assemblies. 2017 International Conference on Image and Vision Computing New Zealand (IVCNZ). Available at: …

  72. Simultaneous retrieval of coherently illuminated defocused objects

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    05 Jul 2018 | BioXFEL Publications | Contributor(s): Joe Chen, Richard Kirian

    http://dx.doi.org/10.1109/ivcnz.2017.8402481 proceedings-article Chen, J.P.J. & Kirian, R.A., 2017. Simultaneous retrieval of coherently illuminated defocused objects. 2017 International Conference on Image and Vision Computing New Zealand (IVCNZ). Available at: …

  73. Computational design of thermostabilizing point mutations for G protein-coupled receptors

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    21 Jun 2018 | BioXFEL Publications | Contributor(s): Petr Popov, Yao Peng, Ling Shen, Raymond C Stevens, Vadim Cherezov, Zhi-Jie Liu, Vsevolod Katritch

    http://dx.doi.org/10.7554/elife.34729 Engineering of GPCR constructs with improved thermostability is a key for successful structural and biochemical studies of this transmembrane protein family, targeted by 40% of all therapeutic drugs. Here we introduce a comprehensive computational approach to …

  74. Chapter 2. Delivery of GPCR Crystals for Serial Femtosecond Crystallography

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    19 Jun 2018 | BioXFEL Publications | Contributor(s): E. E. Abola, U. Weierstall, W. Liu, V. Cherezov

    http://dx.doi.org/10.1039/9781788010504-00028 book-chapter Abola, E.E. et al., Chapter 2. Delivery of GPCR Crystals for Serial Femtosecond Crystallography. Chemical Biology, pp.28–53. Available at: http://dx.doi.org/10.1039/9781788010504-00028. E. E. Abola and U. Weierstall and W. Liu and V. …

  75. Chapter 8. Crystallography with X-ray Free Electron Lasers

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    19 Jun 2018 | BioXFEL Publications | Contributor(s): N. A. Zatsepin

    http://dx.doi.org/10.1039/9781788010504-00181 book-chapter NSF-STC Biology with X-ray Lasers (NSF-1231306) Zatsepin, N.A., Chapter 8. Crystallography with X-ray Free Electron Lasers. Chemical Biology, pp.181–224. Available at: http://dx.doi.org/10.1039/9781788010504-00181. N. A. Zatsepin

  76. Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser

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    14 Jun 2018 | BioXFEL Publications | Contributor(s): Przemyslaw Nogly, Tobias Weinert, Daniel James, Sergio Carbajo, Dmitry Ozerov, Antonia Furrer, Dardan Gashi, Veniamin Borin, Petr Skopintsev, Kathrin Jaeger, Karol Nass, Petra Båth, Robert William Bosman, Jason Koglin, Matthew Seaberg, Thomas Lane, Demet Kekilli, Steffen Brünle, Tomoyuki Tanaka, Wenting Wu, Christopher Milne, Thomas White, Anton Barty, Uwe Weierstall, Valerie Panneels, Eriko Nango, So Iwata, Mark S. Hunter, Igor Schapiro, Gebhard F.X. Schertler, Richard Neutze, Jörg Standfuss

    http://dx.doi.org/10.1126/science.aat0094 journal-article Nogly, P. et al., 2018. Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser. Science, p.eaat0094. Available at: http://dx.doi.org/10.1126/science.aat0094. Przemyslaw Nogly and Tobias Weinert and Daniel James …

  77. An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

    0.0 out of 5 stars 

    06 Jun 2018 | BioXFEL Publications | Contributor(s): Daniel A Keedy, Zachary B Hill, Justin T Biel, Emily Kang, T Justin Rettenmaier, José Brandão-Neto, Nicholas M Pearce, Frank Von Delft, James A Wells, James Fraser

    http://dx.doi.org/10.7554/elife.36307 Allostery is an inherent feature of proteins, but it remains challenging to reveal the mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic circuitry would afford new opportunities to modulate protein function. Here, we …

  78. Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography

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    30 May 2018 | BioXFEL Publications | Contributor(s): Jose L. Olmos, Suraj Pandey, Jose M. Martin-Garcia, George Douglas Calvey, Andrea Katz, Juraj Knoska, Christopher Kupitz, Mark S. Hunter, Mengning Liang, Dominik Oberthuer, Oleksandr Yefanov, Max Oliver Wiedorn, Michael Heyman, Mark Holl, Kanupriya Pande, Anton Barty, Mitchell Miller, Stephan Stern, Shatabdi Roy-Chowdhury, Jesse David Coe, Nirupa Nagaratnam, James D Zook, Jacob Christopher Verburgt, Tyler Norwood, Ishwor Poudyal, David Xu, Jason Koglin, Matthew H. Seaberg, Yun Zhao, Saša Bajt, Thomas Grant, Valerio Mariani, Garrett Charles Nelson, GANESH SUBRAMANIAN, Euiyoung Bae, Raimund Fromme, Russell Fung, Peter Schwander, Matthias Frank, Thomas A. White, Uwe Weierstall, Nadia Zatsepin, John Spence, Petra Fromme, Henry Chapman, Lois Pollack, Lee Tremblay, Abbas Ourmazd, George Phillips, Marius Schmidt

    http://dx.doi.org/10.1186/s12915-018-0524-5 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Olmos, J.L. et al., 2018. Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography. BMC Biology, 16(1). Available at: …

  79. Difference structures from time-resolved small-angle and wide-angle x-ray scattering

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    17 May 2018 | BioXFEL Publications | Contributor(s): Prakash Nepal, D. K. Saldin

    http://dx.doi.org/10.1103/physrevb.97.195426 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Nepal, P. & Saldin, D.K., 2018. Difference structures from time-resolved small-angle and wide-angle x-ray scattering. Physical Review B, 97(19). Available at: …

  80. Ultrafast nonthermal heating of water initiated by an X-ray Free-Electron Laser

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    14 May 2018 | BioXFEL Publications | Contributor(s): Kenneth R. Beyerlein, H. Olof Jönsson, Roberto Alonso-Mori, Andrew Aquila, Saša Bajt, Anton Barty, Richard Bean, Jason E. Koglin, Marc Messerschmidt, Davide Ragazzon, Dimosthenis Sokaras, Garth J. Williams, Stefan Hau-Riege, Sébastien Boutet, Henry Chapman, Nicuşor Tîmneanu, Carl Caleman

    http://dx.doi.org/10.1073/pnas.1711220115 journal-article Beyerlein, K.R. et al., 2018. Ultrafast nonthermal heating of water initiated by an X-ray Free-Electron Laser. Proceedings of the National Academy of Sciences, p.201711220. Available at: http://dx.doi.org/10.1073/pnas.1711220115. Kenneth …

  81. Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

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    03 May 2018 | BioXFEL Publications | Contributor(s): Carolin Seuring, Kartik Ayyer, Eleftheria Filippaki, Miriam Barthelmess, Jean-Nicolas Longchamp, Philippe Ringler, Tommaso Pardini, David H. Wojtas, Matthew Coleman, Katerina Dörner, Silje Fuglerud, Greger Hammarin, Birgit Habenstein, Annette E. Langkilde, Antoine Loquet, Alke Meents, Roland Riek, Henning Stahlberg, Sébastien Boutet, Mark S. Hunter, Jason Koglin, Mengning Liang, Helen M. Ginn, Rick P. Millane, Matthias Frank, Anton Barty, Henry Chapman

    http://dx.doi.org/10.1038/s41467-018-04116-9 journal-article Seuring, C. et al., 2018. Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene. Nature Communications, 9(1). Available at: http://dx.doi.org/10.1038/s41467-018-04116-9. Carolin Seuring and Kartik …

  82. Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography

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    24 Apr 2018 | BioXFEL Publications | Contributor(s): Yannig Gicquel, Robin Schubert, Svetlana Kapis, Gleb Bourenkov, Thomas Schneider, Markus Perbandt, Christian Betzel, Henry Chapman, Michael Heymann

    http://dx.doi.org/10.3791/57133 journal-article Gicquel, Y. et al., 2018. Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography. Journal of Visualized Experiments, (134). Available at: http://dx.doi.org/10.3791/57133. Yannig …

  83. Revealing the distinct folding phases of an RNA three-helix junction

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    24 Apr 2018 | BioXFEL Publications | Contributor(s): Alex Plumridge, Andrea Katz, George Douglas Calvey, Ron Elber, Serdal Kirmizialtin, Lois Pollack

    http://dx.doi.org/10.1093/nar/gky363 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Plumridge, A. et al., 2018. Revealing the distinct folding phases of an RNA three-helix junction. Nucleic Acids Research. Available at: http://dx.doi.org/10.1093/nar/gky363. Alex Plumridge and …

  84. Molecular biophysical characterization of the third FF domain of Homo sapiens Prp40 homolog A

    0.0 out of 5 stars 

    19 Apr 2018 | BioXFEL Publications | Contributor(s): Adalberto Díaz Casas, Gabriela Casanova Sepúlveda, Odalys Sánchez Negrón, Andrea P. Caro Muñiz, Stewart R. Malavé Ramos, Ana R. Cebollero López, Belinda Pastrana-Ríos

    http://dx.doi.org/10.1016/j.molstruc.2018.04.059 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Díaz Casas, A. et al., 2018. Molecular biophysical characterization of the third FF domain of Homo sapiens Prp40 homolog A. Journal of Molecular Structure, 1167, pp.174–179. …

  85. Trajectories of the ribosome as a Brownian nanomachine

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    12 Apr 2018 | BioXFEL Publications | Contributor(s): Ali Dashti, Peter Schwander, Robert Langlois, Russell Fung, Wen Li, Ahmad Hosseinizadeh, Hstau Y. Liao, Jesper Pallesen, Gyanesh Sharma, Vera A. Stupina, Anne E. Simon, Jonathan D. Dinman, Joachim Frank, Abbas Ourmazd

    http://dx.doi.org/10.1142/9789813234864_0048 book-chapter Dashti, A. et al., 2018. Trajectories of the ribosome as a Brownian nanomachine. Single-Particle Cryo-Electron Microscopy, pp.463–475. Available at: http://dx.doi.org/10.1142/9789813234864_0048. Ali Dashti and Peter Schwander and Robert …

  86. Dose efficient Compton X-ray microscopy

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    10 Apr 2018 | BioXFEL Publications | Contributor(s): P. Villanueva-Perez, S. Bajt, H. N. Chapman

    http://dx.doi.org/10.1364/optica.5.000450 journal-article Villanueva-Perez, P., Bajt, S. & Chapman, H.N., 2018. Dose efficient Compton X-ray microscopy. Optica, 5(4), p.450. Available at: http://dx.doi.org/10.1364/optica.5.000450. P. Villanueva-Perez and S. Bajt and H. N. Chapman

  87. X-ray and UV radiation-damage-induced phasing using synchrotron serial crystallography

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    06 Apr 2018 | BioXFEL Publications | Contributor(s): Nicolas Foos, Carolin Seuring, Robin Schubert, Anja Burkhardt, Olof Svensson, Alke Meents, Henry Chapman, Max H. Nanao

    http://dx.doi.org/10.1107/s2059798318001535 Specific radiation damage can be used to determine phases de novo from macromolecular crystals. This method is known as radiation-damage-induced phasing (RIP). One limitation of the method is that the dose of individual data sets must be minimized, which …

  88. Rescue of conformational dynamics in enzyme catalysis by directed evolution

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    03 Apr 2018 | BioXFEL Publications | Contributor(s): Renee Otten, Lin Liu, Lillian R. Kenner, Michael W. Clarkson, David Mavor, Dan S. Tawfik, Dorothee Kern, James Fraser

    http://dx.doi.org/10.1038/s41467-018-03562-9 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Otten, R. et al., 2018. Rescue of conformational dynamics in enzyme catalysis by directed evolution. Nature Communications, 9(1). Available at: …

  89. Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots

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    30 Mar 2018 | BioXFEL Publications | Contributor(s): Ali Dashti, Mrinal Shekhar, Danya Ben Hail, Ghoncheh Mashayekhi, Peter Schwander, Amedee Des Georges, Joachim Frank, Abhishek Singharoy, Abbas Ourmazd

    http://dx.doi.org/10.1101/291922 We present a new approach to determining the conformational changes associated with biological function, and demonstrate its capabilities in the context of experimental single-particle cryo-EM snapshots of ryanodine receptor (RyR1), a Ca2+-channel involved in …

  90. X-ray focusing with efficient high-NA multilayer Laue lenses

    0.0 out of 5 stars 

    23 Mar 2018 | BioXFEL Publications | Contributor(s): Saša Bajt, Mauro Prasciolu, Holger Fleckenstein, Martin Domaracký, Henry Chapman, Andrew J Morgan, Oleksandr Yefanov, Marc Messerschmidt, Yang Du, Kevin T Murray, Valerio Mariani, Manuela Kuhn, Steven Aplin, Kanupriya Pande, Pablo Villanueva-Perez, Karolina Stachnik, Joe Chen, Andrzej Andrejczuk, Alke Meents, Anja Burkhardt, David Pennicard, Xiaojing Huang, Hanfei Yan, Evgeny Nazaretski, Yong S Chu, Christian E Hamm

    http://dx.doi.org/10.1038/lsa.2017.162 journal-article Bajt, S. et al., 2017. X-ray focusing with efficient high-NA multilayer Laue lenses. Light: Science & Applications, 7(3), p.17162. Available at: http://dx.doi.org/10.1038/lsa.2017.162. Saša Bajt and Mauro Prasciolu and Holger Fleckenstein …

  91. The ATPase motor of the Chd1 chromatin remodeler stimulates DNA unwrapping from the nucleosome

    0.0 out of 5 stars 

    16 Mar 2018 | BioXFEL Publications | Contributor(s): Joshua M Tokuda, Ren Ren, Robert F Levendosky, Rebecca J Tay, Ming Yan, Lois Pollack, Gregory D Bowman

    http://dx.doi.org/10.1093/nar/gky206 journal-article Tokuda, J.M. et al., 2018. The ATPase motor of the Chd1 chromatin remodeler stimulates DNA unwrapping from the nucleosome. Nucleic Acids Research, 46(10), pp.4978–4990. Available at: http://dx.doi.org/10.1093/nar/gky206. Joshua M Tokuda and …

  92. Structural biology of G protein-coupled receptors: new opportunities from XFELs and cryoEM

    0.0 out of 5 stars 

    16 Mar 2018 | BioXFEL Publications | Contributor(s): Andrii Ishchenko, Cornelius Gati, Vadim Cherezov

    http://dx.doi.org/10.1016/j.sbi.2018.03.009 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Ishchenko, A., Gati, C. & Cherezov, V., 2018. Structural biology of G protein-coupled receptors: new opportunities from XFELs and cryoEM. Current Opinion in Structural Biology, 51, …

  93. Serial Femtosecond Crystallography of G Protein–Coupled Receptors

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    15 Mar 2018 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Vadim Cherezov

    http://dx.doi.org/10.1146/annurev-biophys-070317-033239 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Stauch, B. & Cherezov, V., 2018. Serial Femtosecond Crystallography of G Protein–Coupled Receptors. Annual Review of Biophysics, 47(1). Available at: …

  94. Femtosecond profiling of shaped x-ray pulses

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    08 Mar 2018 | BioXFEL Publications | Contributor(s): M C Hoffmann, I Grguraš, C Behrens, C Bostedt, J Bozek, H Bromberger, R Coffee, J T Costello, L F DiMauro, Y Ding, G Doumy, W Helml, M Ilchen, R Kienberger, S Lee, A R Maier, T Mazza, M Meyer, M Messerschmidt, S Schorb, W Schweinberger, K Zhang, A L Cavalieri

    http://dx.doi.org/10.1088/1367-2630/aab548 journal-article Hoffmann, M.C. et al., 2018. Femtosecond profiling of shaped x-ray pulses. New Journal of Physics, 20(3), p.033008. Available at: http://dx.doi.org/10.1088/1367-2630/aab548. M C Hoffmann and I Grguraš and C Behrens and C Bostedt and J …

  95. Direct Structural and Chemical Characterization of the Photolytic Intermediates of Methylcobalamin Using Time-Resolved X-ray Absorption Spectroscopy

    0.0 out of 5 stars 

    06 Mar 2018 | BioXFEL Publications | Contributor(s): GANESH SUBRAMANIAN, Xiaoyi Zhang, Gerdenis Kodis, Qingyu Kong, Cunming Liu, Andrew Chizmeshya, Uwe Weierstall, John Spence

    http://dx.doi.org/10.1021/acs.jpclett.8b00083 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Subramanian, G. et al., 2018. Direct Structural and Chemical Characterization of the Photolytic Intermediates of Methylcobalamin Using Time-Resolved X-ray Absorption Spectroscopy. The …

  96. Deterministic Ratchet for Sub-micrometer (Bio)particle Separation

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    06 Mar 2018 | BioXFEL Publications | Contributor(s): Daihyun Kim, Jinghui Luo, Edgar A. Arriaga, Alexandra Ros

    http://dx.doi.org/10.1021/acs.analchem.7b03774 journal-article Kim, D. et al., 2018. Deterministic Ratchet for Sub-micrometer (Bio)particle Separation. Analytical Chemistry. Available at: http://dx.doi.org/10.1021/acs.analchem.7b03774. Daihyun Kim and Jinghui Luo and Edgar A. Arriaga and …

  97. FreeDam – A Webtool for Free-Electron Laser-Induced Damage in Femtosecond X-ray Crystallography

    0.0 out of 5 stars 

    21 Feb 2018 | BioXFEL Publications | Contributor(s): H. Olof Jönsson, Christofer Östlin, Howard A. Scott, Henry Chapman, Steve J. Aplin, Nicuşor Tîmneanu, Carl Caleman

    http://dx.doi.org/10.1016/j.hedp.2018.02.004 journal-article Jönsson, H.O. et al., 2018. FreeDam – A Webtool for Free-Electron Laser-Induced Damage in Femtosecond X-ray Crystallography. High Energy Density Physics. Available at: http://dx.doi.org/10.1016/j.hedp.2018.02.004. H. Olof Jönsson …

  98. Femtosecond X-ray Fourier holography imaging of free-flying nanoparticles

    0.0 out of 5 stars 

    16 Feb 2018 | BioXFEL Publications | Contributor(s): Tais Gorkhover, Anatoli Ulmer, Ken Ferguson, Max Bucher, Filipe R. N. C. Maia, Johan Bielecki, Tomas Ekeberg, Max F. Hantke, Benedikt J. Daurer, Carl Nettelblad, Jakob Andreasson, Anton Barty, Petr Bruza, Sebastian Carron, Dirk Hasse, Jacek Krzywinski, Daniel S. D. Larsson, Andrew Morgan, Kerstin Mühlig, Maria Müller, Kenta Okamoto, Alberto Pietrini, Daniela Rupp, Mario Sauppe, Gijs Van Der Schot, Marvin Seibert, Jonas A. Sellberg, Martin Svenda, Michelle Swiggers, Nicusor Timneanu, Daniel Westphal, Garth Williams, Alessandro Zani, Henry Chapman, Gyula Faigel, Thomas Möller, Janos Hajdu, Christoph Bostedt

    http://dx.doi.org/10.1038/s41566-018-0110-y journal-article Gorkhover, T. et al., 2018. Femtosecond X-ray Fourier holography imaging of free-flying nanoparticles. Nature Photonics, 12(3), pp.150–153. Available at: http://dx.doi.org/10.1038/s41566-018-0110-y. Tais Gorkhover and Anatoli Ulmer …

  99. Bringing diffuse X-ray scattering into focus

    0.0 out of 5 stars 

    15 Feb 2018 | BioXFEL Publications | Contributor(s): Michael E Wall, Alexander M Wolff, James Fraser

    http://dx.doi.org/10.1016/j.sbi.2018.01.009 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Wall, M.E., Wolff, A.M. & Fraser, J.S., 2018. Bringing diffuse X-ray scattering into focus. Current Opinion in Structural Biology, 50, pp.109–116. Available at: …

  100. Structure of the 30S ribosomal decoding complex at ambient temperature

    0.0 out of 5 stars 

    12 Feb 2018 | BioXFEL Publications | Contributor(s): E. Han Dao, Frederic Poitevin, Raymond G. Sierra, Cornelius Gati, Yashas Rao, Halil Ibrahim Ciftci, Fulya Akşit, Alex McGurk, Trevor Obrinski, Paul Mgbam, Brandon Hayes, Casper De Lichtenberg, Fatima Pardo-Avila, Nicholas Corsepius, Lindsey Zhang, Matt Seaberg, Mark S. Hunter, Mengling Liang, Jason E. Koglin, Soichi Wakatsuki, Hasan Demirci

    http://dx.doi.org/10.1101/262972 The ribosome translates nucleotide sequences of messenger RNA to proteins through selection of cognate transfer RNA according to the genetic code. To date, structural studies of ribosomal decoding complexes yielding high-resolution data have predominantly relied on …