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  1. Liquid-like and rigid-body motions in molecular-dynamics simulations of a crystalline protein

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    18 Dec 2019 | BioXFEL Publications | Contributor(s): David C. Wych, James Fraser, David L. Mobley, Michael E. Wall

    http://dx.doi.org/10.1063/1.5132692 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Wych, D.C. et al., 2019. Liquid-like and rigid-body motions in molecular-dynamics simulations of a crystalline protein. Structural Dynamics, 6(6), p.064704. Available at: …

  2. Low-signal limit of X-ray single particle diffractive imaging

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    12 Dec 2019 | BioXFEL Publications | Contributor(s): Kartik Ayyer, Andrew J. Morgan, Andrew Aquila, Hasan Demirci, Brenda Hogue, Richard Kirian, P. Lourdu Xavier, Chun Hong Yoon, Henry Chapman, Anton Barty

    http://dx.doi.org/10.1364/oe.27.037816 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Ayyer, K. et al., 2019. Low-signal limit of X-ray single particle diffractive imaging. Optics Express, 27(26), p.37816. Available at: http://dx.doi.org/10.1364/oe.27.037816. Kartik Ayyer and …

  3. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

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    06 Dec 2019 | BioXFEL Publications | Contributor(s): Anastasiia Gusach, Aleksandra Luginina, Egor Marin, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Andrii Ishchenko, Petr Popov, Nilkanth N Patel, Taku Fujimoto, Toru Maruyama, Benjamin Stauch, Margarita Ergasheva, Daria Romanovskaia, Anastasiia Stepko, Kirill Kovalev, Mikhail Shevtsov, Valentin Gordeliy, Gye Won Han, Vsevolod Katritch, Valentin Borshchevskiy, Philippe Sarret, Alexey Mishin, Vadim Cherezov

    http://dx.doi.org/10.1038/s41467-019-13348-2 journal-article Gusach, A. et al., 2019. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nature Communications, 10(1). Available at: http://dx.doi.org/10.1038/s41467-019-13348-2. Anastasiia Gusach and …

  4. Visualizing Disordered Single-Stranded RNA: Connecting Sequence, Structure, and Electrostatics

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    05 Dec 2019 | BioXFEL Publications | Contributor(s): Alex Plumridge, Kurt Andresen, Lois Pollack

    http://dx.doi.org/10.1021/jacs.9b04461 journal-article Plumridge, A., Andresen, K. & Pollack, L., 2019. Visualizing Disordered Single-Stranded RNA: Connecting Sequence, Structure, and Electrostatics. Journal of the American Chemical Society. Available at: http://dx.doi.org/10.1021/jacs.9b04461. …

  5. High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application

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    03 Dec 2019 | BioXFEL Publications | Contributor(s): Geoffrey W. Grime, Oliver B. Zeldin, Mary E. Snell, Edward D. Lowe, John F. Hunt, Gaetano T. Montelione, Liang Tong, Edward Snell, Elspeth F. Garman

    http://dx.doi.org/10.1021/jacs.9b09186 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Grime, G.W. et al., 2019. High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application. Journal of the American Chemical …

  6. Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

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    27 Nov 2019 | BioXFEL Publications | Contributor(s): Tobias Claff, Jing Yu, Véronique Blais, Nilkanth N Patel, Charlotte Martin, Lijie Wu, Gye Won Han, Brian J. Holleran, Olivier Van Der Poorten, Kate L. White, Michael A. Hanson, Philippe Sarret, Louis Gendron, Vadim Cherezov, Vsevolod Katritch, Steven Ballet, Zhi-Jie Liu, Christa E. Müller, Raymond C. Stevens

    http://dx.doi.org/10.1126/sciadv.aax9115 Selective activation of the δ-opioid receptor (DOP) has great potential for the treatment of chronic pain, benefitting from ancillary anxiolytic and antidepressant-like effects. Moreover, DOP agonists show reduced adverse effects as compared to μ-opioid …

  7. Computational design of a modular protein sense-response system

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    25 Nov 2019 | BioXFEL Publications | Contributor(s): Anum A. Glasgow, Yao-Ming Huang, Daniel J. Mandell, Michael Thompson, Ryan Ritterson, Amanda L. Loshbaugh, Jenna Pellegrino, Cody Krivacic, Roland A. Pache, Kyle A. Barlow, Noah Ollikainen, Deborah Jeon, Mark J. S. Kelly, James Fraser, Tanja Kortemme

    http://dx.doi.org/10.1126/science.aax8780 Sensing and responding to signals is a fundamental ability of living systems, but despite substantial progress in the computational design of new protein structures, there is no general approach for engineering arbitrary new protein sensors. Here, we …

  8. A fixed-target platform for serial femtosecond crystallography in a hydrated environment

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    21 Nov 2019 | BioXFEL Publications | Contributor(s): M. L. Shelby, D. Gilbile, T. D. Grant, C. Seuring, B. W. Segelke, W. He, A. C. Evans, T. Pakendorf, P. Fischer, M. S. Hunter, A. Batyuk, M. Barthelmess, A. Meents, M. A. Coleman, T. L. Kuhl, M. Frank

    http://dx.doi.org/10.1107/s2052252519014003 For serial femtosecond crystallography at X-ray free-electron lasers, which entails collection of single-pulse diffraction patterns from a constantly refreshed supply of microcrystalline sample, delivery of the sample into the X-ray beam path while …

  9. Time-resolved serial femtosecond crystallography at the European XFEL

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    18 Nov 2019 | BioXFEL Publications | Contributor(s): Suraj Pandey, Richard Bean, Tokushi Sato, Ishwor Poudyal, Johan Bielecki, Jorvani Cruz Villarreal, Oleksandr Yefanov, Valerio Mariani, Thomas A. White, Christopher Kupitz, Mark S. Hunter, Mohamed H. Abdellatif, Saša Bajt, Valerii Bondar, Austin Echelmeier, Diandra Doppler, Moritz Emons, Matthias Frank, Raimund Fromme, Yaroslav Gevorkov, Gabriele Giovanetti, Man Jiang, Daihyun Kim, Yoonhee Kim, Henry Kirkwood, Anna Klimovskaia, Juraj Knoska, Faisal Hammad Mekky Koua, Romain Letrun, Stella Lisova, Luis Maia, Victoria Mazalova, Domingo Meza, Thomas Michelat, Abbas Ourmazd, Guido Palmer, Marco Ramilli, Robin Schubert, Peter Schwander, Alessandro Silenzi, Jolanta Sztuk-Dambietz, Alexandra Tolstikova, Henry Chapman, Alexandra Ros, Anton Barty, Petra Fromme, Adrian P. Mancuso, Marius Schmidt

    http://dx.doi.org/10.1038/s41592-019-0628-z journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Pandey, S. et al., 2019. Time-resolved serial femtosecond crystallography at the European XFEL. Nature Methods. Available at: http://dx.doi.org/10.1038/s41592-019-0628-z. Suraj Pandey and …

  10. Structural Insights into Melatonin Receptors

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    06 Nov 2019 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda C. Johansson, Vadim Cherezov

    http://dx.doi.org/10.1111/febs.15128 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Stauch, B., Johansson, L.C. & Cherezov, V., 2019. Structural Insights into Melatonin Receptors. The FEBS Journal. Available at: http://dx.doi.org/10.1111/febs.15128. Benjamin Stauch and Linda C. …

  11. Membrane protein megahertz crystallography at the European XFEL

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    04 Nov 2019 | BioXFEL Publications | Contributor(s): Chris Gisriel, Jesse David Coe, Romain Letrun, Oleksandr M. Yefanov, Cesar Luna-Chavez, Natasha Stander, Stella Lisova, Valerio Mariani, Manuela Kuhn, Steve Aplin, Thomas D. Grant, Katerina Dörner, Tokushi Sato, Austin Echelmeier, Jorvani Cruz Villarreal, Mark S. Hunter, Max Oliver Wiedorn, Juraj Knoska, Victoria Mazalova, Shatabdi Roy-Chowdhury, Jay-How Yang, Alex Jones, Richard Bean, Johan Bielecki, Yoonhee Kim, Grant Mills, Britta Weinhausen, Jose D. Meza, Nasser Al-Qudami, Saša Bajt, Gerrit Brehm, Sabine Botha, Djelloul Boukhelef, Sandor Brockhauser, Barry D. Bruce, Matthew Coleman, Cyril Danilevski, Erin Discianno, Zachary Dobson, Hans Fangohr, Jose M. Martin-Garcia, Yaroslav Gevorkov, Steffen Hauf, Ahmad Hosseinizadeh, Friederike Januschek, Gihan Kaushylal Ketawala, Christopher Kupitz, Luis Maia, Maurizio Manetti, Marc Messerschmidt, Thomas Michelat, Jyotirmoy Mondal, Abbas Ourmazd, Gianpietro Previtali, Iosifina Sarrou, Silvan Schön, Peter Schwander, Megan Shelby, Alessandro Silenzi, Jolanta Sztuk-Dambietz, Janusz Szuba, Monica Turcato, Thomas A. White, Krzysztof Wrona, Chen Xu, Mohamed H. Abdellatif, James D Zook, John Spence, Henry Chapman, Anton Barty, Richard Kirian, Matthias Frank, Alexandra Ros, Marius Schmidt, Raimund Fromme, Adrian P. Mancuso, Petra Fromme, Nadia Zatsepin

    http://dx.doi.org/10.1038/s41467-019-12955-3 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Gisriel, C. et al., 2019. Membrane protein megahertz crystallography at the European XFEL. Nature Communications, 10(1). Available at: http://dx.doi.org/10.1038/s41467-019-12955-3. Chris …

  12. Toward G protein-coupled receptor structure-based drug design using X-ray lasers

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    24 Oct 2019 | BioXFEL Publications | Contributor(s): Andrii Ishchenko, Benjamin Stauch, Gye Won Han, Alexander Batyuk, Anna Shiriaeva, Chufeng Li, Nadia Zatsepin, Uwe Weierstall, Wei Liu, Eriko Nango, Takanori Nakane, Rie Tanaka, Kensuke Tono, Yasumasa Joti, So Iwata, Isabel Moraes, Cornelius Gati, Vadim Cherezov

    http://dx.doi.org/10.1107/s2052252519013137 Rational structure-based drug design (SBDD) relies on the availability of a large number of co-crystal structures to map the ligand-binding pocket of the target protein and use this information for lead-compound optimization via an iterative process. …

  13. Salt Dependence of A-Form RNA Duplexes: Structures and Implications

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    23 Oct 2019 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Lois Pollack

    http://dx.doi.org/10.1021/acs.jpcb.9b07502 journal-article Chen, Y.-L. & Pollack, L., 2019. Salt Dependence of A-Form RNA Duplexes: Structures and Implications. The Journal of Physical Chemistry B. Available at: http://dx.doi.org/10.1021/acs.jpcb.9b07502. Yen-Lin Chen and Lois Pollack

  14. Correction to: Spatiotemporal Pattern Extraction by Spectral Analysis of Vector-Valued Observables

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    23 Oct 2019 | BioXFEL Publications | Contributor(s): Dimitrios Giannakis, Abbas Ourmazd, Joanna Slawinska, Zhizhen Zhao

    http://dx.doi.org/10.1007/s00332-019-09586-9 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Giannakis, D. et al., 2019. Correction to: Spatiotemporal Pattern Extraction by Spectral Analysis of Vector-Valued Observables. Journal of Nonlinear Science. Available at: …

  15. Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

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    09 Oct 2019 | BioXFEL Publications | Contributor(s): Aleksandra Luginina, Anastasiia Gusach, Egor Marin, Alexey Mishin, Rebecca Brouillette, Petr Popov, Anna Shiriaeva, Élie Besserer-Offroy, Jean-Michel Longpré, Elizaveta Lyapina, Andrii Ishchenko, Nilkanth N Patel, Vitaly Polovinkin, Nadezhda Safronova, Andrey Bogorodskiy, Evelina Edelweiss, Hao Hu, Uwe Weierstall, Wei Liu, Alexander Batyuk, Valentin Gordeliy, Gye Won Han, Philippe Sarret, Vsevolod Katritch, Valentin Borshchevskiy, Vadim Cherezov

    http://dx.doi.org/10.1126/sciadv.aax2518 The G protein–coupled cysteinyl leukotriene receptor CysLT1R mediates inflammatory processes and plays a major role in numerous disorders, including asthma, allergic rhinitis, cardiovascular disease, and cancer. Selective CysLT1R antagonists are widely …

  16. Co-occurring Alterations in the RAS–MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer

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    23 Sep 2019 | BioXFEL Publications | Contributor(s): Julia K. Rotow, Philippe Gui, Wei Wu, Victoria M. Raymond, Richard B. Lanman, Frederic J. Kaye, Nir Peled, Ferran Fece De La Cruz, Brandon Nadres, Ryan B. Corcoran, Iwei Yeh, Boris C. Bastian, Petr Starostik, Kimberly Newsom, Victor R. Olivas, Alexander M. Wolff, James Fraser, Eric A. Collisson, Caroline E. McCoach, D. Ross Camidge, Jose Pacheco, Lyudmila Bazhenova, Tianhong Li, Trever G. Bivona, Collin M. Blakely

    http://dx.doi.org/10.1158/1078-0432.ccr-19-1667 Abstract Purpose: Although patients with advanced-stage non–small cell lung cancers (NSCLC) harboring MET exon 14 skipping mutations (METex14) often benefit from MET tyrosine kinase inhibitor (TKI) …

  17. Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme

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    16 Sep 2019 | BioXFEL Publications | Contributor(s): Michael Thompson, Benjamin A. Barad, Alexander M. Wolff, Hyun Sun Cho, Friedrich Schotte, Daniel M. C. Schwarz, Philip Anfinrud, James Fraser

    http://dx.doi.org/10.1038/s41557-019-0329-3 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Thompson, M.C. et al., 2019. Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme. Nature Chemistry, 11(11), pp.1058–1066. Available at: …

  18. 3D printed droplet generation devices for serial femtosecond crystallography enabled by surface coating

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    29 Aug 2019 | BioXFEL Publications | Contributor(s): Austin Echelmeier, Daihyun Kim, Jorvani Cruz Villarreal, Jesse David Coe, Sebastian E Quintana, Gerrit Brehm, Ana Egatz-Gomez, Reza Nazari, Raymond G. Sierra, Jason E. Koglin, Alexander Batyuk, Mark S. Hunter, Sébastien Boutet, Nadia Zatsepin, Richard Kirian, Thomas D. Grant, Petra Fromme, Alexandra Ros

    http://dx.doi.org/10.1107/s1600576719010343 The role of surface wetting properties and their impact on the performance of 3D printed microfluidic droplet generation devices for serial femtosecond crystallography (SFX) are reported. SFX is a novel crystallography method enabling structure …

  19. Reconstruction of Objects from Their Averaged Finite Crystal Diffraction Intensity

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    26 Aug 2019 | BioXFEL Publications | Contributor(s): J. P. J. Chen, K. E. Schmidt, R. A. Kirian, J. J. Donatelli

    http://dx.doi.org/10.1109/icip.2019.8804468 proceedings-article Chen, J.P.J. et al., 2019. Reconstruction of Objects from Their Averaged Finite Crystal Diffraction Intensity. 2019 IEEE International Conference on Image Processing (ICIP). Available at: http://dx.doi.org/10.1109/icip.2019.8804468. …

  20. A Remarkable Return On Investment In Fundamental Research: 40 Years of Basic Energy Sciences at the Department of Energy

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    02 Aug 2019 | BioXFEL Publications | Contributor(s): Persis Drell, Dawn A. Bonnell, Jingguang Chen, Sue Clark, Beatriz Roldan Cuenya, Helmut Dosch, Cynthia Friend, Yan Gao, Sharon Hammes-Schiffer, Marc Kastner, Bruce Kay, Stephen R. Leone, Despina Louca, Monica Olvera De La Cruz, Abbas Ourmazd, Philippe Piot, Ian Robertson, Anthony Rollett, Frances Ross, Gary Rubloff, Maria Santore, Esther S. Takeuchi, John Tranquada, Stephen Wasserman

    http://dx.doi.org/10.2172/1545686 report Drell, P. et al., 2018. A Remarkable Return On Investment In Fundamental Research: 40 Years of Basic Energy Sciences at the Department of Energy. Available at: http://dx.doi.org/10.2172/1545686. Persis Drell and Dawn A. Bonnell and Jingguang Chen and Sue …

  21. Electric Triggering for Enhanced Control of Droplet Generation

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    01 Jul 2019 | BioXFEL Publications | Contributor(s): Daihyun Kim, Austin Echelmeier, Jorvani Cruz Villarreal, Sahir Ilyas Gandhi, Sebastian E Quintana, Ana Egatz-Gomez, Alexandra Ros

    http://dx.doi.org/10.1021/acs.analchem.9b01449 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Kim, D. et al., 2019. Electric Triggering for Enhanced Control of Droplet Generation. Analytical Chemistry, 91(15), pp.9792–9799. Available at: …

  22. Microfluidic sample delivery for serial crystallography using XFELs

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    27 Jun 2019 | BioXFEL Publications | Contributor(s): Austin Echelmeier, Mukul Sonker, Alexandra Ros

    http://dx.doi.org/10.1007/s00216-019-01977-x journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Echelmeier, A., Sonker, M. & Ros, A., 2019. Microfluidic sample delivery for serial crystallography using XFELs. Analytical and Bioanalytical Chemistry, 411(25), pp.6535–6547. Available …

  23. Four amino acids define the CO2binding pocket of enoyl-CoA carboxylases/reductases

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    26 Jun 2019 | BioXFEL Publications | Contributor(s): Gabriele M. M. Stoffel, David Adrian Saez, Hasan Demirci, Bastian Vögeli, Yashas Rao, Jan Zarzycki, Yasuo Yoshikuni, Soichi Wakatsuki, Esteban Vöhringer-Martinez, Tobias J. Erb

    http://dx.doi.org/10.1073/pnas.1901471116 Carboxylases are biocatalysts that capture and convert carbon dioxide (CO2) under mild conditions and atmospheric concentrations at a scale of more than 400 Gt annually. However, how these enzymes bind and control the gaseous CO2molecule during catalysis is …

  24. Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both

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    24 Jun 2019 | BioXFEL Publications | Contributor(s): Helena Taberman, Charles S. Bury, Mark J. Van Der Woerd, Edward Snell, Elspeth F. Garman

    http://dx.doi.org/10.1107/s1600577519005599 Xylose isomerase (XI) is an industrially important metalloprotein studied for decades. Its reaction mechanism has been postulated to involve movement of the catalytic metal cofactor to several different conformations. Here, a dose-dependent approach was …

  25. Coherent diffractive imaging of microtubules using an X-ray laser

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    13 Jun 2019 | BioXFEL Publications | Contributor(s): Gisela Brändén, Greger Hammarin, Rajiv Harimoorthy, Alexander Johansson, David Arnlund, Erik Malmerberg, Anton Barty, Stefan Tångefjord, Peter Berntsen, Daniel P. DePonte, Carolin Seuring, Thomas A. White, Francesco Stellato, Richard Bean, Kenneth R. Beyerlein, Leonard M. G. Chavas, Holger Fleckenstein, Cornelius Gati, Umesh Ghoshdastider, Lars Gumprecht, Dominik Oberthür, David Popp, Marvin Seibert, Thomas Tilp, Marc Messerschmidt, Garth J. Williams, N. Duane Loh, Henry Chapman, Peter Zwart, Mengning Liang, Sébastien Boutet, Robert C. Robinson, Richard Neutze

    http://dx.doi.org/10.1038/s41467-019-10448-x journal-article Brändén, G. et al., 2019. Coherent diffractive imaging of microtubules using an X-ray laser. Nature Communications, 10(1). Available at: http://dx.doi.org/10.1038/s41467-019-10448-x. Gisela Brändén and Greger Hammarin and Rajiv …

  26. 7th Annual BioXFEL International Conference

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    23 May 2019 | Downloads

    …

  27. Spatial characterization of FLASH2 pulses: current status and future plan (Conference Presentation)

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    14 May 2019 | BioXFEL Publications | Contributor(s): Masoud Mehrjoo, Elke Plönjes, Barbara Keitel, Marion Kuhlmann, Mabel Ruiz-Lopez, Thomas Wodzinski, Klaus Giewekemeyer, Patrik Vagovic, Yoonhee Kim, Mohammadreza Banjafar, Marc Messerschmidt, Tomáš Burian

    http://dx.doi.org/10.1117/12.2523254 proceedings-article Mehrjoo, M. et al., 2019. Spatial characterization of FLASH2 pulses: current status and future plan (Conference Presentation) T. Tschentscher et al., eds. X-Ray Free-Electron Lasers: Advances in Source Development and Instrumentation V. …

  28. Spatiotemporal Pattern Extraction by Spectral Analysis of Vector-Valued Observables

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    13 May 2019 | BioXFEL Publications | Contributor(s): Dimitrios Giannakis, Abbas Ourmazd, Joanna Slawinska, Zhizhen Zhao

    http://dx.doi.org/10.1007/s00332-019-09548-1 journal-article Giannakis, D. et al., 2019. Spatiotemporal Pattern Extraction by Spectral Analysis of Vector-Valued Observables. Journal of Nonlinear Science. Available at: http://dx.doi.org/10.1007/s00332-019-09548-1. Dimitrios Giannakis and Abbas …

  29. Abstract P6-19-01: Evaluation of multiple transcriptomic gene risk signatures in male breast cancer

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    11 May 2019 | BioXFEL Publications | Contributor(s): J Bayani, C Poncet, CQ Yao, C Crozier, N Anouk, T Piper, C Cunningham, M Sobol, S Aebi, K Benstead, O Bogler, L Dal Lago, J Fraser, FH Hilbers, I Hedenfalk, L Korde, B Linderholm, J Martens, L Middleton, M Murray, C Kelly, C Nilsson, M Nowaczyk, S Peeters, A Peric, P Porter, C Schröder, IT Rubio, KJ Ruddy, C Van Asperen, D Van Den Weyngaert, C Van Deurzen, E Van Leeuwen-Stok, J Vermeij, E Winer, PC Boutros, SH Giordano, F Cardoso, JM Bartlett

    http://dx.doi.org/10.1158/1538-7445.sabcs18-p6-19-01 proceedings-article Bayani, J. et al., 2019. Abstract P6-19-01: Evaluation of multiple transcriptomic gene risk signatures in male breast cancer. Poster Session Abstracts. Available at: http://dx.doi.org/10.1158/1538-7445.sabcs18-p6-19-01. J …

  30. Microfluidic Mixing Injector Holder Enables Routine Structural Enzymology Measurements with Mix-and-Inject Serial Crystallography Using X-ray Free Electron Lasers

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    07 May 2019 | BioXFEL Publications | Contributor(s): George Douglas Calvey, Andrea Katz, Lois Pollack

    http://dx.doi.org/10.1021/acs.analchem.9b00311 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Calvey, G.D., Katz, A.M. & Pollack, L., 2019. Microfluidic Mixing Injector Holder Enables Routine Structural Enzymology Measurements with Mix-and-Inject Serial Crystallography Using X-ray …

  31. Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor

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    02 May 2019 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda C. Johansson, John D. McCorvy, Nilkanth N Patel, Gye Won Han, Xi-Ping Huang, Cornelius Gati, Alexander Batyuk, Samuel T. Slocum, Andrii Ishchenko, Wolfgang Brehm, Thomas A. White, Nairie Michaelian, Caleb Alexander Madsen, Lan Zhu, Thomas D. Grant, Jessica M. Grandner, Anna Shiriaeva, Reid H. J. Olsen, Alexandra R. Tribo, Saïd Yous, Raymond C. Stevens, Uwe Weierstall, Vsevolod Katritch, Bryan L. Roth, Wei Liu, Vadim Cherezov

    http://dx.doi.org/10.1038/s41586-019-1209-0 journal-article Stauch, B. et al., 2019. Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature, 569(7756), pp.E6–E6. Available at: http://dx.doi.org/10.1038/s41586-019-1209-0. Benjamin Stauch and …

  32. The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state

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    30 Apr 2019 | BioXFEL Publications | Contributor(s): M. Gertrude Gutierrez, Jacob Deyell, Kate L. White, Lucia C. Dalle Ore, Vadim Cherezov, Raymond C. Stevens, Noah Malmstadt

    http://dx.doi.org/10.1039/c8cc10130b As cholesterol fraction increases, ligand-bound receptor occupies more vesicle surface area, demonstrating co-localization with the cholesterol-rich phase. journal-article Gutierrez, M.G. et al., 2019. The lipid phase preference of the adenosine A2A receptor …

  33. Structural basis of ligand recognition at the human MT1 melatonin receptor

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    24 Apr 2019 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda C. Johansson, John D. McCorvy, Nilkanth N Patel, Gye Won Han, Xi-Ping Huang, Cornelius Gati, Alexander Batyuk, Samuel T. Slocum, Andrii Ishchenko, Wolfgang Brehm, Thomas A. White, Nairie Michaelian, Caleb Alexander Madsen, Lan Zhu, Thomas D. Grant, Jessica M. Grandner, Anna Shiriaeva, Reid H. J. Olsen, Alexandra R. Tribo, Saïd Yous, Raymond C. Stevens, Uwe Weierstall, Vsevolod Katritch, Bryan L. Roth, Wei Liu, Vadim Cherezov

    http://dx.doi.org/10.1038/s41586-019-1141-3 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Stauch, B. et al., 2019. Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature. Available at: http://dx.doi.org/10.1038/s41586-019-1141-3. Benjamin Stauch and …

  34. XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

    0.0 out of 5 stars 

    24 Apr 2019 | BioXFEL Publications | Contributor(s): Linda C. Johansson, Benjamin Stauch, John D. McCorvy, Gye Won Han, Nilkanth N Patel, Xi-Ping Huang, Alexander Batyuk, Cornelius Gati, Samuel T. Slocum, Chufeng Li, Jessica M. Grandner, Shuming Hao, Reid H. J. Olsen, Alexandra R. Tribo, Sahba Zaare, Lan Zhu, Nadia Zatsepin, Uwe Weierstall, Saïd Yous, Raymond C. Stevens, Wei Liu, Bryan L. Roth, Vsevolod Katritch, Vadim Cherezov

    http://dx.doi.org/10.1038/s41586-019-1144-0 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Johansson, L.C. et al., 2019. XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity. Nature. Available at: http://dx.doi.org/10.1038/s41586-019-1144-0. …

  35. The Single Particles, Clusters and Biomolecules and Serial Femtosecond Crystallography instrument of the European XFEL: initial installation

    0.0 out of 5 stars 

    12 Apr 2019 | BioXFEL Publications | Contributor(s): Adrian P. Mancuso, Andrew Aquila, Lewis Batchelor, Richard J. Bean, Johan Bielecki, Gannon Borchers, Katerina Doerner, Klaus Giewekemeyer, Rita Graceffa, Oliver D. Kelsey, Yoonhee Kim, Henry J. Kirkwood, Alexis Legrand, Romain Letrun, Bradley Manning, Luis Lopez Morillo, Marc Messerschmidt, Grant Mills, Steffen Raabe, Nadja Reimers, Adam Round, Tokushi Sato, Joachim Schulz, Cedric Signe Takem, Marcin Sikorski, Stephan Stern, Prasad Thute, Patrik Vagovič, Britta Weinhausen, Thomas Tschentscher

    http://dx.doi.org/10.1107/s1600577519003308 The European X-ray Free-Electron Laser (FEL) became the first operational high-repetition-rate hard X-ray FEL with first lasing in May 2017. Biological structure determination has already benefitted from the unique properties and capabilities of X-ray …

  36. High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source

    0.0 out of 5 stars 

    04 Apr 2019 | BioXFEL Publications | Contributor(s): Jose M. Martin-Garcia, Lan Zhu, Derek Mendez, Ming-Yue Lee, Eugene Chun, Chufeng Li, Hao Hu, GANESH SUBRAMANIAN, David Kissick, Craig Ogata, Robert Henning, Andrii Ishchenko, Zachary Dobson, Shangji Zhang, Uwe Weierstall, John Spence, Petra Fromme, Nadia Zatsepin, Robert F. Fischetti, Vadim Cherezov, Wei Liu

    http://dx.doi.org/10.1107/s205225251900263x Since the first successful serial crystallography (SX) experiment at a synchrotron radiation source, the popularity of this approach has continued to grow showing that third-generation synchrotrons can be viable alternatives to scarce X-ray free-electron …

  37. Serial Femtosecond X-Ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature

    0.0 out of 5 stars 

    04 Apr 2019 | BioXFEL Publications | Contributor(s): Halil I Ciftci, Raymond G Sierra, Chun Yoon, Zhen Su, Hiroshi Tateishi, Ryoko Koga, Koiwai Kotaro, Fumiaki Yumoto, Toshiya Senda, Mengling Liang, Soichi Wakatsuki, Masami Otsuka, Mikako Fujita, Hasan Demirci

    http://dx.doi.org/10.3390/ijms20071675 The Human immunodeficiency virus-1 (HIV-1) matrix (MA) domain is involved in the highly regulated assembly process of the virus particles that occur at the host cell’s plasma membrane. High-resolution structures of the MA domain determined using cryo X-ray …

  38. DENSS: Ab Initio Electron Density Maps from Biological SAXS Data

    0.0 out of 5 stars 

    20 Mar 2019 | Seminars | Contributor(s): Thomas Grant

    Small angle scattering is an experimental technique used to analyze the molecular structures of a wide variety of biological and non-biological samples in solution. In contrast to X-ray crystallography and cryo-electron microscopy, where 3D electron density maps are calculated, available methods …

  39. Generalized Born Implicit Solvent Models for Biomolecules

    0.0 out of 5 stars 

    11 Mar 2019 | BioXFEL Publications | Contributor(s): Alexey V. Onufriev, David Case

    http://dx.doi.org/10.1146/annurev-biophys-052118-115325 It would often be useful in computer simulations to use an implicit description of solvation effects, instead of explicitly representing the individual solvent molecules. Continuum dielectric models often work well in describing the …

  40. Protein and RNA dynamical fingerprinting

    0.0 out of 5 stars 

    04 Mar 2019 | BioXFEL Publications | Contributor(s): Katherine A. Niessen, Mengyang Xu, Deepu K. George, Michael C. Chen, Adrian R. Ferré-D’Amaré, Edward Snell, Vivian Cody, James Pace, Marius Schmidt, Andrea Markelz

    http://dx.doi.org/10.1038/s41467-019-08926-3 journal-article Niessen, K.A. et al., 2019. Protein and RNA dynamical fingerprinting. Nature Communications, 10(1). Available at: http://dx.doi.org/10.1038/s41467-019-08926-3. Katherine A. Niessen and Mengyang Xu and Deepu K. George and Michael C. …

  41. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data

    0.0 out of 5 stars 

    01 Mar 2019 | BioXFEL Publications

    http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.pdf component Shi, Y. et al., 2019. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data. Available at: http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.pdf. Yingchen Shi and Ke Yin and …

  42. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data

    0.0 out of 5 stars 

    01 Mar 2019 | BioXFEL Publications | Contributor(s): Yingchen Shi, Ke Yin, Xuecheng Tai, Hasan Demirci, Ahmad Hosseinizadeh, Brenda Hogue, Haoyuan Li, Abbas Ourmazd, Peter Schwander, Ivan A. Vartanyants, Chun Hong Yoon, Andrew Aquila, Haiguang Liu

    http://dx.doi.org/10.1107/s2052252519001854 Using X-ray free-electron lasers (XFELs), it is possible to determine three-dimensional structures of nanoscale particles using single-particle imaging methods. Classification algorithms are needed to sort out the single-particle diffraction patterns from …

  43. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data

    0.0 out of 5 stars 

    01 Mar 2019 | BioXFEL Publications

    http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.docx component Shi, Y. et al., 2019. Evaluation of the performance of classification algorithms for XFEL single-particle imaging data. Available at: http://dx.doi.org/10.1107/s2052252519001854/cw5020sup1.docx. Yingchen Shi and Ke Yin and …

  44. Shape transform phasing of edgy nanocrystals

    0.0 out of 5 stars 

    28 Feb 2019 | BioXFEL Publications | Contributor(s): J. P. J. Chen, J. J. Donatelli, K. E. Schmidt, R. A. Kirian

    http://dx.doi.org/10.1107/s205327331900113x Diffraction patterns from small protein crystals illuminated by highly coherent X-rays often contain measurable interference signals between Bragg peaks. This coherent `shape transform' signal introduces enough additional information to allow the …

  45. The Macromolecular Femtosecond Crystallography Instrument at the Linac Coherent Light Source

    0.0 out of 5 stars 

    22 Feb 2019 | BioXFEL Publications | Contributor(s): Raymond G. Sierra, Alexander Batyuk, Zhibin Sun, Andrew Aquila, Mark S. Hunter, Thomas J. Lane, Mengning Liang, Chun Hong Yoon, Roberto Alonso-Mori, Rebecca Armenta, Jean-Charles Castagna, Michael Hollenbeck, Ted O. Osier, Matt Hayes, Jeff Aldrich, Robin Curtis, Jason E. Koglin, Theodore Rendahl, Evan Rodriguez, Sergio Carbajo, Serge Guillet, Rob Paul, Philip Hart, Kazutaka Nakahara, Gabriella Carini, Hasan Demirci, E. Han Dao, Brandon Hayes, Yashas P. Rao, Matthieu Chollet, Yiping Feng, Franklin D. Fuller, Christopher Kupitz, Takahiro Sato, Matthew H. Seaberg, Sanghoon Song, Tim B. Van Driel, Hasan Yavas, Diling Zhu, Aina E. Cohen, Soichi Wakatsuki, Sébastien Boutet

    http://dx.doi.org/10.1107/s1600577519001577 The Macromolecular Femtosecond Crystallography (MFX) instrument at the Linac Coherent Light Source (LCLS) is the seventh and newest instrument at the world's first hard X-ray free-electron laser. It was designed with a primary focus on structural biology, …

  46. Following Folding Pathways of Common Riboswitch Motifs with Time-Resolved Single-Molecule FRET

    0.0 out of 5 stars 

    15 Feb 2019 | BioXFEL Publications | Contributor(s): Alex Plumridge, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.1931 poster Plumridge, A. & Pollack, L., 2019. Following Folding Pathways of Common Riboswitch Motifs with Time-Resolved Single-Molecule FRET. Biophysical Journal, 116(3), p.355a. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.1931. Alex Plumridge …

  47. Time-Resolved Contrast Variation SAXS for Studying RNA-Protein Interactions

    0.0 out of 5 stars 

    15 Feb 2019 | BioXFEL Publications | Contributor(s): Suzette A. Pabit, Andrea Katz, George Douglas Calvey, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.1733 poster Pabit, S.A. et al., 2019. Time-Resolved Contrast Variation SAXS for Studying RNA-Protein Interactions. Biophysical Journal, 116(3), p.319a–320a. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.1733. Suzette A. Pabit and Andrea M. Katz …

  48. DNA Sequence and Histone Core Composition Control the Unwrapping of DNA from Nucleosome Core Particles

    0.0 out of 5 stars 

    15 Feb 2019 | BioXFEL Publications | Contributor(s): Alex Mauney, Joshua Tokuda, Yujie Chen, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.1179 poster Mauney, A. et al., 2019. DNA Sequence and Histone Core Composition Control the Unwrapping of DNA from Nucleosome Core Particles. Biophysical Journal, 116(3), p.214a. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.1179. Alex Mauney and …

  49. Virus Dynamics Studied by Time-Resolved Small Angle X-Ray Scattering

    0.0 out of 5 stars 

    15 Feb 2019 | BioXFEL Publications | Contributor(s): Josue San Emeterio, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.2321 journal-article San Emeterio, J., & Pollack, L. (2019). Virus Dynamics Studied by Time-Resolved Small Angle X-Ray Scattering. Biophysical Journal, 116(3), 431a. https://doi.org/10.1016/j.bpj.2018.11.2321 Josue San Emeterio and Lois Pollack

  50. A novel form of allosteric regulation in Bacillus subtilis ribonucleotide reductase revealed by SAXS and cryo-electron microscopy

    0.0 out of 5 stars 

    05 Feb 2019 | BioXFEL Publications | Contributor(s): William C. Thomas, Frederick P. Brooks, Mackenzie J. Parker, David Case, Jason T. Kaelber, JoAnne Stubbe, James Chen, Nozomi Ando

    http://dx.doi.org/10.1107/s0108767318099142 journal-article Thomas, W. C., Brooks, F. P., Parker, M. J., Case, D. A., Kaelber, J. T., Stubbe, J., Chen, J., & Ando, N. (2018). A novel form of allosteric regulation in Bacillus subtilis ribonucleotide reductase revealed by SAXS and cryo-electron …

  51. Separation Phenomena in Tailored Micro- and Nanofluidic Environments

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    30 Jan 2019 | BioXFEL Publications | Contributor(s): Mukul Sonker, Daihyun Kim, Ana Egatz-Gomez, Alexandra Ros

    http://dx.doi.org/10.1146/annurev-anchem-061417-125758 journal-article Sonker, M. et al., 2019. Separation Phenomena in Tailored Micro- and Nanofluidic Environments. Annual Review of Analytical Chemistry, 12(1). Available at: http://dx.doi.org/10.1146/annurev-anchem-061417-125758. Mukul Sonker …

  52. Cysteine modification can gate non-equilibrium conformational dynamics during enzyme catalysis: Supplemental Information

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    19 Jan 2019 | BioXFEL Publications | Contributor(s): Medhanjali DasGupta, Dominik Budday, Peter Madzelan, Javier Seravalli, Brandon Hayes, Raymond G. Sierra, Roberto Alonso-Mori, Aaron S. Brewster, Nicholas K. Sauter, Gregory A. Applegate, Virendra Tiwari, David B. Berkowitz, Michael Thompson, James Fraser, Michael E. Wall, Henry Van Den Bedem, Mark A. Wilson

    http://dx.doi.org/10.1101/524751 Post-translational modification of cysteine residues can regulate protein function and is essential for catalysis by cysteine-dependent enzymes. Covalent modifications neutralize charge on the reactive cysteine thiolate anion and thus alter the active site …

  53. Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The “Undoing” of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network

    0.0 out of 5 stars 

    15 Jan 2019 | BioXFEL Publications | Contributor(s): Shenshen Hu, Adam R. Offenbacher, Erin M. Thompson, Christine L. Gee, Jarett Wilcoxen, Cody A. M. Carr, Daniil M. Prigozhin, Vanessa Yang, Tom Alber, R. David Britt, James Fraser, Judith P. Klinman

    http://dx.doi.org/10.1021/jacs.8b10992 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Hu, S. et al., 2019. Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The “Undoing” of Precise Substrate Positioning Relative to Metal Cofactor and an …

  54. The Catalytic Cycle of Water Oxidation in Crystallized Photosystem II Complexes: Performance and Requirements for Formation of Intermediates

    0.0 out of 5 stars 

    04 Jan 2019 | BioXFEL Publications | Contributor(s): Gennady Ananyev, Shatabdi Roy-Chowdhury, Colin Gates, Petra Fromme, G. Charles Dismukes

    http://dx.doi.org/10.1021/acscatal.8b04513 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Ananyev, G. et al., 2019. The Catalytic Cycle of Water Oxidation in Crystallized Photosystem II Complexes: Performance and Requirements for Formation of Intermediates. ACS Catalysis, …

  55. SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response

    0.0 out of 5 stars 

    02 Jan 2019 | BioXFEL Publications | Contributor(s): Shi-chun Du, Lan Zhu, Yu-xing Wang, Jie Liu, Die Zhang, Yu-lu Chen, Qing Peng, Wei Liu, Bin Liu

    http://dx.doi.org/10.1186/s12935-018-0722-9 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Du, S. et al., 2019. SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response. Cancer Cell International, 19(1). Available at: …

  56. Phasing Serial Crystallography Data

    0.0 out of 5 stars 

    27 Dec 2018 | BioXFEL Publications | Contributor(s): Richard Kirian, Joe Chen, John Spence

    http://dx.doi.org/10.1007/978-3-030-00551-1_8 book-chapter NSF-STC Biology with X-ray Lasers (NSF-1231306) Kirian, R.A., Chen, J.P.J. & Spence, J.C.H., 2018. Phasing Serial Crystallography Data. X-ray Free Electron Lasers, pp.235–252. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1_8. …

  57. Advances in Structure Determination of G Protein-Coupled Receptors by SFX

    0.0 out of 5 stars 

    27 Dec 2018 | BioXFEL Publications | Contributor(s): Benjamin Stauch, Linda Johansson, Andrii Ishchenko, Gye Won Han, Alexander Batyuk, Vadim Cherezov

    http://dx.doi.org/10.1007/978-3-030-00551-1_10 book-chapter Stauch, B. et al., 2018. Advances in Structure Determination of G Protein-Coupled Receptors by SFX. X-ray Free Electron Lasers, pp.301–329. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1_10. Benjamin Stauch and Linda …

  58. Small Is Beautiful: Growth and Detection of Nanocrystals

    0.0 out of 5 stars 

    27 Dec 2018 | BioXFEL Publications | Contributor(s): Jesse David Coe, Alexandra Ros

    http://dx.doi.org/10.1007/978-3-030-00551-1_3 book-chapter Coe, J. & Ros, A., 2018. Small Is Beautiful: Growth and Detection of Nanocrystals. X-ray Free Electron Lasers, pp.59–85. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1_3. Jesse Coe and Alexandra Ros

  59. X-ray Free Electron Lasers

    0.0 out of 5 stars 

    27 Dec 2018 | BioXFEL Publications

    http://dx.doi.org/10.1007/978-3-030-00551-1 book Boutet, S., Fromme, P. & Hunter, M.S. eds., 2018. X-ray Free Electron Lasers. Available at: http://dx.doi.org/10.1007/978-3-030-00551-1.

  60. Ab initio phasing of the diffraction of crystals with translational disorder

    0.0 out of 5 stars 

    20 Dec 2018 | BioXFEL Publications | Contributor(s): Andrew J. Morgan, Kartik Ayyer, Anton Barty, Joe Chen, Tomas Ekeberg, Dominik Oberthuer, Thomas A. White, Oleksandr Yefanov, Henry Chapman

    http://dx.doi.org/10.1107/s2053273318015395 To date X-ray protein crystallography is the most successful technique available for the determination of high-resolution 3D structures of biological molecules and their complexes. In X-ray protein crystallography the structure of a protein is refined …

  61. X-ray Emission Spectroscopy at X-ray Free Electron Lasers: Limits to Observation of the Classical Spectroscopic Response for Electronic Structure Analysis

    0.0 out of 5 stars 

    19 Dec 2018 | BioXFEL Publications | Contributor(s): Scott C. Jensen, Brendan Sullivan, Daniel A. Hartzler, Jose Meza Aguilar, Salah Awel, Saša Bajt, Shibom Basu, Richard Bean, Henry Chapman, Chelsie E Conrad, Matthias Frank, Raimund Fromme, Jose M. Martin-Garcia, Thomas D. Grant, Michael Heymann, Mark S. Hunter, Gihan Kaushylal Ketawala, Richard Kirian, Juraj Knoska, Christopher Kupitz, Xuanxuan Li, Mengning Liang, Stella Lisova, Valerio Mariani, Victoria Mazalova, Marc Messerschmidt, Michael Moran, Garrett Charles Nelson, Dominik Oberthür, Alex Schaffer, Raymond G. Sierra, Natalie Vaughn, Uwe Weierstall, Max Oliver Wiedorn, P. Lourdu Xavier, Jay-How Yang, Oleksandr Yefanov, Nadia Zatsepin, Andrew Aquila, Petra Fromme, Sébastien Boutet, Gerald T. Seidler, Yulia Pushkar

    http://dx.doi.org/10.1021/acs.jpclett.8b03595 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Jensen, S.C. et al., 2019. X-ray Emission Spectroscopy at X-ray Free Electron Lasers: Limits to Observation of the Classical Spectroscopic Response for Electronic Structure Analysis. The …

  62. A generalized parametric divisor method for political apportionment

    0.0 out of 5 stars 

    14 Dec 2018 | BioXFEL Publications | Contributor(s): Tatsuo Oyama, Nicholas G. Hall, Kazuhiro Kobayashi

    http://dx.doi.org/10.1111/itor.12622 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Oyama, T., Hall, N.G. & Kobayashi, K., 2018. A generalized parametric divisor method for political apportionment. International Transactions in Operational Research, 28(1), pp.327–355. Available …

  63. SPIND: a reference-based auto-indexing algorithm for sparse serial crystallography data

    0.0 out of 5 stars 

    10 Dec 2018 | BioXFEL Publications | Contributor(s): Chufeng Li, Xuanxuan Li, Richard Kirian, John Spence, Haiguang Liu, Nadia Zatsepin

    http://dx.doi.org/10.1107/s2052252518014951 SPIND (sparse-pattern indexing) is an auto-indexing algorithm for sparse snapshot diffraction patterns (`stills') that requires the positions of only five Bragg peaks in a single pattern, when provided with unit-cell parameters. The …

  64. Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor

    0.0 out of 5 stars 

    29 Nov 2018 | BioXFEL Publications | Contributor(s): Martin Audet, Kate L. White, Billy Breton, Barbara Zarzycka, Gye Won Han, Yan Lu, Cornelius Gati, Alexander Batyuk, Petr Popov, Jeffrey Velasquez, David Manahan, Hao Hu, Uwe Weierstall, Wei Liu, Wenqing Shui, Vsevolod Katritch, Vadim Cherezov, Michael A. Hanson, Raymond C. Stevens

    http://dx.doi.org/10.1038/s41589-018-0160-y journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Audet, M. et al., 2018. Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor. Nature Chemical Biology, 15(1), pp.11–17. Available at: …

  65. Dielectrophoresis: From molecular to micrometer scale analytes

    0.0 out of 5 stars 

    27 Nov 2018 | BioXFEL Publications | Contributor(s): Daihyun Kim, Mukul Sonker, Alexandra Ros

    http://dx.doi.org/10.1021/acs.analchem.8b05454 journal-article Kim, D., Sonker, M. & Ros, A., 2018. Dielectrophoresis: From molecular to micrometer scale analytes. Analytical Chemistry. Available at: http://dx.doi.org/10.1021/acs.analchem.8b05454. Daihyun Kim and Mukul Sonker and Alexandra Ros

  66. Synthesis, structure, docking and cytotoxic studies of ferrocene–hormone conjugates for hormone-dependent breast cancer application

    0.0 out of 5 stars 

    22 Nov 2018 | BioXFEL Publications | Contributor(s): José A. Carmona-Negrón, Alberto Santana, Arnold L. Rheingold, Enrique Meléndez

    http://dx.doi.org/10.1039/c8dt01856a Ferrocene–estrogen conjugates can be recognized by ERα, suggesting that estrogens could serve as vectors to target specifically breast cancer cell lines. journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Carmona-Negrón, J.A. et al., 2019. …

  67. Conformations of an RNA Helix-Junction-Helix Construct revealed by SAXS Refinement of MD Simulations

    0.0 out of 5 stars 

    22 Nov 2018 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Tongsik Lee, Ron Elber, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.11.020 journal-article Chen, Y.-L. et al., 2018. Conformations of an RNA Helix-Junction-Helix Construct revealed by SAXS Refinement of MD Simulations. Biophysical Journal. Available at: http://dx.doi.org/10.1016/j.bpj.2018.11.020. Yen-Lin Chen and Tongsik Lee …

  68. Temperature-Jump Solution X-ray Scattering Reveals Distinct Motions in a Dynamic Enzyme:

    0.0 out of 5 stars 

    22 Nov 2018 | BioXFEL Publications | Contributor(s): Michael Thompson, Benjamin A Barad, Alexander M Wolff, Hyun Sun Cho, Friedrich Schotte, Daniel M.C. Schwarz, Philip Anfinrud, James Fraser

    http://dx.doi.org/10.1101/476432 Correlated motions of proteins and their bound solvent molecules are critical to function, but these features are difficult to resolve using traditional structure determination techniques. Time-resolved methods hold promise for addressing this challenge but have …

  69. qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps

    0.0 out of 5 stars 

    20 Nov 2018 | BioXFEL Publications | Contributor(s): Gydo C. P. Van Zundert, Brandi M. Hudson, Saulo H. P. De Oliveira, Daniel A. Keedy, Rasmus Fonseca, Amelie Heliou, Pooja Suresh, Kenneth Borrelli, Tyler Day, James Fraser, Henry Van Den Bedem

    http://dx.doi.org/10.1021/acs.jmedchem.8b01292 journal-article Van Zundert, G. et al., 2018. qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps. Journal of Medicinal Chemistry. Available at: …

  70. Structure-factor amplitude reconstruction from serial femtosecond crystallography of two-dimensional membrane-protein crystals

    0.0 out of 5 stars 

    12 Nov 2018 | BioXFEL Publications | Contributor(s): Cecilia M. Casadei, Karol Nass, Anton Barty, Mark S. Hunter, Celestino Padeste, Ching-Ju Tsai, Sébastien Boutet, Marc Messerschmidt, Leonardo Sala, Garth J. Williams, Dmitry Ozerov, Matthew Coleman, Xiao-Dan Li, Matthias Frank, Bill Pedrini

    http://dx.doi.org/10.1107/s2052252518014641 Serial femtosecond crystallography of two-dimensional membrane-protein crystals at X-ray free-electron lasers has the potential to address the dynamics of functionally relevant large-scale motions, which can be sterically hindered in three-dimensional …

  71. Cryptic binding sites become accessible through surface reconstruction of the type I collagen fibril

    0.0 out of 5 stars 

    05 Nov 2018 | BioXFEL Publications | Contributor(s): Jie Zhu, Cody L. Hoop, David Case, Jean Baum

    http://dx.doi.org/10.1038/s41598-018-34616-z journal-article Zhu, J. et al., 2018. Cryptic binding sites become accessible through surface reconstruction of the type I collagen fibril. Scientific Reports, 8(1). Available at: http://dx.doi.org/10.1038/s41598-018-34616-z. Jie Zhu and Cody L. Hoop …

  72. Serial Femtosecond Crystallography at Megahertz pulse rates

    0.0 out of 5 stars 

    09 Oct 2018 | BioXFEL Publications | Contributor(s): M.O. Wiedorn, D. Oberthuer, A. Barty, H.N. Chapman

    http://dx.doi.org/10.2210/pdb6ftr/pdb component NSF-STC Biology with X-ray Lasers (NSF-1231306) Wiedorn, M.O. et al., 2018. Serial Femtosecond Crystallography at Megahertz pulse rates. Available at: http://dx.doi.org/10.2210/pdb6ftr/pdb. M.O. Wiedorn and D. Oberthuer and A. Barty and H.N. Chapman

  73. How the Conformations of an Internal Junction Contribute to Fold an RNA Domain

    0.0 out of 5 stars 

    04 Oct 2018 | BioXFEL Publications | Contributor(s): Yen-Lin Chen, Julie L. Sutton, Lois Pollack

    http://dx.doi.org/10.1021/acs.jpcb.8b07262 journal-article Chen, Y.-L., Sutton, J.L. & Pollack, L., 2018. How the Conformations of an Internal Junction Contribute to Fold an RNA Domain. The Journal of Physical Chemistry B. Available at: http://dx.doi.org/10.1021/acs.jpcb.8b07262. Yen-Lin Chen …

  74. Free-electron laser data for multiple-particle fluctuation scattering analysis

    0.0 out of 5 stars 

    02 Oct 2018 | BioXFEL Publications | Contributor(s): Kanupriya Pande, Jeffrey J. Donatelli, Erik Malmerberg, Lutz Foucar, Billy K. Poon, Markus Sutter, Sabine Botha, Shibom Basu, R. Bruce Doak, Katerina Dörner, Sascha W. Epp, Lars Englert, Raimund Fromme, Elisabeth Hartmann, Robert Hartmann, Guenter Hauser, Johan Hattne, Ahmad Hosseinizadeh, Stephan Kassemeyer, Lukas Lomb, Sebastian F. Carron Montero, Andreas Menzel, Daniel Rolles, Artem Rudenko, Marvin M. Seibert, Raymond George Sierra, Peter Schwander, Abbas Ourmazd, Petra Fromme, Nicholas K. Sauter, Michael Bogan, John Bozek, Christoph Bostedt, Ilme Schlichting, Cheryl A. Kerfeld, Petrus H. Zwart

    http://dx.doi.org/10.1038/sdata.2018.201 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Pande, K. et al., 2018. Free-electron laser data for multiple-particle fluctuation scattering analysis. Scientific Data, 5, p.180201. Available at: http://dx.doi.org/10.1038/sdata.2018.201. …

  75. Divalent ions tune the kinetics of a bacterial GTPase center rRNA folding transition from secondary to tertiary structure

    0.0 out of 5 stars 

    25 Sep 2018 | BioXFEL Publications | Contributor(s): Robb Welty, Suzette A. Pabit, Andrea Katz, George Douglas Calvey, Lois Pollack, Kathleen B. Hall

    http://dx.doi.org/10.1261/rna.068361.118 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Welty, R. et al., 2018. Divalent ions tune the kinetics of a bacterial GTPase center rRNA folding transition from secondary to tertiary structure. RNA, 24(12), pp.1828–1838. Available at: …

  76. Single-particle imaging without symmetry constraints at an X-ray free-electron laser

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    21 Sep 2018 | BioXFEL Publications | Contributor(s): Max Rose, Sergey Bobkov, Kartik Ayyer, Ruslan P. Kurta, Dmitry Dzhigaev, Young Yong Kim, Andrew J. Morgan, Chun Hong Yoon, Daniel Westphal, Johan Bielecki, Jonas A. Sellberg, Garth Williams, Filipe R.N.C. Maia, Olexander M. Yefanov, Vyacheslav Ilyin, Adrian P. Mancuso, Henry Chapman, Brenda Hogue, Andrew Aquila, Anton Barty, Ivan A. Vartanyants

    http://dx.doi.org/10.1107/s205225251801120x/it5017sup9.mp4 component Rose, M. et al., 2018. Single-particle imaging without symmetry constraints at an X-ray free-electron laser. Available at: http://dx.doi.org/10.1107/s205225251801120x/it5017sup9.mp4. Max Rose and Sergey Bobkov and Kartik Ayyer …

  77. Biological Small Angle Scattering

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    20 Sep 2018 | BioXFEL Publications | Contributor(s): Eaton E Lattman, Thomas D. Grant, Edward Snell

    http://dx.doi.org/10.1093/oso/9780199670871.001.0001 The technique of small angle solution scattering has been revolutionized in the last two decades. Exponential increases in computing power, parallel algorithm development, and the development of synchrotron, free-electron X-ray sources, and …

  78. Examples of Biological Small Angle Scattering

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    20 Sep 2018 | BioXFEL Publications | Contributor(s): Eaton E Lattman, Thomas D. Grant, Edward Snell

    http://dx.doi.org/10.1093/oso/9780199670871.003.0012 In this chapter we illustrate the biological applications of small angle scattering. We cover examples of contrast matching has been used in the neutron case and with SAXS,. time-resolved studies that have helped reveal mechanism and how SAXS or …

  79. Single-particle imaging without symmetry constraints at an X-ray free-electron laser

    0.0 out of 5 stars 

    18 Sep 2018 | BioXFEL Publications | Contributor(s): Max Rose, Sergey Bobkov, Kartik Ayyer, Ruslan P. Kurta, Dmitry Dzhigaev, Young Yong Kim, Andrew J. Morgan, Chun Hong Yoon, Daniel Westphal, Johan Bielecki, Jonas A. Sellberg, Garth Williams, Filipe R.N.C. Maia, Olexander M. Yefanov, Vyacheslav Ilyin, Adrian P. Mancuso, Henry Chapman, Brenda Hogue, Andrew Aquila, Anton Barty, Ivan A. Vartanyants

    http://dx.doi.org/10.1107/s205225251801120x The analysis of a single-particle imaging (SPI) experiment performed at the AMO beamline at LCLS as part of the SPI initiative is presented here. A workflow for the three-dimensional virus reconstruction of the PR772 bacteriophage from measured …

  80. Rayleigh-scattering microscopy for tracking and sizing nanoparticles in focused aerosol beams

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    11 Sep 2018 | BioXFEL Publications | Contributor(s): Max F. Hantke, Johan Bielecki, Olena Kulyk, Daniel Westphal, Daniel S. D. Larsson, Martin Svenda, Hemanth K. N. Reddy, Richard Kirian, Jakob Andreasson, Janos Hajdu, Filipe R. N. C. Maia

    http://dx.doi.org/10.1107/s2052252518010837 Ultra-bright femtosecond X-ray pulses generated by X-ray free-electron lasers (XFELs) can be used to image high-resolution structures without the need for crystallization. For this approach, aerosol injection has been a successful method to deliver …

  81. A New Approach to Signal Processing of Spatiotemporal Data

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    07 Sep 2018 | BioXFEL Publications | Contributor(s): Joanna Slawinska, Abbas Ourmazd, Dimitrios Giannakis

    http://dx.doi.org/10.1109/ssp.2018.8450704 proceedings-article Slawinska, J., Ourmazd, A. & Giannakis, D., 2018. A New Approach to Signal Processing of Spatiotemporal Data. 2018 IEEE Statistical Signal Processing Workshop (SSP). Available at: http://dx.doi.org/10.1109/ssp.2018.8450704. Joanna …

  82. The phase problem for two-dimensional crystals. II. Simulations

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    03 Sep 2018 | BioXFEL Publications | Contributor(s): Romain D. Arnal, Yun Zhao, Alok K. Mitra, John Spence, Rick P. Millane

    http://dx.doi.org/10.1107/s2053273318008707 Phasing of diffraction data from two-dimensional crystals using only minimal molecular envelope information is investigated by simulation. Two-dimensional crystals are an attractive target for studying membrane proteins using X-ray free-electron lasers, …

  83. Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway

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    29 Aug 2018 | BioXFEL Publications | Contributor(s): Thibault Annaval, Lu Han, Jeffrey D. Rudolf, Guangbo Xie, Dong Yang, Chin-Yuan Chang, Ming Ma, Ivana Crnovcic, Mitchell Miller, Jayashree Soman, Weijun Xu, George Phillips, Ben Shen

    http://dx.doi.org/10.1021/acschembio.8b00673 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Annaval, T. et al., 2018. Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway. ACS Chemical Biology, …

  84. Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome

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    29 Aug 2018 | BioXFEL Publications | Contributor(s): Nicole C. Woitowich, Andrei S. Halavaty, Patricia Waltz, Christopher Kupitz, Joseph Valera, Gregory Tracy, Kevin D. Gallagher, Elin Claesson, Takanori Nakane, Suraj Pandey, Garrett Charles Nelson, Rie Tanaka, Eriko Nango, Eiichi Mizohata, Shigeki Owada, Kensure Tono, Yasumasa Joti, Angela C. Nugent, Hardik Patel, Ayesha Mapara, James Hopkins, Phu Duong, Dorina Bizhga, Svetlana E. Kovaleva, Rachael St. Peter, Cynthia N. Hernandez, Wesley B. Ozarowski, Shatabdi Roy-Chowdhuri, Jay-How Yang, Petra Edlund, Heikki Takala, Janne Ihalainen, Jennifer Brayshaw, Tyler Norwood, Ishwor Poudyal, Petra Fromme, John Spence, Keith Moffat, Sebastian Westenhoff, Marius Schmidt, Emina A. Stojković

    http://dx.doi.org/10.1107/s2052252518010631 Phytochromes are red-light photoreceptors that were first characterized in plants, with homologs in photosynthetic and non-photosynthetic bacteria known as bacteriophytochromes (BphPs). Upon absorption of light, BphPs interconvert between two states …

  85. Structure of the 30S ribosomal decoding complex at ambient temperature

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    23 Aug 2018 | BioXFEL Publications | Contributor(s): E. Han Dao, Frédéric Poitevin, Raymond G. Sierra, Cornelius Gati, Yashas Rao, Halil Ibrahim Ciftci, Fulya Akşit, Alex McGurk, Trevor Obrinski, Paul Mgbam, Brandon Hayes, Casper De Lichtenberg, Fatima Pardo-Avila, Nicholas Corsepius, Lindsey Zhang, Matthew H. Seaberg, Mark S. Hunter, Mengling Liang, Jason E. Koglin, Soichi Wakatsuki, Hasan Demirci

    http://dx.doi.org/10.1261/rna.067660.118 The ribosome translates nucleotide sequences of messenger RNA to proteins through selection of cognate transfer RNA according to the genetic code. To date, structural studies of ribosomal decoding complexes yielding high-resolution data have predominantly …

  86. Megahertz data collection from protein microcrystals at an X-ray free-electron laser

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    22 Aug 2018 | BioXFEL Publications | Contributor(s): Marie Luise Grünbein, Johan Bielecki, Alexander Gorel, Miriam Stricker, Richard Bean, Marco Cammarata, Katerina Dörner, Lars Fröhlich, Elisabeth Hartmann, Steffen Hauf, Mario Hilpert, Yoonhee Kim, Marco Kloos, Romain Letrun, Marc Messerschmidt, Grant Mills, Gabriela Nass Kovacs, Marco Ramilli, Christopher M. Roome, Tokushi Sato, Matthias Scholz, Michel Sliwa, Jolanta Sztuk-Dambietz, Martin Weik, Britta Weinhausen, Nasser Al-Qudami, Djelloul Boukhelef, Sandor Brockhauser, Wajid Ehsan, Moritz Emons, Sergey Esenov, Hans Fangohr, Alexander Kaukher, Thomas Kluyver, Max Lederer, Luis Maia, Maurizio Manetti, Thomas Michelat, Astrid Münnich, Florent Pallas, Guido Palmer, Gianpietro Previtali, Natascha Raab, Alessandro Silenzi, Janusz Szuba, Sandhya Venkatesan, Krzysztof Wrona, Jun Zhu, R. Bruce Doak, Robert L. Shoeman, Lutz Foucar, Jacques-Philippe Colletier, Adrian P. Mancuso, Thomas R. M. Barends, Claudiu A. Stan, Ilme Schlichting

    http://dx.doi.org/10.1038/s41467-018-05953-4 journal-article Grünbein, M.L. et al., 2018. Megahertz data collection from protein microcrystals at an X-ray free-electron laser. Nature Communications, 9(1). Available at: http://dx.doi.org/10.1038/s41467-018-05953-4. Marie Luise Grünbein and …

  87. Scanning Compton X-ray Microscopy

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    10 Aug 2018 | BioXFEL Publications | Contributor(s): Pablo Villanueva-Perez, Sasa Bajt, Henry Chapman

    http://dx.doi.org/10.1017/s1431927618013259 journal-article Villanueva-Perez, P., Bajt, S. & Chapman, H.N., 2018. Scanning Compton X-ray Microscopy. Microscopy and Microanalysis, 24(S2), pp.182–183. Available at: http://dx.doi.org/10.1017/s1431927618013259. Pablo Villanueva-Perez and Sasa Bajt …

  88. Characterization of High Numerical Aperture Multilayer Laue Lenses

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    10 Aug 2018 | BioXFEL Publications | Contributor(s): Kevin T. Murray, Andrew J. Morgan, Mauro Prasciolu, Istvan Mohacsi, Henry Chapman, Saša Bajt

    http://dx.doi.org/10.1017/s1431927618013740 journal-article Murray, K.T. et al., 2018. Characterization of High Numerical Aperture Multilayer Laue Lenses. Microscopy and Microanalysis, 24(S2), pp.282–283. Available at: http://dx.doi.org/10.1017/s1431927618013740. Kevin T. Murray and Andrew J. …

  89. Developments Towards Imaging Nanoscale Biology with XFELs: Some Recent Examples and a Glance to the Future

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    10 Aug 2018 | BioXFEL Publications | Contributor(s): Adrian P. Mancuso, Andrew Aquila, Richard Bean, Johan Bielecki, Carsten Fortmann-Grote, Klaus Giewekemeyer, Yoonhee Kim, Ruslan Kurta, Romain Letrun, Masoud Mehrjoo, Marc Messerschmidt, Grant Mills, Adam Round, Tokushi Sato, Joachim Schulz, Marcin Sikorski, Stephan Stern, Patrik Vagovic, Thomas Tschentscher

    http://dx.doi.org/10.1017/s143192761801276x journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) Mancuso, A.P. et al., 2018. Developments Towards Imaging Nanoscale Biology with XFELs: Some Recent Examples and a Glance to the Future. Microscopy and Microanalysis, 24(S2), pp.76–77. …

  90. De novo protein structure determination by heavy-atom soaking in lipidic cubic phase and SIRAS phasing using serial synchrotron crystallography

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    08 Aug 2018 | BioXFEL Publications | Contributor(s): S. Botha, D. Baitan, K. E. J. Jungnickel, D. Oberthür, C. Schmidt, S. Stern, M. O. Wiedorn, M. Perbandt, H. N. Chapman, C. Betzel

    http://dx.doi.org/10.1107/s2052252518009223 During the past few years, serial crystallography methods have undergone continuous development and serial data collection has become well established at high-intensity synchrotron-radiation beamlines and XFEL radiation sources. However, the application …

  91. CAMP@FLASH: an end-station for imaging, electron- and ion-spectroscopy, and pump–probe experiments at the FLASH free-electron laser

    0.0 out of 5 stars 

    02 Aug 2018 | BioXFEL Publications | Contributor(s): Benjamin Erk, Jan P. Müller, Cédric Bomme, Rebecca Boll, Günter Brenner, Henry Chapman, Jonathan Correa, Stefan Düsterer, Siarhei Dziarzhytski, Stefan Eisebitt, Heinz Graafsma, Sören Grunewald, Lars Gumprecht, Robert Hartmann, Günter Hauser, Barbara Keitel, Clemens Von Korff Schmising, Marion Kuhlmann, Bastian Manschwetus, Laurent Mercadier, Erland Müller, Christopher Passow, Elke Plönjes, Daniel Ramm, Dimitrios Rompotis, Artem Rudenko, Daniela Rupp, Mario Sauppe, Frank Siewert, Dieter Schlosser, Lothar Strüder, Angad Swiderski, Simone Techert, Kai Tiedtke, Thomas Tilp, Rolf Treusch, Ilme Schlichting, Joachim Ullrich, Robert Moshammer, Thomas Möller, Daniel Rolles

    http://dx.doi.org/10.1107/s1600577518008585 The non-monochromatic beamline BL1 at the FLASH free-electron laser facility at DESY was upgraded with new transport and focusing optics, and a new permanent end-station, CAMP, was installed. This multi-purpose instrument is optimized for electron- and …

  92. Local DNA Sequence Controls Asymmetry of DNA Unwrapping from Nucleosome Core Particles

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    30 Jul 2018 | BioXFEL Publications | Contributor(s): Alexander W. Mauney, Joshua M. Tokuda, Lisa M. Gloss, Oscar Gonzalez, Lois Pollack

    http://dx.doi.org/10.1016/j.bpj.2018.07.009 journal-article Mauney, A.W. et al., 2018. Local DNA Sequence Controls Asymmetry of DNA Unwrapping from Nucleosome Core Particles. Biophysical Journal. Available at: http://dx.doi.org/10.1016/j.bpj.2018.07.009. Alexander W. Mauney and Joshua M. Tokuda …

  93. Rapid sample delivery for megahertz serial crystallography at X-ray FELs

    0.0 out of 5 stars 

    27 Jul 2018 | BioXFEL Publications | Contributor(s): Max Oliver Wiedorn, Salah Awel, Andrew J. Morgan, Kartik Ayyer, Yaroslav Gevorkov, Holger Fleckenstein, Nils Roth, Luigi Adriano, Richard Bean, Kenneth R. Beyerlein, Joe Chen, Jesse David Coe, Francisco Cruz-Mazo, Tomas Ekeberg, Rita Graceffa, Michael Heymann, Daniel A. Horke, Juraj Knoška, Valerio Mariani, Reza Nazari, Dominik Oberthür, Amit K. Samanta, Raymond G. Sierra, Claudiu A. Stan, Oleksandr Yefanov, Dimitrios Rompotis, Jonathan Correa, Benjamin Erk, Rolf Treusch, Joachim Schulz, Brenda Hogue, Alfonso M. Gañán-Calvo, Petra Fromme, Jochen Küpper, Andrei V. Rode, Saša Bajt, Richard Kirian, Henry Chapman

    http://dx.doi.org/10.1107/s2052252518008369 Liquid microjets are a common means of delivering protein crystals to the focus of X-ray free-electron lasers (FELs) for serial femtosecond crystallography measurements. The high X-ray intensity in the focus initiates an explosion of the microjet and …

  94. BioXFEL Logos

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    25 Jul 2018 | Downloads | Contributor(s): Sean Kilcullen

    Three BioXFEL logos in PNG format

  95. BioXFEL PowerPoint Template

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    24 Jul 2018 | Downloads

    A PowerPoint template to be used for all BioXFEL presentations.

  96. BioXFEL Poster Template

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    23 Jul 2018 | Downloads

    Please use this template for all BioXFEL-related posters. This version has been updated to reflect the current requirements for the 2019 Annual conference.

  97. Solving protein structure from sparse serial microcrystal diffraction data at a storage-ring synchrotron source

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    20 Jul 2018 | BioXFEL Publications | Contributor(s): Ti-Yen Lan, Jennifer L. Wierman, Mark W. Tate, Hugh T. Philipp, Jose M. Martin-Garcia, Lan Zhu, David Kissick, Petra Fromme, Robert F. Fischetti, Wei Liu, Veit Elser, Sol M. Gruner

    http://dx.doi.org/10.1107/s205225251800903x In recent years, the success of serial femtosecond crystallography and the paucity of beamtime at X-ray free-electron lasers have motivated the development of serial microcrystallography experiments at storage-ring synchrotron sources. However, especially …

  98. Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature

    0.0 out of 5 stars 

    20 Jul 2018 | BioXFEL Publications | Contributor(s): Mary E O’Sullivan, Frédéric Poitevin, Raymond G Sierra, Cornelius Gati, E Han Dao, Yashas Rao, Fulya Aksit, Halilibrahim Ciftci, Nicholas Corsepius, Robert Greenhouse, Brandon Hayes, Mark S Hunter, Mengling Liang, Alex McGurk, Paul Mbgam, Trevor Obrinsky, Fátima Pardo-Avila, Matthew H Seaberg, Alan G Cheng, Anthony J Ricci, Hasan Demirci

    http://dx.doi.org/10.1093/nar/gky693 journal-article NSF-STC Biology with X-ray Lasers (NSF-1231306) O’Sullivan, M.E. et al., 2018. Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature. Nucleic Acids Research, 46(18), pp.9793–9804. Available at: …

  99. Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature

    0.0 out of 5 stars 

    19 Jul 2018 | BioXFEL Publications | Contributor(s): Mary E. O'Sullivan, Frederic Poitevin, Raymond G. Sierra, Cornelius Gati, E. Han Dao, Yashas Rao, Fulya Aksit, Halilibrahim Ciftci, Nicholas Corsepius, Robert Greenhouse, Brandon Hayes, Mark S. Hunter, Mengling Liang, Alex McGurk, Paul Mbgam, Trevor Obrinsky, Fatima Pardo-Avila, Matt Seaberg, Alan G. Cheng, Anthony J. Ricci, Hasan Demirci

    http://dx.doi.org/10.1101/372144 The bacterial 30S ribosomal subunit is a primary antibiotic target. Despite decades of discovery, the mechanisms by which antibiotic binding induces ribosomal dysfunction are not fully understood. Ambient temperature crystallographic techniques allow more …

  100. Orientation and analysis of XFEL serial diffraction patterns from fibrous molecular assemblies

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    05 Jul 2018 | BioXFEL Publications | Contributor(s): David H. Wojtas, Kartik Ayyer, Mengning Liang, Estelle Mossou, Carolin Seuring, V. Trevor Forsyth, Henry Chapman, Rick P. Millane

    http://dx.doi.org/10.1109/ivcnz.2017.8402508 proceedings-article Wojtas, D.H. et al., 2017. Orientation and analysis of XFEL serial diffraction patterns from fibrous molecular assemblies. 2017 International Conference on Image and Vision Computing New Zealand (IVCNZ). Available at: …